경부 갑상선의 유두상 미세암과 동반된 원발성 이소성 종격동내 갑상선종

홍사민,봉진구,방정현<SUP>1<.SUP>,신미정<SUP>2<.SUP>,김현옥<SUP>3<.SUP>,Sa Min Hong,M.D.,Jin Gu Bong,M.D.,Cheong Hyun Bang,M.D.<SUP>1<.SUP>,Mi Jeong Shin,M.D.<SUP>2<.SUP> and Hyun Ok Kim,M.D.<SUP>3<.SUP> 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1

True primary mediastinal ectopic goiters are quite rare, and they occur in less than 1% of all goiters. We report here on a case in which a primary mediastinal ectopic goiter was accompanied with papillary microcarcinoma of the cervical thyroid. The mediastinal ectopic goiter was not connected to the cervical thyroid and its blood was supplied from intrathoracic vessels, which necessitated a thoracotomy or sternotomy for removal rather than a standard cervical collar incision. We performed total thyroidectomy for the papillary microcarcinoma of the cervical thyroid gland and transsternal removal for the mediastinal goiter; this resulted in a favorable outcome. (Korean J Endocrine Surg 2006;6:50-54)

수종 생약이 흰쥐의 유 분필에 미치는 효과

홍사민(Sa Min Hong),이은방(Eun Bang Lee),우원식(Won Sick Woo) 한국생약학회 1984 생약학회지 Vol.15 No.1

In order to evaluate four plants such as Tribulus terrestris (Zygophyllaceae) , Taraxacum platycarpum (Compositae) Chelidonium majus (Papaveraceae) and Panax ginseng (Araliaceae) for the promotion activity of milk secretion, methanol extracts were given to rats to observe the effects on milk yield, development of mammary gland and DNA and RNA contents in the gland. Milk yield were evaluated daily by weighing the litters before and after suckling from 5 to 14 days post-partum, according to the method of C.S. Nicoll et al. On 15th day post-partum, the development of mammary gland was measured by weighing the abdominal mammary gland, and DNA and RNA contents were assayed by H.A. Tucker et al. and by W.Mejbaum, respectively. The extract of T. terrestris showed considerable increase in milk yield and the extract of Tplatycarpum exhibited considerable promotion of mammary gland development. For further study the two extracts were partitioned with hexane and water. DNA and RNA contents in mammary gland and RNA/DNA ratio were not influenced significantly by treatment of the fractions. The water soluble fraction of T. terrestris only, however, showed 40.3% increase in milk yield as compared with control group.

인간 섬유아세포에 대한 마이토마이신 C와 피르페니돈의 독성과 항섬유화효과

박경수,홍사민,이주카요코,김찬윤,성공제.Kyoung Soo Park. MD. Sa Min Hong. MD. Yoko Iizuka. MD. PhD. Chan Yun Kim. MD. Gong Je Seong. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.7

<b>Purpose:</b> The cytotoxicities and anti-fibrotic effects of mitomycin C and pirfenidone on human dermal fibroblast were evaluated. <b>Methods:</b> Initially, 24-hour cell cultures were exposed to transforming growth factor (TGF)-β1, different concentrations of mitomycin C, and pirfenidone solutions in order to evaluate cytotoxicity. Expressions of fibronectin, collagen type 1, α smooth muscle, and β-actin were evaluated by real-time reverse transcription-polymerase chain reaction (RT-PCR) and western blot in mitomycin C solutions at concentrations of 4 μg/mL and 20 μg/mL, and in pirfenidone solutions at 250 μg/mL and 500 μg/mL. <b>Results:</b> In comparison to cell cultures exposed to TGF-β1 solutions, cytotoxicities were increased in solutions of mitomycin C at 4 μg/mL, 20 μg/mL, 40 μg/mL and pirfenidone at 500 μg/mL, 750 μg/mL, 1,000 μg/mL (<em>p</em> < 0.05, Mann Whitney U-test). The results of real-time RT-PCR show that expressions of fibronectin, collagen type 1, and α smooth muscle were significantly more decreased in all concentrations of mitomycin C and pirfenidone compared to those in TGF-β1 solution. In western blot analysis, expressions of fibronectin and α smooth muscle were decreased in all concentrations of mitomycin C and pirfenidone compared to TGF-β1 solution. <b>Conclusions:</b> Both drugs have cytotoxicities and anti-fibrotic effects, but pirfenidone was found to have less cytotoxicity and mitomycin C was found to have more anti-fibrotic effects when compared to each other. J Korean Ophthalmol Soc 2014;55(7):1077-1083

갑상선 유두상 미세암에서 수술범위를 결정하는 데 수술 전 초음파의 유용성

전종현,홍사민,박진현,백선미<SUP>1<,SUP>,정민희<SUP>2<,SUP>,봉진구,Chong Hyun Jeon,M,D,Sa Min Hong,M,D,Jin Hyun Park,M,D,Sun Mi Paik,M,D,<SUP>1<,SUP>,Min Hee Jeong,M,D,<SUP>2<,SUP> and Jin Gu Bong,M,D 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.2

Purpose: Usually papillary microcarcinoma (PMC) grows very slowly with a good prognosis, although it frequently metastasizes to regional lymph nodes and shows multiple tumor formation in the thyroid. Therefore, how to treat papillary microcarcinoma has been controversial. Recently several studies reported that some ultrasonographic features may potentially reflect the biological aggressiveness of a lesion. We investigated which ultrasonographic findings can reflect aggressive characteristics and whether US can helpful in selecting the appropriate surgical treatment of PMC. Methods: We retrospectively reviewed the preoperative ultrasonographic findings and pathologic risk factors of 68 patients who had undergone surgical treatment for PMC at the Wallace Memorial Baptist Hospital from January 2004 to December 2005. Results: The incidences of multifocality, extrathyroidal extension, and lymph node metastasis of PMC were 42.6%, 48.5% and 20.6%, respectively. The Mean sizes of PMC were no significant differences according to age, multifocality, extrathyroidal extension, lymph node metastasis, stage and AMES risk group, and tumor size more than 5 mm was not linked to pathologic prognostic factors. Cases demonstrating multiple nodules in the unilateral or bilateral lobes, as well as those with fine strong calcifications in the tumor on US, were directly linked to multifocality on pathologic finding. US is insensitive technique for detecting lymph node metastasis and it’s sensitivity was only 14.3%, but it’s positive predictive value and specificity were high (100%). Conclusion: The date suggested that complete surgery with appropriate nodal dissection should be performed in patients with PMC which their US demonstrating multiple nodules in the unilateral or bilateral lobes, fine strong calcifications echoes in tumor and US-detected node metastasis. (Korean J Endocrine Surg 2006;6:68-76)

만성 신부전 환자에서 발생한 요독성 시신경병증

이지민(Ji Min Lee),홍사민(Sa min Hong),김찬윤(Chan Yun Kim),성공제(Gong Je Seong) 대한안과학회 2016 대한안과학회지 Vol.57 No.7

목적: 만성 신부전 환자에서 발생한 요독성 시신경병증(uremic optic neuropathy) 1예를 보고하고자 한다. 증례요약: 만성 신부전으로 10년 전부터 복막 투석, 7년 전부터 혈액 투석을 받고 있는 40세 남자 환자가 2일 전부터 좌안으로 보면 어둡게 가려 보이고 눈동자를 돌릴 때 발생하는 통증과 압박감을 주소로 내원하였다. 우안은 특이소견이 발견되지 않았으나, 좌안은 최대교정시력이 0.2였고 시야 검사에서 하측 수평 시야 결손이 나타났으며 안저 검사 및 빛간섭단층촬영 검사에서 시신경부종이 관찰 되었다. 좌안의 요독성 시신경병증 또는 앞허혈시신경병증이 의심되어 혈액 투석과 고용량 스테로이드 정맥 주사를 시행하였다. 치료 후 좌안의 최대교정시력은 0.8로 회복되었으나, 환자가 경구 스테로이드 유지 요법을 자의적으로 중단한 후 좌안의 최대교정시력은 0.4로 다시 악화되었다. 환자가 추가적인 전신 스테로이드 치료를 거부하여 테논낭하에 스테로이드를 주사하였으며, 이후 좌안 최대 교정시력은 1.0으로 회복되었고 안정적인 경과를 보이고 있다. 결론: 만성 신부전 환자에서 갑작스러운 시력 저하와 시야 장애가 발생한 경우 요독성 시신경병증을 비롯한 여러 시신경병증의 가능성을 염두에 두어야 하며, 요독성 시신경병증으로 판단될 경우 신속한 혈액 투석과 스테로이드의 병행 치료를 통해 시력의 호전을 도모할 수 있다. 〈대한안과학회지 2016;57(7):1187-1191〉 Purpose: To report a case of uremic optic neuropathy occurring in a patient with chronic renal failure. Case summary: A 40-year-old male who was diagnosed with chronic renal failure and treated with peritoneal dialysis and hemodialysis for 17 years presented with blurred vision and a moving pain in his left eye for 2 days. The best corrected visual acuity (BCVA) was 0.2 in his left eye, and an inferior altitudinal visual field defect was noted on Humphrey perimetry. Fundus examination and optical coherence tomography showed optic disc swelling in his left eye; the right eye was unremarkable. These findings were compatible with a diagnosis of uremic optic neuropathy or anterior ischemic optic neuropathy of his left eye. After treatment of hemodialysis and intravenous high dose steroid pulse therapy, the BCVA in his left eye was 0.8. However, since he refused oral steroid maintenance therapy, his BCVA later decreased to 0.4. After treatment with subtenon triamcinolone injection, the BCVA in his left eye was 1.0 and showed a stable disease course. Conclusions: When patient with chronic renal failure presents with acute decrease in visual acuity and visual field defect, optic neuropathies including uremic optic neuropathy should be considered and prompt hemodialysis and systemic steroid treatment should be done. J Korean Ophthalmol Soc 2016;57(7):1187-1191

선형회귀 기반 추론 방법을 이용한 게임요소와 게임콘텐츠 소모 시간 간의 연관성 정량화 기법

최정근(Jeong-Geun Choi),신종하(Jong-Ha Shin),이재연(Jae-Yeun Lee),홍사민(Sa-Min Hong),정진우(Jin-Woo Jung) 한국정보기술학회 2019 Proceedings of KIIT Conference Vol.2019 No.6

백내장 수술 후 스펙트럼영역 빛간섭단층촬영에서 나타나는 신경절세포-내망상층 두께 변화

신우범(Woo Beom Shin),정현교(Hyun Kyo Jeong),김지현(Ji Hyun Kim),이준모(Jun Mo Lee),홍사민(Sa Min Hong),김찬윤(Chan Yun Kim),성공제(Gong Je Seong),박경수(Kyoung Soo Park) 대한안과학회 2015 대한안과학회지 Vol.56 No.11

목적: 백내장 수술 전후 스펙트럼영역 빛간섭단층촬영에서 나타나는 신경절세포-내망상층 두께 변화 양상을 알아보고자 하였다. 대상과 방법: 백내장 수술을 받은 33명, 43안을 대상으로 하였다. 백내장 수술 전후로 스펙트럼영역 빛간섭단층촬영을 이용, 시신경유 두 주위 망막신경섬유층 두께, 신경절세포-내망상층 두께를 측정하였다. 신호강도, 사분면, 시구역 망막신경섬유층 두께, 구획별 신경 절세포-내망상층 두께 등의 자료를 비교 분석하였다. 결과: 백내장 수술 후 신호강도, 망막신경섬유층, 신경절세포-내망상층 두께 모두 증가하는 것으로 조사되었다( p <0.05). 다중회귀분 석상 수술 후 신호강도변화에 영향을 주는 인자는 망막신경섬유층의 경우 술 전 내피세포 수, 술 전 신호강도였고, 신경절세포-내망 상층의 경우 술 전 신호강도였다. 단변량회귀분석상 수술 후 망막신경섬유층 두께 변화에 영향을 주는 인자는 나이였고, 신경절세포-내망상층 두께 변화에 영향을 주는 인자는 통계적으로 유의한 결과가 나오지 않았다( p <0.05). 결론: 백내장이 있는 경우 빛간섭단층촬영에 나타나는 수술 전 시신경유두 주위 망막신경섬유층뿐만 아니라 신경절세포-내망상층도 두께와 신호강도가 낮게 나타날 수 있어서 결과해석 시 백내장 정도에 의한 영향을 고려하여야 한다. Purpose: To assess changes in ganglion cell-inner plexiform layer (GCIPL) thickness after cataract surgery using spectral-do-main optical coherence tomography (OCT). Methods: Forty-three eyes of 33 patients, who underwent cataract surgery were imaged with spectral-domain OCT before and after surgery to measure peripapillary retinal nerve fiber layer (RNFL) and GCIPL thickness, signal strength (SS), quadrant, 12 clock-hour RNFL thickness and sectoral GCIPL thickness. Results: The postoperative SS, RNFL and GCIPL thickness were higher than before surgery (p < 0.05). Multivariate analysis showed that endothelial cell count and preoperative SS were significantly correlated with SS changes in RNFL parameters and preoperative SS was significantly correlated with SS changes in GCIPL parameters. Univariate analysis indicated that age was significantly correlated with RNFL thickness changes in RNFL parameters and no factor was correlated with GCIPL thickness in GCIPL parameters (p < 0.05). Conclusions: Cataracts may decrease peripapillary RNFL and GCIPL thickness measurements and SS on OCT scans. Peripapillary RNFL and GCIPL thickness measurements should be interpreted with caution in eyes with significant cataracts.