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게르마늄 복합물 STB-HO-BM의 랫드 및 비글견에서 단회투여 독성연구
송시환(Si Whan Song),정연권(Winston Jung),홍동호(Dong Ho Hong) 한국독성학회 2006 Toxicological Research Vol.22 No.2
The acute toxicity of STB-HO-BM was evaluated in Sprague Dawley (SD) rats and beagle dogs. STB-HO-BM was administered orally to rats at dose levels of 0 and 2,000 ㎎/㎏/day and to dogs at dose levels of 0, 500, 1,000 and 2,000 ㎎/㎏/day. In these experiments, there were no death and clinical changes which were related to STB-HO-BM administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of STB-HO-BM 2,000 ㎎/㎏ in SD rats and up to 2,000 ㎎/㎏ in beagle dogs was proved to be safe, and it is thought that STB-HO-BM may not show any toxicity in its clinical use.
랫드에서 STB-HO-BM에 대한 13주 반복투여 독성연구
송시환(Si Whan Song),정연권(Winston Jung),홍동호(Dong Ho Hong) 한국독성학회 2006 Toxicological Research Vol.22 No.2
This study was performed to evaluate repeated-dose toxicities of STB-HO-BM in Sprague-Dawley rats. STB-HO-BM was administered orally to rats at dose levels of 0, 100, 300 and 1,000 mg/kg/day for 13 weeks. In recent study, there were no dose related changes in mortality, clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, hematological findings, and biochemical examination of all animals treated with STB-HO-BM. Gross and histopathological findings revealed no evidence of specific toxicity related to STB-HO-BM. These results suggest that the oral no observed adverse effect level (NOAEL) of STB-HO-BM may be over 1,000 mg/kg in rats.
게르마늄 복합물인 STB-HO-BM에 대한 유전독성에 관한 연구
송시환(Si Whan Song),정연권(Winston Jung),홍동호(Dong Ho Hong) 한국독성학회 2006 Toxicological Research Vol.22 No.2
We have investigated the genotoxicity of STB-HO-BM using in vitro and in vivo system such as Ames reverse mutation test, chromosomal aberration test and micronucleus test. in Ames reverse mutation test, STB-HO-BM treatment at the dose range up to 5,000 ug/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA102, TA1535, TA1537 and in Escherichia coli WP2 uvrA with and without metabolic activation. Any significant aberration wasn’t observed in chinese hamster lung (CHL) fibroblast cells treated with STB-HO-BM at the concentration of 12.5, 2.5, 5 ㎎/㎖ both in the absense and presence of metabolic activation system. In mouse micrnucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in ICR male mice orally administered with STB-HO-BM at the doses of 0.5, 1.0, 2.0 g/㎏. These results indicate that STB-HO-BM has no mutagenic potential under the condition in this study.
중등학교 축구선수의 셀프리더십이 운동몰입 및 운동성과에 미치는 영향
홍동호(Hong, Dong-Ho),정진욱(Jung, Jinuk) 한국체육과학회 2021 한국체육과학회지 Vol.30 No.5
In this study, to investigate the effect of self-leadership of secondary school soccer players on athletic immersion and athletic performance, secondary school enrolled in secondary school enrolled in the secondary school in region A to conduct an empirical study of secondary school soccer players For football players, 250 copies were collected using the convenience sampling method. Among the collected questionnaires, 224 valid samples were obtained, excluding 26 copies of questionnaires that were considered inappropriate as research data, such as missing entries, double entries, and biased entries. For data analysis regression analysis were performed using SPSS version 18.0. The research results are as follows. First. self-leadership according to the personal characteristics of secondary school soccer players showed a significant difference in behavior-oriented (p <.05) depending on the position. Second, self-leadership of secondary school soccer players was found to have a significant effect on cognitive commitment and behavioral commitment, which are sub-factors of exercise commitment. Third, the immersion of secondary school soccer players has a significant effect on athletic performance. Fourth, self-leadership of secondary school soccer players was found to have a significant effect on athletic performance and one of the sub-factors.
대남광산 농경지 토양 내 중금속 특성에 따른 물리적 선별 처리효율에 관한 연구
박찬오,홍동호,이재영,이영재,이진수,ParK, Chan Oh,Hong, Dong-Ho,Lee, Jai-Young,Lee, Young Jae,Lee, Jin-Soo 한국지하수토양환경학회 2013 지하수토양환경 Vol.18 No.5
The main objective was to evaluate the efficiencies of different separation techniques, such as gravity separation, magnetic separation, and aerial separation. Zinc and cadmium removal efficiencies by gravity separation and magnetic separation were 28.3~29.3% and 19.1%, respectively, and were higher than the efficiency obtained by aerial separation. Results showed that the combination of gravity separation and magnetic separation in series which was to maximize the removal efficiencies gave removal efficiency of 21.5~38.7% for zinc and 22.1~23.4% for cadmium. The mass of soil meeting the regulation standards for zinc and cadmium after retrieval from the combined separation process accounted for approximately 80% of the treated soil that would be reusable without the pre-treatment procedure as the neutralization process using in the soil washing method. Physical separation techniques utilizing heavy metal properties are the alternative method to remediate heavy-metal contaminated soils in environmental and economic aspects.
CDMA 통신망의 하드핸드오프 지원을 위한 적응형 파일럿 비콘에 관한 연구
정기혁,홍동호,홍완표,나극환,Jeong Ki Hyeok,Hong Dong Ho,Hong Wan Pyo,Ra Keuk Hwawn 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.10A
본 논문에서는 직접대역 확산 통신 기법을 사용하는 이동통신 시스템에서 하향링크상의 무선신호를 이용하여 오버헤드 채널상의 정보를 취득하고 이 정보를 이용하여 파일롯 채널을 생성함으로써 기지국 간 하드핸드오프를 가능하게 하는 적응형 파일롯 비콘 장치를 제안한다. 본 적응형 파일롯 비콘 장치는 무선 신호 중에서 파일롯 채널 만을 선별하여 생성 및 전송하므로 상대적으로 낮은 전력으로 서비스가 가능하며, CDMA 수신부에서 하향링크상의 파일롯 채널로부터 기지국의 시간동기 및 주파수 동기를 획득하여 장치의 오프셋을 보정하므로 GPS에 의한 시간동기가 필요하지 않으며 기지국 순방향 신호의 수신이 가능한 임의의 장소에 설치가 가능한 장점이 있다. CDMA수신기에서 하향링크 파일롯 신호를 탐색하는 파일롯 서처는 FPGA와 DSP를 이용하며, FPGA에서 구현된 파일롯 서처는 초기동기 획득용으로 사용되곤 DSP에서 구현되는 파일롯 서처는 비콘장치의 클럭과 기지국 장치의 클럭사이에 발생하는 오프셋 오차를 보정하는 역할을 수행한다. 적응형 파일롯 비콘 장치의 CDMA 송신부는 CDMA 수신부에서 취득한 파일롯 채널의 시간정보인 타임오프???V을 이용하여, 기지국에 동기된 하향링크 파일롯 신호를 생성한다. FIR필터를 통하여 출력된 1차 중간주파신호는 RF모듈웨서 상향변환된 후 고출력증폭기와 안테나를 통하여 방사하게 된다. This paper proposes an adaptive pilot beacon equipment for mobile communication systems based on direct spread spectrum technology which generates the pilot channel for handoff between base stations by using the information acquired from the downstream wireless signal regarding the overhead channel information. Such an adaptive pilot beacon equipment will enable low power operation since among the wireless signals, only the pilot channel will be generated and transmitted. The pilot channel in the downstream link of the CDMA receiver is used to acquire time and frequency synchronization and this is used to calibrate the offset for the beacon, which implies that time synchronization using GPS is not required and any location where forward receive signal can be received can be used as the installation site. The downstream link pilot signal searching within the CDMA receiver is performed by FPGA and DSP. The FPGA is used to perform the initial synchronization for the pilot searcher and DSP is used to perform the offset correction between beacon clock and base station clock. The CDMA transmitter the adaptive pilot beacon equipment will use the timing offset information in the pilot channel acquired from the CDMA receiver and generate the downstream link pilot signal synchronized to the base station. The intermediate frequency signal is passed through the FIR filter and subsequently upconverted and amplified before being radiated through the antenna.
권철희,홍동호,이동언,이종순,김영빈,Kwon, Cheol-Hee,Hong, Dong-Ho,Lee, Dong-Yun,Lee, Jong-Soon,Kim, Young-Vin 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.6
In this paper, we have proposed the design and implementation for efficient Command Control and Alert(C2A). Information fusion must be done for knowing the state and identification of targets using multi-sensor. The threat priority of targets which are processed and identified by information fusion is calculated by air-defence operation logic. The threat targets are assigned to the valid and effective weapons by nearest neighborhood algorithm. Furthermore, the assignment result allows operators to effectively operate C2A by providing the operators with visualizing symbol color and the assignment pairing color line. We introduce the prototype which is implemented by the proposed design and algorithm.
새로운 관절염 CONP01의 생식독성연구: 랫드 배·태자 발생시험
이정숙(June-Suk Lee),홍동호(Dong Ho Hong),김광호(Kwang-Ho Kim),장호송(Hu-Song Zhang),길기현(Gi Hyun Gil),한명규(Myong Kyu Han),양현주(Hyun Ju Yang),배진숙(Jin-Sook Bae),김남두(Nam Du Kim),송시환(Si Whan Song) 한국독성학회 2005 Toxicological Research Vol.21 No.1
A developmental study of CONP01, a new antiarthritic agent, was conducted in Sprague- Dawley rats. Dosage of CONP01 0, 111, 333, and 1000 mg/kg/day were administered to dams orally from day 6 to day 16 of gestation. Two-third of dams per group were subjected to caesarean section on day day 20 of pregnancy for examination of their fetuses, and the remaining one-third of dams per group were allowed to deliver naturally for postnatal examination of their offspring. There was no change in the dams body weights, food consumptions, specific clinical sings and gross findings. There was significant decrease only in the absolute and relative weights of right ovary in 111 mg/kg treatment group, when compared with the vehicle control, whereas other organ weights were not changed. Moreover, no increase in the frequencies of external, visceral and skeletal malformation of fetuses were observed in the treated groups. These results suggest that the oral NOAEL (no observed adverse effect level) of CONP01 may be over 1,000 mg/kg in dams and fetuses of rats.