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석고(石膏)가 streptozotocin 으로 유발된 rat의 당뇨병성(糖尿炳性) 신증(腎症)에 미치는 영향(影響)
홍광해,이권호,정기훈,김용성,이현주,Hong, Gwang-Hae,Lee, Kwun-Ho,Jeong, Gi-Hoon,Kim, Young-Seong,Lee, Hyun-Ju 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : The aim of present study was to investigate recovery effects of gypsum, which has been used clinically in diabetes therapy. Methods : We established three groups, normal, control, and gypsum, and assigned 6 rats to each group. The normal group was not treated by any process and fed normal saline. The control & gypsum groups were administered streptozotocin(STZ) to induce diabetes. Gypsum extract was orally administered to the gypsum group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, level of glycation end-product (AGE) and transforming growth factor ($TGF-{\beta}1$) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex. renal transforming growth factor ($TGF-{\beta}1$) expression, macrophage/monocyte antigen (ED-1), and type IV collagen expression were studied. Results : The following results were obtained. The protein amount in urine per 24hrs of the gypsum-treated group as compared to the control was significantly reduced. The BUN and creatinine level in serum of the gypsum-treated group as compared to the control was significantly inhibited. The construction change in the kidneys of the gypsum-treated group as compared to the control was significantly inhibited. The factor of the gypsum-treated group as compared to the control was significantly inhibited. which induced the structural change in the kidneys. Conclusions : The above results suggest that gypsum partially improved kidney function.
중풍 후 운동장애에 대한 지황음자(地黃飮子) 투여 2례
홍광해,이현주,황규동,Hong, Gwang-Hae,Lee, Hyun-Ju,Hwang, Kyu-Dong 대한중풍순환신경학회 2008 대한중풍.순환신경학회지 Vol.9 No.1
Cerebrovascular disease causes various symptoms like hemiparalysis, facial palsy, dysphagia, dysphasia etc. Although patients take lots of time to treatment, there are many cases symptoms could not be cured completely and patients could get sequelae. Jihwangeumja(dihuangyinzi) is used the cerebrovascular disease with dysphasia and motor impairment of the lower extremities due to weakness of kidney. The purpose of this study was to investigate the effect of Jihwangeumja on lower extremity weakness caught by cerebrovascular disease. In this study, we administered Jihwangeumja to two stroke patients with lower extremity weakness and analyzed the clinical progresses. As a result of the treatment, patients showed improved symptoms.
과민성(過敏性) 대장증후군(大腸症候群)에 대한 문헌적(文獻的) 고찰(考察)
조윤성,정종안,홍광해,정경아,Cho, Yoon-Sung,Jung, Jong-An,Hong, Gwang-Hae,Jeong, Kyoung-Ah 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.2
Objective & Methods : Irritable Bowel Syndrome is occurred frequently in daily life. Nevertheless. medical treatment of the Irritable Bowel Syndrome is almost dependent on western cure, but that cure is not effective enough. So we chose the oriental medicine textbook that were dealing with the oriental concept and the treatment of Irritable Bowel Syndrome. we got these results. Results were as follows : 1. Irritable Bowel Syndrome is characterised by recurrent or chronic abdominal pain, with distension, disturbed defecation and psychic problems without organic lesions. 2. The etiology of Irritable Bowel Syndrome include stress. disharmony of liver and spleen, the coldness of spleen and kidney and the lack of qi or yin, etc. 3. The oriental treatments of Irritable Bowel Syndrome are warming spleen and kidney, easing liver and stopping diarrhea. 4. The internal medication of Irritable Bowel Syndrome was the most used 11 times Tongsayobang(痛瀉要方) and 10 times Yijungtang(理中湯). 5. The most many used herb were Atractylodjs macrocephalae rhjzoma(白朮), Gjnseng Radix (人蔘), Cjnnamomj Cortex(肉桂), Polyporus(猪笭), etc.