http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
간이혈당측정기를 이용한 정맥 혈당 측정의 타당성 검증 - 간이혈당측정기의 타당성 검증 -
홍경섭,배균섭,임형석,정재용,김묘경,백정미,강경자,박귀주,신상구,장인진,Hong, Kyoung-Sup,Bae, Kyun-Seop,Lim, Hyeong-Seok,Chung, Jae-Yong,Kim, Myo-Kyoung,Baik, Jung-Mi,Kang, Kyoung-Ja,Park, Gui-Ju,Shin, Sang-Goo,Jang, In-Jin 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.1
Background : Measurement of blood glucose is a basic part of patient care. Increasingly, blood glucose measurement has become a part of self-care. Devices featuring convenience and quickness are used to measure blood glucose and are used in settings often unsupervised by knowledgeable health care personnel. In this context, a validation test of a handy assurances that the devices that they are using or purchasing are capable of producing valid results. Method : In this study, we fulfilled requirements from the ICH Q2 guidelines for assurance of accuracy, precision, linearity and range. From the two subjects, blood glucose was measured repeatedly at post-prandial 1h/2h/3h/4h, 12 times each, by two investigators and with two instruments. Then, we compared the results of a handy blood sugar measuring instrument with those of a chemistry analyzer, Hitachi 7070 auto-analyzer, in a core laboratory in Clinical Trial Center, Seoul National University Hospital. Results : Mean accuracy, intra-assay precision and intermediate precision were 92.6%, 2.3%(min. 1.07%, max. 4.51%), 1.73%(min. 0%, max. 5.65%) each. In scatter plot of the results of a handy blood sugar measuring instrument and Hitachi 7070 auto-analyzer, linearity was apparent and the correlation coefficient(r), $r^2$ was 0.986 and 0.972 each. Conclusions : Mean accuracy was not satisfactory regarding the criteria for quality control of blood glucose $measurement(within {\pm}5%)$ in SNUH. The intermediate precision was also not satisfactory regarding the criteria for Quality Control (less than 5%).
홍경섭 ( Kyoung Sup Hong ),박규주 ( Kyu Joo Park ),박성혜 ( Sung Hye Park ),김상균 ( Sang Gyun Kim ),정현채 ( Hyun Chae Jung ),송인성 ( In Sung Song ),김주성 ( Joo Sung Kim ) 대한장연구학회 2008 Intestinal Research Vol.6 No.2
Chronic colonic pseudo-obstruction is a rare disease that results in colorectal dilatation without any obstructing lesions. Colonic dilatation does not usually cause colonic wall thickening and colonic visceral myopathy with muscular hypertrophy has not been reported in Korea. A 31-year-old female patient was transferred for treatment of refractory constipation accompanied by megacolon. She had suffered from recurrent attacks of severe abdominal pain with the sensation of a mass in the left lower quadrant. An abdominal CT revealed a large luminal dilatation of the sigmoid colon where massive stool was impacted. There was no obstructing lesion or luminal dilatation of the rectum. To relieve her refractory symptoms, a total colectomy with an ileorectal anastomosis was performed. Pathologic examination of the sigmoid colon revealed that the muscle layers were dysplastic and hypertrophied, and the innervations into the muscle fibers were markedly decreased. She was discharged without any intra-abdominal symptoms. (Intest Res 2008;6:145-149)
거대 우심실 종양혈전을 동반한 간내 육종양 담관암 1예
홍경섭 ( Kyoung Sup Hong ),김인경 ( In Kyoung Kim ),이재경 ( Jae Kyung Lee ),김진원 ( Jin Won Kim ),김혜령 ( Hae Ryoung Kim ),황진혁 ( Jin Hyeok Hwang ) 대한내과학회 2008 대한내과학회지 Vol.75 No.5
원발성 간암 중 간내 담관암은 간세포암에 비해 더욱 예후가 나쁜 종양으로, 드물게 육종양 변화가 보고된 바 있다. 저자들은 진단 당시 광범위한 원격 및 국소 전이, 다량의 우심실 혈전이 동반되어 있었고, 조직검사 및 면역조직화학염색으로 간내 육종양 담관암으로 확진 된 1예를 문헌고찰과 함께 보고하는 바이다. A 69-year-old female patient presented with a huge liver mass at another hospital. Computed tomography (CT) revealed a huge, well-demarcated, low-attenuated mass in the right lobe of the liver and multiple nodules in both lungs. The liver mass invaded the colon at the hepatic flexure and infiltrated into the retroperitoneum. Spiral CT revealed a huge tumor thrombus in the right ventricle (RV). The enhancement pattern of the right ventricular mass was identical to that of the liver mass. After ultrasonography-guided needle biopsy of the liver mass, the patient was diagnosed with intrahepatic sarcomatoid cholangiocarcinoma. Although we recommended debulking open-heart surgery for the prevention of sudden death caused by massive pulmonary embolism, the patient and her family opted against surgery due to high operation-related mortality and old age. The patient later died of massive pulmonary embolism at another hospital a few weeks later. (Korean J Med 75:569-573, 2008)
홍경섭 ( Kyoung Sup Hong ),정기욱 ( Kee Wook Jung ),이태희 ( Tae Hee Lee ),이봉은 ( Bong Eun Lee ),박선영 ( Sun Young Park ),신정은 ( Jeong Eun Shin ),김성은 ( Seong Eun Kim ),박경식 ( Kyung Sik Park ),최석채 ( Suck Chei Choi ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.3
Chronic constipation is a very common clinical problem with its prevalence of up to 14% in the general population. It is not a life-threatening disease, but since patient``s satisfaction to the treatment is known to be as low as 50%, chronic constipation still remains a clinically challenging problem. Fortunately, many new treatments have been introduced or are to be introduced in the near future. This article will review the basic concepts and the results of recent studies on the new treatments for chronic constipation. (Korean J Gastroenterol 2014;64:148-153)
건강한 한국인 자원자에서 테가세로드(Tegaserod) 반복 투여에 의한 안전성 및 약동학 평가
정재용,임형석,홍경섭,배균섭,유경상,조주연,이소영,고재욱,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Hong, Kyoung-Sup,Bae, Kyun-Seop,Yu, Kyung-Sang,Cho, Joo-Youn,Yi, So-Young,Ko, Jae-Wook,Jang, In-Jin,Shin, Sang-Goo 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2
Background: Tegaserod is a selective partial agonist at the $5HT_4$ receptor. Tegaserod belongs to a new class of agents in development for the treatment of functional motility disorders of the gastrointestinal(GD tract. This Phase I clinical study was conducted to evaluate the safety and pharmacokinetics(PK) of tegaserod in Korean for bridging foreign clinical data. Methods: A randomized, double blind, placebo controlled, multiple oral dosing(2 mg, 6 mg, twice a day for 7 days) study was conducted in 32 healthy Korean volunteers(M:F=16:16). Serial blood samples for pharmacokinetic analysis were taken. Safety evaluation was performed by adverse event monitoring, physical examination including vital signs, ECG and clinical labororatory analysis. Results: Plasma concentration of tegaserod reached peak levels $1.0{\sim}1.5$ hours after single and multiple dose administration and declined with a terminal half life of about 12 hours. PK parameters of 2 mg group were not calculated well due to low plasma concentration. Tegaserod showed linear pharmacokinetic characteristics, and little accumulation occurred after multiple administrations. There were no gender differences in PK parameters. Neither serious nor dose-limiting adverse events were observed. PK of tegaserod in Koreans was comparable to Caucasian data. Conclusion: Tegaserod was found to be safe and showed similar PK characteristics to Caucasians. This study demonstrates comparability between Korean and Caucasian healthy subjects in the PK of tegaserod and supports the use of Caucasian data in the evaluation of PK, safety, and efficacy for Korean patients.
홍성노 ( Sung Noh Hong ),신정은 ( Jeong Eun Shin ),홍경섭 ( Kyoung Sup Hong ),정기욱 ( Kee Wook Jung ),이태희 ( Tae Hee Lee ),이봉은 ( Bong Eun Lee ),박선영 ( Sun Young Park ),김성은 ( Seong Eun Kim ),박경식 ( Kyung Sik Park ) 대한내과학회 2015 대한내과학회지 Vol.88 No.1
A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medicationshave been introduced for patients refractory to conventional laxatives, such as prucalopride, lubiprostone, linaclotide, andelobixibat. Prucalopride is a novel gastrointestinal prokinetic agent that acts as a 5-hydroxytryptamine type 4 (5-HT4) agonist. Compared with older nonselective 5-HT4 agonists, the higher selectivity of prucalopride for 5-HT4 receptors can reduce the risk ofsignificant adverse cardiovascular events. Prucalopride improves stool frequency and consistency, and reduces the need for rescuemedications. Lubiprostone, a chloride channel activator, increases the secretion of intestinal fluid, improves the stool frequency andconsistency, and reduces straining. Linaclotide, a guanylate cyclase-C agonist, is effective in treating patients with chronic constipationand its effect on visceral sensitivity, as shown mainly in animal studies, provides an attractive pharmaceutical option for patients with irritable bowel syndrome with constipation. Elobixibat is an ileal sodium-dependent bile acid transporter inhibitor thatblocks the enterohepatic circulation of bile acids, increasing the bile acid concentration in the intestine, which accelerates colonictransit and softens the stool. A phase III trial of the treatment of chronic constipation and irritable bowel syndrome with constipationis underway. The clinical application of new-generation laxatives will contribute to the management of chronic constipation refractoryto conventional laxatives.
Laxatives 제대로 알기 ; 변비 약물 치료의 지침 - 어떤 약제를, 언제 사용해야 하는가?
신정은 ( Jeong Eun Shin ),홍경섭 ( Kyoung Sup Hong ),정기욱 ( Kee Wook Jung ),이태희 ( Tae Hee Lee ),이봉은 ( Bong Eun Lee ),박선영 ( Seon Young Park ),홍성노 ( Sung Noh Hong ),김성은 ( Seong Eun Kim ),박경식 ( Kyung Sik Park ) 대한내과학회 2015 대한내과학회지 Vol.88 No.1
To manage chronic constipation, dietary and lifestyle modifications should be tried before pharmacological intervention. Although there is no standardized treatment guideline for medical practice, the key considerations in the choice of laxative includethe treatment duration, dosing schedule, type of agent, effects and side effects of the agent, and cost. The first-line treatment is abulking or osmotic laxative. If the patient is still symptomatic, the physician can add or switch to other laxatives. Next, prucalopride,a highly selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist, could be considered. If the constipation is refractory tocombination therapy with conventional laxatives and prucalopride, patients should be referred for further evaluation, includingphysiological testing.
건강 자원자에서 레베셀$^{\circledR}$주(DDB-S)의 안정성, 약동학적 특성평가를 위한 제 1상 임상시험
정재용,임형석,배균섭,유경상,홍경섭,조주연,이소영,문전옥,이치오,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Bae, Kyun-Seop,Yu, Kyung-Sang,Hong, Kyoung-Sup,Cho, Joo-Youn,Yi, So-Young,Moon, Jun-Ok,Lee, Chi-Oh,Jang, In-Jin,Shin, Sang- 대한임상약리학회 2001 臨床藥理學會誌 Vol.9 No.2
Background : Low solubility and poor oral absorption have been major problems of DDB(Dimethyl Dime-thoxy Biphenylate), the liver protection agent. The purpose of the study was to evaluate safety, tolerablilty, and pharmacokinetics of DDB-S(Dimethoxybiphenylmonocarboxylate hydro-chloride) which was the newly developed soluble injectable form of DDB. Method : Single dose trial was conducted in 24 healthy Korean subjects with single blind, randomized, placebo controlled parallel-group design( 4 groups : 7.5, 15, 30, 60mg). DDB-S was administrated by intravenous infusion during 60 minutes. Serial blood and urine sample were collected till 24 hours after the drug administration. Plasma concentrations were assayed by HPLC. Pharmacokinetic parameters were analyzed by noncompartmental methods. Results : Total 13 cases of adverse events from 7 subjects were reported. All the events were mild, temporary, and spontaneously resolved. There were no differences in dose normalized AUC, dose normalized Cmax, CL, Vd, Tmax, Fe, $CL_R$ and elimination rate constant between groups. Linear regression analysis confirmed PK linearity within this dose range. Half of the dose$(49.86{\pm}10.97%)$ was excreted as an unchanged form through kidney. Conclusion : DDB-S was safe in Korean healthy subjects. It showed linear pharmacokinetic characteristics. Phase II clinical study for patients will be conducted.
오른쪽 새끼 손가락 말단의 연부조직으로 전이한 유방암 1예
김진원 ( Jin Won Kim ),최병용 ( Byoung Yong Choi ),홍경섭 ( Kyoung Sup Hong ),박원서 ( Weon Seo Park ),이근석 ( Keun Seok Lee ),노정실 ( Jung Sil Ro ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1
전이암이 사지 말단으로 전이되는 경우는 매우 드물다. 임상적으로 전이성 병변의 마지막 단계로 발생하는 경우가 흔하다. 흔히 병변이 양성종양이나 감염증과 비슷한 양상으로 오진되기도 한다. 드물게 사지 말단의 뼈로 전이된 예를 보고하지만 국내에서는 보고가 드물다. 본 환자는 손가락 끝 연부조직에 국한된 종괴로 발견되었으며 처음에는 유방암의 전이로 생각하지 않았던 증례로 조직검사를 통해 유방암의 전이로 확인되어 보고하는 바이다. Acral metastasis to the finger is a very rare phenomenon. We report herein a case of cutaneous acrometastasis to the right 5th finger tip in a 36-year-old woman with metastatic breast cancer. The patient underwent a right modified radical mastectomy for T3N3 invasive ductal carcinoma and received adjuvant chemotherapy and radiotherapy. After 2 years, she developed metastasis to the brain, bones, and lungs. She was found to have a growing tender mass on the tip of right 5th finger. A well-demarcated, soft tissue mass was identified on sonography. Under the clinical impression of a possible benign process, the nodule was surgically removed. The pathologic finding was consistent with metastatic breast cancer. Immunohistochemical staining for estrogen receptor, progesterone receptor, and HER2 were all negative, as in the primary tumor. Radiation was given to the finger tip and systemic chemotherapy with capecitabine was tried for systemic metastatic disease. (Korean J Med 75:112-114, 2008)
Laxatives 제대로 알기 ; 변비의 국소 치료: 관장과 좌약
김성은 ( Seong Eun Kim ),신정은 ( Jeong Eun Shin ),홍경섭 ( Kyoung Sup Hong ),이태희 ( Tae Hee Lee ),이봉은 ( Bong Eun Lee ),박선영 ( Seon Young Park ),홍성노 ( Sung Noh Hong ),정기욱 ( Kee Wook Jung ),박경식 ( Kyung Sik Park ) 대한내과학회 2015 대한내과학회지 Vol.88 No.1
The treatment for constipation should be individualized and dependent on the cause, coexisting morbidities, and patient’s cognitivestatus. Although most cases of constipation respond to conservative treatment, including dietary and life-style changes, or mildlaxatives, some patients still complain of consistent symptoms and need an assessment of defecatory dysfunction. There is insufficientevidence to support the use of enemas in chronic constipation, although many clinicians and patients find them useful andeffective for the treatment of fecal impaction when used with other modalities. In addition, suppositories can be considered as an initialtrial for the treatment of defecatory dysfunction, since they help to initiate or facilitate rectal evacuation. The routine use of enemasis typically discouraged, especially sodium phosphate enemas, although tap-water enemas seem safe for more regular use. Soapsuds enemas are not recommended due to possible rectal mucosal damage.