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앵엽(櫻葉) 에탄올 추출물의 혈관이완 효능 및 작용기전에 대한 연구
이경진 ( Kyung Jin Lee ),김광우 ( Kwang Woo Kim ),허희승 ( Hee Seung Heo ),함인혜 ( In Hye Ham ),이미화 ( Mi Hwa Lee ),김범정 ( Bum Jung Kim ),부영민 ( Young Min Bu ),김호철 ( Ho Cheol Kim ),최호영 ( Ho Young Choi ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.4
Objectives : The purpose of present study was to investigate the vasorelaxant activities and mechanisms of action of the ethanol extract of P. yedoensis leaf (PYL) on isolated rat aortic rings. Methods : Dried P. yedoensis leaves were extracted 3 times with 100% ethanol for 3 h in a reflux apparatus. Isolated rat aortic rings were suspended in organ chambers containing 10 ml Krebs-Henseleit (K-H) solution. The rings were maintained at 37℃ and aerated with a mixture of 95% O2 and 5% CO2. Changes in their tension were recorded via isometric transducers connected to a data acquisition system. Results : PYL relaxed the contraction of aortic rings induced by phenylephrine (PE, 1 μM) or KCl (60 mM) in a concentration dependent manner. However, the vasorelaxant effects of PYL on endothelium-denuded aortic rings were lower than endothelium-intact aortic rings. And the vasorelaxant effects of PYL on endothelium-intact aortic rings were reduced by pre-treatment with Nω-Nitro-L-arginine methyl ester (10 μM), methylene blue (10 μM), 1-H-[1,2,4]-oxadiazolo-[4,3-α]-quinoxalin-1-one (10 μM), tetraethylammonium (5 mM). In addition, PYL inhibited the contraction induced by extracellular Ca2+ in endothelium-denuded aortic rings pre-contracted by PE or KCl in Ca2+-free K-H solution. Conclusions : These results suggest that PYL exerts its vasorelaxant effects via the activation of Nitric Oxide (NO) formation by means of L-arginine and NO-cGMP pathways and via the blockage of receptor operated calcium channels, voltage dependent calcium channels and calcium-activated potassium channels.
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