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로제트형성 Glioneuronal Tumors 2례 -증례보고-
서동광 ( Dong Kwang Seo ),허윤희 ( Yoon Hee Huh ),박진훈 ( Jin Hoon Park ),조영현 ( Young Hyun Cho ),김정훈 ( Jeong Hoon Kim ),김창진 ( Chang Jin Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2011 대한뇌종양학회지 Vol.10 No.2
Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a mixed glioneuronal tumor, recently included in the 2007 World Health Organization (WHO) classification of tumors of the central nervous system. Forty-eight cases have been reported up to now; most occurring in the fourth ventricle. But recent cases have reported other locations also. These two cases were histopathologically diagnosed; one is a 58-year-old male with RGNT involving cerebellum and the other is an 11-year-old female with RGNT in the temporal and thalamic location. These cases differ in radiologic and clinical features. However, they share the classic RGNT histology, characterized by biphasic neurocytic and glial architecture. We report two cases of RGNTs involving the extra fourth ventricular locations and discuss the distinctive features of this entity.
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차선화 ( Sun Hwa Cha ),한정열 ( Jung Yeol Han ),김해숙 ( Hae Suk Kim ),전선영 ( Seon Young Jeon ),허윤희 ( Yoon Hee Huh ),이경자 ( Kyong Ja Lee ),안현경 ( Hyun Kyong Ahn ),최준식 ( June Seek Choi ),김경아 ( Kyung Ah Kim ),신손문 ( 대한주산의학회 2003 Perinatology Vol.14 No.3
목적: 수유부에서 약물 노출의 종류와 빈도 및 이들 약물에 노출시 수유아에 어느 정도 우려되는 영향을 미치는지 느끼는 정도와 이러한 우려가 모유 수유율에 영향을 미치는지 평가하고자 한다. 방법: 2003년 4월 15일부터 2003년 5월 15일까지 삼성제일병원 산부인과 외래에 출산 후 8주에 내원한 산모 중 설문에 답했던 91례를 대상으로 하였다. 설문은 출산력, 분만방법, 모유수유 여부, 약물 노출의 빈도와 종류를 포함하고 있으며, 10cm Visual analogue scale를 이용하여 수유부가 복용했던 약물에 의해 영아에 미치는 영향에 대한 우려정도를 측정하였다. 결과: 연구 대상자의 평균 나이는 31세였으며, 평균 출산 아기 수는 1.3 명이었다. 이들의 출산 후 8주에 수유율은 65.9%(60/91)이었다. 모유수유를 선택하지 않고 분유를 선택한 이유는 젖이 잘 나오지 않아서가 38.7%(12/31)이었으며, 직장 12.9%(4/31), 함몰유두 6.5%(2/31), 약물복용 3.2%(1/31), 유방울혈 3.2%(1/31), 순이었으며, 기타는 35.5%(11/31)이었다. 모유 수유율과 관련된 변수들 중 산모의 나이와 출산아이의 수는 통계학적으로 유의하지 않았으나, 출산 방법에 따른 모유 수유율은 정상자연분만은 76.9%(30/39), 유도분만에 따른 정상질식분만 70.0%(14/20), 그리고 제왕절개술 50%(16/32)로 통계학적으로 유의한 결과를 나타내었다(P<0.05). 수유 중 약물 사용율은 50%(30/60)이었으며, 복용한 약물의 종류는 단일 노출로는 한약이 가장 많아 36.7%(11/30)이었으며, 영양제 10%(3/30), 감기약 6.7%(2/30)순이었고, 복합적으로 처방 받은 예를 포함하면 한약은 46.7%에 이른다. 수유 중 약물 노출 후 수유부가 느끼는 영아에 미치는 나쁜 영향의 정도는 약 49%이며, 출산방법에 따른 차이를 비교하면 자연질식분만이 46.5±6.6%, 유도분만 48.9±8.6%, 그리고 제왕절개술 51.2±8.2%으로 통계학적인 차이는 없었지만, 분만과정에서 중재가 심할수록 산모가 느끼는 약물이 신생아에 미치는 우려의 정도가 크게 나타났다. 결론: 대부분의 수유부는 수유 중 모체의 약물 복용이 수유아에 악영향을 미칠 수 있다고 생각하며, 실제 이는 모유 수유율을 감소시키는 한 요인으로 작용한다. Objective: To determine the type and frequency of medication taken by breast-feeding women and to evaluate the effects of maternal anxiety related to medication during lactation on the breast-feeding rate. Methods: From April 15 to May 15 2003, we conducted a survey with a prepared questionnaire on ninety-one mothers who visited the obstetric clinics of Samsung Cheil hospital at eight weeks after delivery. The questionnaire contained information about parity, mode of delivery, whether to feed breast-milk, and the type and frequency of medicinal exposure. We also asked the degree of perceived adverse effects on her baby associated with maternal medication using 10cm visual analogue scale. Results: The mean age of respondents was thirty-one years and the mean number of children born to the respondents was 1.3. At the eighth week after delivery the breast-feeding rate was 65.9%. The breast-feeding rate was not related to maternal age or the number of children but rather, the mode of delivery, which was 76.9% in NSVD, 70.0% in vaginal delivery with labor induction and 50% in cesarean delivery(P<0.05). The frequency of maternal medication intake during lactation was 50%. The most frequent type of medicine was herb medicine (36.7%). The average score of perceived adverse effect on a respondent`s baby during breast-feeding was about 49% in total, which was 46.5% in NSVD, 48.9% in vaginal delivery with labor induction, and 51.2% in cesarean delivery. Conclusion: Most nursing mothers think that their medications during lactation affect adversely their babies, who, in turn, may be associated with the decrease of breast-feeding rate.
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γ-Poly(glutamic acid) 분해 세균의 분리 및 동정
허윤희,고영환 제주대학교 환경연구소 1998 환경연구논문집 : 제주대 Vol.6 No.-
r-poly(glutamic acid) (r-PGA) was produced in the culture filtrate of Bacillus licheniformis 9945a. It is a water soluble and naturally derived polyamide consisted of glutamic acid repeating units that are linked between the a-amino and r-carboxylic acid functionalites. It is the mapr composition of the capsular substances from Bacillus species. r-PGA is not toxic to human health and biodegradable. It has a potential to be used in the field of medicine, artificial human organ, food additives, plastic manufacture and oil industry. Even though its production has been studied steadily, few research reports concerning its biodegradation have appeared. Few informations about depolymerizing enzyme, degradation mechanism and organisms, which are necessary for industrial applications, are available. The principal purpose of this study was to isolate and identify a r-PGA degradmg bacterium from fermented soy paste. Eight strains from soy paste were isolated and 3 of those apparently decreased the viscosity of the culture filtrate with r-PGA. The isolate No. 5 which decreased most rapidly the viscosity of the culture with r-PGA was chosen and identified. The isolate No. 5 was very similar to Bacillus licheniformiis and Bacdlus pumilus according to the keys in Bergey's Mannual of Systematic Bacteriology. The fatty acid composition of the bacteria also confirmed its identity as Bacillus species. According to MIDI program the isolate No. 5 showed 91.8% similarity to Bacillus licheniformis.
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감귤 부패 사상균에 대한 감귤 정유와 시판 합성 농약의 항균 효과
고정삼,고영환,김유경,허윤희 한국농화학회 1999 Applied Biological Chemistry (Appl Biol Chem) Vol.42 No.4
Growth-inhibitory effects of citrus oils and agricultural fungicides, which were on the market, on several molds isolated from putrefied citrus fruits were investigated. When fungicidal activities of 11 kinds of synthetic agrochemicals against 6 species of molds, Alternaria alternata, Rhizopus sp., Botrytis cinerea, Monilia candida, Penicillium italicum and Penicillium digitatum, were investigated, agrochemicals containing mancozeb or fluazinam as an effective component had the broadest fungicidal spectrum. Agrochemicals containing iprodione, benomyl, azoxystrobin or thiophanate were less effective on the molds and those containing conazole derivative were intermediately effective. Resistance of the molds to the agrochemicals were species- and agrochemical-dependent. Among those molds tested, Penicillium italicum and Alternaria alternata showed relatively higher level of survival in the presence of synthetic fungicides. On the other hand, when the molds were exposed to citrus oils by direct contact, no cell could survive regardless of the species. The fungicidal activity of citrus oils was also confirmed by paper disk method and microscopic observation. These results suggested that citrus oils had broad killing activity against molds. Therefore, it would be necessary to design method for the application of citrus oils in order to improve post-harvest storage of citrus fruits.
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