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여드름 환자의 동반증상 연구 및 환자 특성별 HRV 분석
허수정 ( Su Jeong Heo ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),이경섭 ( Kyung Sub Lee ),장준복 ( Jun Bock Jang ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.2
Objectives: The purpose of this study is to investigate the symptoms accompanied with acne and HRV pattern of the acne patients. Methods: We reviewed 60 acne patients(age 15-38) who visited ○○ hospital from January 2010 to October 2011. We investigated the symptoms accompanied with acne of 60 patients and evaluated HRV of 41 acne patients. The data were analyzed by Mann-Whitney test using SPSS/PC ver 13.0 program. Results: 1. Prevalence of female post-adolescent acne was 66.7% in this study. The symptoms accompanied with acne were dischezia(35%), gastric discomfort(28.3%) in all patients and dysmenorrhea(40%), leukorrhea(38%), irregular menstrual period (24%) in female patients. 2. SDNN, RMSSD, VLF and HF of female were significantly lower than male. 3. SDNN, TP and VLF of un-dysmenorrhea group were significantly lower than dysmenorrhea group. 4. PSI of under 6 months group was significantly higer than over 6 months group. 5. In postadolescent acne patients SDNN, RMSSD, TP, LF and HF were significantly lower and PSI was significantly higher than adolescent acne patients. Conclusions: There are many female post-adolescent acne pateints and the assessment of the symptoms accompanied with acne and stress degree is helpful in treating acne. The further research and development about the diagnostic and therapeutic methods of acne are needed in oriental obstetrics and gynecology field.
원저 : 한방비만프로그램을 통한 체중과 부위별 복부둘레의 경과 관찰 및 상관성 연구
허수정 ( Su Jeong Heo ),이재은 ( Jae Eun Ie ),김현진 ( Hyun Jin Kim ),조현주 ( Hyun Ju Cho ),명성민 ( Sung Min Myoung ) 한방비만학회 2009 한방비만학회지 Vol.9 No.2
The purpose of this study was to investigate the progress of weight and waist circumference(WC) through oriental obesity treatment and clarify the correlation between weight loss and WC change. Methods The subjects were treated from January 2007 to September 2009 in J Oriental Medical Center. Herbal medicine, electro acupuncture, oriental obesity physiotherapy were performed for a month. We checked the change of weight and WC at every treatment. We classified the WC into upper, middle, lower parts specifically and measured them individually. Measurements were analyzed by using one-way repeated measures ANOVA and we also investigated correlation between weight loss and WC change. Results (1) During the first and second treatment sessions, the weight loss was the highest, 0.96±0.86 kg(1.46±1.32 %) and during the 5th and 6th treatment sessions, the lowest 0.37±0.61 kg. The final weight loss was 3.71±1.47 kg(5.51±2.12 %). (2) After 8 treatment sessions, the reductions of upper, middle and lower WC were 3.59±2.26 %, 5.93±2.75 %, 5.51±3.22 %, respectively. As the patients received more treatment, there was a progressive decline in the variation of weight and middle WC. However, the decline rate of upper and middle WC fluctuated during the treatments, forming a W-shaped curve. (3) Analysis of the correlation between the weight loss and WC change shows that the reduction of middle WC was most closely associated with the weight loss. Conclusions This study indicated that the rate of weight loss and WC reduction showed stagnation during the 5th and 6th treatment sessions, and the reduction of middle WC was most closely associated with the weight loss. Since the progress of weight and WC change is an important field of research on obesity, further systemic studies would be needed for the foundation of a clinical guideline.
지패산(芷貝散) 추출물의 염증억제와 선천면역 활성에 의한 항암 효과
허수정 ( Su Jeong Heo ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),이경섭 ( Kyung Sub Lee ),장준복 ( Jun Bock Jang ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4
Objectives: This study was designed to investigate the anti-tumor metastasis by anti-inflammatory and innate immunomodulating effects of extracts of Jipae-san on cancer cells. Methods: Antimetastatic experiments were conducted in vivo mouse model by using 4T1 mouse mammary carcinoma cells. Cell viability of Jipae-san was tested with 4T1 mouse mammary carcinoma cells, colon 26-M3.1 carcinoma cells and macrophage. In addition expression of TNF-α and NO induced by LPS was measured after treating with Jipae-san. To observe innate immunomodulating effects of Jipae-san on macrophage, we measured TNF-α, IL-12, IL-6 and MCP-1, respectively. Cell cytotoxicity was tested with the macrophage stimulated with Jipae-san and we evaluated the activation of TNF-α and NO. And the effect of Jipae-san on metastasis was measured without NK-cell using GM1 serum. Results: Intravenous inoculation of Jipae-san significantly inhibited metastasis of 4T1 mouse mammary carcinoma cells. In an in vitro cytotoxicity analysis, cell growth are closer to 100% less than 1,000 μg/ml concentration. The expression of TNF-α and NO induced by LPS after treating Jipae-san was down regulated in dose-dependent manner. Level of cytokines such as TNF-α, IL-12, IL-6 and MCP-1 of Jipae-san group were up regulated in compared to the control group. The macrophage stimulated with Jipae-san significantly inhibits the cancer cell at ratio of 10:1, 20:1. The activation of NO was significantly up regualted in a group of 5:1, 10:1, 20:1. The depletion of NK-cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Jipae-san on tumor metastasis. Conclusions: Jipae-san appears to have considerable activity on the anti-metastasis by inflammation control and activation of innate immune system.