악성 근상피종의 세침흡인 세포학적 소견 -1 예 보고-

이재화,박진경,허방,Lee, Jae-Hwa,Park, Jean-Kyung,Hur, Bang 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.1

Malignant myoepithelioma (myoepithelial carcinoma), is a very rare malignant epithelial accounting for less than 1% of all salivary gland tumors and has an intermediate malignant potential. We report a case of malignant myoepithelioma arising in the left parotid giand in a 54-year-old man, which was difficult to differentiate from pleomorphic adenoma and other malignant salivary gland neoplasms. Fine needle aspiration cytology of the parotid gland showed cellular smear, composed of overlapped sheets and clusters or individually scattered tumor cells without any acinic or ductal structures. The tumor cells were rather uniform, with distinct cell borders and moderate amount of cytoplasm. The eccentrically located nuclei were oval to round and pleomorphic and showed prominent nucleoli. A few clear cells were noted in the cellular aggregates Metachromatic matrix was seen between individual tumor cells in a lacelike fashion, resembling pleomorphic adenoma. According to the immunohistochemical staining, we recognized that the component cells are myoeplthelial in nature, showing reactivity for the S-100 protein, vimentin, and actin.

납중독에 대한 마늘의 치료와 방어효과

이용환,박명호,최명원,천봉권,허방,탁효정,황인철,Lee, Yong-Hwan,Park, Myung-Ho,Choi, Myung-Won,Chun, Bong-Kwon,Hur, Bang,Tak, Hyo-Jung,Hwang, In-Chul 한국생명과학회 2001 생명과학회지 Vol.11 No.6

마늘 속에서 중금속 중독 시에 킬에이트 작용을 일으킬수 있다는 다량의 황 화합물이 함유되어 있으므로 납 중독 흰쥐에서 그 효과를 확인하고자 본 연구를 실시한 결과 마늘 500mg/kg 투여 흰쥐군에서 유의한 납 배설량의 증가가 있었으며, 납과 마늘의 동시에 투여했을 경우에는 납 단독 투여군 보다 신장에서의 병리조직학적 변화가 경미한 것을 관찰할수 있었다. 이러한 결과는 마늘이 납 중독에대한 킬레이트제로서의 이용 가능성이 있음을 나타내고 있다. Lead poisoning is currently one of the major public health problems in industrialized countries. Several chelating agents have been developed and used to treat the lead poisoning. It was recently proposed that garlic, having a large quantity of S-S compounds, may react readily with lead, producing various sulfur componds, and thus provide curative and protective effects on the lead toxicity. The present study was undertaken to evaluate this possibility in experimental animals. The garlic treatment on rats pre-exposed to lead significantly enhanced urinary excretion of lead at a garlic dose of 500 mg/kg and decreased the bloon level of lead at both 250 and 500 mg/kg doses. The administration of grilic 500mg/kg along with lead significantly alleviated the renal histological alterations induced by lead. These results suggest that garilic has a curative as well as a protective effect against lead poisoning , thus it may act as a chelator of lead.

위암 환자에서 Epstein-Barr 바이러스의 상관성

최경헌(Kyung Hyun Choi),허방(Bang Hur),장명웅(Myung Woong Chang),이상호(Sang Ho Lee),송재현(Jae Hyun Song) 대한외과학회 2003 Annals of Surgical Treatment and Research Vol.65 No.1

담도 폐색증 환자의 수술 치험 22례 와 장기 생존율

최경현,유중재,신연명,허방,박재선,Choi, Kyung-Hyun,Yoo, Jung-Jae,Shin, Yeon-Myung,Hur, Bang,Park, Jae-Sun 대한소아외과학회 2007 소아외과 Vol.13 No.2

Biliary atresia (BA) is an uncommon neonatal surgical disease that has a fatal outcome if not properly treated. The survival rates of the patients with native liver after Kasai's operation in countries outside Japan are not so good. We reviewed the results of 22 cases of biliary atresia treated in Kosin University Hospital between October 1987 and March 2001. There were 13 males and 9 females aged from 21 to 106 days (mean 52 days). There were 3 cases of Type I (13.6%), and 3 of Type II (13.6%), and 16 Type III (72.7%). The operative methods were resection of the common bile duct remnant and cyst followed by Roux-en-Y hepaticojejunostomy in 3 cases for Type I BA; Kasai I in 15 cases, Kasai II in 1 case, and Ueda's operation in 3 cases for Types II and III BA. There was no death within the first 30 days after operation. We were able to follow 21 of the 22 patients (95.4%) for more than 5 years. The actual 5 year survival rate (YSR) was 40.9%. One Type I case received a living-related liver transplantation at 6 years of age because of the multiple intrahepatic stones and liver cirrhosis. Five YSR after biliostomy group (Kasai II and Ueda op.) was 75 % (3/4) while that of Kasai I was 20% (3/15). One case had no bile duct in the resected fibrotic plaque on microscopic review and died 8 months after Kasai I operation, would have been a strong candidate for early liver transplantation. From the above result, our conclusions are as follows; (1) early liver transplantation should be considered for cases of no bile duct after pathologic examination of the resected specimen, (2) measures to prevent postoperative cholangitis and prevention of postoperative liver cirrhosis are needed, (3) liver transplantation program should be available for failed cases.

새로운 액체성 색전물질(Embol)을 이용한 신동맥 색전술: 토끼에서의 실험적 연구

정규식,고지호,김현철,이상희,오경승,허진도,조영덕,허방,박상수,Jung, Gyoo-Sik,Ko, Ji-Ho,Kim, Hyun-Chul,Lee, Sang-Hee,Oh, Kyung-Seung,Huh, Jin-Do,Joh, Young-Duk,Hur, Bang,Park, Sang-Soo 대한영상의학회 2002 대한영상의학회지 Vol.46 No.1

목적: 새로 개발된 액체성 색전물질로 토끼에서 신동맥 색전술을 시행하여 그 효과와 안전성을 입증하고 영구적 색전물질로서의 임상적용 가능성을 평가할 목적으로 이 연구를 시행하였다. 대상과 방법: 사용한 색전물질은 Polyvinylacetate(PVAc)를 부분 가수분해하여 만든 Embol로서 45%의 에탄올과 55%의 비이온성 수용성조영제를 용매로 사용하므로 우수한 방사선비투과성을 가진다. 15마리의 토끼를 실험동물로 사용하였으며, 투시 하에서 평균 0.8(0.5-0.9)cc의 Embol을 신동맥에 주입하여 색전을 하였고 5분 후에 추적 혈관조영술을 시행하여 색전의 효과를 확인한 뒤에 시술을 마쳤다. 토끼를 5마리씩 3군으로 나누어 각각 3일(I군), 2주(II 군), 4주(III군)후에 추적 혈관조영술을 시행한 뒤 토끼를 희생시켜 양측 신장과 신동맥을 적출하여 조직표본을 제작하였다. 각군에서 시술 직후와 추적기간 동안의 혈관조영술 소견과 조직 소견을 관찰하였다. 각군의 토끼 1마리에서 시술전과 희생시키기 전에 DMSA 신스캔을 시행하였고, 다른 3마리에서는 시술 전과 시술 후 1, 3, 5, 7, 14일에 혈액을 채취하여 혈청 BUN, Creatinine, Sodium(Na), Potassium(K)의 수치를 조사하였다. 결과: Embol은 투시 하에서 색전과정의 관찰이 용이할 정도로 방사선비투과성이 우수하여 안전하게 주입할 수 있었다. 시술 5분 후에 시행한 혈관조영술에서는 신동맥 원위부의 완전한 폐색이 14예, 엽간동맥(interlobar artery)의 폐색이 1예에서 관찰되어 전예에서 색전술은 성공적이었다. 시술 후 혈청 전해질 수치는 약간 증가하였으나 모두 정상범위였다. 각 군에서의 추적 혈관조영술에서는 I군과 III군의 각각 1마리를 제외한 모든 토끼에서 신동맥의 폐색이 유지되었다. 각군에서 시행한 신스캔에서는 모두 색전을 시행한 신장의 섭취가 전혀 관찰되지 않았다. 추적기간동안의 색전을 시행한 신장의 크기는 I 군에서는 정상 신장에 비해 커졌으나 II군과 III군에서는 계속해서 크기가 감소하였다. 조직 소견은 3 군 모두 신조직의 전반적인 응고괴사 소견이 관찰되었으며, III군에서는 신피질에 두꺼운 띠모양의 석회화가 관찰되었다. I군에서는 신동맥 내강이 기질화되지 않은 혈전으로 차 있었고, II군과 III군에서는 신동맥 내강은 기질화된 혈전으로 차 있었으며 III군에서는 혈전의 석회화도 관찰되었다. 결론: Embol을 이용한 토끼에서의 신동맥 색전술은 이 색전물질의 우수한 방사선비투과성으로 안전하게 사용할 수 있었으며 또한 효과적이고 영구적인 신조직의 괴사를 유발하여 앞으로 임상적용이 가능하다고 생각된다. Purpose: To evaluate the effectiveness and safety of a new liquid embolic agent in renal arterial embolization in the rabbit, and its clinical applicability. Materials and Methods: A new embolic agent, Embol, was obtained by partial hydrolysis of polyvinyl acetate and dissolved in a mixture of 45% ethanol and 55% non-ionic contrast medium. Its radioopacity was therefore good. An average of 0.8 cc(0.5-0.9 cc) of Embol was used to embolize the renal artery of one kidney in 15 rabbits. The immediate effect of this was examined angiographically 5 minutes after the procedure. To permit histologic examination, five rabbits in each group were sacrificed 3 days (I), 2 weeks (II), and 4 weeks (III) after embolization: prior to embolization and prior to sacrifice, one rabbit in each group underwent renal scanning, and prior to sacrifice all underwent follow-up angiography. In three rabbits, blood urea nitrogen (BUN), creatinine, sodium(Na), and potassium(K) levels were measured before and 1, 3, 5, 7 and 14 days after embolization. Results: Embol was easy to use and its radiopacity was good. Five minutes after embolization, angiography showed that total occlusion of the main renal or interlobar artery had been achieved in all rabbits. Serum BUN, creatinine, Na and K levels were within normal limits. Follow-up angiogram obtained in each group showed persistent occlusion of the renal artery in all but one rabbit in group I and one in group III. Renal scans revealed no evidence of radionuclide uptake in embolized kidneys, which were slightly enlarged in group I but became gradually smaller in groups II and III. In all animals, histologic examination showed diffuse coagulation necrosis of the embolized kidneys and in group III the cortex of these was extensively calcified. In group I the renal artery showed an apparently fresh occluding thrombosis, and in groups II and III a completely organized thrombosis was present. In group III this was calcified. Conclusion: Because of its good radioopacity, Embol is easy to controa, and is effective for renal artery embolization. As a permanent embolic agent, it appears suitable for clinical applications.

Aspergillus fumigatus 각막염이 유발된 토끼각막에서 Adhesion Molecules의 분포

최석용(Seok Yong Choi),서동석(Dong Suk Seo),허방(Bang Hur),한영호(Young Ho Hahn) 대한안과학회 1999 대한안과학회지 Vol.40 No.2

소장의 Malignant Fibrous Histiocytoma 1예

유대우(Dae Woo Yoo),신동훈(Dong Hoon Shin),박명선(Myeng Sun Park),허방(Bang Hur),이충한(Choong Han Lee) 대한외과학회 2001 Annals of Surgical Treatment and Research Vol.60 No.5

소프트 콘택트렌즈로 인한 실험적 Pseudomonas aeruginosa 각막염

양호성(Ho Sung Yang),한영호(Young Ho Hahn),이상준(Sang Joon Lee),허방(Bang Hur) 대한안과학회 1999 대한안과학회지 Vol.40 No.12

자궁경부의 원발성 악성 흑색종 1 예

김원규(Won Gue Kim),이인철(In Cheol Lee),허방(Bang Hur) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

Malignant melanoma is usually a neoplasm of the skin and mucous membranes which is relatively rare, comprising 1% of all cancers. In women, approximately 3% of malignant melanoma are located in the genitalia with the vast majority occuring in the vulva and very rarely on the ovary, uterus, and uterine cervix. Opinions about its histogenesis, diagnostic criteria and elective treatment are controversial, because of rare manifestation. We report a case of primary malignant melanoma of uterine cervix with a brief review of the literature.

각막내피세포에 대한 Benzalkonium Chloride 의 독성

한영호(Young Ho Hahn),박세광(Seh Kwang Park),허방(Bang Hur) 대한안과학회 1995 대한안과학회지 Vol.36 No.7