http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인 성인형 스틸병 환자에서 Interleukin-18 유전자 다형성
허민영 ( Min Young Her ),김숙경 ( Sook Kyoung Kim ),성윤경 ( Yoon Kyoung Sung ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정원태 ( Won Tae Chung ),최정윤 ( Jung Yoon Choe ),장현 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.2
Objective: It has been suggested that overproduction of interleukin -18 (IL-18) may contribute to the pathogenesis of adult onset Still`s disease (AOSD). Recently, positive association between a polymorphism in the IL-18 gene and different diseases like diabetes, sarcoidosis and asthma has been reported. The aim of the present study was to investigate the potential association of two single-nucleotide polymorphisms (SNPs) at position -137 (G/C) and -607 (C/A) in the promoter region of the IL-18 gene with susceptibility and clinical feature of AOSD in the Korean population. Methods: We examined two SNPs of IL-18 in 70 patients with AOSD and 204 healthy control individuals. The genotyping were performed using sequence specific PCR. Haplotypes were analyzed by the estimated haplotype program. The patients with AOSD were subdivided into groups according to disease course: monocyclic systemic, polycyclic systemic, and chronic articular type. Results: As for the -607 genotypes, 13 of the 69 patients had CC genotype (18.8%), 36 the CA type (52.2%) and 20 the AA type (29.0%). AOSD patients had higher frequency of A allele at -607 when compared to controls (OR 1.48, 95% CI 1.00∼2.18, p=0.048). AOSD patients had significantly higher frequency of AA genotypes at -607 when compared to controls (AA vs CA& CC, OR 1.90, 95% CI 1.01∼3.58, p=0.044). As for the -137 genotypes, of the 68 patients, 57 had GG genotype (83.8%), 9 the GC type (13.2%) and 2 (2.9%) had the CC type. No differences were found in allele and genotype frequencies between two groups. The haplotype frequencies of the IL-18 polymorphism were not significantly different between patients with AOSD and controls. The frequency of-137 GG genotype was significantly increased in chronic articular type compared to healthy control and systemic type of AOSD. Conclusion: In IL-18 gene polymorphisms, the A allele and AA genotye at position -607 might be genetic risk factors for the development of AOSD in Korean population. Further investigation in larger groups is required to provide more conclusive evidence regarding the role of the IL-18 gene polymorphism in AOSD.
다발성 경화증의 임상양상으로 내원한 전신홍반루푸스 2예
허민영 ( Min Young Her ),노은지 ( Eun Ji No ),김동욱 ( Dong Yook Kim ),김성은 ( Sung Eun Kim ),이동훈 ( Dong Hoon Lee ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1
Neurologic manifestations rarely occur as presenting feature of systemic lupus erythematosus (SLE). We describe two women who presented with several episodes of neurologic symptoms mimicking multiple sclerosis. Several years after disease onset, clinical and laboratory finding were compatible with SLE. These cases show that demyelinating syndrome resembling multiple sclerosis may present as a first manifestation of SLE.
허민영 ( Min Young Her ),신동혁 ( Dong Hyuk Sheen ),김태환 ( Tae Hwan Kim ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
The conventional approach to treatment of patients with ankylosing spondylitis (AS) have been rather limited in the last decades. Evidence is accumulating that tumor necrosis factor (TNF) blocker is highly effective in AS. This article reviews the most recent and the most pertinent advances in the treatment in AS. TNF blocker have been evaluated in a number of randomized controlled trials in AS and have been demonstrated to be effective in disease activity, function, and quality of life in these patients. TNF blocker is emerging as the best therapeutic option available for patients with AS.
허민영 ( Min Young Her ),서우선 ( Woo Seon Seo ),문치숙 ( Chi Sook Moon ),윤혁진 ( Hyuk Jin Yoon ),김양욱 ( Yang Wook Kim ),김영훈 ( Yeung Hoon Kim ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.2
Neuroletic malignant syndrome is a rare, idiosyncratic and potentially lethal side effect that occurs patients receiving neuroleptic drugs. Characteristic sings and symtoms include muscle rigidity, fever, altered consciousness, and autonomic dysfuction. The most common serious complication is rhabdomyolysis ,which produces acute myoglobiuric renal failure. We present a case of 32-year-old man in whom had NMS and acute renal failure after he had received a combination of chloropromazine and haloperiodol. The patients recovered after treatment by immediate hydration, diuretics and other conservative measure.
송영진 ( Young Jin Song ),허민영 ( Min Young Her ),김태희 ( Tae Hee Kim ),김지현 ( Ji Hyun Kim ),김동욱 ( Dong Yook Kim ),이상혁 ( Sang Hyuk Lee ),윤혜경 ( Hye Kyoung Yoon ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.1
Gastric carcinoid tumor is a rare neoplasm and it accounts for only 0.3% of all the gastric neoplasms. Gastric carcinoid tumor has high incidence in patients who are aged between 50 and 70 years, and it usually develops over a long period of time. Type I gastric carcinoid tumors are associated with autoimmune atrophic gastritis and pernicious anemia, and there are a few cases of gastric carcinoids in patients with other autoimmune diseases like Sjogren`s syndrome and autoimmune thyroiditis. Here, we report on a case of recurrent type I gastric carcinoid tumors in a 42-years old woman who suffered with systemic lupus erythematosus.
원위 경골 및 비골에 발생한 만성 재발성 다발성 골수염
김전교(Jeon-Gyo Kim),곽희철(Heui-Chul Gwak),허민영(Min Young Her),김동균(Dong-Gyun Kim) 대한정형외과학회 2015 대한정형외과학회지 Vol.50 No.2
만성 재발성 다발성 골수염은 비감염성 염증성 골병변으로 주로 소아와 청소년에게 발생하는 질환이다. 임상적으로 모호한 골성 동통을 호소하며, 방사선학적 소견 및 조직학적 소견이 감염성 골수염과 유사하다. 또한 비교적 드문 질환으로서 다른 질환과의 감별이 어려워 종종 오진을 할 수 있다. 본원에서 11세 남아의 원위 경골 및 비골에 발생한 만성 재발성 골수염 1예를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. Chronic recurrent multifocal osteomyelitis (CRMO) is a non-infectious inflammatory bone disease that occurs mainly in children and adolescents. The clinical presentation shows imprecise bone pain, while radiologic findings and histologic exam are similar to those of infectious osteomyelitis. It is a rare disease, which is difficult to distinguish from other diseases, therefore it could be misdiagnosed. We report on a case of CRMO on the distal tibia and fibula in an 11-year-old boy.
이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-
Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.
18세 원발성 고혈압 환자에서 발생한 비Q파 심근 경색 1례
배경임,이재호,서우선,허민영,정수룡,조길현,이영민,김대경,김두일,김동수 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
Myocardial infarction in persons under the age of 45 years accounts for 6% to 10% of all myocardial infarction in the United states. In this age group, it is predominantly a disease of men. Important risk factors include a family history of myocardial infarction before age 55 years, hyperlipidemia, smoking, and obesity. Unlike older patients, approximately half of young patients have single-vessel coronary disease, and in up to 20%. The cause is not related to atherosclerosis. Coronary angiography may be warrannnnted in young patients with myocardial infarction to define the anatomy of the disease and to permit optimal management. We report case that was diagnosed non Q myocardial infarction with history of hypertension in the young women.