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위선암종에서 핵의 Retinoic Acid Receptor (RAR) 및 cAMP Response Element Binding Protein (CREB)의 면역조직화학적 발현양상
한호선,김용석,박중민,최유신,차성재,김미경,지경천,Han, Ho-Sun,Kim, Yong-Seok,Park, Joong-Min,Choi, Yoo-Shin,Cha, Seong-Jae,Kim, Mi-Kyung,Chi, Kyung-Choun 대한위암학회 2008 대한위암학회지 Vol.8 No.4
목적: 인체 내 여러 조직에서 상피세포의 분화 및 증식에 중요한 역할을 담당한다고 알려진 retinoic acid (RA)와 여러 유전자들에서 전사조절인자로 성장관여 유전자들의 활성화에 관여하며 세포증식 및 분화에 매우 중요한 세포내 조절인자인 CREB의 발현정도와 위선암종간의 상호 연관성 및 병리학적 인자들과의 관계를 관찰하였다. 대상 및 방법: 중앙대학교 의과대학 용산병원에서 1998년 1월부터 2007년 12월까지 위절제술을 시행 받고 위선암종으로 진단받은 환자의 위조직표본 중 보존상태가 양호한 파라핀 포매괴 150예를 연구대상으로 조직 표본에서 면역 조직화학적 염색을 통해 관찰하였다. 결과: 1. RAR의 발현은 장형 위선암종(72.2%)에서 미만형 위선암종(40.5%)보다 높게 나타났으며(P<0.01), 림프절 전이가 있는 경우(74.7%)가 림프절 전이가 없는 경우(49.2%)보다 의미 있는 발현양상을 나타냈다(P<0.01). 2. cAMP response element binding protein (CREB)의 발현은 장형 위선암종(69.4%)에서 미만형 위선암종(38.1%)보다 높게 나타났으며(P<0.01), 림프절 전이가 있는 경우(71.1%)가 림프절 전이가 없는 경우(47.8%)보다 높은 발현양상을 나타냈다(P<0.01). 3. 총 150예의 위선암종에서 RAR은 63.3% (95/150), CREB은 60.7%(91/150)에서 발현을 나타냈다(P<0.01). 결론: 이상의 결과로 RAR과 CREB은 조직학적 분화도 및 종양의 전이와 관련이 있고, 이들의 발현이 장형 위선암종에서의 생물학적 악성도에 관한 예후인자로서 관련이 있으나 이들의 발현이 위선암종에 미치는 생물학적 기전에 대한 추가 연구가 필요하다. Purpose: Transcriptional factors of CREB (cAMP response element binding protein) are involved in regulating the gene expression in response to a variety of signaling pathways. The proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues. This study examined the expressions of RAR and CREB and their relationship with the clinicopathologic factors and their significance. Materials and Methods: The levels of the RAR and CREB expressions were measured in 150 gastric adenocarcinomas by performing immunohistochemical staining. Results: 1. An RAR protein expression was found in 63.3% of the adenocarcinomas (95/150) and a CREB expression was found in 60.7% (91/150) of the adenocarcinomas. 2. An RAR protein expression was found in 72.2% (78/108) of the intestinal type adenocarcinomas and in 40.5% (17/42) of the diffuse type adenocarcinomas (P<0.05). Based on the depth of invasion, an RAR protein expression was found in 58.3% (14/24) of the T1 adenocarcinomas, in 61.9% (13/21) of the T2 adenocarcinomas, in 63.5% (61/96) of the T3 adenocarcinomas, in 77.8% (7/9) of the T4 adenocarcinomas and in 74.7% (62/83) of the adenocarcinomas with lymph node metastasis and in 49.2% (33/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 3. A CREB expression was found in 69.4% (75/108) of the intestinal type and in 38.1% (16/42) of the diffuse type (P>0.05). Based on the depth of invasion, a CREB expression was found in 50% (12/24) of the T1 adenocarcinomas, in 52.4% (11/21) of the T2 adenocarcinomas, in 64.6% (62/96) of the T3 adenocarcinomas, in 66.6% (6/9) of the T4 adenocarcinomas, in 71.1% (59/83) of the adenocarcinomas with lymph node metastasis and in 47.8% (32/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 4. The RAR protein and CREB expressions coincided in 71.4% of the gastric adenocarcinomas and a significant correlation between them was found (P<0.05). Conclusion: We found a significant relationship between the expression of RAR and CREB and the histology and lymph node metastasis of gastric cancer. Further studies are needed to confirm their biologic meaning in gastric carcinogenesis.
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최정원 ( Jung Won Choi ),한호선 ( Ho Sun Han ),이미영 ( Mi Young Lee ),안준모 ( Jun Mo Ahn ) 한국생산성학회 2015 生産性論集 Vol.29 No.1
Traditional corporate bankruptcy prediction methodology basically relies on financial accounting data to objectively reflect the status of companies. However, since financial accounting data is difficult to immediately reflect changes in the status of companies, real-time financial data such as stock and bond prices are also used in order to make up for the shortcomings. In this study, we use news text information which is a typical real-time information to study the corporate bankruptcy prediction models. In the past, news text information was difficult to use in quantitative analysis but not any more due to the recent advances of information processing technology and text-mining techniques. For bankruptcy prediction using news information, we collect news text for six months before the bankruptcy events of companies actually occur and study the possibility of bankruptcy prediction based on the data by utilizing text-mining techniques. Results indicate that we can not get such a high level of predictability as that of existing corporate bankruptcy prediction models, but that there exists a high potential of this approach enough to increase the predictability of bankruptcy models. Further research on bankruptcy prediction model using news text information will be promising.
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韓灝鮮 수원대학교 1990 地域社會開發 Vol.2 No.-
Pathing through industrialization process of the past three decades, Korean agriculture and rural society have undergone drastic changes, consequently falled behind the manufacture/urban sector. The rural problem is outlined now by the unstable agricultural prices, accumulated farmer's debt, and old-aged and feminized manpower in the rural community. During the period, the 1433 agricultural cooperatives at nationwides, as the strategic organization for the rural community development, have given their full efforts to satisfy the farmer members' needs and striven to catch up those disparities with urban. In rural community development, the cooperatives have covered the overall aspects of the rural people in farming, living and even socio-cultural welfares-cooperative education, supports for the villages' grass-root groups, mobilization of the rural savings, agricultural development and increases of the farm income, supports for housing, health and community infrastructures and others-by doing their purposive businesses and activities. The agricultural/rural sector recently, is distinctly confronted the problematic import-open pressure by Uruguay-Round, while the cooperatives should settle down its democratization process concretely after achieving the direct-voting device for the cooperative presidents. It is also very predictable that the autonomic power of the local government may be materialized in a near future, however this political reform is under hotly debating. This trend shall stimulate the community development movement for entering a new era wherein the self-reliable grass-root organization of the rural area will eagerly and actively participate in their own local development programs. In this turmoil situation, it is timely worth to discuss the role-adjustment of the cooperative in community development in terms of the basic principles of the two, for accomodating the various farmers' needs in the context of the changed environments and policies for rural community system. This study tried to review the past role of the cooperative and thus to re-draw the future role-expectation through literatures review and second-data analyses.
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