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      • KCI등재
      • KCI등재

        구조활성상관(QSAR)에 의한 피마엽 추출물의 HIV-1 효소억제활성인자 예측

        한창호,유영법,Han, Chang-Ho,Yu, Young-Beob 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

        Objectives : For the purpose of developing new anti-HIV agents from natural sources, the extracts of Ricinus communis were tested for their inhibitory effects on essential enzymes reverse transcriptase (RT), protease and alpha-glucosidase. Inhibition activity of major compounds of Ricinus communis were predicted from quantitative structure activity relationships (QSAR) in silico. Methods and Results : In the anti-HIV-1 RT using enzyme-linked oligonucleotide sorbent assay (ELOSA) method, water and methanol extracts (100ug/ml) of Ricinus communis showed strong activity of 94.2% and 82.7%, respectively. In the HIV-1 protease and alpha-glucosidase inhibition assay, neither water nor methanol extracts of Ricinus communis inhibited the activity of the enzyme to cleave any substrates as oligopeptides and oligosaccharides. Conclusions : We found that for these samples it is possible that the inhibition of the RT in vitro is due to the secondary metabolites of Ricinus communis such as ricinine and quercetin. It would beof great interest to identify the compounds which are responsible for this inhibition, since all therapeutically useful agents up to date are RT inhibitors.

      • KCI등재

        도광판의 자동결함검출을 위한 템플릿 검사와 블록 매칭 방법

        한창호,조상희,오춘석,유영기,Han Chang-Ho,Cho Sang-Hee,Oh Choon-Suk,Ryu Young-Kee 한국정보처리학회 2006 정보처리학회논문지B Vol.13 No.4

        In this paper, two methods based on the use of morphology and pattern matching prior to detect classified defects automatically on the back light unit which is a part of display equipments are proposed. One is the template check method which detects small size defects by using closing and opening method, and the other is the block matching method which detects big size defects by comparing with four regions of uniform blocks. The TC algorithm also can detect defects on the non-uniform pattern of BLU by using revised Otsu method. The proposed method has been implemented on the automatic defect detection system we developed and has been tested image data of BLU captured by the system. 본 논문에서는 자동결함검출 방법으로 도광판의 다양한 패턴에 나타나는 돌출, 함몰, 점 등과 같은 작은 결함들을 검출하기 위해 모폴로지의 닫힘, 열림 방법을 이용하는 템플레이트 검사 방법을 사용하였고, 얼룩, 스크래치와 같은 큰 결함을 검출하기 위해 영상에서 격자와 같은 일정한 블록을 형성하여 각 블록을 비교하여 결함을 찾는 블록매칭 방법을 사용하였다. 또한 일정한 패턴이 없는 도광판의 결함에 대해 결함을 검출할 수 있는 개선된 오쯔 방법을 이용하였다. 이 알고리즘을 적용한 결과 결함 검출에 좋은 성능이 있음을 보여준다. 제안된 알고리즘은 자체 개발한 장비에서 실제 도광판의 영상을 얻어 테스트 하였다.

      • KCI등재

        중풍환자에 대한 일차 한의임상진료 가이드라인

        한창호,Han, Chang-Ho 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

        The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on stroke management for clinical practitioners. Many countries are already well engaged in developing and releasing their own clinical practice guidelines, whereas Korean Medicine (KM) is still beginning. It will take time and effort to develop evidence-based guidelines and recommendations of KM or other traditional medicine because they are weak in the area of scientific evidence. The clinical practice guideline of Korean medicine for stroke was formulated through extensive review of published literature and consensus meeting of Korean medicine specialists. This project was supported by a grant of the Oriental Medicine R&D Project, the Ministry of Health and Welfare. Referring to guidelines developed in other countries, the experts in the subject tried to organize and develop guidelines and recommendations adequate for domestic medical circumstances. In December, 2008, a multi-disciplinary team called the Evidence Based Clinical Practice Guidelines Development Group (EBCPGsDG) for Stroke was organized. The writing committee was comprised of experts in internal medicine, acupuncture, rehabilitation, and Sasang constitution. Outside specialists and associated panels were invited for consultation. The scope of the guideline encompasses acupuncture, moxibustion and herbal medicine (including Korean medicine, traditional Chinese medicine, Kampo medicine) as interventions for stroke patients. It includes statements about ischemic stroke (I63), stroke not specified as hemorrhage or infarction (I64), and sequelae of cerebrovascular disease (I69) according to the International Classification of Disease (ICD). The committee subdivided the description of herbal medications into acute stroke management, subacute stroke management, post-stroke management, and secondary prevention of stroke. Guidelines on the practice of acupuncture and moxibustion were described in order for acute stroke management, subacute stroke management, chronic stroke management, and post-stroke rehabilitation. Clinicians who are working in the field of stroke care can adopt this guideline for their practice.

      • KCI등재후보

        뇌실-복강 단락술 후 증상 호전 없었던 Normal Pressure Hydrocephalus 환자의 치험 1례

        윤경선,권건록,한창호,정승현,신길조,이원철,정현정,Yoon, Kyoung-Sun,Kwon, Gun-Rok,Han, Chang-Ho,Jung, Seung-Hyun,Sin, Gil-Jo,Lee, Won-Chul,Jung, Hyun-Jung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4

        The basic mechanism of normal pressure hydrocephalus(NPH) is found in an impediment to CSF absorption. In about half of the cases, the etiology remains obscure. NPH is more frequently found in elderly people. The main symptoms are gait disturbances, urinary incontinence and various degree of cognitive changes. The current treatment is ventriculo-peritoneal shunting, ideally using an adjustable valve. In about half of surgical operations, results are poor. Hyeongbangjihwang-tang(荊防地黃湯) is used to treat Soyangin(少陽人) weakness(虛弱) and edema(浮腫). It is and important Gang-Yin(降陰) medicine. A Soyangin patient diagnosed with NPH, who had undergone surgery for ventriculo-peritoneal shunting, was treated with Hyeongbangjihwang-tang. Significant improvement of clinical symptoms was seen, so it is here reported.

      • KCI등재

        지속가능 디자인의 영속적, 일시적 문화 산물 기준의 상관성 연구

        김별 ( Byul Kim ),한창호 ( Chang Ho Han ) 한국기초조형학회 2012 기초조형학연구 Vol.13 No.1

        산업의 발달로 인한 생태계의 파괴로 지속가능디자인은 경제, 사회, 문화 등 다양한 측면에서 연구된다. 이는 마이클 톰프슨(Michael Thompson)의 고물 이론(Rubbish Theory)과도 연관된다. 그는 경제적 가치와 직접적인 연관을 가진 사물의 유형을 세 가지 기호학적인 유형으로 설명하였다. 사물은 고물, 일시적 문화가치, 영속적 문화가치의 유형으로 분류되며 각 범주로 이동할 수 있다. 이 이론을 배경으로 버려진 폐공간이 다시 지속가능한 공간으로 활용되는 사례를 조사했다. 그 결과 도상적인 기호는 폐건물이나 폐자원의 활용이나 이를 통해 역사적 맥락위에 혁신적인 미래를 암시한다고 볼 수 있다. 또한 이를 통해 지역 커뮤니티를 활성화하고 지역을 랜드 마크 화 함으로 도시재생의 역할을 한다고 할수 있다. 경험적인 관점에서는 감각과 감성, 관계라는 체험을 바탕으로 하고 있었다. 또한, 감각에서 감성, 감성에서 관계라는 연결고리가 생성된다. 더욱 세분화하면 감각은 실용성과 예술성, 감성은 능동적과 수동적, 관계는 공공과 개인화 로 더욱 세분화 할 수 있었다. 감각에서 감성, 관계의 단계로 진행할수록 영속적 문화 산물의 성격이 짙어진다. 그중 실용성, 수동성, 개인화는 일시적 문화 산물로 규정되는 단계이며 예술성, 능동성, 공공은 영속적 문화 산물로 규정되는 요소이다. 본 연구를 통해 최근 활발한 연구가 일어나는 지속가능디자인이 영속적인 가치를 지닌 디자인으로 가능성을 제시하고자 하였다. The destruction of ecosystem due to the development and growth of the industry is becoming the greatest danger in area for human. Sustainable design is awareness about nature. Environmental concerns and interests is associated with Michael Thompson`s essay, ``Rubbish Theory``. He explained the type of things that have a direct impact with economic value in three types of semiotics. Obeject can be devided into rubbish, temporary culture value, and persistent culture value. It can be moved to each categories and its value may change. In this research, in order to find the standard of deviding temporary and persistent culture values, I studied the cases by deviding them into semiology and experimental perspectives. As a result, a sign iconography is a usage of deserted space. But iconic symbols suggest innovative future on history. Also, local community can advance and make it landmarked. In experimental perspectives, sense, feeling, relation can decide the temporary and persistent culture value. Sense is composited with practicality and artistry. Feeling is composited with active and passive. Relation is composited with public and personal. It becomes a persistent culture value when it processes in an order of sense, feeling and relation. Especially, when practicalty, passive, and personalization increases, it becomes a temporary culture value. When artistry, active and public increase, it becomes a persistent culture value. I wish the result of this study can be a help for turning the sustainable value into persistent value.

      • KCI등재
      • 교류 유전영동 및 횡단면 전열유동 기반의 선택적인 박테리아 채집을 위한 미세유체 장치

        한창호(Chang-Ho Han),김명우(Myeong-Woo Kim),김기훈(Gi Hoon Kim),김동민(Dongmin Kim),박재형(Jae Hyeong Park),하준엽(Jun Yeop Ha),장재성(Jaesung Jang) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12

        Dielectrophoresis (DEP) is an effective technique for manipulating a specific species of particle from mixtures when they are applied to microfluidic devices, and this can be used for many analyses like disease diagnosis, food hygiene, or microorganism monitoring. Planar electrodes, such as interdigitated electrodes, are widely used to induce DEP in microfluidic devices because of its simple fabrication processes, but as the DEP needs high spatial non-uniform electric fields, the particles which are distant from the electrodes are not manipulated properly. So, for the enough particle manipulation by DEP in microfluidic channel with keeping using the planar electrodes, AC electrothermal (ET) flow were used to assist those works. On the main channel flow whose direction is longitudinal, the electrothermal flow were intended to be induced in cross-sectional direction of the microchannel to induce the flow continuously. To operate the DEP and ET flow simultaneously using AC signals, the planar electrodes were designed properly, and at 1 MHz of AC frequency, the target bacteria Escherichia coli (E. coli) can be captured by positive DEP on to the electrodes, and ET flow can be induced as well. So, many of distant bacteria can be pulled to the electrodes by ET flow, and captured by positive DEP. In a microchannel of 300 um width and 160 um height, around 60% of bacteria coming into the microfluidic device can be selectively captured even many of them were located further from the electrodes.

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