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복수를 침범한 소세포형 T-세포 전림프구성 백혈병의 세포소견 -1예 보고-
한지영,김진수,김동훈,김루시아,박인서,김준미,주영채,최석진,Han, Jee-Young,Kim, Jin-Soo,Kim, Dong-Hoon,Kim, Lucia,Park, In-Suh,Kim, Joon-Mee,Chu, Young-Chae,Choi, Suk-Jin The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.2
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell lymphoproliferative disorder with a post-thymic mature T-cell phenotype. The disease is characterized by rapidly rising lymphocytosis, lym-phadenopathy, and splenomegaly. The clinical course is usually aggressive and progresses with frequent skin lesions and serous effusions. In 25% of cases, leukemic cells are small and tumor cells may not have a discrete nucleolus under light microscopy. Although the presence of characteristic cytoplasmic protrusions or blebs in tumor cells is a common morphologic finding in the peripheral blood film irrespective of the nuclear features, small cell variants lacking the typical nuclear features can cause diagnostic problems in clinical cytology. Furthermore, the small leukemic cells can share some cytologic findings with lymphocyte-rich serous effusions caused by non-neoplastic reactive lymphocytosis as well as other small lymphocytic lymphoproliferative disorders. Here, we describe the cytological findings of ascitic fluid complicated by small cell variant T-PLL in a 54-year-old man, the cytology of which was initially interpreted as small lymphocytic malignancy such as small lymphocytic lymphoma/chronic lymphocytic leukemia.
한지영,이광길,Han, Jee-Young,Lee, Kwang-Gil 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.1
A case of paraganglioma of the retroperitoneum diagnosed by fine needle aspiration cytology is described. A 60-year-old man presented with abdominal discomfort for 4 months. The smear revealed cellular sheets with partly rosettoid appearance. Many piexiform capillaries were distributed between the cellular sheets or encircled the cellular nests forming zell-ballen pattern. The tumor cells were monotonous and oval to round. The cytoplasm was amphophillc, finely granular and poorly defined. The nuclei were round and had evenly dispersed chromatin and small nucleoli. Cells having large or spindle nuclei were some-times observed. The tissue sections showed typical findings of paragnglima. The cytological differential diagnoses included islet cell tumor of the pancreas and carcinold tumor. The clinical and histoloigic findings as well as cytologic findings were helpful to confirm the diagnosis.
Warthin 종양의 세침흡인 세포학적 소견 - 3 예 보고 -
한지영,이광길,Han, Jee-Young,Lee, Kwang-Gil 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
Warthin's tumor is a benign salivary gland tumor, occurring primarily in the parotid gland. It's incidence is 4% of all salivary gland tumors. The cytologic finding of Warthin's tumor is characteristic and it consists of sheets of oncocytes and scattered lymphocytes in the background of granular material. We reports three cases of Warthin's tumor showing characteristic cytologic findings. The patients consisted of two males and a female and their ages were 60, 73, and 69 years, respectively. All the lesions were in the parotid gland. The cytologic findings showed sheets of oncocytic epithelial cells and scattered lymphocytes in the back-ground of granular materials and many red blood cells. In one case, the back-ground was composed of many Inflammatory cells including lymphocytes, neutrophils and macrophages.
증례 : 혈액종양 ; 비장절제술로 진단된 아시아변종 혈관내대B세포림프종 1예
한지영 ( Jee Young Han ),이현규 ( Hyeon Gyu Yi ),이진수 ( Jin Soo Lee ),최석진 ( Suk Jin Choi ),임주한 ( Joo Han Lim ),김철수 ( Chul Soo Kim ),이문희 ( Moon Hee Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
저자들은 불명열, 비장경색을 동반한 비장종대를 주요 임상양상으로 발현하여, 최종적으로 비장절제술에 의해 확진 된 아시아변종 혈관내대B세포림프종을 경험하였고, 불명열 및 비장경색의 감별진단으로 아시아변종 혈관내대B세포림프종을 고려해야 하는 것을 알리고자 한다. Intravascular large B cell lymphoma (IVLBCL) is a rare form of non-Hodgkin`s lymphoma, characterized by systemic proliferation of neoplastic B cells within blood vessels. The diagnosis is frequently delayed, because of the lack of clues in imaging studies. The course is usually aggressive and fatal. Asian-variant intravascular large B cell lymphoma (AIVL) shows characteristic clinical manifestation as hemophagocytic syndrome, associated with bone marrow and hepatosplenic involvement and, rarely, neurological abnormalities and skin manifestations. We report the case of a 51-year-old female who was considered initially to have fever of unknown origin with splenic infarction and was confirmed as AIVL by splenectomy involving liver, spleen, and bone marrow, with hemophagocytic features. (Korean J Med 77:S1309-S1313, 2009)
사례보고 : Alverine citrate에 의해 유발된 급성 간염 1예
한지영 ( Jee Young Han ),이진우 ( Jin Woo Lee ),김준미 ( Joon Mee Kim ),주고운 ( Kowoon Joo ),천웅 ( Ung Chon ),이정일 ( Jung Il Lee ),정석 ( Seok Jeong ),이돈행 ( Don Haeng Lee ),김영수 ( Young Soo Kim ),민경선 ( Kyung Sun Min 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.1
저자들은 75세 여자 환자에서 국내 처음으로 발생한 alverine citrate에 의한 약인성 간염 1예를 경험하였으며 이를 문헌고찰과 함께 보고하고자 한다. Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome. Alverine-citrate-induced hepatotoxicity is extremely rare, with only a few cases having been reported worldwide. We present a case of a 75-year-old female patient who experienced complicated jaundice and abdominal discomfort after taking alverine citrate. Other causes of hepatitis were ruled out and the results of the liver function test returned to normal after ceasing the drug. This is the first case report in Korea of alverine-citrate-induced hepatotoxicity. (Korean J Hepatol 2010;16:75-78)
당뇨병성 신증 : 아포지단백 E 제거 백서에서 장기적인 Deoxycorticosterone acetate 투여가 미치는 영향에 관한 연구
고강지 ( Gang Jee Ko ),강영선 ( Young Sun Kang ),송혜경 ( Hye Kyoung Song ),이미화 ( Mi Hwa Lee ),권오성 ( Oh Sung Kwon ),한금현 ( Kum Hyun Han ),한상엽 ( Sang Youb Han ),한지영 ( Jee Young Han ),김형규 ( Hyoung Kyu Kim ),차대룡 ( 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1
실험적 신질환 : 제 2형 당뇨 모델인 db/db mice에서 ACE inhibitor와 ARB의 병합투여가 인슐린저항성에 미치는 효과
이미화 ( Mi Hwa Lee ),송혜경 ( Hye Kyoung Song ),고강지 ( Gang Jee Ko ),강영선 ( Young Sun Kang ),권오성 ( Oh Sung Kwon ),한금현 ( Kum Hyun Han ),한상엽 ( Sang Youb Han ),한지영 ( Jee Young Han ),김형규 ( Hyoung Kyu Kim ),차대룡 ( 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1
김루시아,한지영,박인서,최석진,김준미,주영채,Kim, Lucia,Han, Jee-Young,Park, In-Suh,Choi, Suk-Jin,Kim, Joon-Mee,Chu, Young-Chae 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1
Parathyroid tumors may be difficult to distinguish from thyroid follicular lesions, especially when a tumor is nonfunctioning. We report here two cases of asymptomatic parathyroid carcinoma preoperatively misdiagnosed as thyroid follicular lesions, and one case of parathyroid adenoma showing hyperparathyroidism, and review the cytologic features favoring the diagnosis of parathyroid neoplasm. The cytologic findings that are characterized by clean background, monomorphic small cells, cohesive three-dimensional papillary clusters, small tight clusters with scattered naked nuclei, and well-defined clear cytoplasm favor a diagnosis for the parathyroid lesions. Cytologic findings such as macrofollicular structure, presence of colloid and macrophages, and presence of perivacuolar cytoplasmic granules on May-Grunwald-Giemsa stain support a diagnosis of a thyroid follicular lesion. The cytomorphology of parathyroid tumors is so variable that the distinction from a thyroid lesion cannot be based on the presence or absence of a single feature only but on the cytologic features as a whole.