비인강 점막성 악성흑색종 2예

한지연(Ji Youn Han),김민식(Min Sik Kim),장홍석(Hong Seok Jang),김훈교(Hoon Kyo Kim),홍영선(Young Seon Hong),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),박영학(Young Hak Park),조승호(Seung Ho Cho),서병도(Byung Do Seo),윤세철(Sei Chul 대한두경부종양학회 1995 대한두경부 종양학회지 Vol.11 No.1

Melanoma of the mucous membrane is a rare condition and has the worse prognosis than that of any other sites. It is usually asymptomatic in early stage and difficult to find out the primary lesion by visual examination, and these facts lead to delay in diagnosis and reduce the curability. The major factor of failure in treatment of melanoma is local recurrence rather than regional spread. Because the radical procedure is difficult in head and neck lesion due to anatomical limitation, radiation therapy and chemotherapy can be used in the treatment of local recurrence. We experienced two cases of nasopharyngeal melanoma in advanced stage and treated them with radiation therapy and/or chemotherapy. And both patients showed relatively favorable response to these palliative treatments.

GIS를 활용한 쓰레기 매립지 입지 선정과정의 체계화 연구

한지연(Han, Ji Youn) 대한공간정보학회 2014 대한공간정보학회지 Vol.22 No.3

쓰레기 매립지는 기피시설로 입지를 선정하는 초기부터 심각한 갈등을 야기하고 설치과정에 있어서도 많은 어려움을 동반하는 사회적 문제로 인식되는 경우가 대부분이다. 본 연구에서는 매립지의 설치에 있어서 그러한 어려움을 최소화하고 그 과정을 보다 객관화하는 방법으로 매립지 입지선정과정의 체계화 및 표준화를 제시하였으며, 그 내용은 다음과 같다. 첫째, 매립지 입지선정과정을 구체적 사항들로 세분화하기 보다는 보다 보편적인 내용으로 구성하여 크게 4단계로 나누어 각 단계별로 대표적인 필요사항들을 제시함으로써 다양한 경우에도 융통성 있는 적용이 가능하도록 하였고 이를 통한 매립지 입지 선정과정의 표준화를 유도하였다. 둘째, 단계별로 제시된 과정을 진행함에 있어서 GIS(Geographic Information System)와 다 기준의사결정방법 중 하나인 PAPRIKA(Potentially All Pairwise RanKings of all possible Alternatives)를 적용하여 보다 객관적이고 과학적인 방법의 활용을 유도하였다. 셋째, 이러한 내용을 바탕으로 청주 시를 대상으로 가상적 사례 연구를 진행하였으며, 그 결과를 분석하여 최종 결론을 도출함으로써 매립지 입지선정과정의 단계별 적용 실용성과 과정의 객관성을 증명하였다. Waste landfill site which is the facility usually rejected by communities is generally perceived as one of the serious social problems. It causes serious conflicts between interested parties from the beginning of the site selection process and produces various difficulties throughout the installation process. This study suggests the systematization and standardization of the landfill site selection process to reduce those problems and to objectify the process. The study process and results are as follows. First, the landfill site selection process was divided into 4 general phases rather than more specific fragmented phases and the requirements for each phase were suggested accordingly. This can make the process clearly organized and bring the standardization of the process by increasing the applicability of each phase for various situations. Second, the utilization of GIS(Geographic Information System) and PAPRIKA (Potentially All Pairwise RanKings of all possible Alternatives) among the various MCDA(Multi-Criteria Decision Analysis) methods was suggested as the objective and scientific method. Third, the hypothetical case study on the landfill site selection process of Cheongju city was conducted based on the information above and the results show the practicability and objectivity of the newly defined landfill site selection process in this study.

줄넘기와 걷기의 복합운동 트레이닝이 중년 여성의 신체구성, 체력, 혈중 지질 및 인슐린 저항성에 미치는 영향

한지연 ( Ji Youn Han ),이만균 ( Man Gyoon Lee ),성순창 ( Soon Chang Sung ) 한국스포츠정책과학원(구 한국스포츠개발원) 2009 체육과학연구 Vol.20 No.2

본 연구의 목적은 줄넘기와 걷기의 복합운동 트레이닝이 일반 중년 여성의 신체구성, 체력, 혈중 지질, 그리고 인슐린 저항성(insulin resistance)에 미치는 영향을 규명하는 것이었다. 트레이닝 집단의 피검자 9명은 최대 심박수의 65~80%로 24분간 실시하는 줄넘기와 최대심박수의 55~70%로 30분간 실시하는 걷기로 구성된 복합운동 트레이닝에 주 3~5회씩, 8주간에 걸쳐 참여하여 완료하였고, 통제 집단의 피검자 7명은 동일한 기간 동안 일상생활을 평소대로 유지하였다. 처치 전·후에 신체구성(근육량, 체지방량, 체지방률 및 BMI), 체력(악력, 팔굽혀펴기, 앉아윗몸앞으로굽히기, 눈감고외발서기, 제자리멀리뛰기, 윗몸일으키기 및 1,200m 달리기), 혈중 지질(FFA, TC, HDL-C, LDL-C 및 TG), 그리고 인슐린 저항성 관련 변인(혈중 글루코스, 혈중 인슐린 및 HOMA-IR)을 측정하였으며, 반복 이원변량분석(repeated two-way ANOVA)을 이용하여 집단 간에, 그리고 검사 간에 평균의 차이를 검증하였다. 본 연구에서 얻은 주요 결과는 다음과 같다. 첫째, 트레이닝 집단은 체중, 체지방량, 그리고 BMI가 유의하게 감소된 반면, 통제 집단은 모든 신체구성 관련 변인에서 유의한 변화가 나타나지 않았다. 둘째, 트레이닝 집단은 악력, 앉아 윗몸 앞으로 굽히기, 그리고 1,200m 달리기 기록이 유의하게 향상된 반면, 통제 집단은 제자리멀리뛰기 기록이 유의하게 저하되었다. 셋째, 트레이닝 집단은 FFA와 HDL-C가 유의하게 증가되었고, TC, LDL-C, 그리고 TG는 감소되는 경향을 보였다. 넷째, 트레이닝 집단은 혈중 인슐린 농도와 HOMA-IR이 유의하게 감소되었다. 따라서 8주간의 줄넘기와 걷기의 복합 트레이닝이 신체구성의 긍정적인 변화, 근력, 유연성, 순발력 및 심폐지구력의 향상, 그리고 혈중 지질 특성과 인슐린 저항성의 개선에 효과적이었다고 결론지을 수 있다. 본 연구를 통하여 일반인이 쉽게, 그리고 경제적으로 실시할 수 있는 줄넘기와 걷기 운동을 복합적으로 수행하는 것이 일반 중년 여성의 건강에 긍정적인 영향을 미친다는 사실이 밝혀졌으며, 이는 현장 적용 측면에서 의미가 크다고 판단된다. This study was designed to examine the effects of combined training of rope skipping and walking on body composition, physical fitness, blood lipids, and insulin resistance. Sixteen middle-aged women volunteered to participate in this study as subjects and were randomly assigned to either combined training group (TR: n=9) or control group (CON: n=7). Subjects in TR undertook the rope skipping at 65~80% of HRmax for 24 min/session and walking on treadmill at 55~70% of HRmax for 30 min/session, three to five times per week for 8 weeks, whereas subjects in CON were asked to maintain their normal life patterns throughout the intervention period. Body composition(muscle weight, fat weight, percent body fat, and BMI), physical fitness(grip strength, push-up, sit-and-reach, one leg standing with eye-closed, standing long jump, side step, sit-up, and 1,200m run/walk), blood lipids(FFA, TC, HDL-C, LDL-C, and TG), and insulin resistance-related variables(blood glucose, insulin, and HOMA-IR) were measured in both groups before and after the interventions. The mean values of the variables were compared between two groups and between two tests using repeated two-way ANOVA. Main results of the study were as follows: 1) Body weight, fat weight, and BMI decreased significantly in TR, whereas no significant change was found in body composition-related variables in CON. 2) Grip strength, sit-and-reach, and 1,200m run/walk improved significantly in TR, whereas standing long jump decreased significantly in CON. 3) There was significant increase in FFA and HDL-C in TR. In addition, TC, LDL-C, and TG showed a tendency to decrease in TR. 4) Fasting insulin and HOMA-IR decreased significantly in TR. It was concluded that the 8 weeks of combined training of rope skipping and walking would have positive effect on body composition, physical fitness, blood lipids profile, and insulin resistance.

Epstein-Barr Virus in Nasal Angiocentric Lymphoma with Malignant Histiocytosis-like Hemophagocytic Syndrome

한지연(Ji Youn Han),김훈교(Hoon Kyo Kim),문한림(Han lim Moon),서은주(Eun Joo Seo),권희정(Hi Jeong Kwon),박연준(Yeon Joon Park),민기옥(Ki Ouk Min),윤세철(Sei Cheol Yoon),김민식(Min Shik Kim),조승호(Seong Ho Cho),김병기(Byung Kee Kim) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.1

서론 : 혈구탐식증후근은 고열, 범혈구감소증, 간비장종대, 림프절비대 및 혈액응고장애 등을 동반하는 전신적 질환으로 대부분 면역억제 상태에서 바이러스 및 각종 병원체의 감염에 의해서 유발되고 예후가 불량하다. 조직학적으로 림프세망기관의 조직구의 증가와 혈관탐식현상이 빈번히 관찰되고 이와 같은 현상을 보이는 악성조직구증식증과의 감별이 어렵다. 코의 혈관중심위 림프종은 거의 일정한 Epstein-Barr 바이러스(EBV)양성을 보인다고 보고되고 있고 병의 경과중 혈관탐식증추군이 빈번하게 발생되는데 이는 EBV감염에 의해서 유발된다고 보아지고 있다. 재료 및 방법 : 1985년 1월부터 1995년 12까지 강남성모병원과 성바오로병원에서 코의 혈관중심위 림프종으로 진단 받았던 환자 42명 중 혈구탐식증후근을 동반한 10명을 대상으로 임상양상을 관찰하고, 조직표본에 면역조직화학염색법과 교잡반응을 사용하여 악성세포의 표현형을 살펴보고 EBV와의 관련성을 관찰하였다. 결과 : 10명의 환자 중 5명은 혈관중심위 림프종 진단당시, 3명은 재발시기, 2명은 관해 시기에 혈구탐식증후군을 동반하였다. 모든 환자에서 실시된 치료방법에 상관없이 치명적인 경과를 보였으며 중앙생존기간은 18일(2-44일)이었다. 대상 모두에서 T형세포 표현형과 교잡반응상 EBV양성을 보였으며, EBV는 주로 악성림프종세포에 분포양상을 보였다. 결론 : 혈구탐식증추군은 코의 혈관중심위 림프종의 흔한 합병증으로 불량한 예후를 보인다. 임상적 양상 및 조직학적 검사상 악성 조직구증가증과 유사한 소견을 보여 감별이 어렵고, 치명적 결과를 초래하므로 치료에 어려움을 주고 있다. 코의 혈관중심위 림프종과 밀접한 관계를 보이는 EBV에 의해서 유발된다고 보아지고 있으며 치료의 개선을 위하여 앞으로 병인적연구가 필요하다고 생각된다. Malignant histiocytosis(MH)-like hemophagocytic syndrome(HS) is a fatal complication of nasal angiocentric lymphoma(AL) and difficult to distinguish from MH. Ten of total 42 patients with nasal AL had HS and 9 of them were initially suspected to have MH. Five patients had HS as initial manifestation, 3 at the time of relapse, and 2 during the clinical remission of lymphoma. Four patients were treated by combination chemotherapy(CHOP) and others had only supportive care. Immunohistochemical study and in situ hybridization were performed on the specimen obtained from 10 patients. The median survival of all patients from HS was 18 days(range 2 - 44 days) and all had fatal outcome regardless of the treatment-modality. All cases were positive for UCHL1(CD45RO) and Epstein-Barr virus (EBV) by EBER in situ hybridization. MH-like HS is a fatal complication of nasal AL and has a high association with EBV. Reactivation of EBV may contribute to HS and further investigation of predictive factors and effective treatment of HS should be pursued in future.

유아교육기관 종사자의 구강보건 실천에 관한 연구(서울, 경기지역을 중심으로)

한지연 ( Ji Youn Han ) 단국대학교 정책과학연구소 2011 정책과학연구 Vol.20 No.1

유아교육기관을 이용하고 있는 유아들과 하루일과의 대부분을 같이 보내고, 유아들에게 교육자의 역할, 보호자 및 양육자의 역할을 대신 담당하고 있는 유아교육기관 종사자의 구강보건에 대한 실천 정도를 살펴보고, 향후 유아교육기관 종사자를 위한 구강보건교육 프로그램개발의 기초 자료 및 방향을 제시하고자 한다. 서울·경기 유아교육기관에 근무하는 종사자를 대상으로 2007넌 9월17일부터 10월17일까지 310명을 우편을 이용한 자기기입식 설문조사방식으로 진행하였다. 이중 불성실한 응답의 설문지를 6부 제외한 304부를 본 연구의 자료 분석의 대상으로 하였다. 자료의 분석은 SPSS(Statiscal Package for Social Sciences for Windows) 12.0를 이용하여 빈도분석과 Chi-square test, one-way ANOVA를 실시하였고, T-test를 수행하였다. 본 연구 결과 재직 교육기관의 유형에 따른 구강보건지식과의 관련성을 보면 직장보육시설의 교사가 구강보건지식 5점 만점에 3.72점으로 가장 높았으며, 다음으로 국공립 보육시설 교사가 3.61점, 국공립유치원 교사가 3.44점이였으며, 통계적으로 유의한 차이를 보였다. (p<0.05) 재직 교육기관의 유형에 따른 유아구강보건교육실시 여부를 보면 국공립보육시설, 국공립유치원, 직장보육시설에서 90.7%, 84.0%, 81.8%가 구강보건교육을 실시하는 것으로 나타났으며, 이는 통계적으로 유의한 차이를 보였다. (p<0.05) 유아의 정기적 구강검진도 직장보육시설과 국공립보육시설이 90.9%, 89.7%로 높게 나왔으며, 가정 보육시설에서는 정기적 구강검진을 50%만이 시행하고 있었으며 통계적으로 유의한 차이를 보였다. (p<0.05) 이와 같은 결과를 통해서 유아교육기관 종사자들은 유아기에 빈발하는 우리나라 국민의 중대구강병인 치아우식증과 치주병에 대한 지식이 유아교사의 지식으로 볼 때 정확성이 결여되었고, 실천에 있어서 올바른 구강관리 습관이 형성되어 있지 않았다. 그러므로 유아교사들을 위한 구강보건교육지침이 필요할 것이며, 유아교육기관 종사자들에 대한 연수 시 구강관리에 대한 교육이 제공되어야 한다고 사료된다. The study examined the level of oral health knowledge and its practice of those who engaged in childhood education facilities, spent their time with children, were roles of teachers, and were on behalf of guardians and fosterers. The study also tried to suggest a basic material and direction of oral health education program development for those who engaged in childhood education facilities. The subjects were 310 people who engaged in childhood education facilities in Seoul and Gyeonggy. The research were fulfilled with self-administered questionnaire method by post from September 17, 2007 to October 17, 2007. Among 310 questionnaires, only 304 questionnaires were analysed because 6 questionnaires were unreliable. With the analyses of the data used by SPSS (Statistical Package for Social Sciences for Windows) 12.0, frequency analysis and one-way ANOVA were fulfilled and T-test was taken. According to the result, teachers who worked in employer supported childhood facilities got 3.72 points out of 5 and they got the highest score of the three groups, followed by teachers who worked in public child care centers getting 3.6lpoints, and the last was teachers who worked in public kindergartens got 3.44 points in terms of oral health knowledge of education facilities. The difference was statistically meaningful. (p <0.05) When it came to childhood oral education practice of child care centers, 90.7% of public child care centers, 84.0% of public kindergartens, and 81.8% of employed supported childhood facilities educated children and preschoolers. The difference was statistically meaningful.(p<0.05) And 90.9% of employer supported childhood facilities and 89.7% of public child care centers fulfilled periodic oral examination and 50% of family day care center fulfilled it. Employer supported childhood facilities was the highest. The difference was statistically meaningful.(p<0.05) Based on this result, those who worked in childhood education facilities didn``t have accurate ideas of serious oral diseases such as cavity and periodontal disease and when it came to practice, they didn``t have accurate oral management habit. So, oral health education guideline is required for child care center teachers, and those who work in childhood education facilities should be educated about oral management during training workshops.

가성고인산혈증을 동반한 다발성 골수종

한지연(Ji Youn Han),이제훈(Je Hoon Lee),최병길(Byung Gil Choi),문연숙(Youn Sook Moon),진승원(Seong Won Jin),한원희(Won Hee Han),김용구(Yong Gu Kim),홍영선(Young Sun Hong),김훈교(Hoon Kyo Kim),김병기(Byoung Kee Kim),이경식(Kyung Shik 대한내과학회 1996 대한내과학회지 Vol.51 No.2

N/A Objectives: Pseudohyperphosphatemia without clinical manifestations of hyperphosphatemia can be developed in multiple myeloma without renal failure due to the interference with the colorimetric assay by high serum globulin concentrations or due to the specific biochemical feature of paraprotein. We re- viewed the clinical spectrums of multiple myeloma patients with pseudohyperphosphatemia and assessed the mechanism of pseudohyperphosphatemia. Methods: Six patients with pseudohyperphosphatemia out of 67 patients with multiple myeloma diagnosed at a single institution between 1984 and 1994 were analysed. Serum inorganic phosphate concentrations were rechecked after deproteinization processing with 5% trichloracetic acid or 5% ammonium sulfate by Hitachi-747 automatic analyzer in 2 patients. Results: Pseudohyperphosphatemia with hyperglobulinemia involved six patients ; three were male and the median age was 47.5 years old. Six patients diagnosed as multiple myeloma stage IIIA; three were at the initial presentation and the othre three were during the period of disease progression. Three patients died; two were due to disease progession and 1 was due to acute respiratory failure with pneumonia. The concentrations of serum phosphate showed linear correlation with the concentrations of the serum globulin, and returned to normal value after effective treatments of multiple myeloma including chemotherapy and plasmapheresis. The concentrations of phosphate in deproteinized sera were normal in 2 patients. Conclusion: Pseudohyperphosphatemia was developed in 6 out of 67 patients with multiple myeloma(9.0%) during the peak of hyperglobulinemia and accompanied by hyperviscosity syndrome, The concentrations of serum inorganic phosphate showed liner correlation with the concentrations of serum globulin and normalized after effective treatment of multiple myeloma. These data suggest that pseudohyperphosphatemia needs the effective treatment for the underlying multiple myeloma rather than the hyperphosphatemia itself.

국소성 두경부 악성 임파종의 임상적 특징 및 치료 성적 분석

한지연(Ji Youn Han),최병길(Byung Gil Choi),김민식(Min Sik Kim),장홍석(Hong Seok Jang),김훈교(Hoon Kyo Kim),홍영선(Young Sun Hong),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),박영학(Young Hak Park),조승호(Seung Ho Cho),서병도(Byung Do 대한두경부종양학회 1995 대한두경부 종양학회지 Vol.11 No.1

Localized non-Hodgkin's lymphomas of head and neck are generally treated with radiation therapy with or without chemotherapy and the results of treatments are favorable, but the recurrences in the primary site or distant sites are a major contributor to failure, We experiened 19 cases of localized non-Hodgkin's lymphomas for 4-year period and retrogradely analized them. We treated patients with Ann Arbor stage I and low grade histology in Working formulation with radiation therapy and patients with Ann Arbor stage II, moderate to high grade histology or extensive tumor size with combination chemotherapy, The complete responses were occurred in 15 of 19 patients (radiation therapy, 5/6 (83.3%); chemotherapy 10/13(76.9%)). 3 relapses were occurred; 2 were in local relapses and 1 was in distant leptomeningeal relapse and the counter-therapeutic modalities were successful in 2 cases. Our results suggest that Ann Arbor stage is significant prognostic factor and appropriate staging with extensive methods is important to improve the results of treatment.

코의 Angiocentric Immunoproliferative Lesions(AILs)

한지연(Ji Youn Han),김재유(Jae You Kim),이연수(Youn Soo Lee),정수미(Su Mee Chung),김민식(Min Shik Kim),윤세철(Sei Chul Yoon),김훈교(Hoon Kyo Kim),조승호(Seung Ho Cho),김병기(Byung Kee Kim),경식(Kyung Shik Lee),김동집(Dong Jip Kim) 대한두경부종양학회 1996 대한두경부 종양학회지 Vol.12 No.1

Lymphomatoid granulomatosis, polymorphic reticulosis, midline malignant reticulosis, or lethal midline granuloma have similar histologic features of an angiocentric and angiodestructive lymphoreticular proliferation representing the same nosologic entity. The term 'angiocentric immunoproliferative lesion' (AIL) was proposed by Jaffe, Costa, and Martin. The malignant potential of AILs is originally uncertain, but the facts that AILs have a relatively short survival, and most of them usually progress to an overt malignant lymphoma and survival is inversely proportional to the large, atypical lymphoreticular cells suggest that AILs are malignane. We experienced 17 AILs in nose during 16-year period and retrogradely analized them to recognize the problems in the diagnosis and to establish the further therapeutic strategies. The results were as follows; Twelve of total 17 patients who had diagnosed as histologic grade 1 and 2 had received radiation therapy as an initial treatment and the complete response rate was 91.7%(11/12), but 6 out of 11 had local recurrence and 5 had progress to overt maligant lymphoma within 2years. Three patients with the histologic grade 3 and 2 with unclear histologic grade had received CHOP chemotherapy and there was 1 case with complete response. Two patients with unclear histologic grade had been proved to be malignant histiocytosis by bone marrow biopsy during the clinical course. The overall duration of survival was 2 - 119 months and the 5-year survival rate was 71.9%. And the achievement of initial complete response was the most important prognostic factor of overall survival(P=0.006). Our results suggest that the treatment strategy according to the histologic grading scheme is efficient and more aggressive combination chemotherapy may be necessary to achieve complete response in patients with histologic grade III and II, because most of them progress to overt malignant lymphoma during its process.

위암의 조기검진에 의한 병기이전(stage shift) 효과

구정완,박조현,한지연,정인식,백남선,김훈교,이원철,Koo, Jung-Wan,Park, Cho-Hyun,Han, Ji-Youn,Chung, In-Sik,Paik, Nam-Sun,Kim, Hoon-Kyo,Lee, Won-Chul 대한예방의학회 2000 예방의학회지 Vol.33 No.1

Objectives : This study was performed to evaluate the effect of stage shift according to screening of stomach cancer. Methods : Total 840 cases of stomach cancer patients, undergone a surgical operation at Department of Surgery, Kangnam St. Mary's Hospital, The Catholic University of Korea from Jan. 1989 to Dec. 1995, were reviewed by stomach cancer working sheet, and classified as asymptomatic and symptomatic group based on the presence of subjective symptoms on their hospital visit. Their histopathologic stages were analysed. We compared the histopathologic stages of asymptomatic stomach cancer patients with those of symptomatic patients. Results : From the total of 840 patients, asymptomatic patients group comprised 28 cases (3.3%). Proportion of asymptomatic patients tended to increase from 1.9% in 1990, 0.9% in 1991 to 8.6% in 1995. Proportions of asymptomatic patients by stages were 78.6% (stage I), 3.6% (stage III), 17.9% (stage IV) and that of symptomatic patients by stages were 38.2% (stage I), 16.5% (stage II), 24.8% (stage III), 19.1% (stage IV). In less than 40 years old, 50.5% of symptomatic patients were diagnosed as stage I. With increment of ages, proportions of stage I were makedly decreased. It was significantly different between proportion of early gastric cancer in asymptomatic patients (60.1%) and that in symptomatic patients (25.0%). Conclusions : We confirmed stage shift according to screening of stomach cancer. And proportion of early gastric cancer in asymptomatic patients was higher than that in symptomatic patients. This results suggest that screening of gastric cancer be important to reduce mortality and if be indirectly started from 40 years old.

감각신경모세포종: 증례 보고와 문헌 고찰

심병용,박진노,한지연,홍영선,김훈교,이경식,김민식,조승호,정수미,이연수,강진형,Shim Byoung-Yong,Park Jin-No,Han Ji-Youn,Hong Young-Sun,Kim Hoon-Kyo,Lee Kyung-Shick,Kim Min-Sik,Cho Seung-Ho,Chung Su-Mi,Lee Youn-Soo,Kang Jin-Hyoung 대한두경부종양학회 2000 대한두경부 종양학회지 Vol.16 No.2

Objectives: Esthesioneuroblastoma is a rare malignant neoplasm that originates from the olfactory sensory cells. This tumor grows from the upper nasal cavity and ethmoid sinus and invades surrounding structures through the cribriform plate into intracranium or orbit in advanced stage. Even though there has been some controversies in determining standard treatment due to rarity of this tumor, the combination treatment of surgery and adjuvant radiation has been recommended for the locally advanced esthesioneuroblastomas. However, the recent clinical experiences of advanced cases showed that combination chemotherapy is highly effective to reduce tumor mass and improve clinical outcomes. Materials and Methods: The authors conducted a retrospective analysis of 6 esthesioneuroblastoma patients who were treated in our hospital from 1986. Results: The age of these patients was between 19 and 86 year-old. Among the 6 cases, 2 were diagnosed at stage B and 4 at stage C, according to Kadish classification. Anti-tumor treatments were performed in 5 patients. One patient refused active treatment and was lost to follow-up. Better survival outcome were observed in 3 patients who were treated with combination chemotherapy alone or combined modality treatment including chemotherapy. Conclusion: Based on our retrospective study, the combined treatment consisting of surgery, radiotherapy, and combination chemotherapy should be used to improve treatment results. And furthermore, innovative clinical approaches such as neoadjuvant chemotherapy, high-dose chemotherapy and autologous peripheral stem cell transplantation, which have been reported to have good therapeutic results, should be considered and applied actively.