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라미부딘 치료 후 라미부딘 내성을 보이지 않는 환자에서 엔테카비어 효과
하경호 ( Kyung Ho Ha ),주동욱 ( Dong Wook Joo ),김지숙 ( Ji Suk Kim ),김병석 ( Byung Seok Kim ),이창형 ( Chang Hyeong Lee ) 대한내과학회 2013 대한내과학회지 Vol.84 No.6
Background/Aims: The effect of entecavir (ETV) in treatment-naive chronic hepatitis B (CHB) is well established. This study aimed to assess the efficacy of ETV treatment at 0.5 mg/day in ETV-switch and ETV-retreatment groups of CHB patients without lamivudine (LMV)-resistance from LMV monotherapy. Methods: Study subjects included 350 CHB patients who had been treated with 0.5 mg/day of ETV for at least 6 months. Patients were divided into two groups: an LMV-naive group (n = 263) and an LMV-experienced group (n = 87). The LMV-experienced group was further subdivided into an ETV-switch group (n = 43) and an ETV-retreatment group (n = 44) defined by the period between stopping LMV and restarting ETV. Results: There were no significant differences in mean age, sex ratio, prevalence of liver cirrhosis and hepatitis B e antigen (HBeAg) positivity between the LMV-naive and -experienced groups. However, the LMV-naive group had higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and a shorter ETV treatment duration than the LMV-experienced group. There were also distributional differences in the hepatitis B virus (HBV) DNA levels of LMV-naive and -experienced patients prior to ETV treatment. After ETV treatment, there were no significant differences between the two groups in the rates of undetectable HBV DNA at 6, 12 and 18 months; HBeAg loss and seroconversion; normalization of ALT; virologic breakthrough; and ETV-genotypic resistance. Lastly, the effect of ETV did not differ between the ETV-switch and -retreatment groups. Conclusions: The effect of ETV in the LMV-experienced group without LMV-resistance did not differ from that in the LMV-naive group. Furthermore, there was no difference in the effect of ETV between the ETV-switch and -retreatment groups. (Korean J Med 2013;84:810-817)
영구자석형 모터의 고정자 철심에서 자계의 거동 및 철손 분석
河京鎬(Kyung-Ho Ha),車相潤(Sang-Yoon Cha),金在寬(Jae-Kwan Kim),洪正杓(Jung-Pyo Hong) 대한전기학회 2006 전기학회논문지 B Vol.55 No.2
This paper investigates the magnetic field behavior and its iron losses in the stator core using electrical steels. The analysis model is a brushless motor with the permanent magnet. The elliptical rotating and alternating flux distributions with non-sinusoidal waveform are obtained by Finite Element Method and then their harmonic components are extracted. Based on these results, the local iron losses in the stator core caused by the harmonic flux are calculated. And then this paper explains the relation between flux waveform and iron loss produced in each part of the stator core. Furthermore, the iron loss at no load condition is measured and compared with the analysis results.
영구자석형 모터의 프릭션 토크 저감을 위한 고정자 철심의 열처리 및 발생원 분산
河京鎬(Kyung-Ho Ha),林良洙(Yang-Su Lim),權五烈(Oh-Yeoul Kwon),金智鉉(Ji-Hyun Kim),金在寬(Jae-Kwan Kim) 대한전기학회 2008 전기학회논문지 Vol.57 No.10
This paper deals with the reduction of friction torque in permanent magnet motors by using the heat treatment of stator core. The stator core is made of electrical steel sheared by the punching die. From the punching process, large mechanical stress acting on the edge of stator tooth induces significant plastic and elastic deformation and then cause the change of magnetization properties. Then, the mechanical and magnetic unbalance in the sheared region of stator tooth produced by material cutting has influence on the friction torque. This paper investigated the effect of the punching process on the magnetization process and the mechanical deformation, and then proposed the stress relief annealing method for the reduction of friction torque among one of motor characteristics.