http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신경베체트병 환자의 양성자(1H) 자기공명분광 영상 2예
강형주 ( Hyong Ju Kang ),태현정 ( Hyon Jung Tae ),김명철 ( Myoung Cheol Kim ),김완욱 ( Wan Uk Kim ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.1
Magnetic resonance imaging (MRI) and computed tomography had been used to detect the neurologic lesions of the Behcet`s disease. However, there are a number of cases which can not be detected by conventional imaging studies in neuro-Behcet`s disease. To overcome this problem, magnetic resonance spectroscopy (MRS) has been introduced in several autoimmune diseases involving central nervous system such as neuropsychiatric lupus, but which was rarely performed in Behcet`s disease. In the present study, we report two cases of neuro-Behcet`s disease that showed normal MRI but abnormal proton MRS (1H MRS) findings. MRS in two cases revealed a reduction of the N-acetyl aspartate (NAA)/creatine (Cr) ratio in the substantia nigra and thalamus, respectively, which were the areas without abnormality on MRI, suggesting a functional defect of neurons in these areas. In a case with thalamic dysfunction, abnormal NAA/Cr ratio was normalized in parallel with clinical improvement after treatment with high-dose steroids and immuno-suppressive agents. These observations suggest that MRS may be useful to early detect the functional abnormality in neuro-Behcet`s disease and to monitor neurologic status after treatment with immuno-suppressive agents.