에탄올로 발기부전을 유도한 흰쥐의 성기능 개선에 마카추출물이 미치는 영향

최혜란,이민정,이수정,박희전,송지영,김일수,신대근,Choi, Hye Ran,Lee, Min Jung,Lee, Su Jung,Park, Hee Jeon,Song, Ji-Young,Kim, Il Su,Shin, Daekeun 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.3

The purpose of this study was to examine the effects of Maca water and/or ethanol extract on the nitric oxide (NO) production in human umbilical vein endothelial cells HUVAC and on erectile dysfunction in rats. Maca was extracted due to both solutions, which are water and ethanol. Each Maca extract was applied to HUVAC, and NO production was checked. Additionally, three different dosages (250, 500 and 1,000 mg/kg) of Maca ethanol extract was administered to Sprague-Dawley rats for 4 weeks. All rats were sacrificed and each sample was collected for analysis. The control rats received only the saline vehicle. The NO production of HUVAC was significantly increased by domestic and homemade Maca water extracted at $60^{\circ}C$ group. Both NO generation and testosterone release were not influenced due to the oral administration of Maca. In the EtOH group rats, the number of sperm was reduced compared to that of the control group. All Maca groups had a high number of sperm and each sperm count had increased as a result of the Maca extract dose. The results of this research suggest that Maca has a positive effect on male erectile dysfunction, which need to be examined further in future studies.

교육 연극을 활용한 감성 중심 환경교육이 초등학생의 환경 소양에 미치는 영향

최혜란(Hye Ran Choi),이상원(Sang Won Lee) 한국환경교육학회 2009 環境 敎育 Vol.22 No.1

The purpose of this study was to investigate the influences of environmental education program through educational theatre on student’s environmental literacy of 5th graders in an elementary school in Seoul. The students were divided into an experimental group and a control group. Then, the experimental group had the emotion-centered environmental education program using educational theatre, and the control group had the regular education process, which is a general lecture about the environment. The SPSS 12.0 program was used to analyze the results. The major result of the study was as follows. First, the researcher was able to develop and apply professor-learning model for the environment education using the educational theatre by abstracting and recreating environment-related contents from the 5th grade curriculum. Second, the study has showed that applying the emotion-centered program using the education theatre for the environment education certainly contributes to the improvement of the environment knowledge of the elementary students. Third, the emotion-centered environment education program has influenced evenly on the elements of the environment knowledge divided by the four goal levels of the environment education. Finally, the higher the student’s emotional quotient is, the more improvement of the environment knowledge the student gets when using the emotion-centered environment education program using the education theatre. In conclusion, the emotion-centered environment education program using the education theatre is a usable method to the elementary schools, and has a positive effect on increasing the environment knowledge of 5th grade students. In the time of requiring the diverse environment education methods, this program is worth to try as a new education method. Therefore, it is necessary to research more on the professor-learning activities related to this study.

자폐스펙트럼장애 아동의 의문사 ‘무엇’, ‘누구’, ‘어디’ 이해 특성

최혜란(Choi, Hye Ran) 한국통합치료학회 2009 통합치료연구 Vol.1 No.1

본 연구는 자폐스펙트럼장애 아동을 대상으로 의문사 ‘무엇’, ‘누구’, ‘어디’를 의미ㆍ화용적 분류에 따른 이해능력을 알아보았다. 연구대상은 언어연령 3;0-3;11세에 해당하며 동작성 지능이 -1.5SD이내인 학령전기 자폐스펙트럼장애 아동 15영으로 하였으며, 의문사 질문은 상황이 있는 그림카드를 제시한 후 그림 1장에 두 개의 의문사 질문을 한 후 답하게 하였다. 응답유형으로는 구어표현과 지적하기 반응을 모두 정반응으로 하였으며 연구 결과는 다음과 같다. 첫째, 의문사 종류에 따른 자폐스펙트럼장애 아동과 정상 아동의 이해 평균을 살펴본 결과 의문사 종류에 따라서는 통계적으로 유의한 차이를 보이지 않았으나 집단에 따라서는 유의한 차이를 나타냈다 (P<.05), 언어연령이 3;0-3;11세 수준의 자폐스펙트럼장애 아동은 동일한 언어연령의 정상발달 아동에 비해 의문사 ‘무엇’, ‘누구’, ‘어디’의 의문사 종류에 따른 이해 평균이 낮게 나타났다. 둘째, 자폐스펙트럼장애 아동과 정상 아동을 대상으로 의문사의 의미ㆍ화용적 분류에 따른 이해 평균을 살펴 본 결과 의문사 ‘무엇’은 의미ㆍ화용적 분류 중 ‘사물을 묻는 질문’이 ‘행위를 묻는 질문’에 비해 높은 이해 평균을 나타났으며, 의문사 ‘누구’의 의미ㆍ화용적인 분류 중 ‘그림에 나타나 있는 사람에 대한 질문’이 ‘그림에 나타나지 않은 사람에 대한 질문’보다 높은 이해 평균을 나타냈다. 또한 의문사 ‘어디’ 의 의미ㆍ화용적 분류 중 ‘장소를 묻는 질문’보다 ‘위치를 묻는 질문’에 대한 이해 평균이 더 높은 것으로 나타났다. 본 연구를 통해 자폐스펙트럼장애 아동은 정상 아동에 비해 의문사 ‘무엇’, 누구’, ‘어디’의 이해 평균이 더 낮은 것으로 나타났으며, 의문사의 의미ㆍ화용적 분류에 따라 낮은 이해 평균을 갖는 것으로 나타났다. This study investigated autistic spestrum disorder children’s understanding of interrogatives in an earlier stage of language development such as what, who, and where. The study used questions based on semantic and pragmatic usage: what-questions of an object and a behavior, who-questions of persons present and absent in the picture, and where-questions of a place and a position. All participants were autistic preschoolers at the language ages of 3;0 to 3;11 and with movements IQs of less than -1.5 SD. The participants were given picture cards and asked two questions for each card. The children was able to respond to the questions using their voice or hand gestures. First, autistic spestrum disorder children’s understanding levels of interrogatives were compared to those of normal children. Understanding levels of autistic spestrum disorder children at the speech ages of 3;0 to 3; 11 were low compared to those of normal children at the same speech ages. Secondly, understanding levels of interrogatives sorted by semantic and pragmatic usage were inspected. A what-question of an object showed a higher level of understanding compared to the one of a behavior. An understanding of a who-question of a person present in the picture was higher than the one of a person absent. A where-question of a place was easier to understand than the one of a position.

다양한 관련변수들에 따른 CT 조영제 부작용 원인 및 분석에 관한 연구

최혜란(Hye Ran Choi),김가연(Ga Yeon Kim),김문정(Mun Jeong Kim),신효정(Hyo Jeong Shin),배승환(Seung Hwan Bae),이종인(Jong In Lee),이영진(Youngjin Lee) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.11

청소년의 자아존중감 수준에 따른 스트레스 및 스트레스 대처방식 분석

최혜란(Choi Hye Ran) 한국문화융합학회 2019 문화와 융합 Vol.41 No.3

본 연구는 청소년들의 자아존중감 수준의 차이가 스트레스와 어떤 관계를 갖는지 탐색하고, 스트레스 대처에 대한 자아존중감과 스트레스의 관계를 밝히고자 수행되었다. 연구대상은 남ㆍ녀 청소년 500명을 대상으로 설문조사를 실시하였고, 그 중 5개 이상의 결측치를 제외한 384명을 분석하였다. 연구 결과는 다음과 같다. 첫째, 자아존중감이 높은 청소년들이 자아존중감이 낮은 청소년들 보다 스트레스를 적게 받는 다는 것을 알 수 있었다. 이는 자아존중감이 스트레스를 적게 느끼게 하는 완충제 역할을 한다는 것을 의미한다. 둘째. 자아존중감이 높은 청소년들이 자아존중감이 낮은 청소년들 보다 스트레스 대처 행동에 적극적임을 알 수 있었다. 이는 자아존중감이 높은 청소년들은 자아존중감이 낮은 청소년 보다 자기 자신을 가치 있고 소중하게 생각하고 있기 때문에 보람 있는 삶을 영위하기 위해 스스로 스트레스를 해결하거나 외부를 도움을 받아서라도 적극적으로 해결하려고 한다는 것을 알 수 있었다. 셋째, 스트레스가 높게 나온 청소년들이 스트레스 대처에 더 적극적이었다. 이는 스트레스가 많으면 많을수록 자신의 문제를 해결하기 위해 노력을 한다는 것을 의미한다. 이러한 연구결과는 청소년들의 자아존중감 정도에 따라 스트레스 및 스트레스 대처 방식이 달라진다는 것을 말해 준다. 따라서 청소년들에게 높은 자아존중감이 형성될 수 있도록 하기 위해서 상담 및 교육프로그램을 적극적으로 개발하고 실시해야 할 것이다. This study was conducted to investigate the relationship between level of self-esteem and stress among adolescents, and to clarify the relationship between self-esteem and stress on stress coping. The participants of this study were 500 young men and women in the area, and 384 persons were analyzed, excluding five missing values. The results of the study are as follows: First, adolescents with high self-esteem showed less stress than adolescents with low self-esteem. This means that self-esteem acts as a buffer to reduce perceived stress. Second, it was found that adolescents with high self-esteem were more active in coping with stress than adolescents with low self-esteem. This shows that adolescents with high self-esteem resolve stress by themselves, because they think of themselves as valuable. Third, adolescents with higher stress were more active in coping with stress, indicating that the more stressed a person is, the more they will try to solve their own problems. These findings suggest that stressors and coping styles vary according to the degree of self-esteem in adolescents. Therefore, counseling and education programs should be actively developed and implemented so that high self-esteem can be formed among the youth.

복분자 미숙과 물 추출물이 마우스의 지질대사 및 산화적 스트레스에 미치는 영향

최혜란(Hye Ran Choi),이정현(Jung-Hyun Lee),이수정(Su Jung Lee),이민정(Min Jung Lee),정종태(Jong Tae Jeong),이태범(Tae-Bum Lee) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.4

본 연구는 복분자 미숙과 물 추출물이 in vivo에서 지질대사 및 산화적 스트레스에 미치는 영향을 살펴보고, 기능성 식품으로서의 가능성을 알아보기 위하여 수행되었다. 실험동물은 C57BL/6J mouse를 사용하였으며, 12주 동안 고지질 식이를 급이하면서, 복분자 미숙과 물 추출물을 경구 투여하여 다음과 같은 결과를 얻었다. 고지질대조군과 비교하였을 때, 복분자 미숙과 첨가군에서 체중증가량, 식이효율이 모두 감소되었고, 혈중 콜레스테롤 및 LDL-콜레스테롤의 농도를 유의성 있게 감소시켰을 뿐만 아니라 간 조직에서 총콜레스테롤의 함량이 유의적으로 감소됨을 확인하였다. 콜레스테롤 합성의 가장 중요한 기작인 LDL receptor와 SREBP2의 활성을 증가시킴으로써, 세포 안으로의 LDL 흡수를 촉진하였고, HMG-CoA reductase의 유전자 발현이 증가되면서 체내 콜레스테롤을 조절하며, ABCA1의 활성화로 인해, 콜레스테롤의 배출을 증가시키는 결과를 도출하였다. 또한, 간조직의 지질산화수준(TBARS)을 유의적으로 감소시켰으며, ox-LDL관련 유전자인 CD36을 억제함으로써, 동맥경화를 예방할 것으로 기대한다. 간의 형태학적 변화를 관찰해본 결과, 고지질대조군에 비하여 지방형성이 현저히 줄어들었음을 확인하였다. 결과적으로 복분자 미숙과 물 추출물이 콜레스테롤의 생합성과 배출 및 산화적 스트레스를 조절하여 고지질 및 동맥경화 질환 예방에 긍정적인 효과를 미치는 것으로 사료된다. We examined the effects of unripe black raspberry water extract (UBR-W) on lipid metabolism and oxidative stress in mice. C57BL/6J mice were divided into 4 groups: those administered a control diet (CTL), high-fat diet (HFD), UBR-W and simvastatin for 12 weeks. In the HFD group, LDL cholesterol were significantly higher than in the CTL group. However, the UBR-W treated group showed dose-dependent reduction of plasma LDL levels. Hepatic total lipid, TC, and malondialdehyde were significantly increased in hyperlipidemic mice. However, supplementation with either UBRW or simvastatin effectively reduced these lipid profiles and lipid peroxidation. UBR-W increased mRNA expression of the LDL receptor, sterol regulatory element binding protein 2 (SREBP2), 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and ATP-binding cassette transporter A1 (ABCA1) compared to that observed in the HFD group. In addition, UBR-W and simvastatin showed significantly reduced oxidized LDL uptake by the scavenger receptor CD36. These results suggest that UBR-W is useful for treatment and prevention of hyperlipidemia and lipid peroxidation.

복분자 미숙과 물추출물의 콜레스테롤 개선 효과

최혜란(Hye Ran Choi),이수정(Su Jung Lee),이정현(Jung-Hyun Lee),권지웅(Ji Wung Kwon),이희권(Hee Kwon Lee),정종태(Jong Tae Jeong),이태범(Tae-Bum Lee) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.12

We investigated the effects of unripe black raspberry water extract (UBR-W) and oxidation-LDL treatment on cholesterol levels. Experiments using an established human hepatocellular carcinoma cell line (HepG2) showed a time-dependent increase in expression of LDL receptor after UBR-W treatment. Expression of LDL receptor-related genes, such as SREBP1 and 2, increased upon UBR-W treatment. However, expression of HDL-related genes was unaffected by UBR-W. HMG-CoA reductase activity was reduced by UBR-W treatment, whereas HMG-CoA mRNA expression significantly increased. In addition, the ApoB/ApoA1 mRNA level, which is a predictor of cardiovascular risk, was reduced in a time-dependent manner by UBR-W treatment. Macrophage-like cells (RAW 264.7) showed increased expression of ox-LDL-related genes, such as CD36, scavenger receptor-A, adipophilin, and PPAR-gamma, upon ox-LDL treatment compared to untreated control cells, and quantitative lipid analysis indicated a dramatic increase in lipid accumulation. However, UBR-W treatment significantly reduced expression of ox-LDL-related genes and largely prevented lipid accumulation. The results indicate that UBR-W mediates a cholesterol-lowering effect via inhibition of cholesterol synthesis and induction of LDL uptake through SREBP.

아동청소년 성지식과 성태도의 관계 분석

최혜란(Choi Hye-ran) 전주대학교 한국고전학연구소 2022 공존의 인간학 Vol.- No.7

동과자(冬瓜子)의 항암활성과 방사선에 대한 감작효과

최혜란(Hye-Ran Choi),이경호(Keyong-Ho Lee),김창한(Chang-Han Kim) 한국식품과학회 2003 한국식품과학회지 Vol.35 No.3

심장내과 병동의 텔레메트리 적용 환자 특성

김윤선,최혜란,Kim, Yoon-Seon,Choi, Hye Ran 한국중환자간호학회 2014 중환자간호학회지 Vol.7 No.2

Purpose: The purpose of this study was to provide basic information to develop appropriate nursing guidelines for cardiac telemetry. Methods: This retrospective research was conducted to identify the current usage of cardiac telemetry and considered 1,000 patients hospitalized for telemetry. The collected data were analyzed using IBM (SPSS Statistics for Windows 21.0). Results: Four-hundred and ninety-two patients (49.2%) were diagnosed with arrhythmia and 209 (20.9%) with heart failure. Electrocardiogram (ECG) rhythm changes were detected via telemetry in 464 cases. Major arrhythmias were ventricular tachycardia (183, 39.4%) and bradycardia (99, 21.3%). Interventions after detecting arrhythmia were cardioversion (16, 3.4%), defibrillation (1, 0.2%), and cardiopulmonary cerebral resuscitation (5, 1.1%); other patients were treated conservatively with close observation (381, 82.1%). Conclusion: There was appropriate intervention in 46.4% of the considered cases with the detection of ECG changes before patient notification, which implied that cardiac telemetry could be considered for application to patients with hemodynamic instability. Clear standards and guidelines are required to determine who requires telemetry and when to end the telemetry monitoring.