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가미귀비탕(加味歸脾湯)이 백서(白鼠)의 배란(排卵)에 미치는 영향(影響)
최창민,홍기철,김덕님,김송백,유심근,Choe Chang-Min,Hong Gi-Chul,Kim Duck-Nim,Kim Song-Baeg,Yoo Sim-Keun 대한한의학방제학회 2003 大韓韓醫學方劑學會誌 Vol.11 No.2
Gamiguibitang(GMGBT) is used in amenorrhea and female infertility caused by ovulation disorder. An attempt was made to evaluate the influences of GMGBT on the serum concentrations of FSH, LH, estradiol(E2) and progesterone, the histological and optical changes of ovary of rats. The results of the study were as follows: 1. Blood FSH level significantly increased in experimental group controlled by four times quantity as compared with control group. 2. Blood LH level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 3. Blood E2 level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 4. Blood progesterone level significantly decreased in experimental group controlled by double quantity as compared with control group. 5. In optically observations of ovary, weight of ovary significantly increased in experimental group controlled by double quantity as compared with control group 6. In histological observations of ovary, ovulation significantly increased in experimental group controlled by both double and four times quantity as compared with control group. According to these results, it can be concluded that GMGBT influences the pituitary gland and ovary to increase the ovulation of rats.
최창민,유홍희,Choe, Chang-Min,Yu, Hong-Hui 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.5
Dynamics of a rotating cantilever beam near its critical angular speed is investigated in this paper. The external, force is idealized as a periodic function which has the same period as the rotati ng frequency of the beam. The equations of motion are derived and transformed into a dimensionless form. A prescribed spin-up motion is employed for the rotating motion. Numerical study shows that the steady state and the transient responses of the beam are affected by the spin-up time constant and there exists a time constant at which the maximum transient response becomes minimum.
궁경1호전(宮頸1號煎)이 자궁경부암세포(子宮頸部癌細胞)(HeLa Cell)에 미치는 영향(影響)
강영금,최창민,조한백,유심근,Kang, Young-Keum,Choe, Chang-Min,Cho, Han-Back,Yoo, Sim-Keun 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.1
To address the ability of Kung-Kyung-Ilho-Jeon(KK) to induce cell death, we investigated the effect of KK on cell viability. Forty-eight hours later, loss of viability occurred following KK exposure in a dose-dependent manner. The treatment of KK, a commonly used herb formulation in Korea and China, caused a decrease in cell viability. KK also resulted in apoptotic morphology a brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining, and reduction of cell volume. Our results show that KK induces caspase-3 and -9 activation in a time-dependent manner. In addtion, the translocation of cytochrome c release into cytoplasm has been observed under the presence of $5mg/m{\ell}$ KK. The subsequent loss of mitochondria membrane potential is collapsed by the addition of KK. Our immunoblotting data show that PARP, a well known caspase-3 and -6 substrate, is cleaved by KK. We show that a pro-apoptotic protein, Bax is increased in the presence of KK but that the amount of Bcl-2 is not changed. We suggest that Bax, a critical protein which can regulate channel of mitochondria to release cytochrome c, is a key protein in KK-induced apoptosis of Hela human cervical carcinoma cells