동방결절에서 Ouabain에 의하여 발생하는 일과성 내향전류(TI)에 관한 연구

최정연(Choi, Jung-Yun),홍창의(Hong, Chang-Yee),엄융의(Earm, Yung-E) 대한생리학회 1985 대한생리학회지 Vol.19 No.2

Transient inward current (TI) was studied by the two micro-electrode voltage clamp technique in the sinoatrial node of the rabbit. The author confirmed that in 10^-6 M ouabain TI was found in the SA node and investigated the effects of ions, (Na⁺, K⁺, Ca²⁺, β-agonist (isoprenaline), local anesthetics (quinidine, lidocaine) and Ca-blockers (Co²⁺, verapamil, diltiazem) on the TI recorded during depolarizing voltage clamp pulses to -40 and -20 mV. The results obtained were as follows ; 1) 10^-6 M ouabain increased the frequency of sinus action potential and decreased the amplitude, especially overshoot of action potential. TI was induced by the depolarizing voltage clamp Pulses and the magnitude of the slow inward current (isi) decreased and the time course was slowed by the same depolarizing pulses. 2) 30% Na⁺ and 24mM K⁺ decreased by 10^-6 M ouabain and 6 mM Ca²⁺ and 10^-7 M isoprenaline increased TI, i_si and current oscillations. 3) Quinidine 5 X 10^-7M) reduced TI and i_si but lidocaine (10⁶ -10^-5 M) didn t reduced or increase TI. Current oscillations increased and isi decreased by lidocaine. 4) Ca-blockers decreased the amplitude and the frequency of sinus action potential. TI and i_si decreased significantly but were not abolished completely at the concentrations used in this experiment. Verapamil and diltiazem had inhibitory action on TI in 2 X 10^-7M concentration and showed very slow recovery after wasting out with normal Tyrode solution.

태아기에 좌심형성부전증후군으로 잘못 진단되었던 1례

신윤정,장성희,최정연,한은숙,Shin, Youn Jeong,Jang, Sung Hee,Choi, Jung Yun,Han, Eun Sook 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.2

저자들은 재태 $31^{+5}$주 산전 심초음파검사에서 좌심형성부전 및 대동맥축삭으로 진단되어 추적 관찰한 태아가 출생 후 전부하의 증가에 의해 단기간 내에 좌심실 용적의 증가를 보임으로 생후 최소 며칠은 심근세포 증식의 가능성이 있음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Typical hypoplastic left heart syndrome(HLHS) is a distinct pathologic entity with aortic atresia, mitral atresia, very hypoplastic or absent left ventricle and thread like ascending aorta. Occasionally, the lesser degree of hypoplasia is found and is called hypoplastic left heart complex(HLHC) by some authors. This HLHC is often associated with critical aortic stenosis. Fetal echocardiography has enabled us to observe human fetal heart in-utero and to diagnose congenital heart disease prenatally over the last 20 years. The diagnosis of HLHS in fetal echocardiography is based on 2-dimensional echocardio -graphic evidence of a diminutive ascending aorta, aortic atresia, mitral atresia or severe stenosis and a hypoplastic left ventricle. Abnormal flow direction through atrial septum or through isthmus greatly aids the diagnosis. This report shows a fetal case who showed hypoplastic left side chambers and retrograde isthmic flow and was diagnosed with hypoplastic left heart syndrome. After birth, although the baby had tachy-dyspnea for the first 3 weeks, she finally recovered without any intervention and showed catch up growth of left side chambers. This case illustrates the extreme difficulty of assessing left ventricle in a fetus.

한국군(軍)의 통역자원 운용에 관한 연구: 미국과 독일 사례와의 비교를 중심으로

김동규(Dong Kyu Kim),최정연(Jung Yun Choi) 한국번역학회 2022 번역학연구 Vol.23 No.4

가와사키병 치료를 위한 아스피린 사용 후 발생한 라이 증후군 1예

이준기,강지은,최은화,최정연,Lee, Joon Kee,Kang, Ji Eun,Choi, Eun Hwa,Choi, Jung Yun 대한소아감염학회 2012 Pediatric Infection and Vaccine Vol.19 No.2

라이 증후군은 간부전을 동반하며 급속히 진행하는 뇌증으로, 인플루엔자와 수두 바이러스 등에 감염된 어린이에게 발병한다. 아스피린이 주된 원인 인자로 알려진 이후 소아에서 아스피린의 사용을 줄이면서 현재는 매우 드물게 보고 되고 있다. 저자들은 가와사키병 치료를 위해 정맥내 면역글로불린을 투여받고 아스피린을 복용하던 중 보챔, 강직, 활동량 저하, 식욕 저하, 처짐, 구토, 간수치 상승, 혈액 응고 장애와 고암모니아혈증으로 치료받은 5개월 여아를 보고하는 바이다. Reye syndrome is a rapidly progressive encephalopathy with hepatic dysfunction, which often begins several days after apparent recovery from a viral illness, especially varicella or influenza A or B. Salicylate use was identified as a major precipitating factor for the development of Reye syndrome. With the recommendation to avoid use of salicylates in children, Reye syndrome has virtually disappeared in recent years. We report a case of Reye syndrome in a 5-month-old infant who had been treated with intravenous immunoglobulin and aspirin under the diagnosis of Kawasaki disease, and showed symptoms of sudden onset of irritability, rigidity, decreased activity, vomiting, poor appetite, lethargy, liver dysfunction without jaundice, coagulopathy, and hyperammonemia.

수돗물불소농도 조정사업에 대한 당진군 주민의 의식 및 태도

심수현 ( Soo Hyun Sim ),윤경옥 ( Kyoung Ok Yun ),최정연 ( Jung Young Choi ),서화정 ( Hwa Jeong Seo ) 한국치위생과학회 2012 치위생과학회지 Vol.12 No.1

To contribute the basic data for spread of water fluoridation area, this study provide the awareness and attitudes of local residents for adding fluoride to tap water. The convenience sampling was chosen 534 persons of local residents in Dangjin-gun. Survey was performed from May to September in 2010; below 50 years old person surveyed by self-administered questionnaire method assisted with supervisor, above 50 years old person surveyed by interviewing method. The data analyzed SPSS Ver. 17.0. About the awareness of water fluoridation 49.1% of the subject answered "have heard", but 50.9% "not ever heard". People who answered in favor of the water fluoridation were 63.7%, who answered against were 11.2%. In policy decision method of water fluoridation they highly choose the survey of public opinion in 40.6%, followed by ballot 32.8%, by local government 18.9%, by local councils 5.4%, and other 2.2%. The 71.4% of respondents who replied "have heard" approved the water fluoridation, but only 56.3 percent of respondents who replied "haven`t heard" were in favor of that. More than 59.5% of university graduates respondents who answered "have heard" approved the water fluoridation. People with higher education degree more recognized it and the lower shows tend to be low awareness. In conclusion, to expand of water fluoridation area they need more publicity and education about it to local residents.

소아 양성 일과성 고인산분해효소혈증의 임상양상 및 자연경과에 대한 고찰

오대성,한재준,양혜란,장주영,고재성,최정연,서정기,Oh, Dae-Sung,Han, Jae-Joon,Yang, Hye-Ran,Chang, Ju-Young,Ko, Jae-Sung,Choi, Jung-Yun,Seo, Jeong-Kee 대한소아소화기영양학회 2007 Pediatric gastroenterology, hepatology & nutrition Vol.10 No.2

목 적: 한국인 소아에서 양성 일과성 고인산분해효소 혈증(Benign transient hyperphosphatasemia, BTH)의 임상적 특징 및 자연 경과를 살펴보고자 하였다. 방 법: 2006년 6월부터 2007년 7월까지 분당서울대학교병원 소아과를 내원한 환아 중 Kraut 등의 진단기준에 따라 BTH로 진단된 17명의 의무기록과 검사결과를 후향적으로 분석하였다. 결 과: 총 17명의 환아 중 남아가 6명, 여아가 11명이었으며, 연령은 평균 26.9${\pm}$13.8개월(범위: 9~49개월)이었다. 동반된 질환으로는 감염성 질환이 52.9%로 가장 많았고, 계절적으로 9월에서 12월 사이에 더 높은 발생률을 보였다. 첫 내원 시 측정한 혈청 ALP는 평균 2500.2${\pm}$1165.1 U/L이었고, 모든 환아에서 7주 내에 혈청 ALP가 정상 또는 정상 상한치의 두 배 이내로 감소하였다. ALP isoenzyme 검사를 시행한 7명의 환아 중 3명에서 간 분획과 골 분획의 증가가 있었고, 4명은 골분획의 증가만을 보였다. 결 론: 한국인 소아에서 BTH의 임상적 특징 및 경과를 이해함으로써 ALP 상승 소견을 보이는 영유아에서 불필요한 진단적 검사들을 지양하며 임상 경과의 관찰을 통해 ALP 활성도의 정상화 여부를 확인하도록 하여야 한다. Purpose: This study was conducted to analyze the clinical manifestation and natural course of benign transient hyperphosphatasemia (BTH) in children. Methods: A total of 17 children diagnosed with BTH between June 2006 and July 2007, were included in this study. Clinical records and laboratory tests were analyzed retrospectively for all children. Results: The mean age of the patients was $26.9{\pm}13.8$ months (range: 9 to 49 months). Nine of the 17 BTH cases (52.9%) occurred in patients that had previously suffered from infectious diseases. While the patients were suffering from BTH, the mean serum level of alkaline phosphatase (ALP) was $2,500.2{\pm}1,165.1$ U/L, however, these elevated serum ALP levels normalized within 7 weeks of recovery in all cases. In addition, a seasonal peak in the onset of BTH was observed from September to December. Further, the measurement of ALP isoenzymes in 7 of the patients with BTH, revealed a marked elevation of bone fraction. Conclusion: It is important for pediatricians to understand the clinical manifestation and benign course of BTH to avoid unnecessary diagnostic evaluation in children showing a transient increase in ALP activities.

한국어 어미와 선어말어미의 형태론적 처리

안희돈(Hee Don Ahn),안덕호(Duk Ho An),최정연(Jung Yun Choi),황종배(Jong Bai Hwang),김지현(Ji Hyon Kim),전문기(Moon Gee Jeon) 언어과학회 2011 언어과학연구 Vol.59 No.-

This study investigates how morphologically complex verbs in Korean are processed in the mental lexicon through two priming experiments: In Experiment 1, a visual priming task with SOA of 160ms was applied, while in Experiment 2 a masked priming task with SOA of 40ms was used. Both Experiments examined whether final endings and pre-final endings of Korean verbs were decomposed or processed as a whole. The findings of both experiments showed that priming occurred for morphologically-related conditions; namely, for the final endings and pre-final endings. In these two experiments, however, priming did not occur for the phonologically-related and semantically-related conditions. These results suggest that Korean verbs with final and pre-final endings are decomposed into root, pre-final ending, and final ending in the mental lexicon, thereby supporting the Decomposition Model. (Monkuk University)

人乳中의 高分子糖蛋白質에 관한 硏究

崔禎延,李守遠 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

This study was carried out to compare the high molecular weight glycoprotein isolated from human milk fat globule membrane and whey, and to investigate biochemical or immunological properties of two materials. The results are summerized as follows : 1. The milk fat globule membrane (MFGM) of human milk contained about 15 proteins and 5∼6 major glycoproteins, while human whey contained about 10 proteins and 3∼4 major glycoproteins. 2. Human MFGM and whey contained a high molecular weight glycoprotein, termed PAS-O, which did not migrate in 10% SDS-acrylamide gel elecrophoresis. 3. PAS-O isolated by Sepharose CL-4B chromatography had maximum absorption at 208nm and no absorption at 280nm. 4. On the agglutination test with eight lectins, WGA, PNA, LPA reacted with PAS-O and HM-glycoprotein that suggested to act as surface receptor of them in human milk. 5. Serine, glycine, alanine and glutamic acid were predominant amino acids in the both high-Mr glycoprotein, PAS-O and HM-glycoprotein. On the other hand, sulfur containing amino acids were present in very small amount. 6. The patterns of reactivity of these two glycoproteins, PAS-O and HM-glycoproteins, with some lectins, the similarities in their amino acid compositions and electrophoretic mobilities, suggested that they may be the same molecules.

신생아에 발생한 원인 불명의 일시적인 복부 팽만 3 예

최정연,윤은실,최광해 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

Abdominal distension is not an uncommon symptom in the neonate; it is indistinguishable from Hirschsprung disease by symptoms and X-ray findings. In three patients, severe abdominal distension was found at early infancy and improved with conservative treatment without relapse. The findings were different from those of Hirschsprung disease. Immaturity or poor coordination of peristaltic movement is postulated as the cause. With maturation such problems can normalize. However the pathogenesis remains unclear and further investigation is needed to improve our understanding.

태아 심질환

崔正衍 대한의학협회 1993 대한의학협회지 Vol.36 No.5