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화소 기반 형태분석 방법을 이용한 알츠하이머 치매환자의 회백질 용적감소의 정량적 분석
임현국,최은형,이창욱,Lim, Hyun-Kook,Choi, Eun-Hyung,Lee, Chang-Uk 대한생물정신의학회 2008 생물정신의학 Vol.15 No.2
Objectives : The purpose of this study was to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry(VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Methods : MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software(SPM2). Results : Gray matter volume was significantly reduced in the bilateral parahippocampal gyri, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, bilateral superior temporal gyri Lt. middle temporal gyrus, Lt. superior, bilateral middle, Rt. anterior frontal gyri and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions : These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
노인 입원 환자에 대한 일 대학 병원의 리스페리돈과 올란자핀의 처방 경향 : 자연적 연구
임현국(Hyun Kook Lim),최은형(Eun Hyung Choi),이영란(Young Ran Lee),오근(Keun Oh),배치운(Chi Un Pae),이철(Chul Lee),백인호(In Ho Paik),이창욱(Chang Uk Lee) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.1
Several studies have reported that either risperidone or olanzapine is effective and tolerable in the elderly patients with psychotic symptoms. However, there is a lack of clinical data of risperidone and olanzapine prescription for elderly patients in the Aisan population. We reviewed retrospectively the medical records of risperidone (n=112) and olanzapine (n=96) treated patients older than age 60 who were admitted to a university-affiliated hospital between October 2005 and August 2006. The mean daily dose of risperidone was 3.4±1.5 mg and olanzapine, 8.8±5.6 mg, respectively. The response rate on the CGI (much and very much improved) appeared to be 67.4% in the risperidone group and 70.8% in the olanzapine group, respectively. Adverse events were reported in 48.2% in the risperidone group and 46.9% in the olanzapine group, without serious adverse events, respectively. This study showed that either risperidone or olanzapine would be effective and tolerable in elderly patients with psychotic symptoms and that provides similar results to those reported from western countries.
이윤주(Lee, Yoon-Ju),류종우(Ryu, Jong-Woo),김대현(Kim, Dae-Hyun),최은형(Choi, Eun-Hyung),노원석(Noh, Won-Suck),이상득(Lee, Sang-Deuk),문동주(Moon, Dong-Ju) 한국신재생에너지학회 2006 한국신재생에너지학회 학술대회논문집 Vol.2006 No.11
WGS reaction over Mo2C and ceria based catalysts was investigated to develop an alternative commercial Cu-Zn/Al2O3 catalyst for fuel processor and hydrogen station. The Mo2C catalysts were prepared by a temperature programmed method and the various metal supported cerium oxide catalysts were prepared by an Impregnation method. The catalysts were characterized by the N2 physisorption, Co chemisorption, XRD, TEM and TPR. It was found that Mo2C and 0.2wt% Pt-40wt%, Ni/CeO2 catalysts had higher activity and stability than the Cu-Zn/Al203 above 260?C. Moreover, CO conversion of more than 85% was observed at 280{sim}300?C. But all catalysts were deactivated during the thermal cycling runs. The results suggest that these catalysts are an attractive candidate for the alternative Cu-Zn/Al2O3 catalyst for fuel processor and hydrogen station applications.