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문맥압 항진증을 동반한 간경변 환자에서 propranolol이 문맥압에 미치는 효과
백순구 ( Baeg Sun Gu ),최윤종 ( Choe Yun Jong ),김광현 ( Kim Gwang Hyeon ),이병준 ( Lee Byeong Jun ),지명관 ( Ji Myeong Gwan ),석기태 ( Seog Gi Tae ),김정민 ( Kim Jeong Min ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( 대한내과학회 2003 대한내과학회지 Vol.64 No.6
목적 : Propranolol은 문맥압 항진증을 개선시켜 정맥류 출혈 예방에 효과적이라고 밝혀진 유일한 약물이다. 인종간에 propranolol에 대한 심혈관계의 감수성이 달라 적정 용량 또한 차이가 있는 것으로 알려져 있다. 이에 본 연구는 문맥압 항진증을 동반한 한국인 간경변 환자에서 propranolol이 문맥압에 미치는 효과 및 필요 용량 그리고 약물반응에 영향을 미치는 인자가 있는지 알아보고자 하였다. 방법 : 정맥류 출혈이 있었던 25명의 간 Background : Propranolol is only known drug effective in preventing variceal bleeding by ameliorating portal hypertension. The optimal dose of propranolol is variable due to racial differences of cardiovascular receptor sensitivity. In this prospective st
지명관 ( Ji Myeong Gwan ),최윤종 ( Choe Yun Jong ),백순구 ( Baeg Sun Gu ),윤상진 ( Yun Sang Jin ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),김영주 ( Kim Yeong Ju ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
We report an uncommon case of pyogenic hepatic abscess with hepatobronchial fistula. A 59 year-old male was admitted because of purulent sputum and cough. Ultrasonography and abdominal computed tomography showed an abscess on the superior segment of right
위부분절제술 환자에서 미란성 식도염의 유병률 조사 환자-대조군 연구
석기태 ( Seog Gi Tae ),김현수 ( Kim Hyeon Su ),김정민 ( Kim Jeong Min ),최윤종 ( Choe Yun Jong ),백순구 ( Baeg Sun Gu ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),김대성 ( Kim Dae Seong ),김원중 ( Kim Won Jung ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: Enterogastric bile reflux has been implicated as a definite causative factor for the development of postoperative bile reflux gastritis. However, little is known about the role of bile reflux into the stomach in gastro-esophageal reflux disease in patients with subtotal gastrectomy. In this study, we tried to prove that the bile reflux gastritis does increase the development of erosive esophagitis in patients who underwent subtotal gastrectomy. Methods: From January 1997 to December 2001, 222 patients with previous subtotal gastrectomy were enrolled. We also reviewd the endoscopic findings in 1,633 age and sex-matched healthy controls who had visited our hospital for routine check-up without significant gastrointestinal symptoms. Results: The prevalence of erosive esophagitis is 5% (LA A 2.7%, LA B 2.3%) in gastrectomized patients and 4.9% (LA A 3.2%, LA B 1.7%, LA C 0.0%) in healthy controls. There was no significant difference in the prevalence and the degree of esophagitis between the two groups. Conclusions: These results suggest that subtotal gastrectomy may not be a risk factor for developing the erosive reflux esophagitis. (Korean J Gastroenterol 2003;42:96-101)
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간경변 환자에서 Octreotide 정주가 문맥압에 미치는 영향
박동훈 ( Park Dong Hun ),백순구 ( Baeg Sun Gu ),김문영 ( Kim Mun Yeong ),최윤종 ( Choe Yun Jong ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),김영주 ( Kim Yeong Ju ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
간성상세포의 수축 및 성장에 대한 Angiotensin 2 수용체 길항제의 억제 효과
백순구 ( Baeg Sun Gu ),조호성 ( Jo Ho Seong ),석기태 ( Seog Gi Tae ),김정민 ( Kim Jeong Min ),이병준 ( Lee Byeong Jun ),최윤종 ( Choe Yun Jong ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),이건일 ( Lee G 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Backgrounds/Aims: This study aimed to investigate the effects of angiotensin II (ANG II) and its receptor antagonist (losartan) on the contraction and growth of HSCs. Methods: HSCs were isolated from Sprague Dawley rat and cultured at various conditions as follows: control, pretreatment of 10(-5) M ANG II, pretreatment of 10(-5) M endothelin, and pretreatment of 10(-5) M ANG II and 10(-6) M losartan. We conducted morphologic analysis with cellular area and length by image analysis system to estimate cell growth in each group. In addition, we measured the change of intracellular calcium currents via electrophysiological methods to evaluate the contractile effect of ANG II and losartan on HSCs. Results: At the fifth day of incubation, the mean cellular area of ANG II-pretreated group and ANG II with losartan-pretreated group were 704.68±22.6 um2 and 332.90±32.6 um2, respectively. This difference was statistically significant (p<0.05). ANG II induced an increase in the intracellular calcium current by 22.0±3.0% compared with basal current level (p<0.05). However, when losartan was pretreated, ANG II did not cause a significant increase in calcium current (3.1±0.8%, p>0.05). Conclusion: ANG II accelerates the contraction and growth of HSCs, while its receptor blocker, losartan, inhibits the contraction and growth of HSCs (Korean J Gastroenterol 2003;42:134-141)