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한국인의 반복자연유산 환자에서 Thymidylate Synthase Enhancer Region (TSER) 돌연변이형의 혈중 호모시스테인 양과의 관련성
최윤경,강명서,김남근,김선희,최동희,안명옥,이수만,Choi, Yoon-Kyung,Kang, Myung-Seo,Kim, Nam-Keun,Kim, Sun-Hee,Choi, Dong-Hee,An, Myung-Ok,Lee, Su-Man 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.3
Objectives: Methylenetetrahydrofolate reductase (MTHFR) mutation are commonly associated with hyperhomocysteinemia, and through their defects in homocysteine metabolism, they have been implicated as a risk factor for recurrent spontaneous abortion. Recent report describe that 28-bp tandem repeat polymorphism in thymidylate synthase enhancer region (TSER) that influence enzyme activity would affect plasma homocysteine level. We have investigated the relationship between TSER genotype and plasma homocysteine level in 54 patients with recurrent spontaneous abortion. Methods: Plasma homocysteine level was measured by fluorescent polarizing immunoassay. MTHFR mutation (C677T and A1298C) was identified by PCR-restriction fragment length polymorphism assay and TSER mutation was analyzed by PCR method. The data were analyzed using the program SAS 8.2 for Windows. Results: Total homocysteine level was significantly higher in MTHFR 677TT genotype ($9.80{\pm}3.87{\mu}mol/L$) than MTHFR 677CC genotype ($8.14{\pm}1.74{\mu}mol/L$) in Korean patients with unexplained recurrent spontaneous abortion (p=0.0143). However, the plasma homocysteine level was not significantly different in the MTHFR 1298AA ($8.42{\pm}2.65{\mu}mol/L$) and 1298CC ($6.09{\pm}0.32{\mu}mol/L$; p=0.2058) and, TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and 3R3R ($8.05{\pm}2.81{\mu}mol/L$; p=0.9319) mutant genotypes, respectively. In this study, we found the combination effects of TSER and MTHFR C677T genotypes. Plasma homocysteine levels were the highest ($11.47{\pm}4.66{\mu}mol/L$) in individuals with TSER 3R3R ($8.05{\pm}2.81{\mu}mol/L$) and MTHFR 677TT ($9.80{\pm}3.87{\mu}mol/L$) genotypes. Individuals with a combination of both TSER 2R2R/2R3R and MTHFR 677CC/CT genotypes ($7.69{\pm}1.77{\mu}mol/L$) had lower plasma homocysteine levels than TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and MTHR 677CC ($8.14{\pm}1.74{\mu}mol/L$) genotypes, respectively. The effect of MTHFR polymorphism in the homocysteine metabolism appears to be stronger than that of TSER polymorphism. Conclusion: Although statistically not significant, we found the elevated level of plasma homocysteine in combined genotypes with TSER and MTHFR (C677T and A1298C) in Korean patients with unexplained habitual abortion. In this study, we reported the possibility that TSER polymorphism is a genetic determinant of plasma homocysteine levels in the Korean patients as well as MTHFR C677T polymorphism. A large prospective study is needed to verify our findings.
디지털 강의자원 관리를 위한 메타데이터 요소에 관한 연구
최윤경,정연경,Choi, Yoon-Kyung,Chung, Yeon-Kyoung 한국과학기술정보연구원 과학기술정보센터 2008 Journal of Information Science Theory and Practice Vol.39 No.3
본 연구는 국가 교육 표준 메타데이터인 KEM을 기반으로 국내 대학에서 강의자원을 효과적으로 관리하고 재사용성을 높일 수 있는 강의자원 메타데이터 필수 요소 및 확장 요소를 제안하였다. 이를 위해 문헌 연구와 국내외 사례 분석, 그리고 국내 현황조사 방법을 이용하였다. 국내외 사례 조사 및 현황 분석을 통해 KEM의 요소를 기반으로 국내 대학의 현황을 반영하여 강의자원 메타데이터의 필수 요소와 확장 요소를 제안하였다. 필수 요소로는 69개 요소를 2개 수준으로 제안하였다. 제 1수준의 31개 요소들은 강의자원 관리를 위해 대학에서 공통적으로 사용해야하는 필수 항목이다. 제 2수준 필수 요소는 총 38개로, 강의자원 관리를 위한 핵심 요소는 아니지만, 개별 대학에서 이 요소를 필수 요소로 사용하도록 권고하였다. 확장 요소는 면담 조사 결과를 바탕으로 전체 6개 응답 기관 중 50% 이상에서 확장이 필요하다고 선택한 12개를 제안하였다. The purpose of this study is to propose the mandatory and extensible elements of Korea Education Metadata elements for digital course resources universities in Korea. For the study, literature research, case study and interview were performed. The mandatory elements of KEM consisted of sixty nine elements, and were proposed by two phases. Also, based on interview process twelve items were newly recommended to supplement KEM elements.
유아교사의 근로여건이 전문성에 미치는 영향 분석 -교사의 웰빙과 효능감의 매개효과를 중심으로-
최윤경(Yoon Kyung Choi) 한국보육지원학회 2019 한국보육지원학회지 Vol.15 No.3
Objective: The goal of this study was to investigate the effects of early childhood teachers’ current working conditions such as welfare and wages, working hours, ECEC center’s environmental characteristics, and parental involvement and community engagement on the professionalism of teachers. Method: A total of 988 respondents participated in the nationwide online survey. The data were analyzed by correlation analysis and structual equation modeling. Results: First, there were no statistically significant direct effects of ECEC teachers’ working conditions on teacher professionalism. Second, there were significant direct effects of teacher efficacy and well-being on teacher professionalism. Third, there were significant indirect effects of teachers’ working conditions on their professionalism, via efficacy and well-being, linking the impact of working conditions and the professionalism of teachers. Conclusion/Implication: The results of this structural model imply that policy input for teacher welfare, wage increases, and the enhancement of teachers’ well-being and efficacy are valid and significant for the professional development of ECEC teachers. These results provide the data-driven evidence for the importance of welfare and socio-cognitive approaches for teachers.
학습자 성격유형에 따른 위키기반 협동학습 과제참여도와 학업성취도의 관계
崔胤京(Choi, Yoon-kyung) 중국어문학연구회 2013 중국어문학논집 Vol.0 No.79
This study motivated from the facts that the learner’s concentration is relatively less in online class and some students turn on the class for the attendance and do not watch. When online class and web based cooperative learning in Blended Learning lessons gives taking notes homeworks, the relation between learners’ personality types, participation level of Wiki cooperative learning and learning achievement are statistically analyzed using SPSS version 20.0 program. The ultimate goal of this study is to propose learning environment constructing model for learners’ self-directed learning. The paper shows the guideline of how to utilize and to structure the class when handwriting notes project as cooperative learning challenges is given to the learner.
환경오염물질이 여성 불임에 미치는 영향에 대한 베이지안 잠재계층모형 분석
최윤경(Yoon Kyung Choi),황범석(Beom Seuk Hwang) 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.5
대표적인 환경오염물질인 PCB가 여성의 불임에 미치는 영향에 대해 조사한 LIFE 연구를 기반으로 해서 그 관계를 분석한 잠재계층모형을 제시하였다. 본 모형에서는 피험자의 잠재적인 위험군이 존재한다고 가정하고 잠재계층 변수를 도입하여 PCB와 여성의 불임에 대한 로짓 모형을 연결시켜주었다. 또한 반연속적인 형태를 띠는 PCB값을 다루기 위해 혼합 분포 모형을 적용시켰다. 구체적인 분석 방법으로 MCMC에 기반을 둔 베이지안 접근법을 사용하였고, 모형의 비교를 위해서 DIC를 계산하여 최적의 모형을 찾아내려고 하였다. 분석 결과 피험자들이 속한 잠재작인 위험군에 따라 불임에 대한 확률이 영향을 받고 있음을 확인할 수 있었다. We proposed a latent class model to examine the association between an environmental pollutant (PCB) and female infertility in the LIFE study. We assumed there exist latent risk groups of subjects and linked the PCB exposure and logit model for female infertility through the latent class variable. Also, semicontinuous PCB exposure was analyzed through a mixture of a degenerate distribution at zero and a continuous distribution for nonzero values. We took a Bayesian perspective to inference and used Markov chain Monte Carlo algorithms to obtain posterior estimates of model parameters. We calculated and compared DICs for all comparable models to find the most appropriate model for LIFE study data. As a result, we found that the risk of infertility was affected by latent risk groups of PCB exposure.
중국어 소리 내어 읽기과제가 기억전략 및 인지전략에 미치는 영향
최윤경 ( Yoon Kyung Choi ) 서강대학교 언어정보연구소 2015 언어와 정보 사회 Vol.26 No.-
This study investigates whether Chinese voice reading assignments have positive effects to memory strategies and cognitive strategies. If it has positive effects, statistical method using SPSS is used to evaluate what is more effective teaching method. In conclusion, Chinese voice reading assignments are effective learning methods that help the learners to improve their memory strategies and cognitive strategies. It is proved that the learners who have high academic achievements, used higher level of memory strategies and cognitive strategies than those who have low academic achievements. When the professor figures out the level of academic achievements of the learners as soon as possible and provides adequate feedback according to the level of the learners, the learner can improve the usage of memory strategies and cognitive strategies.