타우린 첨가 식이가 흰쥐에서 혈중 지질과 간 지질 농도에 미치는 영향

최미자,서지나,Choi Mi-Ja,Seo Ji-Na 동아시아식생활학회 2006 동아시아식생활학회지 Vol.16 No.2

This study investigated the effect of dietary taurine supplementation on the plasma and liver lipid concentrations in lats fed a cholesterol free diet Twenty male-Sprague-Dawley rats(body weight $200{\pm}10g$) were divided into two groups, the control and taurine group(2% taurine supplemented in their diet). All the rats were fed on the experimental diet and deionized water for 6 weeks libitum. There were no significant differences body weight gain, food intake and the food efficiency ratio between the control and experimental groups. The rats fed the taurine diet had a significantly lower triglyceride and AI(athrogenic index) than those fed the control diet The liver total cholesterol (p<0.05) and triglyceride levels(p<0.01) were significantly lower in the rats fed the taurine diet than in those fed the control diet. These results suggest a possible role of taurine as a hypolipidemic agent in male rats fed a cholesterol free diet.

난소 절제 쥐에서 홍국의 첨가가 혈중 지질에 미치는 영향과 혈중 콜레스테롤과 골대사 지표 및 호르몬과의 관련성

최미자,유대식,Choi Mi-Ja,Yu Tae-Shick 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.3

This study was performed to evaluate the effect of red-yeast-rice on blood lipids and also to investigated the relation of blood lipids, bone related hormones, and bone mineral density in overiectomized rats. Forty female rats (body weight $210\pm5$g) were divided into two groups. The rats in the first group were ovariectomized which the others received sham operation (SHAM). And then each rat group was further divided into control diet $(casein\;20\%)$ and red-yeast-rice powder supplemented $(0.1\%)$ diet group. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus in spine and femur. Bone formation and bone resorption were measured by serum osteocalcin and urinary deoxypyridinoline (DPD) crosslinks value. Serum growth hormone, IGF-1 and calcitonin were analyzed using radioimmunoassay kits. The red-yeast-rice group had significantly lower the blood triglyceride concentration and had lower the blood total cholesterol concentration than casein group did in ovariectomized rats. And the red-yeast-rice group than casein group in ovariectomized rats. The red-yeast-rice group had significantly lower the atherogenic index than control group within the ovariectomized groups. In the experimental rats, serum total cholesterol concentration was negatively correlated with femur BMC and crosslink value. Crosslink value was negatively correlated with spine BMC and IGF-1. Osteocalcin concentration was negatively correlated with crosslink value. Growth hormone was negatively correlated with crosslink value and positively correlated with spine BMC. The findings of this study suggest that red-yeast-rices are beneficial for blood lipid in ovariectomized rats. And when considering a population-based public health approach to lowering cholesterol and bone loss, and preventing coronary heart disease and osteoporosis, the red-yeast-rice dietary supplement could provide a new approach for the maintenance of healthier cholesterol and bone.

대구 지역 여고생의 체중 조절 관심도와 영양소 섭취 상태

최미자,윤순진,Choi, Mi-Ja,Yun, Soon-Jin 동아시아식생활학회 2007 동아시아식생활학회지 Vol.17 No.3

In this study, the interest of female high school students's(N=500) for weight control, as well as nutrient intake status, were analyzed. The mean age, height, and weight of the subjects were, 19.3 years, 162.2 cm and 55.4 kg respectively. Mean BMI was $21.1 kg/m^2$. According to BMI, the percentage of underweight, normal weight, overweight, and obese were 18.5 %, 60.3%, 11.3%, and 11.3% respectively. By the BMI criteria, 60.3% of the subjects were normal weight while the rate of self-recognition was 41.5%. The degree of satisfaction regarding self-body image was only 17.1% and 60.9% showed an interest in weight control. The reason for weight reduction were appearance(65.1 %) and health(24.2%). The body areas where subjects wanted to lose weight included the thighs(32.9%) and whole body(29.3%). They believed the most effective weight control strategy was exercise(81.1 %) and the strategies they used were diet(59.1 %) and exercise(40.4%). Energy intake was 1,733.4 kcal which was 86.7% of the estimated energy requirements(EER). Calcium, vitamin $B_2$, and vitamin C intakes were less than EAR by 34.4%, 40.4%, and 59.6% respectively. The intake of dietary fiber was 5.1 g only 21.1 % of the adequate intake(AI). In summary, high school females interested in weight control have significantly less calcium intake than their peers. The correlations between interest in weight control and weight and BMI were significant(p<0.001). The results of this study suggest that to achieve optimal growth, improved diets that include calcium, vitamin $B_2$, and vitamin C are recommended. High school females interested in weight control should especially be targeted for education on calcium intake.

식이 내 비타민 D 강화가 성장기 흰쥐의 골밀도에 미치는 영향

최미자,강유정,Choi Mi-Ja,Kang Yu-Jung 동아시아식생활학회 2006 동아시아식생활학회지 Vol.16 No.3

Modification of the diet during childhood and adolescence may be an effective strategy for maximizing the peak bone mass. Many supplementation studies have suggested a positive effect of the increased vitamin D intake on the bone mineral status in the elderly. However to date all studies have been conducted on old men and postmenopausal women. The aim of this study was to examine the effects of vitamin D supplementation on the bone mineral density and bone mineral content in growing rats. Twenty Sprague-Dawley female rats were divided into two groups; Control, and vitamin D supplementation. The bone mineral density(BMD) and bone mineral content(BMC) were measured using PIXImus in the spine and femur. Vitamin D supplementation did not affect the level of weight gain, mean food intake and food efficiency ratio. In addition, vitamin D supplementation had no added effect on the spine and femur BMD, and BMC. There were no significant differences in the spine BMD/weight and BMC/weight between the groups, but the spine BMD/weight and BMC/weight was 11 % higher in the vitamin D supplementation group. The femur BMD/weight and femur BMC/weight were significantly higher in the vitamin D supplementation group 9 weeks after the experiment. These results provide evidence of the beneficial effects of vitamin D supplementation on the BMD during the growth period.

성인여성의 식습관과 영양섭취상태와 골밀도 및 골무기질함량과의 관계

최미자(Choi Mi Ja),정윤정(Jung Yoon Jung) 韓國營養學會 1998 Journal of Nutrition and Health Vol.31 No.9

성인 여성에서 운동과 체조성, 혈압 및 골밀도와의 관계

최미자 ( Mi Ja Choi ),이운정 ( Un Jung Lee ),정윤정 ( Yun Jung Jung ) 한국운동영양학회 2006 Physical Activity and Nutrition (Phys Act Nutr) Vol.10 No.3

난소절제 쥐에서 카페인 첨가식이가 골밀도 및 골함량에 미치는 영향

최미자(Choi Mi-Ja),이주영(Lee Jooyoung) 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.3

본 연구는 0.03%의 카페인 함유 식이를 폐경모델인 난 소절제쥐에서 6주간 섭취시켜 골밀도와 골무기질함량에 미치는 영향을 아래와 같이 요약하였다. 1) 체중증가량은 난소절제군이 Sham군에 비해 유의적으로 높았으며 각 군내에서 카페인 섭취에 따른 차이는 없었다. 2) 혈 중 칼슘 농도는 난소절제군내에서 카페인군이 대조군보다 유의적으로 낮게 나타났다. 3) 혈 중 ALP는 Sham군과 난소절제군 모두에서 카페인 군이 대조군보다 높은 경향을 나타내었다. 혈 중 Osteocalcin은 Sham 군과 난소절제군, 그리고 각 군내에서 카페인 섭 취여부에 따라 유의적인 차이를 나타내지 않았다. 4) 요 중 칼슘 및 인의 농도, 요 중 Deoxypyridinoline (DPD)와 crosslinks value는 Sham 군과 난소절제군, 그리고 각 군내에서 카페인 섭취여부에 따라 유의적인 차이를 나타내지 않았다. 5) 척추골밀도는 Sham군에 비해 난소절제군이 유의적으로 낮았고, 난소절제군내에서 카페인 첨가군과 대조군 간에 차이가 없었다. 6) 대퇴골밀도와 대퇴 골무기질 함량은 Sham군과 난소 절제군 간의 차이는 없었고, 각 군내에서 식이에 따른 차이도 없었다. 따라서 카페인 0.03% caffeine 섭취는 난소절제쥐에서 6주간 섭취 시킨 경우 척추와 대퇴골멸도에 부정적 영향을 미치지 않는 것으로 나타났다. The purpose of this study was to examine the effects of dietary caffeine supplementation on bone mineral density and bone mineral content in ovariectomized rats. Twenty eight female Sprague-Dawley rats (body weight 210±5 g) were divided into two groups, ovariectomy (OVX) and Sham groups, which were each randomly divided into two subgroups that were fed control and control supplemented with caffeine diets (caffeine 0.03% diets). All rats were fed on experimental diet and deionized water ad libitum for 6 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus (GE Lunar Co, Wisconsin) in spine and femur. Serum alkaline phosphatase activity (ALP) and osteocalcin and urinary DPD crosslinks value were measured as markers of bone formation and resorption. The results of this study indicate that body weight gain and food intake were higher in OVX groups than in Sham groups regardless of diets. There were no differences weight gain between the control and caffeine groups in both OVX and Sham groups. Within the OVX groups, serum Ca concentration was lower in rats fed caffeine than in rats fed the control diet. Serum ALP, osteocalcin, urinary Ca, and phosphate were not different in each group. Spine BMD, spine BMD/weight, and spine BMC/weight, femur BMD/weight and femur BMC/weight of ovariectomy groups were significantly lower than Sham groups. Within the OVX group, there were no differences in spine BMD and BMC and femur BMD and BMC. These results indicate that no significant differences in spine and femur BMD were found due to 0.03% caffeine intakes in diet in OVX rats for 6 weeks. No negative effect of caffeine in 0.03% diet on bone mineral density were found in the present study. Further investigation of the relation between caffeine and bone mineral density are warranted. (Korean J Nutr2008; 41(3): 216~223)

카페인 첨가 식이가 성장기 수컷 흰쥐의 혈중 및 간 지질에 미치는 영향

최미자(Mi-Ja Choi),이지은(Ji-Eun Lee) 동아시아식생활학회 2008 동아시아식생활학회지 Vol.18 No.4

대구지역 여중생의 영양소 및 식이섬유 섭취량

최미자 ( Mi Ja Choi ),이상희 ( Sang Hee Lee ) 대한지역사회영양학회 2008 대한지역사회영양학회 춘-추계학술대회지 Vol.2008 No.2

비타민 K₂ 첨가 식이가 난소절제쥐의 골밀도에 미치는 영향

최미자(Choi Mi-ja),김미성(Kim Mi-Seong) 韓國營養學會 2011 Journal of Nutrition and Health Vol.44 No.3

Vitamin K has been suggested to plays a role in bone metabolism. The objective of this study was to determine whether vitamin K₂ supplementation is related to bone mineral density, bone formation markers, and bone resorption in ovari-ectomized(OVX) rats. Forty Sprague-Dawley female rats (body weight, 200 ± 10g) were divided into lour groups: a sham group fed a control diet, a sham group fed a vitamin K₂ supplemented diet, OVX fed a control diet, and OVX fed a vitamin K₂ supplemented diet (3.5 mg vitamin K₂/kg diet). All rats were fed the experimental diets for 6 weeks, and deionized water was provided ad libitum. Serum alkaline phosphatase activity (ALP), osteocalcin, and urinary deoxy-pyridinoline crosslink values were measured as markers of bone formation and resorption. Bone mineral density(BMD) and bone mineral content were measured in the spine and femur using PIXlmus (GE Lunar Co., Madison, WI, USA). No significant differences in body weight gain, food intake, or food efficiency ratio were observed between the control and experimental groups. Serum ALP, osteocalcin, and urinary crosslink values were not significantly different between the vitamin K₂ supplemented groups. No significant differences were observed for any of the variables in the sham group. Spine BMD values were significantly lower in the OVX than those in the sham groups. Spine and femur BMD per weight of vitamin K1 tended to be higher than the control diet group within the OVX group, but no significant differences were observed. In conclusion, dietary vitamin K₂ supplementation may have a beneficial effect on spine and femur BMD in OVX rats. Further research is needed to understand the potential benefits of vitamin K₂ on bone loss in OVX rats.