급성 장간막 경색증의 임상적 고찰

최문기(Mun Ki Choi),이영주(Young Joo Lee),최창식(Chang Sig Choi) 대한외과학회 1990 Annals of Surgical Treatment and Research Vol.38 No.1

위 MALT 림프종의 진단과 치료

최문기 ( Mun Ki Choi ),김광하 ( Gwang Ha Kim ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.5

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma represents approximately 40% of gastric lymphomas, and its incidence is increasing. An early diagnosis for gastric MALT lymphoma is important, but not easy due to non-specific symptoms and endoscopic findings. Diagnosis is based on the histopathologic evaluation of multiple, deep and repeated biopsies taken from normal and any abnormal appearing sites of the stomach. In addition, the presence of Helicobacter pylori (H. pylori) infection must be determined to determine therapeutic approach. Endoscopic ultrasonography (EUS) is essential for the evaluation of regional lymph nodes and the depth of tumor invasion in the gastric wall, for predicting response to H. pylori eradication, and for monitoring tumor regression or recurrence. The eradication of H. pylori is recommended as an initial treatment for low-grade gastric MALT lymphoma with H. pylori infection. Both radiation therapy and chemotherapy are suitable alternative options for H. pylori-negative, refractory, or high-grade gastric MALT lymphoma. But, the role of surgery is diminishing. After treatment, strict endoscopic regular follow-up including EUS is recommended with multiple biopsies. However, controversy remains regarding the best diagnosis, treatment and follow-up strategy for this disease. (Korean J Gastroenterol 2011;57:272-280)

비소에 의해 유도된 상악골 골수염의 증례보고

최보영,유대현,최문기,최정구,이영진,조병호,Choi, Bo-Young,Yoo, Dae-Hyun,Choi, Mun-Ki,Choi, Jung-Goo,Lee, Young-Jin,Jo, Byung-Ho 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.6

Arsenic trioxide is one of the 'tooth pulp devitalizing agents' used through the dental history when anaesthesia was not available. But owing to its capacity to kill cells in surrounding tissues, the use of arsenic trioxide in vital pulpotomy has been reduced. Arsenic trioxide can cause necrosis of gingiva, bone which can cause osteomyelitis of the jaws. But some dentists still continue to use arsenic trioxide in their endodontic practices. The purpose of this article is to present arsenic trioxide induced osteomyelitis on maxilla and treatment process.

자가혈관 동정맥루 생존율에 대한 Cilostazol의 효과

김정섭 ( Jung Sub Kim ),최문기 ( Mun Ki Choi ),최보경 ( Bo Kyung Choi ),이희선 ( Hee Sun Lee ),이나리아 ( Naria Lee ),손정민 ( Jung Min Son ),성은영 ( Eun Young Seong ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4

Purpose: Vascular access failure is the most common reason for hospitalization among hemodialysis (HD) patients. Cilostazol, which has antiplatelet action and vasodialtory effects, significantly reduces the risk of restenosis after percutaneous coronary intervention in many patients. We conducted this study to evaluate the relationship between the use of antiplatelet agents, especially cilostazol, and arteriovenous fistula (AVF) patency in HD patients. Methods: A total of 241 patients underwent native AVF creation from January 2001 to December 2008. Among these patients, we selected 86 patients excluding 38 patients (15.8%) with primary technical failure, 49 patients without complete data and 68 patients used cilostazol less than 1 month. Demographic characteristics, medication history and fistula failure rate were collected and analyzed to elucidate the effect of cilostazol to native AVF. Results: From all groups, AVF failure occurred in 24 patients (27.9%). 28 patients received cilostazol (62.3 %) and mean duration of cilostazol therapy was 229.5±115.7 days. All patients were classified into two groups according to cilostazol (Cilostazol [n=28, 32.6%] vs. non-Cilostazol [n=58, 67.4%]. There was no statisticallly significant difference in failure rate between the two groups (32.1% vs. 25.9%, p=0.543). In diabetes group, patients who received statin have much lower AVF failure rate (0 % vs. 32.4%, p=0.024). Logistic regression analysis showed that female was independent risk factor for access failure (HR 5.549, CI 1.104-27.877, p=0.037). Conclusion: Cilostazol and other antiplatelet agent had a no significant association with AVF patency. Female was an independent risk factor for access failure.

하악 과두 골절에 관한 장기추적조사연구

민승기,박상규,오승환,권경환,최문기,채영원,Min, Seung-Ki,Park, Sang-Kyu,Oh, Seung-Hwan,Kwon, Kyung-Hwan,Choi, Mun-Ki,Chae, Young-Won 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.6

The management of mandibular condyle fractures continues to be a subject of much debate. It is suggested that, if not properly managed, these fractures may give rise to serious problems, such as malocclusion, mouth opening limitation, temporomandibular joint disorders. Treatment planing of mandibular condyle fractures is very important. The aim of this present study was to evaluate the long-term results according to treatment methods in condylar fractures. Also, it was to evaluate results of treatment according to condylar fracture level. We conducted a retrospective analysis of 43 mandibular condyle fractures. 43 patients followed for average period of 9.00 years(mini. 7yr, max. 12yr). All patients underwent a clinical and radiologic evaluation focusing on mouth opening, mandibular movements, TMJ function, change of ramal height, condylar remodelling. If the level of fracture was positioned in high, especially in level II, mandibular movement disability and ramus length loss was more prominent. This results were similar to the cases of treatment of fragment removal. In high level fracture and fragment removal cases, It is thought that more intensive and long term management are needed than other treatment cases using different operation methods. Also, direct fixation by each approach showed good results in mandibular movement, ramal height change and condylar shape. Through this results, accurate reduction of the mandibular condyle fractures was a very important factor in postoperative prognosis.

계층적분석방법을 이용한 차세대 방통융합서비스의 핵심 경쟁 요인에 관한 연구

유재흥(Jae-heung Yoo),최문기(Mun-kee Choi),김선중(Sun-joong Kim),조기성(Ki-sung Cho) 한국통신학회 2011 韓國通信學會論文誌 Vol.24 No.7

본 연구에서는 차세대 방통융합서비스 시장의 핵심 경쟁 요소의 우선 순위를 도출함으로써 관련 기업의 전략수립을 위한 시사점을 제공하고자 한다. 이를 위해 방통융합서비스 시장의 CPNT (Content - Platform - Network - Terminal)가치 사슬을 기반으로 14개의 세부 핵심 자원 요소를 도출하고 전문가 설문을 바탕으로 계층적분석방법을 실시하였다. 분석 결과, 핵심 자원 요소로서 상대적인 중요성은 방송컨텐츠의 확보, TV앱스토어의 구축, 멀티 플랫폼 확보, 무선망에 대한 투자, 휴대 단말의 보급 등의 순으로 나타났다. 한편, 차세대 방통융합서비스 시장에서의 헤게모니 확보에 가장 유리한 전략 대안으로는 플랫폼을 중심으로 한 전후방 자원 통합 전략이 유망한 것으로 나타났다. 논문의 결론부분에서는 이러한 결과를 토대로 몇 가지 시사점을 논의하고 있다. The competition among companies in converged market of broadcasting and telecommunications has become severe. Companies in this market have vertically integrated critical resources by acquiring or strategically allying with relevant companies. However, the expansion of business territory accompanies financial, organizational, and technological risks. As such, it is important to identify critical success factors that highly affect the company's competency. This study is aimed at delivering strategic implications for firms playing in the converged market of broadcasting and telecommunications by drawing the priorities of competitive resources to acquire. To do this, we selected four teen specific core resources on CPNT (content- platform - network - terminal) value chain. Then, we conducted an Analytic Hierarchical Process (AHP) using data from experts in this industry. As a result, the priority for acquisition of competitive resources is presented as follows: broadcasting programs, implementation of TV application store, multi-platform, investment on wireless network, and diffusion of mobile devices. In addition, the result shows that the platform-centric vertical integration is the most promising strategy for competition.

신장 ; 신기능에 따른 폐외결핵의 임상적 특징과 예후

최보경 ( Bo Kyung Choi ),이희선 ( Hee Sun Lee ),황인혜 ( In Hye Hwang ),신경화 ( Kyung Hwa Shin ),최문기 ( Mun Ki Choi ),최보광 ( Bo Gwang Choi ),안강희 ( Kang Hee Ahn ),남형석 ( Hyung Seok Nam ),황종민 ( Jong Min Hwang ),성은영 ( 대한내과학회 2010 대한내과학회지 Vol.79 No.4

목적: 만성 신질환 환자에서 세포성 면역기능이 감소되어 결핵에 이환될 위험성이 높으며, 특히 폐외결핵의 발생 빈도가 높은 것으로 알려져 있다. 이에 신기능에 따른 폐외결핵의 임상양상, 치료 반응, 질환과 연관된 사망률의 차이점을 비교하였다. 방법: 2003년 1월부터 2007년 12월까지 폐외결핵으로 진단된 18세 이상의 환자를 대상으로 하였고, 진단 당시의 크레아티닌 값을 이용하여 MDRD 공식으로 계산한 추정 사구체 여과율(eGFR)이 60 mL/min/1.73 m2을 기준으로 신기능 장애군(Group I)과 정상 신기능군(Group II)으로 분류하여 폐외결핵의 임상상, 치료성공률, 사망률 및 치료기간의 차이를 후향적 비교 분석하였다. 결과: 총 342명의 환자 중 Group I은 30명으로 이중 투석을 시행하고 있는 환자는 6명이었고, Group II는 312명으로, 각각의 평균 사구체 여과율은 34±19 mL/min/1.73 m2, 102±26 mL/min/1.73 m2이었다. Group I에서 고연령, 빈혈, 저알부민증이 많았으며, 고혈압, 당뇨병 및 심혈관계 질환을 동반한 경우가 많았다. 폐외결핵의 발생 부위는 두 환자군 모두 (Group I vs. Group II)에서 흉막(30.0% vs. 28.2%)이 가장 빈도가 높았고, 신경계통(23.3% vs. 16.3%)과 림프절(16.7% vs. 17.6%)의 감염이 흔하였으나, 통계학적 유의성은 없었다 (p=0.379). 모든 환자들은 표준 결핵화학요법인 HERZ, HER 및 HRZ 등을 용량 조절하여 치료하였으며, 두 환자군 모두에서 치료 실패 및 재발은 없었다. 결핵과 연관된 사망률은 Group I에서 높았으며(Group I, 22.2% vs. Group II, 2.8%, p<0.001), 연령, 혈색소 및 알부민, 당뇨병, 고혈압 및 심혈관계 질환의 유무를 보정하였을 경우에도 Group I이 사망의 위험률이 높았다(HR=11.51, 95%CI 2.512~52.741; p=0.002). 치료 중 이탈된 환자 및 사망환자를 제외하였을 경우, Group I이 치료 기간이 짧았다(278±110일 vs. 367±170일, p=0.009). 결론: 신기능 장애 환자에서 폐외결핵에 대한 치료기간이 연장되지 않았고 사망을 제외한 치료실패와 재발이 없었으나 폐외결핵으로 인한 사망률은 높았고, 신기능 저하 자체가 사망의 독립적인 위험 요소였다. 그러므로 신기능 장애 환자에서 폐외결핵에 대한 적극적인 진단 및 치료가 더 요구된다고 판단한다. Background/Aims: There is an increased risk of tuberculosis (TB) with impaired cellular immunity and extrapulmonary TB is more common in patients with chronic kidney disease. We explored the clinical features and treatment outcomes of extrapulmonary TB according to renal function. Methods: This retrospective study reviewed the medical records of patients diagnosed with extrapulmonary TB between January 2003 and December 2007. We classified the patients into two groups using the glomerular filtration rate (eGFR), estimated using the Modification of Diet in Renal Disease (MDRD) formula cut-off of 60 mL/min/1.73 m2 and evaluated their clinical features, treatment outcome and mortality (Group I vs. Group II, ≥ 60 mL/min/1.73 m2). Results: The mean eGFR of Groups I (n=30) and II (n=312) was 34±19 and 102±26 mL/min/1.73 m2, respectively. The pleura was the most frequent site of TB in both groups (Group I, 30.0% vs. Group II, 28.2%; p=0.379). There was no treatment failure or recurrence in either group. The mortality was higher in Group I (22.2% vs. 2.8%; p<0.01). In a multivariate analysis, eGFR<60 mL/min/1.73 m2 was an independent risk factor for mortality (HR=11.51, CI 2.512-52.741; p=0.002). Conclusions: Mortality related to extrapulmonary TB was higher in patients with impaired kidney function and kidney function was an independent predictor. However, there was no difference in treatment failure and recurrence according to renal function. (Korean J Med 79:387-393, 2010)

신규 서비스 개발 시 사용자 참여 효과 및 활용 전략에 관한 연구

양희태(Hee-Tae Yang),이기백(Ki-Baek Lee),최문기(Mun-Kee Choi) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.5

사용자 참여(User involvement)를 통한 신제품 또는 신규 서비스 개발이 내부 직원이나 외부 전문가 활용의 대안으로 각광받고 있다. 그러나 이러한 사용자 참여 방식이 궁극적으로 기업 성과에 긍정적인 영향을 주는지에 대한 정량적 연구는 미흡하며, 기존 연구들도 사용자 참여의 효과성에 대해 상충되는 결론을 내리고 있다. 본 연구는 최근 급성장하고 있는 국내 디지털 콘텐츠 산업에서의 신규 서비스 개발 시 사용자 참여 효과를 실증적으로 분석하고, 이를 바탕으로 세부 활용 전략을 제시하고자 한다. 사용자 활용 현황 및 성과 창출 효과를 다각적으로 분석하기 위해 사용자 군을 선도 사용자와 일반 사용자로 구분하였고, 급진적 서비스와 점진적 서비스로 서비스 유형을 분류하였다. 서비스 개발 단계 또한 아이디어 발굴, 개발, 마케팅으로 나누어, 실제 사용자를 활용하고자 하는 기업들이 서비스 유형 및 개발 단계를 조합하여 적절한 사용자 활용 전략을 수립할 수 있도록 사용자 활용 전략 매트릭스를 제안하였다. User involvement in New Service Development(NSD) has attracted the limelight as a good method, but we still lack an empirical analysis of the effectiveness of user involvement. In addition, positive and negative determinants of user involvement in NSD have not often been dealt with in past research, and this deficiency has been identified as a barrier to the effective utilization and diffusion of user involvement in NSD. To our knowledge, this is the first study to empirically investigate the degree of implementation of user involvement in NSD, the effectiveness of user involvement, and the utilization strategy in the digital content industry. First, we reveal that ordinary user involvement is more effective for NSP performance than lead users or business partner companies. Second, we empirically demonstrate that the effectiveness of involving lead user and ordinary user in NSP is different according to the new service type and service development stage. Based on the results of our analyses, we suggest somestrategic directions for the companies who want to newly adopt or improve their current level of user involvement in NSD. We expect that the implications of this study will be utilized for efficient diffusion of user involvement in NSD and will eventually contribute to tangible achievements for companies in the digital content industry.

제조 기업의 R&D 자원과 혁신 성과의 구조적 관계 : 내부 R&D 역량, 외부 R&D 협력, 정부 지원을 중심으로

정의영 ( Eui Young Chung ),이기백 ( Ki Baek Lee ),최문기 ( Mun Kee Choi ) 포스코경영연구원 2013 POSRI 경영경제연구 Vol.13 No.1

증례 : 내분비-대사 ; 다발성 척추 골절로 내원한 Carney Complex 1예

배민정 ( Min Jung Bae ),최보광 ( Bo Gwang Choi ),안강희 ( Kang Hee Ahn ),최문기 ( Mun Ki Choi ),김상수 ( Sang Soo Kim ),김보현 ( Bo Hyun Kim ),김인주 ( In Joo Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S

Carney complex는 피부의 색소침착과 여러 양성 종양(점액종, 내분비 종양)이 상염색체 우성으로 표현되는 질환이다. 저자들은 다발성 척추 골절로 내원한 젊은 남자에서 쿠싱양 외형을 관찰하여 시행한 검사상 PPNAD 발견하였고, 환자의 입술에 색소 침착을 관찰하여 Carney complex 진단하였다. 이에 좌측 부신절제술 이후 우측 부신절제술 단계적으로 시행하고 조직학적으로 확진된 예를 문헌고찰과 함께 보고하는 바이다. Carney complex is an autosomal dominant syndrome characterized by multiple neoplasias, including myxomas and endocrine tumors, spotty pigmentation, and schwannomas. Primary pigmented nodular adrenal dysplasia (PPNAD) is a cause of Cushing syndrome, independently of adrenocorticotropic hormone. A 21-year-old man was referred for evaluation with multiple spinal compression fractures and adenomas affecting both adrenal glands. Plasma and urinary cortisol levels were elevated and were not suppressed by the administration of a high dose of dexamethasone. The patient was diagnosed with Carney complex manifesting as Cushing syndrome due to PPNAD with multiple pigmented skin lesions. Left adrenalectomy was performed because the nodule on the left adrenal gland was markedly larger than the other nodules. Subsequently, right adrenalectomy was also performed. Pathological analysis revealed that the adrenal glands contained multiple dark brown and black nodules. We describe herein our recent experience of a case of Carney complex manifesting as Cushing syndrome due to PPNAD, with lentigines on the lips, and review the published literature on this subject. (Korean J Med 2011;80:S239-S244)