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일 지역 병원간호사의 심부정맥혈전증에 관한 지식과 간호수행
최동옥,민혜숙,Choi, Dong-Ok,Min, Hye-Sook 한국중환자간호학회 2011 중환자간호학회지 Vol.4 No.1
Purpose: This study was done to investigate the DVT-related knowledge and compliance of hospital nurses. Methods: A survey questionnaire was administrated to a convenience sample of 367 nurses working at 3 university hospitals and 4 general hospitals located in Busan. Results: The mean score of DVT-related knowledge was $16.86{\pm}$3.40$ points out of 26, with a percentage of correct answers of 64.8%. The mean score of DVT-related compliance was $21.40{\pm}6.42$ points out of 32. There was a significant correlation between hospital nurses' DVTrelated knowledge and compliance (r=.309, p=.000). The factors for predicting hospital nurses' DVT-related compliance included knowledge of treatment and care areas, the subcategories of DVT knowledge (${\beta}$=.214), knowledge of the area of risk factors (${\beta}$=.105), whether to perform DVT prevention and treatment based on protocols (${\beta}$=.193), the existence of DVT protocols (${\beta}$=.168) and the degree of interest in DVT (${\beta}$=.102) and the total explanatory power of these was 21.3%. Conclusion: To improve compliance on preventing DVT effectively, it is necessary to improve nurses' DVT-related knowledge and interest in DVT through appropriate education. And, it is necessary to develop standardized protocols and guidelines.
코로나 바이러스 감염증-19의 재조합 S1 RBD 단백질을 이용한 COVID-19 바이러스의 중화항체 검사 키트의 개발
최동옥 ( Dong Ok Choi ),이강문 ( Kang Moon Lee ) 대한임상검사과학회 2021 대한임상검사과학회지(KJCLS) Vol.53 No.3
코로나바이러스감염증-19는 사람의 호흡기관에 다수로 분포하는 안지오텐신전환효소2, angiotensin converting enzyme 2 (ACE2)를 매개하여 감염을 일으키는 β-genus 바이러스이고 완치환자 및 백신 접종자의 항체생성에 대한 효율적인 사후관리가 필요한 질병을 유발하는 바이러스다. 이 논문에서는 임상 시료의 중화항체와 특이적으로 반응하는 재조합 단백질을 개발하고 이를 이용하여 COVID-19 바이러스에 대한 중화항체를 빠르고 편리하게 진단하는 신속 진단 키트를 개발하고 그것의 성능 평가를 통하여 제품화 가능성을 확인하는 것을 목표로 하였다. COVID-19 S1 RBD 재조합 단백질을 사용한 신속 진단 키트의 양성 퍼센트 일치(PPA) 및 음성 퍼센트 일치(NPA)가 미국 FDA EUA에서 승인한 ELISA 키트와 비교했을 때 각각 100% 및 98.3%인 점에서 신속 진단 키트에 적용할 수 있을 것으로 확인하였다. 향후 신속 진단 키트의 성능을 개선하고 정량 분석 장비를 통해 중화항체를 정량적으로 분석이 가능하면 제품화 통해 검체내의 중화항체 유무와 양을 확인함으로써 COVID-19 바이러스에 대한 면역성을 예측하고 추가 예방접종 여부를 판단하는 중요한 자료로 활용될 수 있을 것으로 생각한다. The COVID-19 virus is a β-genus virus that causes infection by mediating the angiotensin convertible enzyme 2 (ACE2) receptor, which is distributed in large numbers in the human respiratory tract. The disease requires effective post-management of antibody production by complete healers and vaccinators because there is no perfect remedy for the virus infection. This study aimed to develop recombinant proteins specifically responsive to neutralizing antibodies in clinical specimens and use them to develop a rapid diagnostic kit to diagnose neutralizing antibodies quickly and conveniently against the COVID-19 virus and confirm the possibility of commercialization through a performance evaluation. Rapid diagnostic kits using COVID-19 S1 RBD recombinant proteins can be applied to rapid diagnostic kits, with positive percentage agreement (PPA) and negative percentage agreement (NPA) of 100% and 98.3%, respectively, compared to the U.S. FDA-approved ELISA kits. If the performance of the rapid diagnostic kit is improved and neutralizing antibodies can be analyzed quantitatively using quantitative analysis equipment, it can be used as important data to predict immunity to the COVID-19 virus and determine additional vaccinations. Copyright Ⓒ 2021 The Korean Society for Clinical Laboratory Science. All rights reserved.
일과성(一過性) 전뇌(前腦) 허혈(虛血) 손상(損傷)에 대한 환도(環跳) (GB30) 전침자극(電鍼刺戟)의 효과(效果)
김풍식 ( Poong Sik Kim ),김재효 ( Jae Hyo Kim ),최동옥 ( Dong Ok Choi ),김경식 ( Kyung Sik Kim ),손인철 ( In Cheul Sohn ) 대한경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.1
Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. However, it was not published the protective effect of the electroacupuncture (EA) of Huan-do (GB30) on the transient forebrain ischemia injury. The neuroprotective effects of EA (2 ms, 10 Hz, and 1-2 mA) of GB30 on the transient forebrain ischemia injury was investigated by western blot of nNOS and hematoxylin and eosin stain in Sprague-Dawley rats. The transient forebrain ischemia injury resulted in increased expression of nNOS in the brain for 6 hrs after ischemia, and EA decreased significantly expression of nNOS protein in brain increased by transient forebrain ischemia injury. The survived neuronal cell stained with hematoxylin and eosin (H&E) decreased in the hippocampus by the 7 days after ischemia comparing with the normal. Comparing with the normal, the survived neurons seriously decreased cell in the hippocampus after the injury. However, the proportion of survived neurons was increased in EA treatment. These results suggest that EA of GB30 have neuroprotective effects on transient forebrain ischemia injury.