http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
혈관질환 억제 효능이 있는 BDR-29의 백서 신장 독성연구
김은주,강대길,이안숙,최덕호,조국현,김성연,이호섭,Kim, Eun-Ju,Kang, Dae-Gill,Lee, An-Sook,Choi, Deok-Ho,Cho, Kuk-Hyun,Kim, Sung-Yun,Lee, Ho-Sub 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.
최덕호,양경탁,김호경 서울産業大學校 2005 논문집 Vol.54 No.2
In this study, SPCC cross-tension type specimens produced under various welding conditions were tensile and fatigue tested. Decrease of 2 kA in normal current condition of 10 kA caused a large amount of reduction in both static joining strength and fatigue life. And 2 kA increase resulted in increase of static joining strength and an increase in low cycle regime but a decrease in high cycle regime, revealing the fact that fatigue strength rather than static joining strength would be a major factor during design process in view of the body endurance. As a results of estimating the fatigue lifetimes of various types of specimens, equivalent stress intensity factor is the proper parameter for predicting the lifetimes of various types of specimens, which can be expressed as ΔK_(eq) (N/mm^(1.5)) = 11550N_(f)^(-0.36)
Seoh, Yoo-Seung,Lee, Eun-Sook,Choi, Deok-Ho,Park, Hyeun-Gyoon,Kim, Ok-Min,Kang, Moo-Jin,Lim, Dong-Yoon 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1
본 연구에서는 인삼사포닌 성분 즉, 총인삼사포닌(GTS), panaxadiol-type saponin (PDS) 및 panaxatriol-type saponin (PTS)이 정상 혈압쥐(NR) 및 자연발증 고혈압쥐(SHR)의 대동맥편에서 혈관수축약물의 수축반응에 대한 영향을 관찰하고자 시도하였으며, 얻어진 연구결과는 다음과 같다. Phenylephrine (아드레날린성 α_1-수용체 효능약)과 고농도 칼륨 (막탈분극약)은 NR 및 SHR의 대동맥편에서 각각 현저한 혈관수축반응을 나타내었다. 이들의 수축반응은 SHR보다 NR에서 현저하게 나타났다. NR에서 고농도 칼륨(5.6x10^-2 M)에 의한 혈관수축반응은 GTS(300 g/ml), PDS(300 g/ml) 및 PTS(300 g/ml)의 존재 하에서 각각 별다른 영향을 받지 않았다. 반면에, phenylephrine (10^-6 M)에 의한 혈관수축반응은 현저하게 억제되었다. SHR에서 고농도 칼륨(5.6x10^-2 M)에 의한 혈관수축반응은 GTS(300 g/ml), PDS(300 g/ml) 및 PTS(300 g/ml)의 존재하에서 각각 별다른 영향을 받지 않았으나 고농도의 PTS(600 g/ml)의 전처치에 의해서 유의하게 억제되었다. Phenylephrine (10^-6 M)에 의한 혈관수축반응은 PTS의 전처치에 의해서 용량 의존적(150-600 g/ml)으로 유의하게 억제되었으나 GTS(300 g/ml) 나 PDS(300 g/ml)의 존재 하에서는 별다른 영향을 받지 않았다. 이상과 같은 실험 결과를 종합하여 보면, 인삼사포닌 성분은 흰쥐 적출 대동맥편에서 아드레날린성 1-아드레날린 수용체 차단작용과 일부 미지의 기전에 의해서 혈관이완작용을 일으키며, 이러한 인삼사포닌 성분에 대한 반응에서 NR과 SHR간에 혈관 평활근의 감수성의 차이가 있는 것으로 생각된다. 또한 인삼사포닌 성분 중 PTS가 혈관이완작용에 대한 효력이 가장 큰 것으로 사료된다. The present study was attempted to investigate the effects of total ginseng saponin (GTS), panaxadiol-type (PDS) and panaxatriol-type saponin (PDS) on contractile responses of vasoconstrictors in aortic smooth muscle stripes of normotensive (NR) and spontaneous hypertensive rats (SHR). Phenylephrine (an adrenergic α1-receptor agonist) and high potassium (a membrane depolarizing agent) caused greatly contractile responses in both NR and SHR aorta, respectively. Phenylephrine- and high potassium-induced contractile responses were greater in NR than those in SHR aortic smooth muscle stripes. In NR, the contractile responses of high potassium (5.6 ×10^-2 M) were not affected in the presence of GTS (300 ㎍/ml), PDS (300 ㎍/ml), and PTS (300 ㎍/ml), respectively whereas phenylephrine (10^-6 M) - induced contractile responses were markedly inhibited. In SHR, the contractile responses of high potassium (5.6×10^-2 M) were not affected in the presence of GTS (300 ㎍/ml), PDS (300 ㎍/ml), and moderate doses of PTS (150-300 ㎍/ml), respectively but greatly blocked by high concentration of PTS (600 ㎍/ml). Phenylephrine (10-6 ㎛)-induced contractile responses were inhibited in a dose dependent fashion (150-600 ㎍/ml) by the pretreatment with PTS while not altered in the presence of GTS (300 ㎍/ml) and PDS (300 ㎍/ml), respectively. Taken together, these experimental results suggest that ginseng saponins cause vascular relaxation through blockade of adrenergic α1-receptors and some unknown mechanisms, and that there is some difference in sensitivity of vascular smooth muscle between NR and SHR in responses to ginseng saponins. It seems that panaxatriol type of some ginseng saponins has the greatest potency in vascular relaxation.