Identification of Genes Connected with the Sensitivity to 5-FU and Cisplatin in Squamous Cell Carcinoma Cell Lines

최나영,김옥준,이금숙,김병국,김재형,장윤영,임원봉,정민아,최홍란,Choi, Na-Young,Kim, Ok-Joon,Lee, Geum-Sug,Kim, Byung-Gook,Kim, Jae-Hyeong,Jang, Youn-Young,Lim, Won-Bong,Chong, Min-A,Choi, Hong-Ran Korean Academy of Orofacial Pain and Oral Medicine 2005 Journal of Oral Medicine and Pain Vol.30 No.3

Squamous cell carcinoma (SCC) in head and neck show a variability in the response to chemotherapy, even when it present with similar histological tumor type, grade, and clinical stage. The purpose of present study it to identify predictive bio-marker for the sensitivity or resistance to conventional chemotherapeutic agents, 5-fluorouracil (5-FU) and Cisplatin Oral cancer cell lines were used in present study. MTT assay was performed to evaluate the sensitivity and/or resistance to 5-FU and Cisplatin. And RT-PCR was carried out for evaluation of the mRNA expressions of various genes associated with mutation, inflammation (COX pathway), cell cycle, senescence and extracellular matrix (ECM). The molecules which are correlated with the sensitivity to 5-FU are XPA, XPC, OGG, APEX, COX-2, PPAR, Cyclin E, Cyclin B1, CDC2, hTERT, hTR, TIMP-3, TIMP-4 and HSP47. And the molecules are correlated with the sensitivity to Cisplatin are COX-1, iNOS, eNOS, PCNA, collagen 1 and MMP-9. Taken together, when choosing the appropriate chemotherpeutic agents for patients, considering the molecules which are correlated or reversely correlated is helpful to choose the resonable agents for cancer patients.

유아의 다문화 인식과 관련한 변인 연구

성영화 ( Young Hwa Sung ),최나영 ( Na Young Choi ) 미래유아교육학회 2012 미래유아교육학회지 Vol.19 No.3

본 연구는 유아의 다문화 인식과 그 관련 변인을 살펴보고자 하였다. 이를 위해 본 연구는 서울 및 경기도에 위치한 유치원에 재원중인 179명의 유아 및 그들의 부모와 16명의 교사를 대상으로 하였다. 연구도구는 유아 다문화 인식, 부모 다문화 인식, 그리고 교사 다문화적 효능감 검사를 사용하였다. 자료는 유치원과 가정에서 각 검사를 실시한 후 수집하였다. 수집된 자료는 이원변량분석과 상관분석을 하였다. 결과는 다음과 같다. 첫째, 유아의 다문화 인식은 연령에 따라 차이가 있었으나 성별에 따라 차이가 없었다. 둘째, 부모의 다문화 인식과 유아의 다문화 인식은 상관이 없었다. 셋째, 교사의 다문화 인식과 유아의 다문화 인식은 부분적으로 상관이 있었다. 이에 따라 유아가 긍정적인 다문화 인식을 갖도록 하기 위해서는 유아의 연령을 고려한 교사교육이 중요하다. The purpose of this study was to explore the relations between young children`s multicultural sensitivity and its related variables. The subjects of this study were 179 young children who were attending kindergarten in seoul and Gyeonggido, each young children`s parents, and 16 teacher. This study used tools like young children`s multicultural sensitivity, parent`s multicultural awareness and teacher`s multicultural efficacy. The data were collected after each test did at kindergarten and home. The data was analyzed with Two Way ANOVA and Correlation Analysis. The results were as follows. First, young children`s multicultural sensitivity were difference by age but not by gender. Second, parent`s multicultural awareness were not correlated with the young children`s multicultural sensitivity. Third, teacher`s multicultural efficacy were partially correlated with the young children`s multicultural sensitivity. As a result, teacher education is important considering the age of the young children to achieve positive multicultural sensitivity.

직물색의 지각에 미치는 광원의 영향

최나영 ( Na Young Choi ),이종숙 ( Jong Sook Lee ),양리나 ( Lee Na Yang ) 服飾文化學會 2007 服飾文化硏究 Vol.15 No.2

광원 변화에 따른 색의 이미지에 관한 주관적 평가

최나영 ( Na Young Choi ),이종숙 ( Jong Sook Lee ) 한국의류산업학회 2006 한국의류산업학회지 Vol.8 No.6

Bennett의 다문화교육과정의 목표를 중심으로 한 미국 워싱턴 주와 한국의 초등 교육과정 비교·분석

최나영(Choi, Na-Young),최진영(Choi, Jinyoung),한현지(Han, Hyun-Ji) 이화여자대학교 교육과학연구소 2014 교육과학연구 Vol.45 No.3

This study aimed to compare elementary curricula of Washington State in the U.S. and Korea, focusing on Bennett"s Goals of a Multicultural Curriculum. For this purpose, the elementary social studies curriculum of Washington State and elementary curricula of three subjects(social studies, moral education, and integrated subjects) in Korea were compared according to the goals of a multicultural curriculum. The main results of this study were as follows. First, the percent of total grade level expectations of the Washington State Curriculum related to the goals of a multicultural curriculum were higher than that of total achievement standards of Korean curricula. Second, there were similarities and differences between the curricula of Washington State and Korea according to the goals of a multicultural curriculum. For example, there was no achievement standard related to developing multiple historical perspectives in Korean curricula. Third, there were differences between the curricula of Washington State and Korea related to several goals of a multicultural curriculum according to grade cluster. Based on the results, implications for developing a multicultural curriculum in Korea were discussed.

피카소의 무대 의상디자인에 관한 연구

최나영(Na Young Choi),김문숙(Mun Sook Kim) 한국복식학회 2001 服飾 Vol.51 No.4

Picasso had deep concern at the designs of theatre costumes as well as art. The art of Picasso influenced deeply to the fashion designs in those days. In these study, to analyze the creative theatre costumes of Parade affected by Picasso`s cubism, we investigate the documentary records, photos, and sketches of Picasso. The design of theatre costumes in Parade was able to be divided by two categories, general theatre costumes and experimental theatre costumes. The first characteristic of general theatre costumes is that the designs of theatre costumes in Parade were influence by the early stages of Picasso`s art. The costumes of the Chinese Conjurer influenced by the Red Era of Picasso`s art and those of the Little American Girl and the Acrobats influenced by the Blue Era of Picasso art may belong to the category of general theatre costumes. The second characteristic of general theatre costumes is the fact that the images of heavenly bodies were used in the costume of the Chinese Conjure and the Acrobats. The characteristic of experimental theatre costumes is the fact that the cubism is introduced to the designs of theatre costumes in Parade. The experimental theatre costumes were presented in the costumes of the Three Managers which were newly created under the influence of Picasso`s cubism.

텍스트 마이닝에 기반한 예술교육 파트너십 국내 연구 경향 분석

최나영 ( Choi Na-young ) 한국예술교육학회 2017 예술교육연구 Vol.15 No.2

본 연구는 예술교육의 파트너십에 대한 국내 연구의 경향과 흐름을 파악함으로써 향후 연구 방향을 모색하고 협력을 통한 예술교육의 활성화 및 개선을 위한 시사점을 제언하는 데 목적이 있다. 2002년부터 2017년까지 발표된 등재후보지 이상의 학술지와 학위논문 75편을 수집하였다. 게재 학술지, 연구방법, 예술교육 분야, 파트너십의 유형을 분석하였다. 연구내용은 텍스트 마이닝 기법을 사용하여 빈출 핵심 단어를 추출하고, 토픽 모델링 방법을 활용하여 시기별로 토픽을 추출한 후 연구내용의 추이를 분석하였다. 분석 결과, 예술교육관련 학술지에서 가장 많은 연구가 발표되었고, 예술교육 전반에 대한 파트너십 연구가 큰 비중을 차지하고 있었다. 또한 행정적 파트너십에 초점을 둔 연구, 질적 연구 중에서도 문헌연구의 비율이 높았다. 텍스트 마이닝 기법을 사용하여 연구내용을 분석한 결과, 예술교육 파트너십의 사례 분석을 통해 프로그램을 개발 또는 개선하려는 연구, 거시적 차원의 파트너십 주체로서 학교·지역·사회에 대한 연구는 지속되는 것으로 나타났다. 반면, 거버넌스에 초점을 둔 연구에서 협력적 예술교육의 참여 주체, 학습자의 경험에 대한 연구로 관심이 이동 하였다. 분석 결과를 토대로 파트너십의 미시적 차원에 대한 관심, 교육 대상의 다양화, 엄격하고 다양한 연구방법론의 적용을 제안하였다. The purpose of this study was to analyze research trends of arts education partnership, to explore the direction of future studies, and to suggest improvements to the partnership. Related articles from the KCI accredited or candidate journals and dissertations since 2002 were collected. Data were analyzed by the published journal, year, research methodology, field of arts education, and the type of the partnership. Their contents were analyzed with the text mining tool, the R-program. As for the contents analysis, first high-frequency words were identified. Second, top four topics of each period were extracted and analyzed, using the topic modeling based on the LDA algorithm. The result is as follows. First, journals generally focusing on arts education published most articles about partnership, and researches on the overall arts education partnership were dominant. Second, studies on the administrative partnership and with the literature review were outnumbered. Third, as to the contents, studies on the program development or improvement according to the analysis of similar cases, and researches of school, region, and society in the aspect of the macro level were continued. Fourth, the research trends moved from the governance-centered studies to participants` experience and students` learning engagement. Some suggestions about the micro-level study, diversification of students, and rigid research method were provided.

연구논문 : 유백피 추출액을 이용한 염색 면포의 항생제 내성균주 증식 억제효능

최나영 ( Na Young Choi ),강선영 ( Sun Young Kang ) 한국의류학회 2015 한국의류학회지 Vol.39 No.2

This research verifies stainability, super bacteria antibacterial features and antibiotic resistance of Ulmus davidiana var. japonica Nakai (UD) extract in dye cotton cloth. UD was extracted with hot water, the test cloth dyed, and then processed by mordanting treatment using FeSO4 7H2O, CuSO4 5H2O and Al2(SO4)3. The surface color and color fastness of the three kinds (original cloth, the cloth without mordancy and mordant cloth) were measured and the influence of dying of cotton cloth and the mordant method on the genesistasis of Methicillin-resistant Staphylococcus aureus (MRSA), antibiotic resistant bacteria. 1. The surface color of the cotton cloth for dyeing (without and with mordancy) displayed a reddish and yellowish color. Stainability was greatest when the mordant of FeSO4 7H2O was used. 2. When a mordant was not used for dyeing, the color fastness to washing, perspiration and friction of the contaminated cloth was satisfactory at 4 to 5 grade in general. 3. As for the antibiotic effect to super bacteria, the growth of germ was meaningfully suppressed both on the cloth without and with mordancy compared to the comparison cloth; in addition, the dyeing method with the biggest antibacterial impact was found to be the mordancy with the mordant of CuSO4 5H2O after dyeing. The results of the experiments that involved dyeing with UD extract showed that cotton cloth processed through mordancy with the mordant of CuSO4 5H2O had the biggest antibiosis to super bacteria and that processed with the mordant of FeSO4 7H2O had the greatest stainability.

퍼스널 컬러 유형별 패션인식 차이에 관한 연구

최나영(Na Young Choi) 한국디자인문화학회 2012 한국디자인문화학회지 Vol.18 No.1

21세기 정보화 사회는 감성의 시대이자 이미지 시대로써 컬러가 중요해 짐에 따라 패션산업에서도 컬러 선택의 필요성이 대두되고 있다. 특히 개개인의 특성이 중요시되면서 패션관련분야에 퍼스널 컬러의 중요성이 날로 커져 가고 여러 뷰티와 패션 산업영역에서 그 비중과 발전이 크게 자리잡아 가고 있다. 따라서 본 연구의 목적은 퍼스널 컬러 시스템을 활용하여 조사대상자를 색상톤과 사계절 유형으로 분류한 후, 유형에 따른 인구통계적 특성과 패션관련 변인즉, 색채, 소재, 패턴, 이미지에 관한 인식 등의 차이를 파악함으로써 패션산업 마케팅을 위한 전략 수립의 기초 자료를 제공하고자 한다. 조사대상자는 퍼스널 컬러에 대해 전혀 듣거나 경험해 본 적이 없는 전북지역 대학생을 선정하여 퍼스널 컬러 진단 방법에 대한 교양강좌나 세미나를 들은 후, 피부색을 육안에 의해 자가 측정할 수 있는 방법을 습득한 대학생 175명을 대상으로 하였다. 조사기간은 2011년 3월부터 11월까지로 설문지와 그룹 인터뷰 법을 병행하였다. 수집된 설문지는 SPSS 18.0을 사용하여 분석하였으며, 통계분석방법은 빈도분석과 교차분석을 사용하였다. 분석결과, 퍼스널 컬러시스템에 따른 대학생들의 컬러이미지 유형은 차가운 톤과 따뜻한 톤이 비슷하게 나타났고, 사계절 유형에서는 가을유형이 가장 많이 나타났다. 색상톤 유형별 인구통계적 특성과 패션인식 차이에 있어서 선호 의상색, 어울리는 의상색, 그리고 어울리는 패턴에서 유형간 유의적인 차이가 나타났다. 사계절 유형별 인구통계적 특성과 패션인식 차이에 있어서 성별, 어울리는 의상색, 선호 패턴, 그리고 어울리는 패턴에서 유형간 유의적인 차이가 나타났다. 따라서 패션관련 업체는 유형별 패션인식차이를 파악하여 고객에게 맞는 맞춤형 마케팅 전략을 수립할 수 있을 것이다. In information society of this 21st century, called the era of sensitivity and image, the necessity of color selection has emerged in the fashion industry. In particular, importance of personal color in the fashion-related field has been continuously increased as characteristics of each person are being magnified, and its importance and development have expanded among the beauty and fashion industries. This research aims to provide the basic information about establishing marketing strategy for the beauty and fashion industry by finding the demographic characteristics and the fashion-related changing causes on each type, i.e., identifying differences of a perception in colors, materials, patterns, and images, after dividing the study subjects into color and season types using the personal color system. Selected university students in Jeollabuk-do who had never heard of or experienced the personal color system took the lecture on the personal color diagnostics, and 175 students who had learned how to determine skin tone with the naked eye in the lecture above were chosen for the research. The research was carried out both by questionnaires and group interviewing from March to November 2011. The collected questionnaires were analyzed using SPSS 18.0, and cross-tabulation analysis and frequency analysis were used. The study showed that, according to the personal color system, the numbers of students who were the cold or warm tone were similar for the color image type, and for the season type, the fall was the highest. For the demographic characteristics and the fashion perception difference of the color type, there was a critical difference in favored colors, and suited colors and patterns, and of the season type, there was a critical difference in all of the above and sex. Therefore, understanding the fashion perception difference on each type would help the beauty and fashion companies to establish customer-tailored marketing strategy.

지역연계 학교예술교육의 질적 성장 및 제고를 위한 교사의 역할과 지원에 대한 고찰

최나영(Na-Young, Choi) 한국문화교육학회 2020 문화예술교육연구 Vol.15 No.4

본 연구의 목적은 지역과 연계하는 학교예술교육의 질적 성장 및 제고를 위하여 핵심적인 실행자인 교사의 역할과 교사의 깊이 있는 실행을 지원하는 방안을 고찰해 봄으로써 지역사회 연계학교예술교육의 질적 제고를 위한 정책적·실천적 제언을 하는 데 있다. 이를 위하여 지역연계 학교예술교육의 핵심 실행자로서의 교사, 지역연계 학교예술교육의 근거가 되는 국가 수준 교육과정의 질 관리 관점과 방향, 지역연계 학교예술교육 질 관리의 관점에서 실행자인 교사와 교사의수업이 모두 배제되는 문제를 탐색하였다. 그리고 지역연계 학교예술교육에서 교사의 위치와 역할을 M. Fullan의 변화 주도자(change agent)의 관점에서 관련 문헌을 중심으로 고찰하였다. 교사가 핵심 실행자로서 지역사회 연계 학교예술교육의 변화를 주도할 수 있도록 지원하는 방안으로써 전문성 강화를 위한 강력한 교사학습공동체 지원, 교사의 상호소통과 교사학습을 장려하는 학교문화 조성, 지역사회 조직화로의 인식 전환과 실천을 중심으로 고찰하였다. 고찰한 결과를 토대로 지역연계 학교예술교육을 위한 질 관리 관점의 재정립, 실질적인 수업 개선을 위한 질 관리, 교사의 전문적 자본 강화를 위한 방안 마련을 제언하였다. The purpose of this study is to make policy-level and practical suggestions to improve the quality of school arts education by contemplating the direction of quality management of local-connected school arts education and the role of teachers who are the main implementers. For this purpose, the view of national curriculum, which is a guideline for the school curriculum, the perspective of evaluation in the quality management cases of local-linked school arts education, and the problems revealed herein were explored. In addition, the position and role of teachers in local-connected school arts education were considered from the perspective of the change agent of M. Fullan. As a necessary support measure for teachers to lead changes in local community-linked school arts education as a key implementer, professional learning community to strengthen professionalism, school culture to encourage mutual communication and teacher learning, and community organizing were considered. Based on the results discussed, it was proposed to redefine quality management perspectives for regional-linked school arts education, manage quality for practical class improvement, and strengthen professional capital of teachers.