http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
증례 : 류마티스 ; 원위신세관산증이 선행한 전신홍반루푸스
강진영 ( Jin Young Kang ),강종완 ( Jong Wan Kang ),김지훈 ( Ji Hun Kim ),진미경 ( Mi Kyung Jin ),임철현 ( Churl Hyun Im ),남언정 ( Eon Jeong Nam ),강영모 ( Young Mo Kang ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
원위신세관산증은 세관내 산 분비의 저하로 소변의 산성화 장애와 전신적인 산혈증 및 저칼륨혈증을 특징으로 하는 질환이다. 루푸스를 비롯한 자가면역질환에 동반되는 원위신세관산증은 대부분 자가면역질환 발현 후에 나타나며 원위신세관산증이 먼저 발생하고 자가면역질환이 수개월에서 수년 후 발생하는 경우는 세계적으로 매우 드물게 보고되어 있다. 저자들은 원위신세관산증으로 진단되고 21년 후에 전형적인 루푸스 임상 증상들이 나타난 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Distal renal tubular acidosis (RTA) is characterized by a decreased net H+ secretion in the collecting tubules, which results in a failure of urine acidification and results in metabolic acidosis, hypokalemia, and nephrocalcinosis. The acquired form of distal RTA is associated with tubulointerstitial involvement of immune-mediated disorders such as Sjogren`s syndrome and systemic lupus erythematosus (SLE). Only a few case reports have indicated that distal RTA precedes SLE by months to years. We present a 39-year-old woman who had manifestations of distal RTA for 21 years before the development of overt symptoms of SLE. (Korean J Med 2011;81:533-536)
대학생이 지각한 부모양육태도가 대인관계문제에 미치는 영향과 내현적 자기애의 매개효과
강지연 ( Ji-yeon Kang ),진미경 ( Mi-kyung Jin ) 한국아동가족복지학회(구 한국가족복지학회) 2018 한국가족복지학 Vol.23 No.3
The purpose of this study was to examine the mediating effects of covert narcissism on the relationship between perceived parenting attitude and interpersonal problems. Participants in this study was 434 university students located in Seoul and Gyeonggi Province. The measurement scales used were PBI, CNS, and IIP. The collected data was analyzed by SPSS 23.0 statistical program. The results are as follows: First, Parents care had significant negative effects on the Interpersonal Problems. Otherwise, Parents overprotection had significant positive effects on the Interpersonal Problems. Second, Parents care had significant negative effects on the Covert Narcissism. Otherwise, Parents overprotection had significant positive effects on the Covert Narcissism. Third, Exploit/ Self-centeredness, Hypersensitivity/ Vulnerability and Timid/ Lack of confidence had significant positive effects on the Covert Narcissism. Fourth, Covert narcissism had partial mediating effects between the parents care and interpersonal problems. Also, Covert narcissism had partial mediating effects between the parents overprotection and interpersonal problems. In conclusion, this study confirmed the mediating effects of covert narcissism on the relationship between Perceived Parenting Attitude and interpersonal problems. Furthermore, this study confirmed the significance of Perceived Parenting Attitude and covert narcissism to explain interpersonal problems.
복막투석 동물모델에서 Adenoviral vector를 이용한 Bone Morphogenic Protein-7 유전자 치료가 복막섬유화에 미치는 영향
최지영 ( Ji Young Choi ),진미경 ( Mi Kyung Jin ),전주현 ( Joo Hyun Chun ),현승혜 ( Seung Hyea Hyun ),최희정 ( Hee Jeong Choi ),최혁준 ( Hyuk Joon Choi ),조지형 ( Ji Hyung Cho ),김미형 ( Mi Hyung Kim ),류혜명 ( Hye Myung Ryu ),오 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4
Purpose: TGF-β-induced epithelial-mesenchymal transition (EMT) is associated with peritoneal fibrosis during PD. We conducted this study to evaluate the effect of BMP-7 adenoviral gene transfer on the functional and structural changes of peritoneum and whether it is associated with peritoneal EMT using an animal PD model. Methods: Forty Sprague-Dawley rats were divided into five groups; Control (C, n=8), Dialysis (D, n= 8), Rest (R, n=8), BMP-7 (B, n=8) and LacZ (L, n=8) group. Peritoneal function was assessed on baseline, 3rd, 6th, 8th weeks after PD. Immunohistochemistry for TGF-β, VEGF, laminin and aquaporin-1 was performed in addition to morphometric analysis of peritoneum. Immunofluorescence staining with western blotting for α-SMA and E-cadherin, as markers of EMT, was performed. Results: The thickness of submesothelial matrix was highest in D and significantly decreased in B compared to D, R and L. D/D0 glucose at 8 weeks was significantly increased in B and L compared to that of at 6 weeks, but there were no significant differences among R, B and L at 8 weeks. TGF-β1 and VEGF expression was observed in submesothelial matrix in D and decreased in R, B and L. Peritoneal fibrosis and functional deterioration of peritoneal membrane were associated with EMT, which was partially reversed in R, B and L. Conclusions: BMP-7 gene transfer to peritoneum was not associated with the additive therapeutic effect on peritoneal function compared to the peritoneal rest, although it improved morphologic changes of peritoneum.
조지형 ( Ji Hyung Cho ),류혜명 ( Hye Myung Ryu ),진미경 ( Mi Kyung Jin ),전주현 ( Joo Hyun Chun ),현승혜 ( Seung Hyea Hyun ),최지영 ( Ji Young Choi ),허인경 ( In Kyong Hur ),이은영 ( Eun Young Lee ),박선희 ( Sun Hee Park ),김용림 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4
목적: 염증반응과 섬유화에 관여하는 Transforming growth factor-β1 (TGF-β1)와 이식신에 대한 cytoprotection에 관여하는 vascular endothelial growth factor (VEGF)는 만성 이식신 신병증 (CAN)의 발생과 연관이 있을 것으로 추측되어 왔다. 이에 저자들은 한국인 신이식 수혜자를 대상으로 TGF-β1 및 VEGF 유전자 SNP과 이식신 생존율 및 CAN과의 상관관계에 대해 조사하였다. 방법: 경북대학교병원에서 신이식을 시행한 환자 중 유전자 분석에 동의한 221명과 건강한 대조군 148명을 대상으로 TGF-β1 유전자의 C-509T 및 T869C, VEGF 유전자에 있는 C-2578A, C405G의 유전자형을 분석하였다. 신이식 후 CAN이나 만성 calcineurin inhibitor 신독성으로 진단된 경우를 신병증군 (n=21)으로 그렇지 않은 경우를 정상 이식군 (n=200)으로 분류하였다. 결과: 신이식 환자군과 정상 대조군에서 확인된 TGF-β1 (C-509T, T869C) 및 VEGF 유전자의 SNP (C- 2578A, C405G)의 유전자형의 빈도는 Hardy-Weinberg 평형에 따른 기대빈도와 유의한 차이가 없었고, 신이식 환자군과 정상 대조군에 있어 TGF-β1 및 VEGF 유전자 SNP의 유전자형과 대립형질의 빈도에는 유의한 차이가 없었다. TGF-β1의 C-509T와 T869C 및 VEGF의 C-2578A와 C405G는 강한 유전적 상관 관계를 보였고 (D`=0.78-0.98), 두 군 간 각각의 일배체형 간의 빈도 차이는 없었다. 전체 신이식 환자를 대상으로 TGF-β1 및 VEGF 유전자 SNP의 유전자형에 따라 두 군으로 나누어 Kaplan-Meier 생존분석을 시행한 결과 이식신 생존율은 유의한 차이가 없었고, 저농도 혹은 고농도의 cytokine 생산과 관련된 유전자형에 따른 이식신 생존율도 각 cytokine 모두 유사하였다. 결론: 본 연구에서 조사한 TGF-β1 및 VEGF 유전자 SNP은 한국인 신이식 수혜자에서 이식신 생존 또는 만성 이식신 신병증 발생 여부에 따라 차이를 보이지 않았다. Purpose: Transforming growth factor-β1 (TGF-β1) has been associated with the promotion of renal allograft interstitial fibrosis and thereby chronic allograft nephropathy (CAN). Vascular endothelial growth factor (VEGF) has been shown to contribute to cytoprotection of the graft after kidney transplantation. We investigated the influence of single nucleotide polymorphisms (SNPs) of the TGF-β1 (C-509T and T869C) and the VEGF gene (C-2578A and C405G) on graft survival and the development of CAN. Methods: Genotyping was carried out using a real-time polymerase chain reaction which was performed on the LightCycler480 in 221 Korean renal transplant recipients and 148 healthy controls. According to the presence of CAN or chronic calcineurin inhibitor nephrotoxicity, the recipients were separated into the CAN (n=21) and the No CAN (n=200) groups. Results: The genotype frequencies of the SNPs were in Hardy-Weinberg equilibrium. The distributions of genotypes and alleles did not differ between recipients and controls. No significant differences were observed in the genotype distributions and allele frequencies between the CAN and the No CAN groups. The frequencies of haplotypes were not significantly different between the two groups, either. There were no statistically significant effects of TGF-β1 and VEGF gene polymorphisms on graft survival. Conclusion: This study did not show any statistically significant effects of four selected SNPs of the TGF-β1 and the VEGF genes on the development of CAN and graft survival in Korean renal transplant recipients.