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한국인 고혈압증 산모 가계에서 미토콘트리아 전이 리보핵산 유전자의 돌연 변이에 관한 연구
지일운(Ill Woon Ji),김학순(Hak Soon Kim),주갑순(Kap Soon Ju) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective: This study was performed to find out mitochondrial deoxyribonucleic acid mutations in preeclampsia because Mendelian models fail to explain all the patterns of inheritance in preeclampsia. Methods: Ten preeclampsia patients and two of their related family members who have the obstetric history of preeclampsia were studied. The mitochondrial transfer ribonucleic acidleu[UUR] gene was amplified using polymerase chain reaction, cut by a restriction endonuclease (Apa , and also sequenced to see the whole gene. Results: There were neither the known mutation at Nucleotide 3243 nor other mutations on the mitochondrial transfer ribonucleic acidleu[UUR] gene in these objects. Conclusion: It seems that the known mutation of mitochondrial transfer ribonucleic acidleu[UUR] gene is not so frequently detected in preeclampsia of South Korean, But it could not be concluded how many South Korean women with preeclampsia have the mutation.
강지연(Ji Yeon Kang),노재숙(Jae Sook Roh),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9
Objective : To evaluate the effectiveness of non-surgical management of ectopic pregnancy, including expectant management and methotrexate(MTX) single injection. Material and Methods : Ninety-four patients were treated for ectopic pregnancy. The diagnosis was decided by clinical symptoms and signs, positive urine-hCG test, serial serum β-hCG levels, no intrauterine gestational sac by transvaginal USG, and/or adnexal mass, and occasional endometrial biopsies. Hemodynamically stable patients were managed by non-surgical methods. The inclusion criteria for MTX method were defined as an increasing tendency of serum β-hCG values or a visible extrauterine fetal heart beat. The inclusion criterion for expectancy was decreasing tendency of serum β-hCG values. Results : Forty-six patients were treated by non-surgical management, and 78% resolved successfully without surgery, including 14 out of 21 in MTX management(67%) and 22 out of 25 in expectancy(88%). The initial β-hCG value was significantly higher in MTX group compared to expectancy. There were no difference in initial β-hCG value, gestational age and hemoglobin level between success and fail in MTX management. Four cases were failed among 5 MTX cases that had moderate amount of cul-de-sac fluid over 3cm. The successful group in expectancy had significantly lower initial β-hCG value than the failed one, almost represented below 1,000mIU/ml. Three cases were failed among 5 expectancy cases that had high initial β-hCG level over 1,000mIU/ml. Conclusion : Non-surgical management of ectopic pregnancy is quite effective. if appropriate patients were selected carefully, it can reduce unnecessary operation and preserve reproductive potential.
만삭 질식 분만된 건강한 신생아의 제대 동맥혈 가스분석
오예근(Ye Keun Oh),지일운(Ill Woon Ji),노재숙(Jae Sook Roh),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
목적: 임신 중 합병증이 없었던 단태 산모에서 만삭 질식 분만으로 태어난 건강한 정상 신생아의 제대 동맥혈 가스 분포를 알아보고자 하였다. 연구 방법: 1995년 3월부터 1998년 6월 까지 충북대학교병원 산부인과에서 태어난 신생아에서, 분만 즉시 태반측 제대 동맥에서 혈액을 채취하여 pH를 비롯한 혈액 가스(PaCO2, PaO2, actual bicarbonate)를 측정하였다. 그 중에서 산모는 과거에 중대한 질병을 앓은 적이 없고, 정상 단태 임신으로 임신 중에 별다른 합병증이 없었으며, 만삭에 두정위 질식 분만으로 출생한 신생아는 임신 중 성장이 적절하였고, 어떠한 선천성 기형도 없으면서, 출생 후 1분과 5분 아프가 점수가 모두 7점 이상인 경우로 제한하였다. 그래서 총 457명의 건강한 신생아의 제대 동맥혈 가스분포를 분석하였다. 결과: 제대 동맥혈의 가장 낮은 pH 값은 7.04이었고 가장 높은 값은 7.51이었다. 10 퍼센타일은 7.23이고 90 퍼센타일은 7.39인 한편 중앙값(median)은 7.31이었다. 7.20 미만은 5%에 해당하였다. PaCO2의 값은 25.0mmHg에서 67.2mmHg의 범위였으며 중앙값은 44.1mmHg이었다. PaCO2의 값의 10 퍼센타일은 33.4mmHg인 반면 90 퍼센타일은 56.5mmHg이었다. 제대 동맥혈의 PaO2의 값은 4.6mmHg에서 36.9mmHg의 범위였다. 중앙값은 17.3mmHg인 한편 10 퍼센타일은 11.5mmHg이었고 90 퍼센타일은 24.2mmHg이었다. Bicarbonate의 수치는 13.2mmol/L에서 30.0mmol/L의 범위에 있었으며 10 퍼센타일은 18.4mmol/L이었고 90 퍼센타일은 26.5mmol/L이었으며 중앙값은 22.6mmol/L로 나왔다. 결론: 본 연구에서는 합병증이 없었던 만삭 단태 임신부에서 정상적으로 질식 분만된 건강한 신생아 457 명을 대상으로 하여 제대 동맥혈 가스 분석을 함으로써 건강한 정상 신생아의 혈액 가스 값의 정상역을 제시하였다. Objectives: To study the distributions of pH and gas values in umbilical arterial(UA) blood of normal newborns following uncomplicated pregnancies and vaginal births. Methods: In 457 consecutive normal term infants who were born between March 1995 and June 1998, we examined the UA pH and blood gas values obtained immediately following delivery. Maternal inclusion criteria were defined as an uncomplicated singleton pregnancy and a normal full term spontaneous vaginal delivery. And also neonatal inclusion criteria were defined as a normal intrauterine growth appropriate for gestational age without any malformations and Apgar score of 7 or more at both one and five minutes after birth. Umbilical artery blood samples were collected at each birth and were evaluated for pH, carbon dioxide pressure (PaCO2), oxygen pressure (PaO2) and actual bicarbonate. Results: Histogram of UA pH value resemble normal distribution curve. The lowest UA pH was 7.04 and the 10th percentile value was 7.23. The median UA pH was 7.31 and 5% was below 7.20. The lowest UA PaO2 was 4.6mmHg and the 10th percentile value was 11.5mmHg. The highest UA PaCO2 was 67.2mmHg and the 90th percentile value was 56.5mmHg. The lowest bicarbonate value was 13.2mmol/L and the 10th percentile value was 18.4mmol/L. Conclusion: The distributions of the UA pH and gas values of the collective of normal newborns were illustrated. None of the UA pH was below 7.0.
난소내 혈관상피성장인자 ( Vascular Endothelial Growth Factor ) 의 발현 양상
노재숙(Jae Sook Roh),강지연(Ji Yeon Kang),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),안치석(Chi Seok Ahn),김학순(Hak Soon Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A Objective: The ovarian cycle is characterized by repeating patterns of cellular proliferation and differentiation that accompany follicular development and the formation and regression of the corpus luteum (CL). That angiogenesis may play an important role in this process. Angiogenesis is supposed to be regulated by vascular endothelial growth factor (VEGF). The goal of the present investigation, therefore, was to determine whether the expression of VEGF was changed in the normally cycling human ovary. We also investigated VEGF expression in the regressed CL (ie, nonfunctiong CL) of normal term pregnancy to define the association with steroidogenic activity. To our knowledge there is no report available on VEGF expression in the CL of term pregnancy. Methods: We assessed VEGF expression in ovaries obtained from, 26-42 yr of age, and from patients undergoing hysterectomy and salpingo-oophorectomy for nonendocrinological or nonovarian disorders. Tissue samples from premenopausal women included specimens from follicular (n=4) and luteal (n 4) phases. In addition, we studied ovarian specimens from pregnant women (n=3). Immunohistochemical analysis for VEGF was performed using a rabbit polyclonal antibody directed against human VEGF. Results: These data demonstrate a development-related VEGF expression in the follicle and indirectly show that VEGF expression may be up to the existence of LH-receptor. And also, VEGF was overexpressed in the regressed CL of pregnant women compared with the functioning CL of nonpregnant cycles Conclusion: This study suggests that the intensity of VEGF expression is not correlated with steroidogenic activity, although both of them are stimulated by LH.
한국인 전자간증 임부에서 Factor V 유전자의 다형성에 관한 연구
홍승화 ( Seung Hwa Hong ),김정규 ( Jeong Kyu Kim ),최정원 ( Jeong Weon Choi ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 본 연구는 한국의 전자간증 임부에서 전자간증과 factor V 유전자의 다형성간에 연관성을 평가하는데 그 목적이 있다. 연구 방법: 2000년 3월부터 2002년 3월까지 충북대학병원을 방문하여 분만한 100명의 정상 대조군과 113명의 전자간증 임부를 대상으로 말초혈액채취의 방법으로 DNA를 얻어 PCR을 시행하고 제한효소로 절단하여 2% 한천젤에 전기영동하였으며, 자외선 형광하에서 절단된 band의 크기를 확인하였다. 결과: 정상 대조군과 전 Objective: This study was to evaluate the association of the G1691A mutation of factor V gene with preeclamptic patients in Korea. Methods: Factor V genotype were determined in 113 preeclamptic patients and 100 normotensive pregnant women. A 267 base-pair
임신 2기의 임신중절에서 misoprostol과 sulprostone의 임상적 효용성 비교
김정규 ( Jeong Kyu Kim ),문종필 ( Jong Pil Moon ),김용범 ( Yong Beom Kim ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 임신 2기의 유산에 있어서 misoprostol과 sulprostone의 임상적 효용성을 비교해 보고자 하였다. 연구 방법 : 임신 2기에 유산을 요하는 환자들을 misoprostol군과 sulprostone군으로 무작위로 배정한 후, 임신 20주를 기준으로 각각 다시 세분하였다. Misoprostol군에서 임신 20주 이하는 misoprostol 400 킽을 4시간마다 질내에 삽입하였고, 임신 20주 이후에는 200 킽을 6시간마다 삽입하였다 Objective : Our purpose was to compare the clinical efficacy of intravaginal misoprostol and that of intravenous sulprostone for termination of second-trimester pregnancy. Methods : The patients were assigned to misoprostol and sulprostone group, and the
한국인 중증 전자간증 산모에서 Thermolabile Methylenetetrahydrofolate Reductase 유전자의 다양성에 관한 연구
홍승화(Seung Hwa Hong),김용범(Yong Beom Kim),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim),노재숙(Jae Sook Rho),김정규(Jeong Kyu Kim),조명찬(Myeong Chan Cho) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : This study was performed to evaluate C to T substitution at nucleotide 677 of meth- ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. Methods : Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. Results : The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). Conclusion : It seems like that there is no evidence of association of preeclampsia with methylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.
태아심박동이 있는 자궁경관임신에서 태낭내 methotrexate 직접주입법에 의한 보존적 치료
신서규(Seo Kyu Sin),윤태진(Tae Jin Yoon),홍승화(Seung Hwa Hong),김용범(Yong Beom Kim),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : The purpose of this study was to determine the effectiveness of intra-amniotic methotrexate instillation for the treatment of viable cervical pregnancy. Materials and Methods : Four patients were enrolled in this study after confirmation of cervical pregnancy by ultrasonography. Viable cervical pregnancy was determined by ultrasonographic findings with the entire chorionic sac containing a live fetus below the internal os, empty uterine cavity, and significantly dilated or barrel shaped cervical canal. Under the transvaginal ultrasonographic guidence, 50 mg of methotrexate was injected directly into the amniotic sac after complete aspiration of amniotic fluid. Serial serum β-human chorionic gonadotropin (β-hCG) was evaluated weekly until normalized. Results : All the patients were successfully treated with conservative method and one patient received hysterectomy due to arterio-venous malformation diagnosed during follow up. Initial serum β-hCG concentration was 22,484-93,803 mIU/ml and decreased by log scale after treatment. Conclusion : Intra-amniotic methotrexate instillation without concomitant feticide injection or feticidal procedure can be used for the initial treatment in viable cervical pregnancy. Initial titer or falling rate pattern of serum β-hCG did not seem to be related with the prognosis.
김유래 ( Yu Re Kim ),김만기 ( Man Gi Kim ),경규상 ( Kyu Sang Kyeong ),조아라 ( A Ra Jo ),홍승화 ( Seung Hwa Hong ),박연진 ( Yeon Jin Park ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ),이옥준 ( Ok Jun L 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.9
Large cell neuroendocrine carcinoma of the uterine cervix is a rare and highly aggressive cervical neoplasm. Metastases and recurrences of the tumor are common. Cervical large cell neuroendocrine carcinomas are distinctive cervical carcinomas that are frequently misdiagnosed and have unfavorable prognosis. So prudential care must be considered for proper diagnosis and multimodal treatment may be required for better survival. We experienced one case of large cell neuroendocrine carcinoma accompanied with adenocarcinoma of the uterine cervix in 52 year old woman. The uterine cervix covered and infiltrated with adenocarcinoma cells and attached polypoid mass (3.2×2.1 ㎝) composed of large cell neuroendocrine carcinoma cells. The diagnosis was confirmed by immuno-staining using cytokeratin (+), synaptophysin (+), chromogranin (+), neuron-specific enolase (+), CD 56 (+), and vimentin (-). So we report the case with brief review of the literature.
자궁내막증 환자의 임상증상에 따른 난포액과 복강액내 prostaglandin E2 및 F2a 농도비교
이종철 ( Jong Cheol Lee ),경규상 ( Kyu Sang Kyoung ),조아라 ( A Ra Cho ),박민아 ( Min Ah Park ),이영미 ( Young Mi Lee ),홍승화 ( Seung Hwa Hong ),박연진 ( Yeon Jin Park ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( H 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.8