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지상은 ( Sang Eun Chi ),정명숙 ( Myung Suk Chung ),박창범 ( Chang Bum Park ),이지영 ( Ji Young Lee ),김현택 ( Hyun Taek Kim ) 한국감성과학회 2002 추계학술대회 Vol.2002 No.-
본 연구는 특성(trait) 이론에 기반한 Eysenck의 EPQ-R 설문지와 EEG 변수들간의 상관 관계에 대한 실험적 연구로서, 피험자들은 한국판 EPQ-R 설문지를 작성하였고, 2회에 걸쳐 눈을 감은 조건, 눈을 뜬 조건, 암산과제 수행조건에서 EEG를 측정하였다. Neuroticism 은 눈을 뜬 조건에서 theta 파와 부적 상관을 보였으며, Psychoticism 은 눈을 감은 조건에서 alpha파와 정적상관, delta파와 부적 상관을 보였는데, 이것은 Robinson(2001)의 이론과 일치하는 결과이다.
지상은(Sang Eun Chi),김종우(Jong Woo Kim),황의완(Wei Wan Whang),조황성(Hwang Sung Cho) 대한한방신경정신과학회 1997 동의신경정신과학회지 Vol.8 No.2
N/A The questionnaire which was based on the characteristics of psychological and physiological symptoms of Hwabyung patients was distributed to Hwabyung patients and normal control group. The following results were obtained. 1. It was observed in this study that the rate of occurrence of Hwabyung was higher in female and the people with lower economical and educational background. And this result was in accordance with the previous studies. 2. The personality, defense mechanism and coping strategy of Hwabyung patients was found to be inclined to yin(陰) disposition in this study. 3. Family life of Hwabyung patients was found to be worse than that of nomal control group in every respect. 4. In terms of evaluation of their lives, the emotion of Hwabyung patients was characterized as Hahn(恨). And it is postulated that this emotional complex falsifies the reaction of Ki(氣) to the seven emotions(七情).
지상철(Sang Cheol Chi),박은석(Eun Seok Park),단현광(Hyun Kwang Tan),이윤석(Yun Seok Rhee) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.4
The effects of formulation variables of topical lotion on the skin permeation of ketoprofen were evaluated using excised rat skins. The formulation variables were the amounts of poloxamer 407, drug and ethanol, and penetration enhancers. The Keshary-Chien diffusion cells were used for the diffusion study. The flux of ketoprofen linearly decreased as the concentration of poloxamer increased from 5% to 15% in the preparation, and linearly increased as the amount of drug increased. Penetration enhancers such as fatty acids and fatty alcohols showed markedly enhancing effects at the level of 5%. Among them, the highest flux was shown in linolenic acid. From these results, optimum formula containing 3% ketoprofen, 5% poloxamer 407, 40% ethanol and 5% linolenic acid having the flux of 537.6 ㎍/㎠/hr were noted.
생물정보학을 이용한 체질정보의 정량에 관한 이론적 고찰
지상은,한성규,최선미,Chi, Sang-eun,Han, Sung-Kyu,Choi, Sun-mi 사상체질의학회 2001 사상체질의학회지 Vol.13 No.1
Purpose This study was carried out ro apply the knowledge of bioinformatics to the quantification of constitutional information. Methods To objectify consitirutional knowledge, several uselful methods including Bayesian estimate, position specific score matrix, entropy, phylogenetic tree, simulated annealing were discussed. Results and Conclusion It is obvious that bioinformatic methods can be the most important tool for the objectification of constitutional medicine.
HLA typing을 이용한 체질유전자 분석에 관한 연구
한성규,지상은,최선미,Han, Sung-kyu,Chi, Sang-eun,Choi, Seon-mi 사상체질의학회 2001 사상체질의학회지 Vol.13 No.1
Purpose This study was designed co determine the possibility of HLA typing in the objeccification of constitution. Methods We selected 100 patients who showed Taeyang characteristics, and divided them into Soum-inclined group and Soyang-inclined group. HLA-A, B, DRBI typing was perfomed by ARMS-PCR and PCR-SSOP method. Results Taeyang characteristic group as a whole showed significant difference in A1, A11, B37, B70/71, DRBI*15,DRB1*14 alleles in comparison with normal control group. Soum-inclined group showed significant difference in All, B70/71, Soyang-inclined group in DRBl*15, hard drinker group in DRBl*15, DRBl*13, drink-rejecting group in All, B37, DRBl*7, DRB1*14 in comparison with normal control group. Conclusion : There were significant relations between constitutional information and HLA types.
한성규,지상은,최선미,Han, Sung-Kyu,Chi, Sang-Eun,Choi, Sun-Mi 사상체질의학회 2003 사상체질의학회지 Vol.15 No.1
There have been several the reports that the mechanism of Sasang consititution might be understood in the level of genes. Previous study of the authors showed that HLA types and constitutional information had significant relationships. One hundred subjects who showed Taeum characteristics were selected in the present study. HLA-A, HLA-B, HLA-DRB1, ACE, ${\beta}-IIAR$, ${\beta}-IIIAR$, UCP-1, and ALDH2 polymorphisms were analyzed. Also, ACE, ${\beta}-IIAR$, ${\beta}-IIIAR$, UCP-1, and ALDH2 analyses were performed on the 100 samples of previous study who showed Taeyang characteristics. Despite of several significant differences of HLA allele frequencies between Taeum-inclined group and normal control group, this significance level was not sufficient ro support the association between constitution and HLA genes, because of the raised alpha error rate. The polymorphisrns of ACE, ${\beta}-IIAR$, ${\beta}-IIIAR$, UCP-1, and ALDH2 genes did not show relationship between Taeyang-inclined and Taeum-inclined groups, whereas BMI showed difference between Taeyang-inclined and Taeum-inclined groups. ALDH2 in Taeyang-inclined group confirmed the protective role of ALDH2*2 allele against alcoholism.