Th2 세포에서 IL-12에 의한 IL-18R ${\alpha}$의 발현유지 및 IL-18 자극에 의한 GATA-3의 유도

주인숙,선민정,김동영,이수진,하윤문,조정제,박증석,안현종,Joo, In-Sook,Sun, Min-Jung,Kim, Dong-Young,Lee, Su-Jin,Ha, Youn-Mun,Cho, Jeong-Je,Park, Cheung-Seog,Ahn, Hyun-Jong 대한면역학회 2005 Immune Network Vol.5 No.1

Background: IL-18 was originally cloned as a IFN-${\gamma}$ inducing factor in primed T cells. In synergy with IL-12, IL-18 has been shown to induce strikingly high levels of IFN-${\gamma}$ production by T cells and to enhance Th1 development. Also this cytokine exerts induction of Th2 development through IL-4 induction. Methods: Resting $CD4^+$ T cells were sorted by negative selection and activated by anti-CD3 plus anti-CD28 Ab. Expression of IL-12 binding sites, IL-18 binding sites, IL-18R ${\alpha}$, and GATA-3 mRNA were analysed by FACS and RT-PCR, respectively. Results: Resting $CD4^+$ T cells expressed IL-18R ${\alpha}$ chain but not IL-18 binding sites, suggesting a lack of IL-18R ${\beta}$ expression. IL-18R ${\alpha}$ was maintained on the Th1 and Th2 committed cells. IL-18 binding sites were induced on the Th1 but not Th2 cells. Exposure of these cells to IL-18 led to up-regulation of GATA-3 mRNA expression only in Th2 committed cells. To elucidate the relationship between IL-18R ${\alpha}$ expression and GATA-3 induction by IL-18, Th1 and Th2 committed cells were further cultured in medium with or without IL-12 for 2 days. IL-12 binding sites were maintained on the Th1 and Th2 cells regardless of IL-12 treatment, but IL-18R a expression was rapidly down-regulated on the IL12-untreated Th2 cells which did not induce GATA-3 mRNA expression followed by IL-18 stimulation. Conclusion: IL-12 supports expression of IL-18R ${\alpha}$ and GATA-3 mRNA expression was induced by IL-18 through IL-18R ${\alpha}$ without expression of IL-18 binding site in Th2 cells.

자궁내막 전체의 표재성 전파 동반 및 양측 난관 장막을 관통하여 양측 난소를 침범한 자궁경부편평세포암종

주정경 ( Jung Kyung Joo ),강지현 ( Ji Hyun Kang ),주인숙 ( In Sook Joo ),박양순 ( Yang Soon Park ),이정원 ( Jung Won Lee ),서경용 ( Kyoung Young Seo ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.7

Squamous cell carcinoma is one of the commonest malignancies of the uterine cervix and it is a significantly rare phenomenon of metastases to the bilateral ovaries by endometrial and transtubal spreading in the absence of lymph node involvement. The data is limited because it is still difficult to determine the optimal treatment and the prognostic significance is uncertain. We report a 66-year-old woman with squamous cell carcinoma, International Federation of Gynecology and Obstetrics stage Ia2, without previous radiation therapy, associated with superficial spreading squamous cell cervical carcinoma involving the entire endometrial cavity, bilateral tubes and bilateral ovaries.

자궁근층 침윤을 동반한 일차성 자궁장막임신

강민정 ( Min Jung Kang ),주정경 ( Jung Kyung Joo ),강지현 ( Ji Hyun Kang ),주인숙 ( In Sook Joo ),박양순 ( Yang Soon Park ),서경용 ( Kyoung Young Seo ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3

Ectopic pregnancy is reported to be 1.5%-2% of all pregnancies. Ectopic pregnancy varies with the site of implantation; abdominal pregnancy has been reported to occur in approximately 1% of patients with ectopic pregnancy. Especially, uterine serosal pregnancy is an extremely rare form of abdominal pregnancy. Although variable diagnostic imaging methods have been developed, accurate diagnosis of the abdominal pregnancy using noninvasive imaging study is still diffi cult. Delayed diagnosis leads to high maternal morbidity and mortality in relation to massive bleeding. Therefore, diagnostic laparoscopy or laparotomy is generally considered to patients with uncertain diagnosis of the abdominal pregnancy. We experienced a case of primary uterine serosal pregnancy that had a rupture of gestational sac with myometrial invasion. We finally confirmed a definite site of the ectopic pregnancy through laparoscopic exploration. That precise location could be not found by pelvic ultrasonography and magnetic resonance imaging. The patient underwent a subtotal hysterectomy.

한국여성에서 폐경 후 Drospirenone 2 mg과 17-β-Estradiol 1 mg 투여의 혈압 및 체중에 대한 효과

신미영 ( Mi Young Shin ),위찬우 ( Chan Woo Wee ),주정경 ( Jung Kyung Joo ),강지현 ( Ji Hyun Kang ),주인숙 ( In Sook Ju ),서경용 ( Kyoung Young Seo ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10

목적: 폐경 후 한국 여성에서 Drospirenone 2 mg (DRSP)과 17-β-Estradiol 1 mg (E2) 투여의 혈압 및 체중에 대한 효과를 평가하였다. 연구 방법: DRSP/E2 투여 전과 3개월 후에 혈압과 체중을 측정하였다. DRSP/E2 투여 전 혈압이 정상혈압 (group 1, 대조군)과 높은정상혈압 (group 2)인 군의 혈압과 체중의 변화를 비교하였으며, 항고혈압제를 복용 중인 고혈압 환자로 DRSP/E2를 추가 투여한 군 (group 3)과 투여하지 않은 군 (group 4, 대조군)의 혈압과 체중도 비교하였다. 결과: Group 1의 평균 수축기 및 이완기 혈압은 변화 없었으나 (P=0.152/P=0.088), group 2의 평균 수축기 및 이완기 혈압은 유의하게 감소하였다 (P<0.001/P=0.002). Group 3의 평균 수축기 및 이완기 혈압은 유의하게 감소하였으며 (P<0.001/P<0.001), group 4의 평균 수축기 및 이완기 혈압도 유의하게 감소하였다 (P=0.002/P<0.001). 그러나 group 3의 혈압 감소가 group 4보다 유의하게 컸다 (P=0.041/P=0.024). DRSP/E2 투여 전, 후 체중은 모든 군 유의한 변화는 없었다. 결론: 폐경 후 한국 여성에서 DRSP/E2의 투여는 높은정상혈압 이상의 혈압을 낮추며, 고혈압 환자에서 항고혈압제와 병용시 더 크게 낮추는 경향을 보였다. 그러나 투여 전, 후 체중의 유의한 차이는 없었다. Objective: To evaluate effects of Drospirenone 2 mg (DRSP) with 17-β-Estradiol 1 mg (E2) on blood pressure (BP) and body weight in postmenopausal Korean women. Methods: BP and body weight were measured at baseline and 3 months of the treatment. We compared the change in BP and body weight between normotensive (group 1, control) and high-normotensive (group 2) group during treatment. And we compared the change in BP and body weight between hypertensive group receiving anti-hypertensive with (group 3) and without (group 4, control) DRSP/E2 during treatment. Results: The mean systolic BP/diastolic BP of group 1 was not significantly decreased from baseline (116.9/75.0 mmHg) after treatment with DRSP/E2 for 3 months (116.1/73.2 mmHg) (P<0.152/P=0.088), however that of group 2 was significantly decreased from baseline (128.8/81.8 mmHg) after treatment with DRSP/E2 for 3 months (126.2/79.3 mmHg) (P<0.001/P=0.002). The mean systolic BP/diastolic BP of group 3 was significantly decreased from baseline (133.5/82.5 mmHg) after treatment with DRSP/E2 for 3 months (129.3/77.9 mmHg) (P<0.001/P<0.001), and that of group 4 was also significantly decreased from baseline (133.2/80.7 mmHg) after treatment with DRSP/E2 for 3 months (131.0/78.3 mmHg) (P=0.002/P<0.001). However change in the mean systolic BP/diastolic BP of group 3 was greater than that of group 4 (P=0.041/P=0.024). There was no weight change in all four groups. Conclusion: The use of DRSP/E2 showed a tendency to decrease the BP of high-normotensive or above in postmenopausal Korean women, and hypertensive patients receiving anti-hypertensive showed greater decline in BP. However there was no statistical significance in body weight change.

병합임신의 1례

송진범 ( Jin Berm Song ),이혜은 ( Hye Eun Lee ),정병훈 ( Byung Hoon Jung ),주인숙 ( In Sook Joo ),서경용 ( Kyung Young Seo ),심재식 ( Jae Sik Sim ) 대한주산의학회 2001 Perinatology Vol.12 No.2

임신 제 3 분기에 자연 파열된 비장동맥류파열 1 예

이혜은(Hea Eun Lee),정병훈(Byoung Hun Joung),노주영(Ju Young No),주인숙(In Sook Joo),심재식(Jae Sik Shim),서경용(Kyung Young Seo) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

The spontaneous rupture of splenic artery aneurysm during pregnancy is a rare but catastrophic event. Two thirds of all ruptures happen during the third trimester. Clinical presentation is often non-specific, with good hemodynamic compensation, followed by a rapid deterioration. Active management and operation are the most important procedures for diagnosis and therapy of the bleeding. Abdominal delivery will help to establish diagnosis and should be performed immediately. We report a case of a patient at 38 weeks of gestation suffering epigastric pain and fetal distress. At emergency cesarean delivery, an aneurysmal rupture of the splenic artery was found to be the reason for the hemoperitoneum. Spleen, aneurysm and the tail of the pancreas were removed. In spite of fatal hemorrhage, the patient survived but her fetus was dead. With a review of the literature on this topic, diagnostic aspects and treatment options are discussed.

자궁 원인대의 복막외 부위에 발생한 자궁내막증 2 예

황종대(Jong Dae Whang),박창수(Chang Soo Park),배덕수(Duk Soo Bae),이제호(Je Ho Lee),노정수(Jeong Soo Noh),김정식(Jeong Sik Kim),주인숙(In Sook Joo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1

Extraperitoneal inguinal endometriosis often presents as an inguinal mass in women of reproductive age, Approximately 40 cases of inguinal endometriosis have been documented in the sutgical and gynecological literature. The overall incidence is in the range of 0.4% of patients with endometriosis. The right side is much more commonly involved than the left (almost 90% of the time in one series of 23 patients), and rarely is the condition bilateral. The most frequent complaint of patients with inguinal endometriosis is an inguinal mass, followed by pain and enlargement of the mass near menstruation. Authors have experienced two cases of endometriosis of the extraperitoneal portion of the round ligament of uterus and report with a brief literature review.

78年度 釜山大學校 新入生의 實態 調査

張赫杓,周仁淑 부산대학교 학생생활연구소 1978 硏究報 Vol.14 No.1

건강 수진자에서 혈청 CA 125 증가의 임상적 의미

신경자,황종대,주인숙,배덕수 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3

Objectives: Our study was to determine the usefulness of CA 125 screening for asymptomatic female subjects. Though CA 125 has been used as a useful marker for the detection of ovarian cancer, its efficacy to detect early ovarian cancer in asymptomatic women has not been established. Study Design: From April 1995 to December 1997, a total of 13,038 subjects who visited our Center for Health Promotion were screened. Serum CA 125 level was measured by a radioimmunoassay kit (Centocor, USA). In most cases transvaginal ultrasound was done at the same time. The specificity, sensitivity and positive predictive value were obtained on the basis of normal CA 125 range between 2.4 ∼36.3 U/㎖. Result: 1) Two cases of ovarian cancer were detected out of 13,038 subjects screened. One ovarian cancer patient showed 1,625 U/㎖ of CA 125 levels, on the other hand, the other level patient showed 27 U/㎖. 2) Therefore, the sensitivity, specificity, and positive predictive value were 50%, 97.3%, and 0.3%, respectively. Since 346 cases out of 13,038 screened subjects showed false positive results on the basis of the upper limit of normal CA 125 level set at 36.3 U/㎖, the false positive was 2.6% 3) The CA 125 levels in false positive cases ranged from 36.3 U/㎖ to 352.8 U/㎖ with the mean value of 66.19±51.47 (S.D.). 4) The clinical features of the false positive cases included uterine myoma including adenomoysis (150), benign ovarian cyst (19), cervicitis (6), tuberculosis (3), pregnancy (2), and each one case of breast cancer, mammary cyst, endomerritis, lung cancer, liver cirrhois, pancreatic cancer, cervical cancer, renal cyst, uterine anomaly, and post TAH state. In the remainder of false positive 156 cases, no abnormal findings were observed. Among 258 patients who underwent combined tests of CA 125 and transvaginal ultrasound, the sensitivity of ovarian cancer was 100%. 5) The false positive rate was lower in the older age group ($gt;50) than in the younger group ($lt;50). Conclusion: The prevalence of ovarian cancer in our study was 0.0153% (15.3 per 100.000 population) which is comparable to the rate of 15.8 per 100.000 population reported by the Korean Medical Insurance Corporation. Although the CA 125 test by itself shows a low positive predictive value, its clinical usefulness as a screening test can be enhanced dramatically by the combined use of transvaginal ultrasound examination, especially in postmenopausal women.

자궁경부 원추절제술 후 조직 병리 정도와 절단경계면의 침범 여부에 의한 잔류 종양의 예측에 관한 연구

송상용,문종택,황종대,배덕수,주인숙,박창수,이제호 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.1

$quot;Objective: To evaluate the status of cone margins and severity of cervical neoplasia as predictors of residual lesions in the remaining cervices, and provide guideline for further treatment or close follow-up. Method: We performed a 3-year retrospective study and reviewed 95 patients who had undergone cervical conization followed by subsequent hysterectomy. Result: The prevalence rates of positive cone margins were 33, 50, 44, 71 and 88% respectively in patients with cervical intraepithelial neoplasia(CIN)Ⅱ, CIN Ⅲ, cervical cancer stage Ia1, Ia2 and Ib1. The prevalence rates of positive residual lesions in postcone hy-sterectomy specimens were 0, 31, 19, 29 and 59% respectively in patient with CIN Ⅱ, CIN Ⅲ, cervical cancer Ia1, Ia2 and Ib1. Residual lesions were significantly more frequently found in patients with positive cone margins(51%) than in those with negative margins(4.8%). Positive predictive values of margin status for the presence of residual lesions were 0, 56, 36, 40 and 67% respectively. Negative predictive values of margin status for the absence of residual lesions were 100, 94, 94, 100 and 100% respectively. Conclusions: (1) The prevalence of positive cone margin and residual lesion increased with more severe cervical neoplasia. (2) Positive cone margins had significantly higher risks of residual lesion than negative cone margins. (3) Positive cone margin does not invariably indicate the presence of residual lesion. (4) Negative cone margin does not ensure the absence of residual lesion. Subsequent hysterectomy may be reserved for the patient with CIN Ⅲ or cervix cancer having positive cone margin or invasive lesion, or the patient who is not reliable for continuous follow-up.$quot;