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ICR 마우스를 이용한 Bacillus subtilis JNS 균주의 단회경구투여 독성시험
김경훈(Kyoung-Hoon Kim),정창화(Chang Hwa Jeong),주성제(Seong-Je Joo),박종훈(Jong-Hoon Park),문지영(Ji-Young Moon),조은지(Eun-Ji Cho),이현태(Hyun-Tai Lee),권현주(Hyun-Ju Kwon),김병우(Byung-Woo Kim),엄성환(Sung-Hwan Eom),이은우(Eun-Woo 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.1
청국장에서 분리한 항균활성이 우수한 Bacillus subtilis JNS의 probiotics로서의 활용성을 검증하기 위해 단기투여에 의한 안전성을 확인하고자 실험을 실시하였다. 경구투여용 존데를 이용하여 임상적용 경로인 경구로 투여하였으며, 최고투여용량은 2,000 mg/kg으로 설정하였다. ICR계 암수마우스에서 14일간 관찰한 결과 일반증상, 사망률, 체중, 임상증상 및 육안적 소견 등에서 무처리 대조군과 비교해서 유의성 있는 차이를 보이지 않았다. 부검 후의 주요 장기에 대한 육안적 검사에서 또한 대조군과 비교하여 이상소견이나 병변이 관찰되지 않았다. 이상의 결과로부터 시험물질인 B. subtilis JNS는 경구투여 시 ICR계 암수 마우스에서 독성학적인 변화가 관찰되지 않았으며, 경구투여가 2,000 mg/kg 이상인 저독성의 안전한 물질로 사료된다. The present study was carried out to investigate the in vivo single-dose acute toxicity of Bacillus subtilis JNS isolated from Cheonggukjang, which is a probiotic candidate showing strong and broad antibacterial activity. The test sample was orally administrated to male and female ICR mice at a highest dose of 2,000 mg/kg for 14 days. No significant change in general conditions, mortalities, body weight changes, clinical signs, autopsy findings, or presence of gross lesions was observed in either sex of mice. The results indicate that up to 2,000 mg/kg of B. subtilis JNS had no adverse effect on ICR mice.
연구논문 : 오배자(Rhus javanica) 추출물의 어병세균 Vibrio ichthyoenteri 와 Streptococcus iniae 에 대한 항균활성
김경훈 ( Kyoung Hoon Kim ),김아라 ( Ah Ra Kim ),조은지 ( Eun Ji Cho ),주성제 ( Seong Je Joo ),박종훈 ( Jong Hoom Park ),문지영 ( Ji Young Moon ),염종화 ( Jong Hwa Yum ),김태훈 ( Tae Hoon Kim ),권현주 ( Hyun Ju Kwon ),이은우 ( Hyun 한국수산과학회(구 한국수산학회) 2014 한국수산과학회지 Vol.47 No.1
The antibacterial activities of methanol extracts of 19 commercial herbal medicines were measured against the fish pathogens Vibrio ichthyoenteri and Streptococcus iniae, which cause several fish diseases. Rhus javanica showed the strongest antibacterial activity against V. ichthyoenteri and S. iniae. The methanol extract of R. javanica was extracted further using several organic solvents with different polarities. The extract from the ethyl acetate fraction showed strong activity against both fish pathogens. The minimum inhibitory concentration (MIC) of the R. javanica extract was 32μg/mL for V. ichthyoenteri and 128μg/mL for S. iniae. Further purification and isolation of the active com- pound (s) responsible for these activities and further study of the synergistic effect using combinations of antibiotics against pathogenic bacteria are needed.
멸치(Engraulis japonicus)젓 잔사 분말칼슘이 난소적출 흰쥐의 골다공증에 미치는 영향
문지영 ( Ji Young Moon ),조은지 ( Eun Ji Cho ),주성제 ( Seong Je Joo ),박종훈 ( Jong Hoon Park ),윤성호 ( Sung Ho Yoon ),김만도 ( Man Do Kim ),김영만 ( Young Man Kim ),현숙경 ( Sook Kyung Hyun ),임은서 ( Eun Seo Lim ),김태훈 ( Tea 한국수산과학회 2015 한국수산과학회지 Vol.48 No.4
This study examined the effect of calcium (AC) extracted from salt fermented anchovy Engraulis japonicus on osteoporosis in ovariectomized (OVX) SD female rats. After AC treatment for 8 weeks, the body weight of the OVX-AC group decreased, while the weight of the OVX group (control) increased 43.9%. The blood osteocalcin, calcium, and ALP levels were examined as physiological markers for osteoporosis. The concentrations of all markers were elevated in the OVX-AC group compared to the OVX group. Thus, anchovy calcium is useful as an organic calcium supplement.