강직성 척추염에서의 척추계의 정방형화 : 방사선학적 진단 Rodiological Assessment

주경빈 최신의학사 1992 最新醫學 Vol.35 No.12

관절염 진단에 있어서 X-ray의 유용성

주경빈,김성윤 한국의학사 1993 診斷과治療 Vol.13 No.12

광학 정리를 이용한 콜로이드 입자 크기 측정

주경빈,김경호,이만희,한영희,이형일 한국물리학회 2022 새물리 Vol.72 No.1

광학정리는 전방산란 진폭과 입자의 산란 단면적의 관계를 나타내는 식으로써, 빛-입자 산란 실험에적용하여 입자의 크기를 측정하는데 활용될 수 있다. 그러나 보통의 실험에서 흔히 사용되는 가우시안(Gaussian) 빔에 대하여, 입자의 산란신호는 입자의 크기뿐만 아니라 입자의 위치에 따라 달라진다. 따라서 입자의 크기를 결정하기 위해 광학정리를 적용하기 어렵다. 우리는 집속된 가우시안 빔에 의한입자 산란 신호를 사분할 광 검출기로 측정하고 광학정리를 적용하여 입자의 크기를 결정하는 방법을 제시한다. 사분할 광 검출기 신호를 분석하여 입자에 의해 산란되는 빛의 전체 세기와 검출기의 상하/ 좌우 세기변화를 통해 입자 움직임의 경로를 알 수 있다. 이를 통해 집속된 가우시안 빔의 초점 영역을무작위로 지나가는 입자 가운데 초점의 정중앙을 관통하는 입자의 산란 신호를 추출할 수 있고, 여기에광학정리를 적용하여 입자의 크기를 예측한다. 우리는 지름 565 – 1,300 nm크기의 입자 측정을 통해 제시된 방법을 검증한다. 이러한 방법은 반도체 연마 공정 슬러리 용액의 입자 분포를 조사하는데 적용될 수 있다.

산과영역에 있어서 초음파진단법

주경빈 대한영상의학회 1980 대한영상의학회지 Vol.16 No.1

The clinical evaluation of 535 cases of sonogram from Mar.1, 1979 to Oct. 30 , 1979 in obstetric field at department of Radiology & Ob. & Gy. Eul-Ji general hospitla . We present these cases : normal pregnancy, missed abortion, twin pregnancy, hydatidiform mole and ectopic pregnancy, with brief review of literature.

$^99mTc-MDP$를 이용한 전이성 골종양에 관한 연구

주경빈 대한영상의학회 1988 대한영상의학회지 Vol.24 No.1

A radiographic bone survey and radionucilde bone scan are the principal methods for the detection of metastaic bone diseases. A retrospective study of 99m Tc-MDP bone scan in 169 patients with various tumors over a period of 2 years recealed 82 patients having metastasis to skeletal system. The bone scan findings in these 82 cases were correlated with clinical symptoms laboratory data and radiographic studies. The results were as follows : 1. Male to female ratio was 47:35 . The 7th decade (25 cases, 30.5%) was the most prevalent age group followed by the 8th decade (22 cases 26.9%) and the 6th decade (21 cases 25.6%) 2. The primary sites of metastases were lung (36 cases 43.9%) followed by stomach and prostate (9 cases each 43.9%) breast (8 cases 9.7%) liver (4 cases 4.7%) Kidney and lymphoma (3 cases 3.7%) 3. False negative radiographic bone survey was seen in 47 cases (57.3%) of 82. 4. 52 cases(63.4%) showed elevated serum alkaline phoshatase and it was significant especially in patients with bone pain alog with the elevation of serum calcium and phosphorus. 6. The metastatic sites in skeletal system were ribs and sternum(35 cases) lumber spine(32 cases) thoracic spine (25 cases) lower extremity (19 cases pelvis (18 cases), upper extremity (6 cases) and skull and face (2 cases).

류마티스 관절염의 방사선학적 진단

주경빈 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.1

Rheumatoid arthritis is a common articular disorder with a characteristic radiographic picture. A symmetric polyarticular disease of the synovial joints of the appendicular skeleton is apparent, with prominent abnormalities of the proximal interphalangeal and metacarpophalangeal articulations of the hand, the wrist, the metatarsophalangel joints of the foot, the posterior and plantar aspects of the calcaneus. the knee, the elbow, the glenohumeral and acromioclavicular joints, the ankle and the hip; these abnormalities are commonly combined with changes in the cervical spine. This distribution of synovial joint involvement is sufficiently common to allow accurate diagnosis, especially when the involvement is characterized by fusiform soft tissue swelling, periarticular osteoporosis, marginal and central osseous erosions and cyst, and diffuse loss of interosseous space. Occasionally a rheumatoid arthritis patient will have a coexistent articular disorder and in these cases, careful analysis of the radiographic changes usually provides some clue indicating the presence of a second disease.

다골성 Paget병 1예 보고

이은희,주경빈 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

Paget's disease is a common skeletal disorder affecting middle and later age groups in Western countries, but extremely rare in Asia and Africa. It is characterized pathologically by the simultaneous or alternative phases of abnormal bone resorption and regeneration, and radiographically by the irregular bony fragments with thickened and disorganized trabeculr (mosaic) pattern. Authors experienced a case of polyostotic Paget's disease involving skull, humerus, scapula, rib, spine, pelvis, fermur and tibia with a pathologic fracture in th proximal femur.

염증성 관절염에서 Nitric Oxide(NO)의 역할에 관한 연구

권용화,배상철,김성윤,주경빈 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.2

Nitric Oxide(NO) is a toxid, inorganic, gaseous free redical produced during the metabolism of L-Arginine by NO synthase(NOS). It has been implicated in a rapidly in a rapidly growing number of physiological and pathophysiological processes such as cytotoxic effects against mocrobes and tumor cells, blood vessel dilation and neurotransmitter, NOS exists as several isoenzymes, the major distinction being between inducible forms(iNOS) and constitutive forms(cNOS). Cells which contain the latter enzymes rapidly, but transiently, synthesize small amounts of NO. Cells expressing iNOS, in contrast, synthesize large amount of NO for an extended periods following a lag of several hours during which the enzymes are induced. Recently there is growing evidence implicating NO in immune regulation, inflammation, autoimmunity, and arthritis. This study was performed to determine the role of NO in inflammatory arthritis, especially in rheumatoid arthritis(RA). NO production was measured indirectly as nitrite, a breakdown product of NO, ① in serum and synovial fluid from patients with RA and osteoarthritis(OA) and in serum of controls ② in the supernatant of cultured synovial tissue with RA and OA. And it was investigated whether human chondrocytes and synoviocytes can synthesize NO and if so, how the production is regulated by cytokines and antirheumatic drugs. The results are as follows; 1. Serum nitrite concentrations in patients with RA and OA were higher than in controls. In both disease groups synovial fluid nitrite was higher than serum nitrite. Serum and synovial fluid nitrite concentrations in RA were higher than those in OA. However, those findings are not statistically significant. 2. Although these findings are not statistically significant, the concentration of nitrite in the supernatant of cultured synovial tissue with RA was higher than that in OA. 3. IL-1 β and TNF-a induced the biosynthesis of NO by chondrocytes and synoviocytes. While IGF-1 and TGF-β failed to provoke the production of NO. The biosynthesis of NO required an induction period of approximately 6 hours and was inhibited by L-NMMA and cycloheximide. Dexamethasone, indomethacin, gold sodium thiomalate and methotrexate had no effect on the induction of NO biosynthesis. These results suggest that NO may perform some role as an inflammatory mediator in inflammatory arthritis. Manipulating the physiologic concentration of NO appears to be clinically useful approach to the treatment of inflammatory arthritis in future.

Human adjuvant disease12예의 임상적 고찰

주경빈,김성윤,김신규,유대현,배상철,최봉근,이인홍,최희윤 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.2

Human adjuvant disease(HAD)means the autoimmune disease of autoimmune disease like syndrome developed after plastic surgery using foreign body implantation. After 1st report of HAD by Miyoshi at 1964, a number of cases have been reported especially from Japan. However, there has been no report regarding HAD in Korea. Therefore authors report 12 cases of HAD which were experienced recently from January, 1988 to September, 1991 12 patients who represented autoimmune disease or autoimmune disease-like syndrome after plastic surgery using foreign body implantation were evaluated clinically and results were as follow : 1) The mean interval from plastic surgery to onset of HAD was 14.9years. 2) Eight of tweleve patients had undergone rhinoplasty and paraffin was presumed most frequently injected. 3) Seven of patients were given the diagnosis of rheumatoid arthritis and the others were unclassified HAD. 4) Five patients underwent the operation to remove forign material. Only one improved markedly and the others had mild improvement. But more long-term follow-up will be necessary. In Korea, there has been done a number of plastic surgery using paraffin or silicone fluid injected. So we have to concern about HAD after plastic surgery using foreign body implantation.

강직성척추염에서 천골장골관절염에 대한 다중 검출기 CT와 단순촬영의 비교

유지연,주경빈,최병규,류정아,김태환,최우정 대한영상의학회 2009 대한영상의학회지 Vol.60 No.3

Purpose: The objective of our study was to compare multidetector row CT and the plain radiographs for making the diagnosis and grading the sacroiliitis that accompanies ankylosing spondylitis. We wanted to determine the role of multidetector row CT for the evaluation of the sacroilitis in patients with ankylosing spondylitis. Materials and Methods: One hundred ninety two patients with clinically suspected ankylosing spondylitis were evaluated by conventional radiography and multidetector row CT. Two musculoskeletal radiologists retrospectively analyzed the images, and they graded the sacroiliitis using the modified New York Criteria. Results: Multidetector row CT demonstrated a significantly higher sensitivity (74.5%, 83.3%) than did plain radiography (59.9%, 66.7%) for detecting early sacroiliitis (p<0.05). Multidetector row CT showed a higher grade of sacroiliitis in 114 and 127 of 384 sacroiliac joints. Conclusion: Performing multidetector row CT rather than plain radiography for making the diagnoses of accompanying ankylosing spondylitis allows an early start of treatment with a subsequently improved prognosis. 목적: 본 연구의 목적은 강직성척추염이 의심되는 환자를 대상으로 천골장골관절염의 진단에 있어 다중 검출기 CT의 유용성에 대해 단순촬영과 비교 분석하는데 있다. 대상과 방법: 임상적으로 강직성척추염이 의심되는 192명의 환자를 대상으로 천골장골관절염의 진단을 위하여 단순촬영과 다중 검출기 CT를 함께 시행하였다. 이 검사들은 두 명의 근골격계 영상의학과 의사에 의해 Modified New York Criteria에 준하여 후향적으로 분석하였다. 결과: 단순촬영과 다중 검출기 CT에서 천골장골관절염 진단에 대한 민감도는 각각 59.9%, 66.7%, 83.3%, 74.5%였고, 다중 검출기 CT를 이용하여 천골장골관절염으로 진단된 환자의 수가 단순촬영을 이용했을 때보다 통계적으로 유의하게 증가함이 관찰되었다( p < 0.05). 등급별 분류에 따른 분석에서는 384개의 천골장골관절 중 114개, 127개(29.7%, 33.1%)의 천골장골관절이 다중 검출기 CT에서 단순촬영보다 높은 등급으로 평가되었다. 결론: 강직성척추염과 동반된 천골장골관절염 평가에 있어 다중 검출기 CT는 단순촬영만으로는 진단이 어려운 조기 천골장골관절염의 진단을 가능하게 하여 치료 방법 결정 및 예후에 도움을 줄 수 유용한 방법이라 하겠다.