항동해제에 따른 생쥐 동결수정란의 생존율및 체외발달율

차상헌,선우재근,박효숙,이임순,조태호,Cha, Sang-Hun,SunWoo, Jae-Gun,Park, Hyo-Suk,Lee, Im-Soon,Cho, Tai-Ho 대한생식의학회 1990 Clinical and Experimental Reproductive Medicine Vol.17 No.2

This study was carried out to clarify the effects of various kinds of cryoprotectants which were frequently used in freezing embryos of domestic animals on the survival of frozen-thawed mouse embryos. Mouse embryos were collected by hyperstimulation induction of ICR mouse. The samples were slowly cooled ($l^{\circ}C/min$) to temperatures between $-7^{\circ}C$ and $-30^{circ}C$ before direct transfer to liquid nitrogen ($-196^{\circ}C$) and thawed rapidly ($-500^{\circ}C$/min). As cryoprotectants, Glycerol, DMSO, Ethylene glycol and Propylene glycol were used and applied each 2 cell, 8 cell, morula in embryo stage. After normal mouse embryos developed to blastocyst by in vitro culture, we observed recovery rate and developing rate of embryos at thawing. The results obtained in these experiments were as follows : 1. The in vitro development rate from the frozen-thawed 2 cell embryos to the blastocyst were 67.7% in ethylene glycol, 65.7% in Propylene glycol, 55.2% in glycerol and 50.0% in DMSO respectively. 2. The in vitro development rate from the frozen-thawed 8 cell embryos to the blastocyst were 83.6% in DMSO, 75.7% in glycerol, 52.2% in propylene glycol respectively. 3. The in vitro development rate from the frozen-thawed morula to the blastocyst were 84.2% in glycerol, 80.0% in DMSO, 66.6% in propylene glycol and 55.2% in ethylene glycol respectively.

복부초음파로 산전진단된 선천성 십이지장 폐색의

김도형 ( Do Hyung Kim ),이정재 ( Jeong Jae Lee ),이임순 ( Im Soon Lee ),이권해 ( Kwon Hae Lee ),조태호 ( Tai Ho Cho ) 대한주산의학회 1993 Perinatology Vol.4 No.4

산전 태아건강상태 평가에서 음진동자극검사의 유용성에 대한 연구

김희범 ( Hee Beom Kim ),이정재 ( Jeong Jae Lee ),김민관 ( Min Kwan Kim ),남계현 ( Kae Hyun Nam ),이순곤 ( Soon Gon Lee ),이권해 ( Kwon Hae Lee ),조태호 ( Tai Ho Cho ) 대한주산의학회 1993 大韓周産醫學會雜誌 Vol.4 No.4

복합 임신 1예

이권해,선우재근,남계현,조태호 순천향대학교 1990 논문집 Vol.13 No.3

Since a combined intrauterine and extrauterine pregnancy was rare and difficult to diagnose, it was mostly found from the rupture of extrauterine pregnancy. About 10 cases were reported in Korea. We must devote to diagnose it early and correctly because a delayed diagnosis makes the patient fatal. We experienced a case of combined pregnancy in 36 years-old unmarried primiparous women, this case was present with brief review of liateratures.

국소 Methotrexate주사 : 자궁외임신의 비수술적 치료방법

이권해,이임순,이정재,남계현,조태호 순천향대학교 1990 논문집 Vol.13 No.3

Methotrexate, a cytotoxic drug that is largely used in cases of gestational trophoblastic disease, had previously shown promise in resolving unruptured ectopic pregnancy when given systemically, thereby eliminating the need for surgery. However, its systemic use exposes the patients to serious side effects and toxicity. To minimize the risk of these side effects and maximize benefit from high tissue concentration of methotrexate in the fallopian tube, the drug was locally applied by one injection to the pregnancy site at laparoscopy. We presented our cases with treating unruptured tubal pregnancy by a local methotrexate injection at laparoscopy.

자궁내막암에 있어서 혈액형 항원의 발현이상

이순곤,조태호 순천향대학교 1991 논문집 Vol.14 No.2

Immunohistochemical investigation of the abnormal expression of blood antigens was carried out by the ABC method (using monoclonal antibodies corresponding to A, B and H) on 10 cases of normal endometrium, 8 cases of endometrial hyperplasia and 38 cases of endometrial carcinoma. (1) A, B and H antigen were observed in endometrial carcinoma at a rate of 52.6%, while no distrinct localization of them was observed in normal endometrium. Precursor H antigen was especially accumulated in endometrial carcinoma. (2) The expression pattern in endometrial carcinoma could be classified into 4 types : (a) no blood group antigens : (b) : existence of precursor blood group antigens : (c) co-existence of the compatible and precursor blood antigens : and (d) existence of the compatible blood group antigens only. (3) The increased rate of expression of H antigen which has fucose in the terminal portion in endometrial carcinoma, suggests that a high, abnormal expression of blood group sugar chains seems to be caused by the acceleration of fucosyl transferase activity.

국소적으로 진행된 침윤성 자궁경부암 Ib 및 Ⅱ기 환자에서 수술전 유도항암화학요법의 역활

이권해,이민철,이순곤,남계현,조태호 순천향대학교 1992 논문집 Vol.15 No.4

Chemotherapy has been traditionally reserved as a last-line treatment for cervical dancer patients because the responses to chemotherapy were low. Recently, higher than expected responses of preoperative adjuvant chemotherapy to locally advanced cervical cancer were reported. This study evaluated the potential value of preoperative chemotherapy to cervical cancer with bulky tumor. The 18 patients (stage Ib and Ⅱ with bulky tumor> 4cm) first received initial chemotherapy of vinblastine, bleomycin, and cis-platinum in a combination regimen (VBP) followed by radical hysterectomy. This therapy induced responses in 13 of the 18 patients (1 complete, 12 partial;overall 73%). The median number of lymph node removed was 29 (range, 17-50). The lower than espected incidence of lymph node metastasis was detected (5/18, 28%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting and leukopenia. Chemotherapy did not seem to complicate surgery in these circumstances. Median follow-up was 32 months (range, 3-47 months). Two recurrences (11%) appeared and one patient died within 18 months after therapy. Preoperative adjuvant chemotherapy to locally advanced cervical cancer is well tolerated and may be beneficial in the management of patients vical cancer is well tolerated and may be beneficial in the management of patients with cervical cancer who are at high risk for failure with conventional treatment.

6태아의 임신 제1기 선택적 임신종결 1예

이정재,이임순,이권해,조창규,이광열,조태호 순천향대학교 1993 논문집 Vol.16 No.4

The induction of grand multiple gestations is a well known complication of the infertility treatment. The hMG that has been used in the treatment of female infertility may increase the frequency of multiple gestations. The over-triplet pregnancies have chances of poor obstetric outcomes than in the lower-number of conceptuses (ie. postpartum hemorrhage, PIH, preterm labor, abortion, cost for the care, etc). The over-quadruplets also have a chance of worse outcome than in the triplets, and it is needed to reduce the number of conceptuses for preventing the poor fetal and maternal morbidity and mortality. We believe that the selective first-trimester termination is an acceptable and suitable answer in these cases. We have experienced a case of the selective first-tirmester termination in sextuplet pregnancy, who had been treated with hMG for infertility treatment. In this case, the gestations were reduced to twins. We present this case with a brief review of literature.

혈소판과 임신 전자간증 중증의 관계

이권해,이순곤,이임순,이환구,이정재,김민관,남계현,조태호 순천향대학교 1993 논문집 Vol.16 No.4

The platelet count was investigated in a group of patient with severe preeclampsia. We prospectively reviewed the charts 98 women with severe preeclampsia who were admitted for delivery to the department of Obstetrics and Gynecology in Soonchunhyang University Hospital from January, 1990 to December, 1991. The results were as follow: 1. The number of platelet was low significantly in severe preeclampsia group. 2. In severe preeclampsia, reduced maternal level of circulating paltelets were found to correlate with fetal complications and/or maternal complications. Furthermore, a low platelet count may be an indicator that the fetus is at extra-risk and that is even though the severe preeclampsia is under control.

악성난소종양의 임상 및 병리학적 고찰

이권해,이순곤,이길우,남계현,조태호 순천향대학교 1991 논문집 Vol.14 No.2

Clinico-pathologic survey were made on 49 malignant ovarian tumors treated at the Department of Obstetrics and Gynecology, School of Medicine, Schoonchunhyang University during the period from July 1, 1979 to July 31, 1990. The results obtained were as follows 1. The incidence of malignant ovarian tumors was 8.6% among the all ovarian tumors. 2. The mean age was 44.7 years with the highest frequently in 50-59 years group. 3. Patients of nulliparity and primary infertility occupied 28.6% and 8.2% respectively. 4. The subjective symptoms were palpable abdomonal masses(44.9%), lower abdominal pain(32.7%), and urinary symptoms(6.1%). On the physical examination pelvic mass(63.3%) and abdominal distension with ascites(34.4%) were noted. 5. Tumor markers of CEA, α-FP, and CA125 were increased in 40.0%, 10.0%, and 87.5% of the selected patients respectively. 6. In Clinical stages based on FIGO classification, Stage I was 43.2%, Stage Ⅱ in 25.0%, Stage Ⅲ in 20.5% and Stage Ⅳ in 11.3%. Bilaterality of tumor was noted in 22.5%. 7. Histologic incidence according to WHO classification was as follow ; Epithelial tumors were found in 65.3%, germ cell tumors in 6.3%, sex-cord stromal tumors in 2.0%, and metastatic tumors in 10.2%. 8. Tumors were completely resected in 77.6% on primary surgery. Postoperative complications were fever(7 cases), wound infection(2 cases), urinary tract infection(1 case), and ileus(1 case). 9. Adjuvant treatment, two patients were received radiation therapy, and 26 patients were treated with multiagent chemotherapy, and 3 patient received single agent chemotherapy postoperatively.