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RISS 인기검색어
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- 저자 : 조춘식(Chun Zhi Zhao) (검색결과 3 건)
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김세혁,조춘식,권오규,이배환,박용구,정상섭,Kim, Se-Hyuk,Zhao, Chun-Zhi,Kwon, Oh-Kyoo,Lee, Bae-Hwan,Park, Yong-Gou,Chung, Sang-Sup 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.8
Objective : There are some advantages of trigeminal evoked potential(TEP) recording compared to other somatosensory evoked potential(SSEP) recordings. The trigeminal sensory pathway has a pure sensory nerve branch, a broader receptive field in cerebral cortex, and a shorter pathway. Despite these advantages, there is little agreement as to what constitutes a normal response and what wave forms truly characterize the intraoperative TEP. This study presents the normative data of TEP recorded on the epidural surface of the rat with a platinum ball electrode. Materials & Methods : Under general anesthesia with urethane, the adult Sprague-Dawley male rats(300-350g) were given electrical stimulation with two stainless steel electrodes which were inserted into the subcutaneous layer of the area around whiskers. A reference electrode was positioned in the temporalis muscle ipsilateral to the recording site. Results : TEPs were recorded in the Par I area of somatosensory cortex and recorded most apparently on the point of 2mm posterior from the bregma and 6mm lateral from the midline. The typical wave form consisted of 5 peaks (N1-P1-N2-P2-N3 according to emerging order, upward negativity). Each latency to corresponding peaks was not influenced by the different intensities of stimulation, especially from 1 to 5mA. Average latencies of 5 peaks were in the following order ; 7.7, 11.1, 15, 22.3, 29.4ms. There was also no significant difference between latencies before and after administration of muscle relaxant(pancuronium). For the electrophysiological localization of recorded waves, the action potential of a single unit was recorded with glass microelectrode(filled with 2M NaCl, $3-5M{\Omega}$) in the thalamus of rat. A sharp wave was recorded in the VPM nucleus, in which the latency was shorter than that of N1. This suggests that all 5 peaks were generated by neural activities in the suprathalamic pathway. Conclusion : In terms of recording near-field potentials, our data also suggests that TEP in the rat may be superior to other SSEPs. In overall, these results may afford normative data for the studies of supratentorial lesions such as hydrocephalus or cerebral ischemia which can have an influence on near-field potentials.
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신현철,박용구,이배환,류재욱,조춘식,정상섭,Shin, Hyun Chul,Park, Yong Gou,Lee, Bae Hwan,Ryou, Jae Wook,Zhao, Chun Zhi,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7
Objective : Somatosensory evoked potentials(SSEPs) have been used widely both experimentally and clinically to monitor the function of central nervous system and peripheral nervous system. Studies of SSEPs have reported the various recording techniques and patterns of SSEP. The previous SSEP studies used scalp recording electrodes, showed mean vector potentials which included relatively constant brainstem potentials(far-field potentials) and unstable thalamocortical pathway potentials(near-field potentials). Even in invasive SSEP recording methods, thalamocortical potentials were variable according to the kinds, depths, and distance of two electrodes. So they were regarded improper method for monitoring of upper level of brainstem. The present study was conducted to investigate the characteristics of somatosensory evoked field potentials(SSEFPs) of the cerebral cortex that evoked by hindlimb stimulation using ball electrode and the pathways of SSEFP by recording the potentials simultaneously in the cortex, VPL nucleus of thalamus, and nucleus gracilis. Methods : In the first experiment, a specially designed recording electrode was inserted into the cerebral cortex perpendicular to the cortical surface in order to recording the constant cortical field potentials and SSEFPs mapped from different areas of somatosensory cortex were analyzed. In the second experiment, SSEPs were recorded in the ipsilateral nucleus gracilis, the contralateral ventroposterolateral thalamic nucleus(VPL), and the cerebral cortex along the conduction pathway of somatosensory information. Results : In the first experiment, we could constantly obtain the SSEFPs in cerebral cortex following the transcutaneous electrical stimulation of the hind limb, and it revealed that the first large positive and following negative waves were largest at the 2mm posterior and 2mm lateral to the bregma in the contralateral somatosensory cortex. The second experiment showed that the SSEPs were conducted by way of posterior column somatosensory pathway and thalamocortical pathway and that specific patterns of the SSEPs were recorded from the nucleus gracilis, VPL, and cerebral cortex. Conclusion : The specially designed recording electrode was found to be very useful in recording the localized SSEFPs and the transcutaneous electrical stimulation using ball electrode was effective in evoking SSEPs. The characteristic shapes, latencies, and conduction velocities of each potentials are expected to be used the fundamental data for the future study of brain functions, including the hydrocephalus model, middle cerebral artery ischemia model, and so forth.
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류재욱,조춘식,이배환,박용구,정상섭 한국심리학회 한국심리학회지 생물 및 생리 Vol.11 No.1
운동유발전위(motor evoked potential;MEP)는 척수 및 운동신경계의 기능에 대한 임상 및 진단, 그리고 척수손상 연구 모형에서와 같은 동물을 이용한 실험적 연구에 많이 이용되고 있다. 그러나 이들 연구들간에는 자극대상, 즉 뇌용적이 작고 추체외로가 상대적으로 잘 발달한 쥐와 같은 설치류에서는 자극방법이나 자극위치에 따라서 MEP의 발생과 형태가 상이하며, 추체로운동유발전위(pyramidal motor evoked potential;PMEP)와 추체외로운동유발전위(extrapyramidal motor evoked potential;EPMEP)가 혼입되어 포착되는 것으로 생각된다. 이러한 문제점을 보완하기 위해서, 본 연구는 새로운 전극을 사용해서 쥐의 대뇌피질을 자극하여 발생시킨 PMEP와 망상핵을 자극하여 발생시킨 EPMEP의 특성을 관찰기록하여, PMEP와 EPMEP의 특성을 비교고찰하였다. 이를 위해 본 연구에서 사용한 새로운 전극은 대뇌피질에 직경이 약 1.4㎜인 원판을 접촉시켜서 이를 음전극으로 하고, 원판의 중심부에서 돌출된 0.2㎜의 두께와 1.5㎜ 길이의 절연된 심을 양전극으로 이용할 수 있게 제작되었다. 그리고 PMEP와 EPMEP는 제6경수위와 제9흉수위에서 기록하였다. 본 연구에서 새로운 자극전극을 이용하여 대뇌피질을 자극함으로써 전류의 전파를 국소화시킨 결과 비교적 일관적인 PMEP를 포착할 수 있었으며, PMEP와 EPMEP의 파형이 상이함을 보여주었다. Motor evoked potentials(MEPs) have been used widely both experimentally and clinically to study the function of the motor nervous system. However, the origins and the waveforms of MEPs in small animals like rats may be different from those of potentials evoked by intracortical microstimulation in carnivore like cats because of current spread. The patterns and characteristics of MEPs also could be affected by recording techinques and methods of stimulation. In the present study, we used a specially designed electrode to stimulate localized cortical area. The pointed tip of a special stimulating electrode was inserted into the cerebral cortex perpendicular to the cortical surface so that the round area gently contacted with the cortical surface. We investigated the characteristics of pyramidal motor evoked potentials (PMEPs) and extrapyramidal motor evoked potentials (EPMEPs) evoked by the electrical stimulation of the mortex cortex and the gigantocellular reticular nucleus. Using this technique, we could constantly obtain the PMEP and EPMEP. The results of the present study showed that the PMEP and the EPMEP were different in their latencies and waveforms.
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