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담석증, 급성 담낭염, 담도염 환자의 Nitrate/Nitrite (NOx)의 측정치와 질병의 중등도와의 관계
최경호(Kyong-Ho Choi),김해성(Hae Seung Kim),최연승(Yun-Seung Choi),조응호(Eung Ho Cho),안승익(Seung-Ik Ahn),이건영(Keon-Young Lee),홍기천(Kee-Chun Hong),최선근(Sun Keun Choi),허윤석(Yoon Seok Hur),김세중(Sei Joong Kim),우제홍(Ze Hong 대한외과학회 2004 Annals of Surgical Treatment and Research(ASRT) Vol.67 No.1
임진호(Jin Ho Yim),김상범(Sang Bum Kim),조응호(Eung Ho Cho),최동욱(Dung Wook Choi) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.3
Background & Purpose : This purpose of this study was to determine the prognostic factors for hepatocellular carcinoma (HCC) in patients who received curative hepatectomies at our institution. Patient and Method : A retrospective analysis was performed on 457 patients who had undergone hepatectomies between Mar 1987 and Feb 2008 for HCC at the Korea Cancer Center Hospital, Seoul, Korea. The number of males enrolled in the study was 366 and the numbr of fenales enrolled was 91. The mean age of the patients was 52.8 years old. Hepatitis B virus-related disease was the most frequent etiology (335/457 patients). Two hundred nine(209) patients had liver cirrhosis, and 93.9% of patients were classified in Child-Pugh Class A. Results : The complication rate was 30.6%(140/457) and the operative mortality was 1.5%(7/457). Reoperation was performed in 7 complicated patients. Five-and 10-year overall survival rates of the patients were 57.7% and 41.8% respectively. Poor prognostic factors of overall survival were Child B class, Edmonson-Steiner histologic grade 3 or 4, tumor vascular invasion, and postoperative complications. Five-and 10-year disease-free survival rates were 42.7% and 32.5%, respectively. Poor prognostic factors for disease free survival included the following an Edmonson-Steiner histologic grade of 3 or 4, tumor vascular invasion, and postoperative complications. Conclusion : Postoperative complication is independently a poor prognostic factor for overall and disease free survival in our study. We suggest that special care is needed while performing hepatic resections for the treatment of HCC in order to reduce postoperative complications.
김용배(Yong Bae Kim),김상범(Sang Bum Kim),조응호(Eung Ho Cho),최동욱(Dong Wook Choi),방호윤(Ho Yoon Bang),이종인(Jong Inn Lee),문난모(Nan Mo Moon) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.1
Introduction: The prognosis of peri-ampullary cancer is poor because of its low respectability and high recurrence rate. Yet cancer of the Ampulla of Vater(AOV) has a relatively good prognosis. The aim of this study is to investigate the outcomes and to determine the factors that affect the survival rate of patients who underwent curative resection for AOV cancer. Methods: From August 1988 to January 2008, 54 patients underwent curative resection for AOV cancer. We retrospectively reviewed the clinocopathologic data. The median follow up period was 45 months. Results: Twenty-seven pancreaticoduodenectomies (PD) and 27 pyrolus-preserving pancreaticoduodenectomies (PPPD) were performed. There was no hospital mortality, but 25 out of 54 patients (47.3%) experienced postoperative complications. The 5-year overall survival (OS) rate was 53.97% and the 5-year disease free survival (DFS) rate was 51.75%. On multivariate analysis, the variables that affected the overall survival rate and the disease free survival rate was poor histologic differentiation (p<0.001). Conclusions: Although the AOV cancer is one of the periampullary cancers that have a very poor outcome, long-term survival and favorable outcomes can be achieved after a curative resection. In this study, poor-histologic differentiation was the only independent factor for a poor prognosis.
간세포암 절제술을 시행받은 환자의 시대별 임상양상의 변화
양회민(Hoe Min Yang),김상범(Sang Bum Kim),조응호(Eung Ho Cho),최동욱(Dong Wook Choi) 한국간담췌외과학회 2010 한국간담췌외과학회지 Vol.14 No.2
Purpose: The purpose of this study was to identify changes over several years in clinical patterns of patients who underwent hepatectomies for HCC. Methods: There were 502 patients who underwent hepatectomies for HCC between January 1986 and July 2009 at the Korea Cancer Center Hospital, Seoul, Korea. Period 1 (n=206) extended from the beginning to December 2000. Period 2 from January 2001 to December 2004 (n=146). Period 3 from January 2005 to July 2009 (n=150). The data for the different periods were compared retrospectively or prospectively. Results: Compared to patients from Period 1, Period 2 and Period 3 patients had operations >6 months from diagnosis (p=0.002), high levels of preoperative AST and ALT (p<0.001), and poor scores on the ICG R15 test (p=0.047). The Frequency of Transfusion during the operation was decreased (p<0.001), but there was no difference in postoperative complication rates (p=0.403). In Periods 2 and 3, there was a higher frequency of multiple tumors (p<0.001) and microvascular invasions histologically (p<0.001). Differences between periods in disease free survival rates were not significant. Conclusion: The reason for the higher frequency, in more recent periods, of patients presenting at surgery with advanced HCC stages is the longer interval between diagnosis and operative time, and an increase in the number of non-surgical treatments before surgery. Because of differences in follow-up intervals, it was difficult to evaluate the influence of period on survival rates. Hence, a longer follow-up period will be required for an accurate evaluation of changes in survival with time.
Cytodex 3 미립담체를 이용한 간세포의 구상체 배양에서 간세포와 미립담체 간의 최적 비율
신우영(Woo Young Shin),이건욱(Kuhn Uk Lee),이해원(Hae Won Lee),조응호(Eung-Ho Cho),이남준(Nam-Joon Yi),서경석(Kyung-Suk Suh) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.3
Purpose: The mass cultivation of functional hepatocytes is a key factor of a bioartificial liver. Combining spheroid and microcarrier cultures has been applied for enhancing the cell viability and metabolic activities. Hence, the optimal number of hepatocytes per microcarrier was investigated. Methods: Firstly, spheroid cultures were carried out with 1 g Cytodex 3 microcarrier plus 2×10?, 4×10? and ?×10? viable hepatocytes per flask. The numbers of hepatocytes per microcarrier were approximately 666.7, 133.3 and 26.7, respectively. The control group consisted of a spheroid culture of 4×10? hepatocytes without any microcarrier. According to the primary experimental results, spheroid cultures with 1×10? of hepatocytes plus 1 g, 2 g and 3 g of the Cytodex 3 microcarrier were performed. The numbers of hepatocytes per microcarrier were approximately 33.3, 16.7 and 11.1, respectively. The control group consisted of a spheroid culture of 1×10? hepatocytes. The cell viabilities were assayed using a Cell Counting Kit-8; with the albumin production assayed using ELISA. Results: According to the primary experiment, the group consisting of 26.7 hepatocytes per microcarrier showed the highest viability (P<0.01). However, there was no statistical difference in the albumin production between the groups (P=0.744). The second Experiment showed the groups consisting of 11.1 and 16.7 hepatocytes per microcarrier had higher viabilities than the other hepatocyte and control groups (P<0.01). The albumin production was similar for each group (P=0.187). Conclusion: With respect to their application to a bioartificial liver, about 130 hepatocytes per microcarrier was appeared to be good for the mass cultivation of a hepatocytes spheroid culture using the Cytodex 3 microcarrier.