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조유숙,임윤정,김성호,이재천,임미경,유빈,문희범 ( You Sook Cho,Yeun Jeong Lim,Jae Cheon Lee,Seoung Ho Kim,Mi Kyoung Lim,Bin Yoo,Hee Bom Moon ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgroand: Oral allergy syndrome(OAS) is composed of it,ching sense and edema in oral cavity, lips, throat, pharynx, and larynx following eating some fresh fruits or vegetables. It has been known that most of patients with OAS are allergic to pollens. Common epitopes were found among pollens, fruits and vegetables. Although OAS is a common farm of food allergy in adults, this is the first epidemiologic study of OAS in Korea. Muterial and metkod: One hundred and fifty one patients who showed positive skin reaction to pollens were telephone-interviewed. Investigation of the prevalence and clinical manifestations of OAS was possible in 81 patients. Result: The prevalence of OAS among these patients was 34.6% (28/81). OAS was found in 24(48%) out of 50 patients sensitized to tree pollens, whereas 4(13%) of 31 grass or weed pol- len-sensitized paients had OAS. Most common causative food was apple and all of 17 apple- OAS patients were sensitized to tree pollens. Peach was the second common food and 14 of 15 peach-OAS patients were sensitized to tree pollens. Besides oral symptoms, rhinitis, asthma, diarrhea, nausea, vomiting or generalized urticaria were accompanied in half of the OAS patients (14/28). Some patients showed OAS to some unique Korean foods such as dropwort, taro and Aster. Conclasion.' OAS was very common in pollen-sensitized patients. Larger epidemiologic studies are needed to find unique Korean foods and their antigensm causing OAS.
조유숙 ( You Sook Cho ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.3
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are 2 representative diseases of chronic obstructive inflammatory airway diseases, and both show a wide range of heterogeneity in their clinical features. Although one end of typical asthma and the other end of COPD are clearly different, both diseases share lots of similarities in biological aspects and clinical manifestations. Currently, 2 different guidelines exist for asthma and COPD management, respectively, and in many clinical situations it is not easy to manage patients especially who have both features and show refractoriness to available medications. Since the features of the diseases are remarkably diverse in terms of clinical courses, prognosis and responses to therapeutic drugs, there have been vigorous efforts to classify appropriate subtypes in order to improve management of the diseases. However, dichotomous thinking about asthma and COPD precludes precise classification of the diseases in the real world. In this article, thus, chronic obstructive airway disease (COAD) ranging from asthma particularly in adults to COPD is proposed as 1 target subject to analyze precise classification based on exact phenotyping and endotyping of the diseases. In the current article, the reasonable precision medicine approach is also suggested based on treatable traits of COAD to achieve the best treatment for COAD patients. (Allergy Asthma Respir Dis 2018;6:141-148)
조유숙 ( You Sook Cho ) 대한내과학회 2012 대한내과학회지 Vol.83 No.4
Severe refractory asthma is a group of asthmatic patients showing heterogeneous phenotypes with frequent exacerbations and progressive airway remodeling despite high levels of therapy. Studies of severe asthma is difficult not only because of diverse pathogenesis, difficulty in translating pre-clinical human and animal models to clinical trials, and absence of biomarkers that predict therapeutic efficacy but because of lack of consensus on precise definition and diagnostic criteria of severe asthma. Furthermore, the burden of severe asthma is considerably high, therefore, there has been an urgent need for researching strategies to overcome severe asthma. In conclusion, precise characterization, exact definition, and appropriate classification of severe asthma would be critical to improve management of this challenging disease and these efforts could help to develop novel therapeutic strategies. (Korean J Med 2012;83:417-423)
Phenotype of Asthma-COPD Overlap in COPD and Severe Asthma Cohorts
조유숙,Park So-Young,Park So Young,Park Seo Young,Kim Sang-Heon,Cho You Sook,Yoo Kwang Ha,Jung Ki Suck,Rhee Chin Kook 대한의학회 2022 Journal of Korean medical science Vol.37 No.30
Background: Asthma and chronic obstructive pulmonary disease (COPD) are airway diseases with similar clinical manifestations, despite differences in pathophysiology. AsthmaCOPD overlap (ACO) is a condition characterized by overlapping clinical features of both diseases. There have been few reports regarding the prevalence of ACO in COPD and severe asthma cohorts. ACO is heterogeneous; patients can be classified on the basis of phenotype differences. This study was performed to analyze the prevalence of ACO in COPD and severe asthma cohorts. In addition, this study compared baseline characteristics among ACO patients according to phenotype. Methods: Patients with COPD were prospectively enrolled into the Korean COPD subgroup study (KOCOSS) cohort. Patients with severe asthma were prospectively enrolled into the Korean Severe Asthma Registry (KoSAR). ACO was defined in accordance with the updated Spanish criteria. In the COPD cohort, ACO was defined as bronchodilator response (BDR) ≥ 15% and ≥ 400 mL from baseline or blood eosinophil count (BEC) ≥ 300 cells/μL. In the severe asthma cohort, ACO was defined as age ≥ 35 years, smoking ≥ 10 pack-years, and postbronchodilator forced expiratory volume in 1 s/forced vital capacity < 0.7. Patients with ACO were divided into four groups according to smoking history (threshold: 20 pack-years) and BEC (threshold: 300 cells/μL). Results: The prevalence of ACO significantly differed between the COPD and severe asthma cohorts (19.8% [365/1,839] vs. 12.5% [104/832], respectively; P < 0.001). The percentage of patients in each group was as follows: group A (light smoker with high BEC) – 9.1%; group B (light smoker with low BEC) – 3.7%; group C (moderate to heavy smoker with high BEC) – 73.8%; and group D (moderate to heavy smoker with low BEC) – 13.4%. Moderate to heavy smoker with high BEC group was oldest, and showed weak BDR response. Age, sex, BDR, comorbidities, and medications significantly differed among the four groups. Conclusion: The prevalence of ACO differed between COPD and severe asthma cohorts. ACO patients can be classified into four phenotype groups, such that each phenotype exhibits distinct characteristics.
성인 급성 림프구성 백혈병의 예후 : - 33 예의 환자들을 대상으로 한 분석 -
조유숙(You Sook Cho),이규형(Kyoo Hyung Lee),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Cheol Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim),지현숙(Hyun Sook Chi),박찬정(Chan Jung Park 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: Rate of complete remission and long-term survival in adult acute lymphoblastic leukemia group has not been as satisfactory as that in childhood ALL. Recently introduction of induction chemotherapy of more intensive combination and various trials of postremission therapy are making improved results better looked forward to. And subtypes of ALL according to the degree of differentiation into T and B cells are identified by using immunologic markers hopefully to work out proper treatment for each subtype. Methods: We analited results of treatment and differences of complete remission rate, remission duration and overall survival as to various immunologic markers and clinicopathologic characteristics in 33adult ALL patients. Results: Eighty five percents of the 27cases that had VPDL chemotherapy achieved complete remission and both overall median survival and mediom duration of remission were 52weeks. No definite prognostic factors were detected influencing complete remission rate, remission duration and overall survival except that patients with serum albumin level higher than 4.0mg/dL showed highter complete remission rate. Although mature B-ALL showed the shortest overall median survival, degree of differenciation of B-cell and other immunologic markers did not influence on complete remission rate, remission duration or overall survival. Conclusion: Further studies are needed to delire the prognostic factors in adult ALL
한국 성인 기관지천식 환자의 삶의 질 평가를 위한 설문의 유용성 평가를 위한 다기관 연구
박중원 ( Jung Won Park ),조유숙 ( You Sook Cho ),이순영 ( Soon Yeung Lee ),남동호 ( Dong Ho Nahm ),김윤근 ( Yoon Keun Kim ),김동기 ( Dong Ki Kim ),손지웅 ( Jee Woong Sohn ),박재경 ( Jae Kyung Park ),지영구 ( Young Koo Jee ),조영주 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3
Background: and objective : Assessment of quality of life (QOL) of patients with chronic illness requires reasonable tools which reflect the patients' cultural and behavioral properties. We developed the quality of life questionnaire for adult Korean asthmatics (QLQAKA) on the basis of the Korean life style and evaluated its reliability and validity. Methods : The QLQAKA consisted of four domains: symptoms (six items), daily activity (five items), emotion (three items) and reaction to environmental stimuli (three items). Patients answered each item according to a five-response scale. The reproducibility and validity of the questionnaire was estimated from the responses of 244 patients who visited the clinics in 15 institutes within a 2-week interval. Results : Items with the most frequent complaints were dyspnea (87%), difficulty in sputum discharge or throat clearing (87%), limitation in strenuous activity (84%) and coughing (82.4%). The QLQAKA reflected the changes of patients' status very well. The value of minimal important differences, such as the clinically significant minimal change in the QOL score, was 0.5. The questionnaire was also highly reproducible with the value of intraclass correlation coefficiency and intraclass standard deviation as 0.940 (p<0.001) and 0.180, respectively. The changes of mean total QLQAKA score correlated weakly with the changes of FEV> and PEFR values. Conclusion: The adult version of QLQAKA was valid and may be a reproducible tool for evaluating and monitoring Korean adult asthma patients.
비정형 림프구증가증과 만성 Epstein-Barr virus 감염을 동반한 모기 침산 과민반응 1례
박소연 ( So Yeon Park ),조유숙 ( You Sook Cho ),김성호 ( Seung Ho Kim ),이창근 ( Chang Keun Lee ),유빈 ( Bin Yoo ),김상위 ( Sang Wi Kim ),오흥범 ( Heung Bum Oh ),박찬정 ( Chan Jeoung Park ),문희범 ( Hee Bom Moon ) 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Hypersensitivity to mosquito bites is a disorder characterized by necrotic skin reactions and systemic generalized symptoms subsequent to mosquito bites. This disease has been reported mostly in Japanese patients in their first two decades of life. Recent
김성호 ( Seong Ho Kim ),임희영 ( Hee Young Lim ),조유숙 ( You Sook Cho ),김찬 ( Chan Kim ),유빈 ( Bin Yoo ),고윤석 ( Yoon Seok Ko ),김우성 ( Woo Seong Kim ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Relapsing polychondritis, a rare multisystem disease, is characterized by widespread potentially destructive inflammatory lesions, involving cartilaginous structures throughout the body. Auricular chondritis is the most frequent presenting sign of this disease, with arthritis being the second. Other clinical menifestations include nasal chondritis, scleritis, damage to tracheobroncheal cartilage, and cardiovascular and renal involvement. We experienced three cases of relapsing polychondritis. One case is 66 year old male with bilateral auricular chondritis with histologic confirmation, episcleritis, polyarthritis, periarterial vasculitis, and sensorineural hearing loss. Another case is 42 year old male with respiratory, nasal, auricular chondritis and psoriasis with arthritis. The third case is 46 year old female with three year history of relapsing polychondritis, presenting bilateral auricular and nasal chondritis and severe respiratory tract involvement with histologic confirmation. We also reviewed the other case reports of relapsing polychondritis in Korea. The major presenting manifestations of relapsing polychondritis in Korea were respiratory tract symptoms of dyspnea, cough, and sputum. That is, auricular chondritis was less frequent than laryngotracheal-bronchial involvement.