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회역산(回逆散)으로 호전을 보인 아토피피부염의 치험 2례
조소현,조은희,김성중,박인해,박민철,Jo, So-Hyun,Jo, Eun-Hee,Kim, Seong-Joung,Park, In-Hae,Park, Min-Cheol 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3
Background and Objective : Atopic dermatitis is a type of dermatitis, an inflammatory, relapsing, non-contagious and itchy skin disorder and affecting up to 30% of children in the Korea. In this study, Huini-san, which is mentioned in Shanghanlun(傷寒論), and acupunture treatment on Atopic Disease was investigated. Methods : We have classified the patients according to the Shanghanlun six meridian patterns diagnostic system and the patients are treated with Huini-san. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Results : After the treatment the SCORAD index and VAS of 2 patients dicreased significantly. Conclusions : Huini-san and acupunture treatment has improved the symptoms of Atopic dermatitis in this study.
복령감초탕(茯?甘草湯)으로 호전을 보인 한포진의 치험 2례
조소현,조은희,박민철,Jo, So-Hyun,Jo, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.4
Background and Objective : Dyshidrotic Eczema is characterized by a pruritic vesicular eruption on the fingers, palms, and soles. It is an acute, chronic, or recurrent dermatosis. The causes of dyshidrosis are unknown. There are many treatments available for dyshidrosis including topical steroids but long term treatment of streoids may have side effects. The purpose of this study is to find out the effect of Fulinggancao-Tang on Dyshidrotic Eczema. Methods : We have diagnosed the patients through the Shanghanlun six meridian patterns diagnostic system and we treated the patients with Fulinggancao-Tang. The severity of Dyshidrotic Eczema was evaluated by visual analogue scale(VAS). Results : After the treatment itching and vesicles of hands and foots were all disappeared in both patients. Conclusions : Fulinggancao-Tang have improved the signs and symptoms of Dyshidrotic Eczema case. It is considered that Fulinggancao-Tang is considerably effective on the treatment of skin disease that especially vulnerable to water.
甘草麻黃湯 추출물의 배합 비율에 따른 투여가 Ovalbumin으로 유발된 천식 생쥐에 미치는 영향
조소현,조은희,박민철,Jo, So-Hyun,Jo, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.4
Background and Objective : Asthma is a chronic inflammatory disease at the mucosa and is associated with excess production of Th2 cytokine and eosinophil accumulation in lung.Gamchomahwang-tangextract(GME) is one of the well known prescription used in oriental medicine for treating asthma. This study was designed to compare the anti-asthmatic effect of GME according to the ratio of 2 compounds.Methods : To examine the effects of GME on asthma, mice were sensitized with 100 ㎍ of OVA and 1 ㎎ of aluminum potassium sulfate(Alum; Sigma) intraperitoneally on day 1 and 15. From day 22, mice were challenged on 3 consecutive days with 5% OVA. The anti-asthmatic effects of GME were evaluated by enhanced pause(Penh), bronchoalveolar lavage fluids (BALF), inflammatory cytokine production and genes expression, serum IgE production. and histological change in lung tissue. GMEⅠ consists of ES and GU in the proportion 2:1(300 ㎎/㎏ group), GMEⅡ consist of ES and GU in the proprtion 4:1(300 ㎎/㎏ group).Results : GMEⅠ,Ⅱ generally inhibited lung inflammation, inflammatory cells infiltration and cytokine production and gene expression such as IL-4, IL-5 and IL-13 in BALF and serum IgE level. GMEⅡ significantly reduced the cytokine production and gene expression such as IL-4, IL-5 and IL-13 in BALF and GMEⅠ decreased cytokine production of IL-4, IL-13 in BALF and gene expression of IL-4, IL-5 in Lung. GMEⅡ potently inhibited the development of Penh and also reduced the number of eosinophil during OVA-induced AHR(airway hyper-reactivity). Overall the results show that GMEⅡ has more effect on inhibiting production, gene expression of cytokine, serum IgE level and development of Penh than GMEⅠ. Consequently, GMEⅡ might be more effective than GMEⅠ at inhibiting allergic asthma on the OVA-induced mice model.Conclusion : These results indicate that GME has a deep inhibitory effects on airway inflammation and hyperresponsiveness in mice model of asthma and that suppression of IL-4, IL-5, IL-13 expression and decrease of IL-4, IL-5, IL-13 production in BALF might contribute this effect. Hence, the results indicate that GME might be useful herbal medicine of allergic asthma. As a result, GMEⅡ mght be superior to GMEⅠ in the aspect of anti-asthmatic effect on the OVA-induced mice model.
마행의감탕(麻杏薏甘湯)으로 호전을 보인 Bowen병의 치험 1례
조소현,백상철,최용주,조은희,박민철,Jo, So-Hyun,Baek, Sang-Chul,Choi, Yong-Ju,Jo, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.4
Background and Objective : Bowen's disease is a type of an in situ squamous cell carcinoma. Typical type of Bowen's disease present as a gradually growing well-dermarcated erythematous plaque with an irregular border and surface crusting or scaling. This case demonstrates that Bowen's disease which had a relapse during applying the topical imiquimod can be treated by herbal medicine. Methods : A 72-year-old man patient presented with a erythematous plaque on his right medial malleolar area. The diagnosis of Bowen's disease was based on the clinical features. The chief complaints were scales, fissures, crusts and dryness of skin, erythema plaque, hyperpigmentation, bleeding, tenderness on the lesion. He was treated with Mahaengeuigam-Tang for 77 days. The severity of Bowen's disease was evaluated by visible assessment to determine the end-point of clearance. Results : After the treatment, fissures, crusts and dryness of skin and bleeding, tenderness on the lesion were vanished. Scales and erythema plaque, hyperpigmentation of the lesion little remained. Conclusions : Mahaengeuigam-Tang can be used on the treatment of skin disease which has characteristics plaques and crusts of skin.
조소현 ( So Hyun Jo ),정현정 ( Hyun Jung Chung ),이성희 ( Seong Hee Lee ),황수정 ( Su Jung Hwang ),엄애선 ( Ae Son Om ),은종방 ( Jong Bang Eun ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.3
본 연구는 채소류의 미생물학적 오염도를 조사하기 위하여 학교 주변 식당 10곳에서 채취한 마늘, 고추, 깻잎, 상추를 대상으로 하여 총세균, 대장균군, 저온균, 효모, 황색포도상구균의 오염도 수준을 분석하였다. 총세균의 경우, 상추는 평균 5.4±0.69log CFU/g, 마늘은 3.4±1.27 log CFU/g로 상추>고추>깻잎>마늘 순으로 높게 나타났고, 조사한 식당의 절반이 넘는 식당에서 채취한 모든 시료에서 대장균군이 검출되었다. 저온균은 고추, 상추, 깻잎, 마늘 순으로 높게 나타나 각각 평균 5.0±1.82 log CFU/g, 4.2±1.91log CFU/g, 4.7±1.55 log CFU/g, 2.4±2.10 log CFU/g로 나타났다. 효모는 깻잎이 평균 4.4±1.41 log CFU/g의 오염 수준으로 가장 높게 나타났으며 마늘은 평균 0.9±1.41 log CFU/g으로 가장 낮은 오염 수준으로 나타났다. 황생포도상구균의 오염 수준은 총 40개의 시료 중에서 27개의 시료에서 0.5~5.2 log CFU/g의 범위에 걸쳐 검출되어 본 연구에서 수집한 27개의 시료 중에서 22개의 시료가 식품공전의 규정 기준보다 높은 수의 호황생포도상구균에 오염된 것으로 나타났다. 따라서 안전한 채소류를 섭취하여, 채소류 섭취로부터 발생할 수 있는 식중독 사고를 예방하기 위해서는 더 위생적이고 체계적인 관리가 필요하다고 사료된다. Microbiological contamination of 4 vegetables (garlic, red pepper, perilla leaf and lettuce) collected from 10 restaurants around university was examined. The vegetables were evaluated for total plate count, coliforms, psychrophiles, yeast, and Staphylococcus aureus. The results of total plate count showed the highest value as 5.4±0.69 log CFU/g in lettuce, following by 4.8±1.53 log CFU/g in red pepper, 4.5±1.65 log CFU/g in perilla leaf and 3.4±1.27 log CFU/g in garlic. The contamination level of coliforms and psychrophiles were highest in red pepper with maximum as 4.7 log CFU/g and 8.2 log CFU/g, respectively. Red pepper of psychrophiles showed the highest average value as 5.0±1.82 log CFU/g followed by 4.2±1.91 log CFU/g in lettuce, 4.7±1.55 log CFU/g in perilla leaf and 2.4±2.10 log CFU/g in garlic. The average number of yeasts were highest in perilla leaf with 4.4±1.41 log CFU/g and were lowet in garlic with 0.9±1.41 log CFU/g. The contamination level of S. aureus was detected in 27 samples among the total 40 samples with the range of 0.5-5.2 log CFU/g. In conclusion, the microbial quality of the fresh vegetables evaluated in this study was not very good. Therefore, it needs to be enhanced through the good sanitation management and production and distribution methods to improve the safety of fresh vegetables.
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 소시호탕(小柴胡湯)을 투여한 양명병(陽明病) 아토피 피부염 치험 1례
민준홍,조소현,Min, Joon-Hong,Jo, So-Hyun 대한상한금궤의학회 2015 대한상한금궤의학회지 Vol.7 No.1
Objective : This case report presents the effect of Soshiho-tang on Atopic Dermatitis. The patient was diagnosed with Yangmyung-byung based on Shanghanlun provisions. Methods : According to Shanghanlun six meridian patterns diagnostic system, we dianosed the patient as Yangmyung-byung and he had trouble getting out of bed and nighttime itch. The patient was treated with Soshiho-tang. We evaluated the results of treatment by Objective SCORAD Index and pictures. Results : After the treatment, Objective SCORAD Index decreased from 61 to 21.5. And he became to have no trouble in getting up and also nighttime itch vanished. Conclusions : This case report sowed and effectiveness of using Soshiho-tang according to Diagnostic system based on Shanghanlun provisions on Atopic Dermatitis.
월비탕(越婢湯)으로 치료된 베체트병의 결절홍반양 병변 치험 1례
백상철,조소현,조은희,박민철,Baek, Sang-Chul,Jo, So-Hyun,Jo, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.2
Background and Objective : Erythema nodosum-like lesions in patients with Behcet's disease is a reactive dermatosis that occurs in response to various stimuli, such as bacterial, fungal and viral infections, drugs and malignancies. We observed and treated a case of erythema nodosum-like lesions with Behcet's disease. We present this case because there were no former reports of erythema nodosum-like lesions with Behcet's disease treated by herbal medicine. Methods : The patient was a 28-year-old. The chief complains were erythema, nodose, edema, burning sensation, tenderness on both legs, forearms and feet, arthralgia and genital ulcers. She was treated with Wolbi-Tang for eleven days. We diagnosed the medication according to the results of manual abdominal examination of the patient. We used the Visual Analogue Scale(VAS). Results : After the treatment the grade of VAS was decreased and clinical symptoms were improved. Conclusions : Wolbi-Tang can be used on the treatment of erythema nodosum-like lesions with Behcet's disease.
치자시탕(梔子豉湯) 투여로 호전된 만성 피부 소양증 치험 2례
이주현,조소현,조은희,박민철,Lee, Ju-Hyun,Jo, So-Hyun,Jo, Eun-Heui,Park, Min-Cheol 대한한방안이비인후피부과학회 2022 한방안이비인후피부과학회지 Vol.35 No.4
Objectives : This study is to report two cases of chronic skin pruritus improved by Chijasi-tang. Methods : Chijasi-tang was prescribed to two chronic skin pruritus patients. One patient took Chijasi-tang for 30 days and the other took it for 15 days. We compared patients' symptoms before and after treatment using self-made standards. Results : Patients who complained of pruritus on the elbow and thigh, pruritus decreased from NRS 8 to 1, and skin symptoms improved from 16 to 2. The other patient who complained of pruritus in the neck and chest, pruritus improved from NRS 9 to 2, and skin symptoms at the lesion site improved from 12 to 2. Also, accompanied symptoms such as heat of the feet and heartburn almost disappeared. Conclusions : After prescribing Chijasi-tang to two chronic skin pruritus patients, significant improvements were observed. It is thought that Chijasi-tang can be used as the treatment of other skin diseases in the future.
감초 추출물 투여가 Ovalbumin으로 유발된 마우스 알레르기성 천식에 미치는 영향
조은희,조일주,박성주,조소현,박민철,Jo, Eun-Hee,Jo, Il-Joo,Park, Seong-Ju,Jo, So-Hyun,Park, Min-Cheol 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3
Objective : Glycyrrhiza uralensis Fisch (GUF) has been used as remedy of allergic diseases for a long time in Korea. In the present study, we investigated the anti-allergic effects of GUF on experimental allergic asthma mouse model using ovalbumin (OVA). Methods : BALB/c mice were sensitized and challenged with 100 ug of OVA and 1 mg of aluminum potassium sulfate of 0.2 ml phosphate-buffered saline (PBS) intraperitoneally on day 1 and 15. Mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 hrs after the last challenge. We examined total inflammatory cell number in bronchoaveloar lavage fluid (BALF), Th2-associated cytokine productions and lung histology. Results : GUF potently inhibited the development of airway hypersensitivity and also reduced the number of BAL cells during OVA-induced allergic asthma. GUF also inhibited cytokine productions such as IL-4, IL-13 in lung tissue. Furthermore, GUF treatment inhibited allergic airway inflammation. Conclusion : These results suggest that GUF may inhibit the production of IL-4, IL-13 and infiltration of inflammatory cell and be beneficial oriental medicine for allergic asthma.