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조성운,강성규,김성수,전해경,최종권,염을건,Jo, Seong Un,Gang, Seong Gyu,Kim, Seong Su,Jeon, Hae Gyeong,Choe, Jong Gwon,Yeom, Eul Geon Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.11
A series of benzimidazole derivatives containing oxycyclic pyridine was prepared and evaluated for their gastric H+ /K+ -ATPase inhibitory activity. Several of the synthesized compound exhibited potent antisecretion in pylorus-ligated rats when administered intradoudenally. Their inhibitory activities were equivalent or comparable to omeprazole.
기본교란 및 분수조화교란을 이용한 원형제트에서의 보텍스병합
조성권,유정열,최해천,Jo, Seong-Gwon,Yu, Jeong-Yeol,Choe, Hae-Cheon 대한기계학회 1997 大韓機械學會論文集B Vol.21 No.10
An experimental study has been performed on vortex pairing under fundamental and subharmonic forcing with controlled initial phase differences through hot-wire measurements and a multi-smoke wire flow visualization. For the range of St$_{D}$ < 0.6, vortex pairing was controlled by means of fundamental and subharmonic forcing with varying initial phase differences. Much larger mixing rate was achieved by two-frequency forcing with a proper phase difference than one frequency forcing. As St$_{D}$ decreased, vortex pairing was limited to a narrow region of the initial phase difference between two disturbances and higher amplitudes of the fundamental and its subharmonic at the nozzle exit were required for more stable pairing. As the amplitude of the subharmonic at the nozzle exit increased for fixed St$_{D}$ and fundamental amplitude, the distribution of the subharmonic mode against the variation of the initial phase difference changed from a sine function form into a cusp-like form. Thus, vortex pairing can be controlled more precisely for the former case. For St$_{D}$ > 0.6, non-pairing advection of vortices due to the improper phase difference was sometimes observed in several fundamental forcing amplitudes when only the fundamental was applied. However, when its subharmonic was added, vortex pairing readily occurred. As the initial amplitude of this subharmonic increased, the position of vortex pairing moved upstream. This was thought to be due to the fact that the variation of the initial phase difference between the fundamental and its subharmonic has less effects on vortex pairing in the region of fundamental-only vortex pairing.pairing.
Trinitrobenzene sulfonic acid에 의해 유발된 랫드의 대장염에서 HemoHIM의 항염증 효과
이해준,김세라,문창종,김종춘,배춘식,강성수,정우희,박혜란,조성기,김성호,Lee, Hae-June,Kim, Se-Ra,Moon, Chang-Jong,Kim, Jong-Choon,Bae, Chun-Sik,Kang, Seong-Soo,Jung, U-Hee,Park, Hae-Ran,Jo, Sung-Kee,Kim, Sung-Ho 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.1
The cause and pathogenesis of inflammatory bowel disease remain unknown and no definitetherapy exists until now. The present study was conducted to investigate the anti-inflammatory effectsof a herbal preparation (HemoHIM) in colitis induced by 30 mg of trinitrobenzene sulfonic acid (TNBS)in rats. Sprague-Dawley rats were divided into 5 groups. Each group was treated with 1 mg ofHemoHIM/ml of drinking water, 4 mg of HemoHIM/ml of drinking water, 50 mg of HemoHIM/kgof body weight (i.p. once every other day) or 10 mg/kg of HemoHIMof body weight (i.p. onceevery other day) from the next day. After 2 weeks, rats were sacrificed and morphologic featuresof colons were examined. Ulceration, adhesion, thickening and dilatation were noticed in the colonicmucosa after TNBS instillation. Intraperitoneal injection of HemoHIM (50 and 100 mg/kg of bodyweight) showed the anti-inflammatory effect on adhesion, thickening, dilatation, ulceration, and theinhibition effect on damage score by 72.7% and 90.9%, respectively. Histologically, the colon of TNBS-treated rat showed inflammatory cell infiltration by polymorphonuclear cells, multiple erosive lesionsignificant improvement in these symptoms. The results obtained suggest marked anti-inflamatoryactivity of the HemoHIM at the dose levels examined.
경남 연안 해만 가리비(Argopecten irradians)의 부위별 마비성 패류독소 분포
김동욱 ( Dong Wook Kim ),박큰바위 ( Kunbawui Park ),하광수 ( Kwang Soo Ha ),류아라 ( Ara Ryu ),유헌재 ( Hean Jae Yu ),조성해 ( Seong Hae Jo ),조성래 ( Sung Rae Jo ),목종수 ( Jong Soo Mok ) 한국수산과학회(구 한국수산학회) 2019 한국수산과학회지 Vol.52 No.3
To understand the characteristics of paralytic shellfish poisoning in a major production area of the bay scallop Argopecten irradians in Korea, the seasonal variation and anatomical distribution of paralytic shellfish toxin (PST) were determined in bay scallops collected from the Gyeongnam coast of Korea from March to May 2018. PST levels in bay scallops in the survey area showed remarkable seasonal variation. PST was first detected at a level of 0.42 mg/kg on April 2, 2018, and the highest toxin level (3.15 mg/kg) was recorded on April 12. Among the tissues of bay scallops, the highest proportion of PST was found in the viscera (54.9%±17.8%), followed by the adductor (22.8%±10.9%), gonads (8.9%±4.6%), gills (7.1%±3.7%), and mantle (6.3%±.8%). In addition, with higher PST levels in the whole tissues of bay scallops, the proportion of PST in the viscera increased, whereas those in the mantle, gill, and gonad tissues decreased. In a high-toxicity group with more than 2.0 mg/kg PST in the whole tissues, the proportion of PST in the viscera was 71.8%±6.7%.