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      • SCOPUSSCIEKCI등재

        척수 종양 654예의 임상 분석(1973-1999)

        최우진,정천기,조병규,김현집,Choe, Woo Jin,Chung, Chun-Kee,Cho, Byung-Kyu,Kim, Hyun Jib 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.8

        Objective : The spinal cord tumors(including vertebral tumors) are increasingly diagnosed and operated due to development of refined diagnostic and therapeutic tools. It is necessary to re-evaluate clinical features and surgical results of spinal cord tumors with increasing cases and developing treatment modalities. The authors reviewed the spinal cord tumor cases to evaluate their clinical characteristics. Material and Methods : The retrospective review of 654 cases of spinal cord tumors between 1973 and 1999 was done. The clinical features, pathological analysis and surgical results were analyzed and compared to the literature. The results of the study are analyzed with a more detailed consideration of each of major pathologies : neurogenic tumors, meningeal tumors, neuroepithelial tumors, and metastatic tumors. Results and Conclusion : The spinal cord tumor was most common in the 5th decade of age(145 cases, 22.1%) and 78 cases(11.9%) were found in children under 15 years of age. The ratio of male to female was 1.2 : 1. The pathologic diagnosis was neurogenic tumor in 266 cases(40.7%), neuroepithelial tumor in 131(20.0%), metastatic tumor in 118(18.0%), and meningeal tumor in 94(14.4%) in the order of frequency. The tumor was located most frequently in the thoracic area(36.5%) and in the intradural extramedullary space(38.1%). The most common initial presentation was pain(40.1%) and the mean duration for presentation to operation was 14.8 months. The total or gross total removal was possible in 404 cases(61.7%) and the surgical result on the postoperative one month was recovery or improvement in 424 cases(64.8%), stationary in 188(28.7%), progression in 42(6.4%). As a surgical complication, there was a spinal deformity(12 cases), wound infection(5 cases), aspiration pneumonia(5 cases) etc. Neurogenic tumors and menigiomas showed good surgical results, whereas neuroepithelial tumors(except ependymoma) and metastatic tumors showed relatively poor prognosis.

      • SCOPUSSCIEKCI등재

        림프구성 누두신경뇌하수체염 : 증례 보고 및 문헌고찰

        손영제,왕규창,최기영,지제근,조병규,Son, Young-Je,Wang, Kyu-Chang,Choe, Gheeyoung,Chi, Je Keun,Cho, Byung-Kyu 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.6

        Lymphocytic infundibuloneurohypophysitis is a rare inflammatory disorder, which may be caused by autoimmune response, affecting the infundibulum and the posterior lobe of the pituitary gland. The authors present a 15-year-old man with central diabetes insipidus, whose sellar magnetic resonance imaging (MRI) showed a focal thickening of the infundibulum and loss of high signal of the normal neurohypophysis on T1-weighted images. The histopathological diagnosis was lymphocytic infundibuloneurohypophysitis. When a patient presents with central diabetes insipidus and infundibular thickening on brain MRI, this entity should be included in the differential diagnosis though it is very rare. The significance of this entity in treatment is that it is basically not a surgical one, and surgery is needed only for tissue diagnosis. Symptomatic treatment and observation make it regress spontaneously.

      • KCI등재

        HLA 기반 실시간 분산 M - SAM 시뮬레이션에서 RTI 성능 측정 및 분석

        최상영(Sang-Yeong Choi),조병규(Byung-Kyu Cho),이길섭(Kil-Sup Lee) 한국정보과학회 2005 정보과학회 컴퓨팅의 실제 논문지 Vol.11 No.2

        HLA는 시뮬레이션 표준 아키텍처로서 민수 및 국방 시뮬레이션 분야에서 관심이 높아가고 있다. 국내외에서 워게임과 같은 구조적 시뮬레이션에서는 HLA를 적용한 성공적인 개발사례를 찾아 볼 수 있다. 그러나 네트워크 시뮬레이터나 인터넷 게임과 같은 실시간 분산 시뮬레이션에서는 그 적용 사례가 아직까지 관찰되고 있지 않다. 그 이유는 실시간 분산 HLA 시뮬레이션에서는 네트워크 수준에서 RTI 를 통한 메시지 전송시간이 컴퓨팅 능력, 시뮬레이션 노드 개수, 전송방식, 전송패킷의 크기에 영향을 받고, 응용 수준에서 메시지의 사건처리시간이 메시지 처리방식에 의존하여 실시간 제약조건을 설정하기가 어렵기 때문이다. 따라서 본 논문에서는 차후 M-SAM 시뮬레이터의 개발을 위하여 RTI의 실시간 제약 조건의 수준을 고찰하고자 한다. 이를 위하여 LAN 환경에서 6대의 PC상에 HLA 기반의 실험용 시뮬레이터를 개발하고 RTI의 성능을 측정하고 분석하였다. 본 연구의 결과로서 이전의 연구에서 제시되지 않았던 다수 노드 환경에서 실제 운용 시나리오와 부하에 따른 메시지 지연시간, RTI 부하 및 RTI 패킷전송 비율에 대한 정량적인 특성 값을 얻을 수 있었고, 이 결과는 향후 M-SAM 시뮬레이터 또는 유사 응용체계의 개발에서 표적 수, 전송주기 및 메시지 처리방식에 대한 설정지침으로 활용이 기대된다. The HLA is the simulation architecture standard that the civilian and military simulation communities are deeply interested in. We can find various successful practices applying HLA to constructive simulations such as war games in domestics and overseas. However, any case of real-time distributed simulations has not been reported. The reason is that a message transmission period via RTI in a network layer varies according to computing power, simulation nodes, transmission types, and packet size; further a message processing time in an application layer depends on its processing methods, thus too difficult to set up real-time constraints for the enhancement of a real-time resolution. Hence, in this paper we have studied the real-time constraints of RTI for the development of the M-SAM simulator. Thus we have developed a HLA based pilot simulator using 6 PC's in LAN and then measured and analysed the performance of the RTI. As the results of our work, we could obtain the quantitative values for message delay, RTI overhead and RTI packet transmission ratio by a real operation scenario and loads, which are not shown in the previous works. We also expect that the results can be used as a guideline to set up the number of targets, transmission frequency, and message processing method in the development of the M-SAM simulator and similar applications.

      • SCOPUSSCIEKCI등재

        전적출후 재발한 소아 두개인두종의 재발인자에 대한 분석

        김승기,왕규창,정영섭,심기범,조병규,Kim, Seung-Ki,Wang, Kyu-Chang,Chung, Young Seob,Sim, Ki-Bum,Cho, Byung-Kyu 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

        Objectives : A substantial number of craniopharyngiomas recur despite gross total excision. The purpose of our study was to investigate pattern of recurrence and to verify prognostic factors for recurrence after gross total excision of craniopharyngiomas in children. Methods : A series of 36 patients with craniopharyngiomas were reviewed. All patients had undergone gross total excision and none of them received radiotherapy after initial surgery. Fifteen were girls and twenty-one were boys, with a mean age of 7.3 years(range, one to 15 years). The mean follow-up period was 52 months(range, one to 149 months). Recurrence was noted in 14 patients within 83 months(mean 31.4 months). Results : The overall three-year recurrence free survival rate was 65%, and the five-year recurrence-free survival rate was 55%. Regular neuroimaging follow-up at six to 12-month intervals detected tumor recurrence of a smaller size before symptoms developed(p<0.05). At the first surgical procedure, the optic nerve/chiasm(n=23) was the most common adhesion site. The most frequent sites of recurrence were the optic nerve/chiasm(n=6) and the pitiutary fossa(n=6). Tumor location was the single significant clinical predictor of recurrence. The five-year recurrence-free survival rate was 39% for those who had an intrasellar tumor component and 81% for those who did not (p<0.05). Conclusion : Craniopharyngiomas with intrasellar components should be followed cautiously and regular followup of patients should be emphasized, even when the tumors are totally resected.

      • SCOPUSSCIEKCI등재

        뇌실내 지주막 낭종 - 증례보고 -

        방재승,오창완,김명수,최기영,조병규,홍승관,한대희,Bang, Jae Seung,Oh, Chang-Wan,Kim, Myoung Soo,Choe, Ghee Young,Cho, Byung-Kyu,Hong, Seung-Koan,Han, Dae Hee 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7

        Intraventricular arachnoid cyst has been rarely reported. Here we present two cases of symptomatic intraventricular arachnoid cysts in the fourth ventricle and right lateral ventricle. The first patient was a 38-year-old female who complained of headache and left facial hypesthesia. Computed tomography and MR scan revealed large cystic lesion in the fourth ventricle. After cyst wall removal, facial hypesthesia disappeared immediately and headache improved slowly. The second patient was a 9-year-old girl who complained of headache, vomiting and paresthesia in her right low extremity. Cystic lesion in the right lateral ventricle was detected in the CT and MR scan. The symptoms improved after cyst wall removal. Surgical findings of these two cases showed that the cyst walls were attached firmly to the choroid plexus. Symptomatic intraventricular arachnoid cyst must be treated appropriately and we recommend complete cyst wall removal.

      • SCOPUSSCIEKCI등재

        뇌반구에 위치한 양성신경교종의 악성전환에 대한 임상적 연구

        조근태,곽호신,정희원,백선하,정영섭,김동규,조병규,Cho, Keun-Tae,Gwak, Ho-Shin,Jung, Hee-Won,Paek, Sun-Ha,Chung, Young Seob,Kim, Dong Gyu,Cho, Byung Kyu 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7

        Introduction : It has been reported that the survival of low-grade glioma patients depends upon the time of malignant transformation. The authors presents the clinical analysis of histologically proven trasformed gliomas. Materials and Method : A total 92 patients who were consecutively treated and histologically confirmed hemispheric low-grade gliomas between 1980 and 1998 were analyzed and followed. All cases meet the criteria of WHO glioma classification of grade II. Results : The mean follow-up period was 73 months. Twenty two among 92 cases(24%) were histologically proven to be transformed into malignant ones. The mean time to transformation was 56 months. The 5-year and 10-year survival rates of the transformed group were 66% and 30% respectively and significantly different from the survival rates of the non-transformed group(p=0.0018). Among clinical factors at presentation, the initial tumor volume had a tendency to be larger in the transformed group than that of the non-transformed group and became significant when it was divided into more than $30cm^3$ or not(p=0.02). Among therapeutic factors, the extent of removal had no influence on the rate of malignant transformation. But postoperative radiation therapy were more frequently given to the pre-transformed group than the non-transformed group and the frequency was significantly different(p=0.02). Conclusions : The authors had found that the initial tumor volume and radiation therapy could be clinical prognostic factors for the malignant transformation of low-grade gliomas.

      • SCOPUSSCIEKCI등재

        비정형성 및 악성 뇌수막종의 임상분석 : 52례 연구

        박홍준,곽호신,황승균,김정은,이상형,정희원,김동규,조병규,Park, Hong-Jun,Gwak, Ho-Shin,Hwang, Sung-Kyun,Kim, Jeong Eun,Lee, Sang Hyung,Jung, Hee-Won,Kim, Dong Gyu,Cho, Byung-Kyu 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.9

        Objective : Atypical and malignant meningiomas(AM, MM) are known to be rare and show aggressive behavior. Limited data are available concerning the clinical features, effectiveness of surgical removal and role of radiation therapy with AM, MM. The authors report our experience of AM, MM, with respect to clinical features. Methods : Twenty-four cases of AM and 28 cases of MM, who were operated between 1988 and 1999 were retro-spectively studied review of medical records and radiological findings. These were compared with control group of 24 cases of menigiomas manifestating usual clinical course, which are selected arbitrarily among operative cases between Apr. 1999 and Dec. 1999. Mean follow-up periods were 26(1-91) months for AM and 23(1-62) for MM. Authors analyzed the prognostic factors for survival, and statistical analysis were accomplished by Kaplan-Meier method and log-rank test. Results : Differences of clinical features between control groups and these atypical and malignant meningioma group were not significant. However, the location of MM was frequent in non-basal area(p<0.01). In AM, there were 4 patients of recurrence, and 3 patients of mortality. Among mortality cases, only one patient died of tumor progression, the other patients died of other causes. The survival at 2 year and 5 year in this group were 88% and 74% respectively, and in MM, 11 patients died due to tumor progression and 2 had spinal metastasis. The survival at 2 year and 5 year were 72% and 20%, respectively. For extent of resection, total removal(Simpson grade 1 or 2) was less often achieved in MM compared with AM(50% vs. 83%). Extent of resection of tumor and postoperative radiation therapy did not affect survival in both AM, MM. Conclusions : Clinical behavior of AM showed more benign than that of MM. Prognostic factor for survival is not related extent of resection of tumor and postoperative radiation therapy. However, further investigation with long-term follow-up and additional cases is mandatory.

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