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조경상,김성윤,임점희,정기화,이청주,Jo, Gyeong-Sang,Kim, Seong-Yun,Im, Jeom-Hui,Jeong, Gi-Hwa,Lee, Cheong-Ju The Korean Society for Integrative Biology 1997 Korean journal of biological sciences Vol.1 No.3
Male accessory glands and ejaculatory duct of Drosophila melanogaster are reproductive organs which synthesize secretory seminal proteins. Several products of these organs involved in egg laying, receptivity, and sperm stability or storage were isolated from their lumens. Despite their secretory process play an important role, exocytosis pathway in these organs is not well known. In the present study, we characterized secretory protein profiles and determined their secretory mechanisms. Eight accessory gland secretory proteins and two ejaculatory duct secretory proteins were detected in their lumens. All these proteins were constitutively synthesized in these organs and secreted to their lumens. Secretion of newly synthesized proteins initiated at about 1 h after synthesis, and reached the peak at 4 h after synthesis. It seems that secretion of the proteins may occur via constitutive exocytosis pathway.
당뇨병성 관상동맥 환자에서 관상동맥 협착에 대한 임상적 특징과 관상동맥 조영술 소견의 비교분석
정수룡 ( Jeong Su Lyong ),김두일 ( Kim Du Il ),김동수 ( Kim Dong Su ),조경임 ( Jo Gyeong Im ),김대경 ( Kim Dae Gyeong ),이원동 ( Lee Won Dong ),이재호 ( Lee Jae Ho ) 대한내과학회 2003 대한내과학회지 Vol.65 No.2
목적 : 당뇨병과 관상동맥 질환의 발생에 대한 상호관계를 비교하여 당뇨병에 따른 관상동맥 질환의 호발부위, 침범정도, 침범하는 혈관의 수를 분석하고 당뇨병이 관상동맥 질환에 미치는 영향을 평가하고자 하였다. 방법 : 2002년 1월부터 2002년 6월까지 인제대학교 부산 백병원 순환기 내과에서 심근허혈의 객관적 증거가 있어 관상동맥 조영술을 시행한 환자 중 당뇨병 39차례와 성별 및 연령이 가능한 일치하는 환자 39예를 대조군으로 선택하였다. 환자연령, Background : Diabetes mellitus is independent risk factor for the development and the extent of coronary artery disease, and increase the morbidity and the mortality of rdiovascular disease. But there is a debate concerning about the severity, distributio
증례 : Clopidogrel에 의해 유발된 호중구 감소증 1예
김민웅 ( Min Woong Kim ),윤지훈 ( Ji Hoon Yoon ),김치훈 ( Chi Hoon Kim ),강화미 ( Hwa Mi Kang ),박정호 ( Jung Ho Park ),조경임 ( Gyeong Im Jo ),김태익 ( Tae Ik Kim ) 대한내과학회 2006 대한내과학회지 Vol.71 No.4
Clopidogrel 사용으로 유발되는 무과립구증은 매우 드문 합병증이다. 저자들은 급성 관동맥증후군의 72세 여자 환자에서 clopidogrel을 복용 11일째 발생한 열을 동반한 중증 호중구 감소증에 대하여 투약 중단과 광범위한 항생제 치료와 granulocyte-colony stimulating factor를 투여하여 호전되었던 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Clopidogrel is an oral agent that blocks ADP receptor-mediated platelet aggregation. Clopidogrel along with aspirin was shown by the CURE trial to result in a 20% relative reduction of cardiovascular death, myocardial infarction or stroke. Ticlopidine has been shown to reduce the incidence of stent thrombosis compared with warfarin, but it may cause serious hematological side effects. However, the reported neutropenia has been similar to clopidogrel and aspirin treatment groups (0.01 vs 0.17%, respectively) with corresponding rates (0.05 vs 0.04%, respectively) of severe neutropenia. We treated a 72-year-old female patient with severe neutropenia who underwent percutaneous coronary intervention with drug-eluting stent placement and had no neutrophils in the peripheral blood at 11 days after clopidogrel use. Therefore, clinicians should be alerted to the possibility of severe neutropenia with clopidogrel treatment.(Korean J Med 71:426-430, 2006)