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크론병 환자의 선별에 있어서 일반적인 검사실 소견의 유용성
정훈용(Hwoon Yong Jung),양석균(Suk Kyun Yang),박종범(Jong Beom Park),김영민(Young Min Kim),이미헌(Mi Hun Lee),장혜숙(Hye Sook Chang),박무인(Moo In Park),명승재(Seung Jae Myung),홍원선(Weon Seon Hong),김진호(Jin Ho KIm),민영일(Young I 대한소화기학회 2002 대한소화기학회지 Vol.39 No.3
Background/Aims: The aim of this study was to evaluate the usefulness of laboratory parameters in the screening of Crohn's disease (CD). Methods: A total of 68 patients who were newly diagnosed as having CD at the Asan Medical Center between October 1989 and November 2000 were included in the present study. In addition, 47 patients with irritable bowel syndrome (IBS) were included as controls. There were no differences between the two groups in sex ratio, age, and duration of symptoms at the time of diagnosis. The values of laboratory parameters, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, platelet, white blood cell (WBC), and albumin were compared between the two groups. Results: The rates of abnormal results were significantly different between CD and IBS in all six parameters: CRP (85.3% vs. 6.4%), hemoglobin (70.6% vs. 8.5%), ESR (69.1% vs. 4.3%), platelet (42.6% vs. 0%), albumin (42.6% vs. 0%), and WBC (11.8% vs. 0%). Conclusions: Our data suggest that the laboratory parameters including CRP, hemoglobin, ESR, etc. are very useful in screening CD. More aggressive evaluation of the small and large intestine is recommended when patients with chronic gastrointestinal symptoms show abnormal values in these parameters. (Korean J Gastroenterol 2002;39:186-191)
위암의 조기진단을 위한 위액과 위 조직에서 Telomerase 및 TERT의 유용성
박영환 ( Young Hwan Park ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),장혜숙 ( Hye Sook Chang ),양석균 ( Suk Kyun Yang ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( Young Il Min ),오현주 ( Hyun Ju Oh ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> Telomerase는 세포의 사멸을 억제하는 효소로 여러 종류의 암 조직에서 활성도가 증가되어 있다. 또한 telomerase의 catalytic subunit인 telomerase reverse transcriptase (TERT)는 telomerase의 활성도를 조절하며, telomerase의 활성도가 나타나기 전에 그 활성도가 증가하는 것으로 알려져 있다. 따라서 telomerase나 TERT를 이용하여 암의 조기진단에 활용하려는 연구들이
졸링거 - 엘리슨 증후군과 동반된 다발성 내분비종 I 형 1 예
이영미(Young Mi Lee),정훈용(Hwoon Yong Jung),최선영(Sung Young Choi),강호형(Ho Hyung Kang),명승재(Seung Jae Myung),양석균(Suk Kyun Yang),홍원선(Weon Seon Hong),김진호(Jin Ho Kim),민영일(Young Il Min) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1
Zollinger-Ellison syndrome (ZES) is characterized by recurrent peptic ulcer and diarrhea caused by gastric acid hypersecretion due to gastrinoma. Approximately, one third of patients with gastrinoma have multiple endocrine neoplasia type I (MEN-I). The diagnosis of gastrinoma is difficult, although it can be cured by surgery after localization. Recently, the somatostatin receptor scintigraphy (SRS) was reported to be more sensitive than any other tumor-localization methods. We report a case of ZES with metachronous MEN-I. A 47-year-old woman had peptic ulcer disease with its complications and recently developed diarrhea. Her serum gastrin level was markedly elevated (1,098pg/mL) but the results of conventional imaging tests were negative. We confirmed the presence of gastrinoma by the selective intraarterial secretin injection and portal vein sampling. Then, the tumor was eventually located by SRS under the diagnosis of ZES. She underwent a Whipple`s operation with the compatible pathologic findings of gastrinoma. She was confirmed to have parathyroid hyperplasia and MEN-I during follow-up. (Korean J Gastroenterol 2002;39:50-54)
원발성 간암의 수술후 재발 양상과 조기 재발에 대한 예견 인자
김영호(Young Ho Kim),김정룡(Chung Yong Kim),이효석(Hyo Suk Lee),정훈용(Hwoon Yong Jung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A To evaluate predictors for early postoperative recurrence, we enrolled 64 patients with hepatocellular carcinoma (HCC) who had underwent curative resections at Seoul National University Hospital from January 1988 to May 1989. Among 64 patients, 5 patients who died of operation-related complications were excluded. During the mean period of follow-up of 16.9 month., recurrence of tumor was found in 37 of the remaining 59 patients; in the residual liver in 33 patients and in the distant organs in 4 patients. I'he recurrence rates at 6 at 12, and at 18 months after curative resection were 18.8%, 38.0% and 58.7%, respectively. The most common pattern of intrahepatic recurrence was bilateral multinodular type (43.2%). The recurrence rate higher in the patients with UICC-stage-III HCC than in those with stage- I or Il HCC. The recurrence rate within 6 months was the highest in the patients with angiographically diffuse infiltrative type regardless of UICC stage The size of tumor did not affect the recurrence rate. We concluded that the patients with UICC stage-III HCC, or those with angiographically diffuse infiltrative type HCC should be considered to be an unsuitable surgical indication, and the consideration of the therapeutic modalities other than surgical resection is warranted to reduce early recurrence and consequently improve patient's survival.
소화성궤양 가이드라인 비출혈 소화성궤양 치료의 가이드라인
정대영 ( Dae Young Cheung ),정훈용 ( Hwoon Yong Jung ),송호준 ( Ho June Song ),정성우 ( Sung Woo Jung ),정현채 ( Hyun Chae Jung ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.5
Over the past century, since the introduction of non steroidal anti-inflammatory drugs (NSAID), antacid, histamine H2-receptor antagonists (H2RA), proton pump inhibitors (PPI), and discovery of Helicobacter pylori infection, the paradigm of peptic ulcer disease has changed with marked decrease in morbidity and mortality. However, peptic ulcer disease still occupies a position as a major health problem with increase of aged population and NSAIDs usage. In daily general practice, the management of peptic ulcer disease is directed according to the presence of bleeding or not. For non-bleeding peptic ulcer disease, proper acid suppression and the correction of underlying causes such as Helicobacter pylori infection and NSAID use is the main stay of treatment. Though a complete understanding of pathophysiology and a perfect treatment strategy are still a challenge, this guideline aims to provide practical recommendations based on evidences or consensus of experts through in-depth literature review and expert meeting. (Korean J Gastroenterol 2009;54:285-297)
1990 년대 한국 성인에서 역류성 식도염의 유병률 변화
정성애(Sung Ae Jung),정훈용(Hwoon Yong Jung),김기락(Ki Rhack Kim),민영일(Young Il Min) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: The prevalence of reflux esophagitis has been considered to be low in Korea, but recent studies suggested that it has been increasing. The prevalence also is generally thought to be less in Korea compared to that in western countries. Methods: Data was collected from the leading medical journals published in Korea dealing with the prevalence of reflux esophagitis for last 10 years between 1990 and 1999 and annual reports of Health Promotion Center in Asan Medical Center of 1997 to 1999. Results: The prevalence was occupied 1.3% in the early period of 1990's, 5.3% in the middle and 7.2% in the late period in symptomatic group and 2.7%, 3.2% and 5.8% in asymptomatic group. The prevalence was reported 5.4% in 1997, 5.3% in 1998 and 7.0% in 1999 in asymptomatic group of annual report of Health Promotion Center in Asan Medical Center. Associated conditions in reflux esophagitis were hiatal hernia, alcohol consumption, smoking and obesity suggesting as risk factors. Conclusions: The prevalence of reflux esophagitis in Korea has increased in last 10 years of 1990' s but is still lower than that in the western countries. Continuous increase in the prevalence of reflux esophagitis in Korea is predictable and it leads to a greater concern for accurate diagnosis and rapid treatment of symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:161-167 )
담낭 답즙에서의 칼슘 결합 단백질 ( Calcium - binding Protein ) 에 관한 연구
김명환(Myung Hwan Kim),정성애(Sung Ae Jung),채희복(Hee Bok Chai),김해경(Hae Kyung Kim),김태형(Tae Hyung Kim),유병무(Byeong Moo Yoo),서동완(Dong Wan Seo),이미화(Mee Hwa Lee),이성구(Sung Koo Lee),정훈용(Hwoon Yong Jung),민영일(Young Il 대한내과학회 1997 대한내과학회지 Vol.52 No.4
N/A Objectives: Calcium salts are usually present in the center of all types of gallstones, including pure cholesterol stones. It has been postulated that precipitation of calcium salts might act as a nidus for gallstone formation. Our goal was to determine whether a calcium-binding protein was present in bile and whether this protein has any calcium-binding properties. Methods: Calcium-binding moiety was obtained by addition of CaC1(2) into the gallbladder bile. Calcium-binding protein was identified by SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). The capacity to bind calcium was confirmed by autoradiography with (45)Ca(+). Results: We identified a protein(M.W.≤kD) that precipitates from bile on addition of CaC1(2) at the final concentration of 0,5mol/L in control subjects. The protein was also observed in bile and stones of gallstone patients. The protein had the capacity to bind calcium and it. was confirmed by autoradio-graphy with (45)Ca(+). Conclusion: The presence of calcium-binding protein in bile and its ability to bind calcium suggest that it may play a functional role in the pathogenesis of gallstones.