여드름 환자에서 Propionibacterium acnes에 대한 항생제의 최저발육저지농도에 관한 연구

임연순(Yeon Soon Lim),명기범(Ki Bum Myung),정낙은(Nak Eun Chung),정화순(Wha Soon Chung) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

Background : Propioriacterium acnes plays an importantol in the development of inflammatory acne, and inflarnmatory lesions are improved by oralnc topical antibiotics. But as Pacnes frequently develop resistance to antibiotics in patients neing long term systemic antibiotic therapy, the theravuti effects diminish, and eventually thay fails. Objective : The purpose of this study is to evaluate theerral susceptability of P. acnes to antibiotics and the difference in the MIC depending on the of oral and/or topical antibiotics, therapeutic effects and disease duration in patients with acie ulgaris. Methods : We used twenty six strains of P. acnes which were obtained from patients with acne and performcd suseptibility testing for antibiotics usir the E test procedure. Results : 1. The growth of P. acnes was completely inhibited by e ythromycin and chloramphenicol at concentrations of 0.023ug/ml and 0.064ug/ml, respectively cefoxitin at 0.094ug/ml, and by tetracycline and clindarnycin at 0.190 ug/ml. 2. P. acnes was mot susceptible to erythromycin, and olwed by chloramphenicol, cefoxitin, tetracycline, clindamycin in order of decreasing susceptibilit . 3. There were no significant differences in the MIC in reat in to previous antibiotic treatment. 4. For tetracycline, The MIC was significantly lower(p<0.01) in patients who improved after treatment. 5, For tetracycline and chloramphenicol, the MIC was grficantly lower(p<0.05) in patients with less than 2 years disease duration. Conclusion : The susptibility of antibiotics for P. acneias highest in erythromycin. There were no significant differences in the MIC in relation to prvious antibiotic treatment, and for some antibiotics the suseptibility was low in patients who dill not show clinical improvement or who had long disease duration. (Kor J Dermatol 1995;33(3): 437-444)

요로계 병원성 Escherichia coli의 부착인자

이경상(Kyung-Sang Lee),김경희(Kyung-Hee Kim),조양자(Yang-Ja Cho),정화순(Wha-Soon Chung) 大韓微生物學會 1993 大韓微生物學會誌 Vol.28 No.2

본태성 혼합 한냉글로부린 혈증 1 예

이창우(Chang Woo Lee),김선종(Seon Jong Kim),김재홍(Jae Hong Kim),정화순(Wha Soon Chung) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1

A 52-year-old woman with esential mixed cryoglobulinemia (type II ), which was confirmed by cryoglobulin elcct,rophoresis and immunofixation elect,rophoresis, had purpuric skin lesions on the legs. The lesions had a tendency of recurrence for the past 2 years, and moderate degrees of arthralgia and myalgia were accompanied in each time. However, the patient had not been suffered from any internal organ distress caused by the disease proress. Histological examinations of a skin lesions revealed a feature of leukocytoclatic vasculitis, and deposits of IgM, IgG and C; were also recognized. A regimen of small doses of prednisolone was effective for the cutaneous lesions in this patient for 4 months follow-up until this writing. It, seems that the patient has had a mild form of the disease among the clinical spectrum of mixed cryoglobulinemia, with a cryocrit value of 2.4% at the time of her initial visit.. (Kor J Dermatol 29(1) .120 125, 1991)

류마티스 관절염 환자에서 저용량 메토트렉세이트 치료 시 혈장 호모시스테인의 농도 변화

장지은 ( Ji Eun Chang ),이지수 ( Ji Soo Lee ),정화순 ( Wha Soon Chung ),이미애 ( Mi Ae Lee ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1

Objective: To determine the effect of short term methotrexate (MTX) therapy and subsequent folic acid (FA) supplementation on plasma homocysteine (p-homocysteine) levels in patients with rheumatoid arthritis (RA). Methods: Sixteen RA patients treated with low dose MTX (10 mg/week) were prospectively studied for 8 weeks. Sixteen age and sex matched healthy individuals were included for control. Serial p-homocysteine levels were determined before the initiation of MTX, 4 weeks after the MTX treatment, and further 4 weeks after FA supplementation. FA and vitamin B12 levels were determined before MTX treatment. Results: Baseline p-homocysteine levels were not significantly different between the RA patients and the controls (7.63 vs 8.40μmol/L). However, in patients with RA, FA levels negatively correlated with the baseline p-homocysteine levels (p=0.009), whereas this negative correlation was not found in the controls. RA patients showed increased tendency in homocysteine levels after MTX treatment without folic acid supplementation but did not reach statistically significance (8.4 vs. 9.06μmol/L, p=0.57). With FA supplementation, the p-homocysteine levels significantly decreased to the level lower than the baseline value before treatment (8.40 vs. 7.05μmol/L, p=0.004). Conclusion: Folic acid nutriture is an important factor in determining baseline p-homocysteine levels. Folic acid supplementation during low dose MTX therapy result in decrease in p-homocysteine level, thereby, may be helpful to decrease the cardiovascular risk in patient with RA receiving MTX.

만성 간질환에서의 ICG - Rmax 와 Thallium - 201 Test per Rectum ( Sunt Index ) 의 임상적 의의

이경상(Kyung Sang Lee),황선호(Seon Ho Hwang),함준수(Joon Soo Hahm),이종철(Jong Chul Rhee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이민호(Min Ho Lee),정화순(Wha Soon Chung),조석신(Seok Shin Cho),이재원(Jae Won Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.1

N/A Objectives: Thallium-201 test per rectum (shunt index) and ICG-Rmax have been used for studying the portosystemic shunt and the functional reserve of liver. The clinical values of shunt index and ICG-Rmax in pateints with chronic liver disease were evaluated using the data obtained in 74patients. Methods: 0.5mCi thallium-201 was administered per rectum to 37 patients witchronic active hepatitis (CAH) and 37Patients with liver cirrhosis, and the heart to liver uptake ratio was taken at 20min. ICG-Rmax was also taken using Paumgartner`s method. We used simple linear regression and ANOVA methods for the correlation between ICG Rmax and shunt index. Results: 1) The mean shunt index was 0.251±0. 140 in CAH group and 0.565±0.351 in cirrhosis group (P<0,005). 2) The mean ICG-Rmax was 1.720±l.320 (mg/kg/ min) in CAH group and 0.867±0.625 in cirrhosis group (P<0 005). 3) There was no significant correlation between ICG- Rmax and shunt index in CAH group (P=0.358). 4) Correlation between ICG-Rmax and shunt index was significant in cirrhosis group (P=0,001; R-square= 0 321; 1/ICG-Rmax=2 64 * shunt index+0.49) Conclusions: Thallium-201 scintigraphy per rectum and ICG-Rmax may be useful in diagnosis of chronic liver diseases, especially differentiating CAH from cirrhosis. These study will help us to predict the prognosis of chronic liver diseases and give us more information for the treatment of chronic liver diseases.

류마티스 관절염 환자에서 빈혈에 대한 임상적 고찰

심승철(Seung Cheol Shim),전재범(Jae Bum Jun),정성수(Sung Soo Jung),이인홍(In Hong Lee),배상철(Sang Cheol Bae),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),정화순(Wha Soon Chung),정낙은(Nak Eun Chung) 대한내과학회 1994 대한내과학회지 Vol.47 No.6

N/A Objectives : Anemia is the most common extra-articular manifestation of rheumatoid arthritis (RA). However neither the frequency of anemia in the patients of RA nor the role of erythroid abnormalities in various types of anemia have been reported previously in Korean population. Methods : To establish the frequency of anemia and the role of erythropoietin in the pathophysiology of anemia, 500 patients with RA were selected randomly from the patients who were diagnosed at Rheumatism center of Hanyang university hospital from January 1993. Results : 1) In the series of 500 RA patients, 196 patients (39.2%) had anemia, and 127 of 196 patients with anemia had mild anemia (Hb more than 10.0 g/dl), the other 69 patients (35%) had moderate to severe anemia. 2) 92 (77.3%) of 120 patients with anemia had anemia of chronic disease (ACD) and iron deficiency anemia (IDA) was observed in 26 patients (22.7%). Other types of anemia were also found: one case had vitamin B12 deficiency anemia, the other case had autoimmune hemolytic anemia. 3) 17 patients with ferritin between 20~100 ng/ml were examined bone marrow aspiration and biopsy. The results of bone marrow biopsy were identical with that of Iron index (=-0.00446×TIBC+1.22765×Log ferritin-0.07824) except one case, 4) ACD had higher value of Ritchie index, ESR, functional class than IDA (p<0.01), Serum iron had no significant differences between ACD and IDA, but TIBC and ferritin had significant differences between two groups (p<0.01). 5) Ritchie index versus Hb (r=-0.38. p<0.01)'and ESR versus Hb (r=-0.53, p<0.01) were negatively related but there were no significant differences in disease duration. 6) Serum erythropoietin was 17.27±1.3 mu/ml in ACD and 35.64±1.7 mu/ml in IDA, and there were significant differences between these two groups (p<0.01). Conclusions : Iron index is a useful method for differential diagnosis between ACD and IDA. In ACD, erythropoietin may be effective in rheumatoid arthritis with moderate to severe anemia.

심한 호산구 증가증을 동반한 류마티스 관절염 1예

손정일 ( Chong Il Sohn ),김명곤 ( Myeong Kon Kim ),이기창 ( Kee Chang Lee ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ),정화순 ( Wha Soon Chung ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.1

호산구 증가증의 원인은 기생충 감염, 알레르기, 약제, 교원성 질환, idiopatic hypereosinophilic syndrme 등에서 나타나며 류마티스 관절염에서는 약 10%의 환자에서 호산구 증가증을 보인다고 한다. 류마티스 질환에서 호산구 증가증은 류마티스 관절염, 다발성 동맥염 및 혈관염, 유육종증 둥과 연관되고 idiopathic hypereosinophilc syndrme이나 골수 증식성 질환, 호산구성 백혈병 등과 감별을 요하며 집중적으로 추적 관찰해야 한다. 저자들은 53세 여자 환자에서 지속적이고, 심한 호산구 증가증이 동반된 류마티스 관절염 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Eosinophilia is usually accompanied by parasite infestation, allergic condition, drug, collagen disease, and idiopathic hypereosinophilic syndrome. In about 10 to 40% of rheumatoid arthritis patients, peripheral blood reveals eosinophilia. Of the rheumatic disease, eosinophilia may occur in rheumatoid arthritis, sarcoidosis, polyarteritis nodosa and other vascultis. Patient with eosinophilia must be carefully followed up due to possibility of progression to eosinophilic leukemia or myeloproliferative disease. We experienced a case of rheumatoid arthritis with severe eosinophilia for a period of more than one year in a 53 year-old female patient, eosinophil more than 85% in the peripheral blood, but in spite of careful laboratory study, there was no evidence of parasite infestation, allergic disease and malignant condition that may cause eosinophilia. Therefore we concluded that her severe eosinophilia was associated with rheumatoid arthritis itself, and now she is intensively followed up at the outpatient department. We have to look for any malignant transformation during her clinical course. Marked eosinophilia associated with rheumatoid arthritis is very rare, so we report this case with a review of literatures.

혈액학검사 신빙도조사 결과보고(1997)

정화순,나동진,도화섭,송경순,양동욱,윤형두,윤홍섭,이웅수,조한익,한경자 대한임상검사정도관리학회 1998 臨床檢査와 精度管理 Vol.20 No.1

1997년도에는 전국 410여기관을 대상으로 4월, 5월, 7월, 8월 4회에 걸쳐 실시한 혈액학 검사의 신빙도 조사는 다음과 같았다. 검사종목은 전년도와 같이 백혈구수, 혈색소, 혈소판수, 적혈구수, 망상적혈구수, 백혈구 감별계산, 혈구형태판독의 7종목이였다. 회신율은 73.1%로 전년도와 유사하였다. 정도관리 실시전에 참여여부를 조사후 실시함이 회신율도 높이고 효과적일 것으로 사료된다. 혈구검사는 3기관을 제외한 전 병원에서 자동화기기로 전환되었다. 백혈구수, 혈색소, 혈소판수, 적혈구수 등의 검사는 평균 변이계수의 추이를 볼 때 상당히 개선이 있었다. 그러나 망상적혈구수, 백혈구 감별계산, 혈구형태판독 등 사람이 직접 현미경으로 관찰하는 검사는 별로 개선이 없이 비슷한 수준에 머물러 실사 및 웍? 등을 통한 교육으로 적극적인 개선이 요구된다. 금년에는 혈액학검사의 가장 기본 검사인 혈구측정기기인 자동혈구계산기의 원리와 보수점검이라는 주제하에 우리나라 대부분 병원에서 사용하고 있는 기기 등을 중심으로 웍?이 개최되었었다. Four trials of external quality assessment in diagnostic hematology were performed in 1997 with 403 participitating laboratories in Korea. We performed quality assessment for complete blood cell count white blood cell count, hemoglobin, red blood cell count, platelet count, reticulocyte count, white cell differential count, red blood cell morphology. Most laboratories 98.5% made was of automated cell counter for CSC. The performance of Quality assessment appeared to be gradually improved year by year.

혈액학검사 신빙도조사 결과보고(1995)

정화순,나동진,도화섭,송경순,양동욱,윤형두,윤홍섭,이옹수,조한익,지현숙,한경자 대한임상검사정도관리학회 1996 臨床檢査와 精度管理 Vol.18 No.1

1995년에 전국 350여기관을 대상으로 5월, 8월, 11월 3회에 걸쳐서 실시한 혈액학 검사의 신빙도 조사결과는 다음과 같았다. 검사종목은 전년도와 같아 백혈구수, 혈색소, 혈소판수, 적혈구수, 망상 적혈구수, 백혈구 감별계산, 혈구형태판독의 7종목 이었다. 자동화기기의 사용은 전년도와 같이 대부분의 병원에서 (97.5%) 자동기기를 사용하고 있고 수동법은 검사의 신뢰도가 매우 낮으므로, 자동화기기로 전환이 요구된다. 대부분 검사의 평균변이계수의 변화추이를 볼 때 상당한 개선이 있어왔다. 결과기록의 오류나 관리검체 사용상의 미숙은 많이 줄어들었으나 이러한 결과가 전기관의 결과에 나쁜 영향을 끼치므로 세심한 주의가 요구된다. Three trials of external quality assessment in diagnostic hematology were performed in 1995 with 351 participitating laboratories in Korea. We performed quality assessment for complete blood cell count(white blood cell count, hemoglobin, red blood cell count, platelet count), reticulocyte count, white cell differential count, red blood cell morphology, Most laboratories (97.5%) made use of automated cell counter for CBC. The performance of quality assessment appeared to be gradually improved year by year.

성인에 발생한 신아세포종 1예

정화순,송옥평,김춘원,김기홍 대한병리학회 1979 Journal of Pathology and Translational Medicine Vol.13 No.3