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RISS 인기검색어
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- 저자 : 정호경 ( Ho Gyeong Jeong ) (검색결과 4 건)
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Endothelin - 1 에 의한 돼지 관상동맥 수축에 미치는 17β - Estradiol 의 효과
정호경(Ho Gyeong Jeong),강병선(Byeong Sun Kang),김민구(Min Gu Kim),박병건(Byeong Gun Park),황진용(Jin Yong Hwang),서봉관(Byeong Sun Kang) 대한내과학회 1997 대한내과학회지 Vol.52 No.2
N/A Objectives: It is widely accepted that estrogen has favorable effects on cardiovascular diseases, especially in the postmenopausal women. Endothelin- 1(ET-I), released from the vascular endothelium, is a 21-amino acid peptide with strong vasoconstrictor activity. However, the effect of estrogen on the vasoconstriction to ET-1 has not been extensively studied. Methods: To investigate the effect of estrogen (175β-estradiol) on the vascular contraction to ET-1, porcine coronary artery(PCA) rings were suspended in organ chambers(37℃, 95% O2/5% CO2) for measurement of isometric tension change. Endothelium was removed mechanically if necessary. In acute experiments, vascular rings were preincubated for 15minutes with 3different concentrations of 170β-estradiol(10(-6), 10(-5), 10(-4)M) and concentration-contraction curves to cumulative doses of ET-1 were constructed. In the experiments after a longer exposure to 17β-estradiol, the vessels with endothelium were exposed in the 5% CO2 incubator to 3different concentrations of 17β-estradiol(10(-9), 10(-8), 10(-7) M) for 44-50 hours, and then concentrationcontraction curves to ET-1 were obtained. Results: Incubation for 15minutes with 170β-estradiol(10 -4)M) inhibited ET-1-induced contraction in the vessels with endothelium(area under the curve and maximal contraction, p<0.05 compared with control). This effect persisted regardless of the sex and the presence or absence of the endotheliurn. Incubation of the vessels far a longer time with 170β-estradiol(44-50 hours) resulted in the inhibition of maximal contraction to ET-1(p<0.05) by a lower concentration of 175β-estradiol(10(-7)M) than in acute experiments in male PCA rings, but an enhanced contraction to ET-1(area under the curve; p<0.05) by 10M of 175β-estradiol was observed in female PCA rings. Conclusion: Short-time incubation with 17Pβ-estradiol has an inhibitory effect on the contraction to ET-1 in PCA rings. This effect is independent of the presence of the endothelium and the sex of the pigs. A longer incubation with 17β-estradiol results in a similar inhibitory effect on male(but not female) PCA rings, suggesting that a sex-related difference may exist concerning the effect of 17β-estradiol on ET-1-induced contraction.
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AMBU(Air Mask Bag Unit) 환기로 복강기종과 종격동기흉이 합병된 중증 천식
조훈 ( Jo Hun ),최병문 ( Choe Byeong Mun ),정호경 ( Jeong Ho Gyeong ),박자영 ( Park Ja Yeong ),장병일 ( Jang Byeong Il ),선우미옥 ( Seonu Mi Og ),서찬희 ( Seo Chan Hui ),성한동 ( Seong Han Dong ),신미정 ( Sin Mi Jeong ),황순철 ( H 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.6
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상부 위장관 아니사키스증 141예에서 점막의 변화 및 영향인자
이은정 ( Eun Jung Lee ),김영채 ( Young Chai Kim ),정호경 ( Ho Gyeong Jeong ),이옥재 ( Ok Jae Lee ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.2
목적: 아니사키스증은 해산물 생식에 의한 기생충감염으로 많은 증례보고가 있으나 아니사키스증의 내시경 특징 및 임상 양상에 대한 분석은 미흡한 실정이다. 이 연구에서는 상부위장관 내시경 검사 중에 진단한 아니사키스증의 내시경 특징과 임상 양상을 분석하여 점막변화에 영향을 미치는 인자를 알아보고자 하였다. 대상 및 방법: 1999년 10월부터 2006년 9월까지 상부위장관 내시경 검사에서 아니사키스를 발견하고 제거하였던 141예를 대상으로 내시경 검사 보고서 및 의무기록을 후향 분석하였다. 결과: 연령은 40대가 63명(44.7%)으로 가장 많았으며, 여자가 남자의 1.82배였다. 발병계절은 겨울이 41.1%로 가장 많았고, 겨울, 봄, 가을, 여름 순으로 발생하였다. 환자의 76.6%에서 회섭식 후 12시간 이내에 증상이 발현하였고, 가장 흔한 증상은 급성 상복부 통증이었다. 유충은 위체부의 하부 중부 대만부에서 가장 흔하게 발견되었고, 유충 위치에 따른 증상 발현에 걸린 시간은 식도가 3시간으로 가장 짧고 위저부가 18.7시간으로 가장 길었다. 내시경 소견은 점막부종이 90.8%로 가장 흔한 소견이었으나, 미란, 출혈, 발적과 함께 위궤양 및 활동 출혈을 보이기도 했으며 점막하종양의 소견을 보인 경우도 31.9%였다. 점막변화의 중증도가 심할수록 내시경 검사를 받기까지 소요시간이 짧았고 경할수록 소요시간이 긴 환자가 많았다(p=0.048). 결론: 아니사키스증의 내시경 소견은 증상발현 후 내시경 검사를 받기까지 소요시간에 따라 매우 다양하며, 검사가 늦을수록 점막변화가 경미하므로 진단이 어려워질 수 있다. 따라서 해산물 생식 후 급성 위장관 증상을 호소하는 환자에서 신속한 내시경 검사가 필요하다. Background/Aims: Anisakiasis is a well known parasitosis resulted from eating raw seafoods and there were many reports of cases. However, its endoscopic and clinical characteristics have not been reviewed well. The aim of this study was to clarify the gastric mucosal changes and influencing factors of upper gastrointestinal (UGI) anisakiasis. Methods: We analyzed retrospectively the endoscopic and clinical characteristics of 141 cases with UGI anisakiasis diagnosed during UGI endoscopy, based on the review of medical records. The patients` data were collected consecutively from October 1999 through September 2006. Results: In the 141 patients with UGI anisakiasis, the peak age was the 40s (44.7%). The female to male ratio was 1.82:1. The most prevailed season was winter (41.1%). The most frequent symptom was acute epigastric pain and 76.6% of the patients developed symptoms within 12 hours after the ingestion of raw seafoods. The greater curvature of body was the most preferred site of anisakid larvae. The median time from meal to symptom onset was shortest in esophageal location and longest in fundus location (3 vs. 18.7 hours). The various mucosal changes were observed and the most frequent mucosal change was edema (90.8%). Submucosal tumor was also found in 31.9% of the patients. The severity of mucosal change was related inversely with the time interval from meal to endoscopy (p=0.048). Conclusions: Anisakiasis presented various mucosal changes depending on the time interval from ingestion of raw seafood to endoscopy. Delayed endoscopy may lead chronic mucosal change and cause difficulty in the detection of anisakiasis. Therefore, the prompt endoscopic examination is required for the patients presenting acute gastrointestinal symptoms after taking raw fish. (Korean J Gastroenterol 2009;53:90-97)
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