비듬에 대한 통계적 관찰 및 진균학적 성상

정현주(Hyeon Joo Jung),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2

Background: Previous studies suggested that Pityrosporum may play an important role in the pathogenesis of dandruff. Objective : Our purpose was to study the statistical and mycobgic findings of dandruff in normal subjects for better understanding of this condition. Methods : Scales frorn the scalp of 384 students were studied stastistically by answer sheets and clinically by a dermatologist. Mycologic studies of Pityrosporum were also performed by direct smear, culture and inoculation to guinea pigs. Results : There were 76.0% subjects with dandruff. Clinically grading the subjects by Kligrnan's scale, grade III and IV(mild caling) were the most. Dandruff developed commonly at the age of 14 to 16, and no seasonal change was observed. Spores of Pityrosporum were observed in all subjects by KOH microscopic examination with Cohens method, and the grading of the dandruff was not related with the number of the spores. In most subjects, P. orbiculare and P. ovae were found together. Positive culture colonies were observed in 93.7%. Inoculation of the cultured colonies to guinea pigs resulted in an experimental dermatitis. Conclusion : Our study shows that Pityrosporum may involve in the pathogenesis of dandruff; however, it is still unclear whether Pityrosporum is a main causative agent of dandruff. (Kor J Dermatol 1993; 31(2): 164-174)

지루 피부염과 아토피 피부염의 임상증상과 두피내 Malassezia균 분포의 비교

황성주 ( Sung Joo Hwang ),이성훈 ( Sung Hoon Lee ),김도원 ( Do Won Kim ),전재복 ( Jae Bok Jun ),정상립 ( Sang Lip Chung ),정현주 ( Hyeon Joo Jung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

A Case of Atypical Thrombotic Microangiopathy

오지영,박세진,김기환,임범진,정현주,기정혜,김기혁,신재일,Oh, Ji Young,Park, Se Jin,Kim, Ki Hwan,Lim, Beom Jin,Jeong, Hyeon Joo,Ki, Jung Hye,Kim, Kee Hyuck,Shin, Jae Il Korean Society of Pediatric Nephrology 2013 Childhood kidney diseases Vol.17 No.2

We report the case of a 14-year-old girl, diagnosed with atypical thrombotic microangiopathy (TMA). The patient presented with persistent fever, nausea, and newly developed peripheral edema. Her laboratory findings indicated chronic anemia with no evidence of hemolysis, thrombocytopenia, or elevated serum creatinine level. A few days after hospitalization, acute renal failure and fever worsened, and proteinuria developed. On day 40 of hospitalization, she experienced a generalized tonic seizure for 5 min, accompanied by renal hypertension. Brain magnetic resonance imaging revealed posterior reversible leukoencephalopathy syndrome. After steroid pulse therapy, a renal biopsy was performed because of delayed recovery from thrombocytopenia. The biopsy findings showed features of thrombotic microangiopathic hemolysis with fibrinoid change restricted. Current diagnostic criteria for TMA have focused on thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, and diagnosis is based on the clinical presentation and etiology, with the consequence that idiopathic and atypical forms of TMA can be overlooked. Developing effective tools to diagnose TMA, such as studying levels of ADAMTS13 or testing for abnormalities in the complement system, will be the first step to improving patient outcomes. 응고성 미세혈관병증은 빠른 진단이 예후에 중요한 인자이나, 현재의 진단 기준에 따라서는 thrombotic thrombocytopenic purpura, haemolytic uremic syndrome 외의 비전형적인 응고성 미세혈관병증의 진단이 늦어짐에 따라 나쁜 예후를 초래하게 되는 경우가 많다고 보고되어 있다. 본 저자들은 시행한 혈액 검사상 용혈의 증거가 없는 빈혈, 혈소판 감소증 그리고 급성 신부전을 보인 소아 환아에서 신조직 검사를 통해 비특이적 응고성 미세혈관병증을 진단받은 1증례를 보고하고자 한다. 14세 여자 환아는 3주간 지속된 발열, 구역과 전신 부종을 주소로 본원으로 전원되었다. 내원하여 시행한 혈액 검사상 빈혈과 혈소판 감소증을 보였으나, 용혈의 증거는 없었으며, 혈정 크레아티닌이 증가되어 있었다. 내원 이후 급성 신부전과 발열은 지속적으로 진행되었으며, 소변 검사상 단백뇨가 발생하였다. 환아는 내원 40일경 신고혈압과 동반된 전신 경련이 5분간 있어 뇌 자기 공명 영상을 촬영하였으며, 가역성 후백질 뇌병증 증후군의 양상을 보여 항 경련제 투여를 시작하였다. 이후 지속되는 혈소판 감소증 및 발열은 고용량 스테로이드 치료를 진행한 후 호전되었으나, 급성 신부전 및 단백뇨가 지속되어 신장 조직 검사를 진행하였으며, 검사 결과상 혈전성 미세혈관병증의 소견을 보였다. 이와 같이 조직검사상에서는 응고성 미세혈관병증을 보이나 전형적인 응고성 미세혈관병증의 혈액학적인 진단 기준이 충족되지 않는 비특이적 형태의 응고성 혈관병증의 효과적인 진단을 위하여 보체 기전이나 ADAMTS 13와 같은 유전자 범위의 보다 활발한 연구를 통한 효과적인 진단 기준의 마련이 되어야 할 것으로 보인다.

두피의 지루피부염에 대한 임상적 관찰과 Pityrosporum의 분포

백승혜,정상립,김도원,정현주,최성관 ( Seung Hye Paek,Sang Lip Chung,Do Won Kim,Hyeon Joo Jung,Sung Kwan Choi ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

Background: Seborrheic dermatitis is a very common chronic inflammatory disease. Previous studies suggested that, Pityrosporum, lipophilic fungi, may play an important role in the pathogenesis of the disease. Objective : The purpose of this study was to investigate the disease clinically and mycologically for better understanding of the pathogenesis. Methods : Two hundred and one new patient.s with seborrheic dermatitis of the scalp and 67 norrnal subjects were obs!,rved clinically by the dermatologist and studied stat,istically by questionnaires. A mycologic study of Pityrosporum was also performed by direct smear. Results : Among a total of 201 patients wit,h seborrheic dermatitis, 72.6% had pityriasis sicca, 10.5% had pityr iasis steartoides and 16.9% had inflammatory seborrheic dermatitis. On clinical grading by the Kligman.. scale, grade III(slightly scaling) was the most common in the patients and 52.6% of the norma. subjects were below grade II (no scaling). Spores of Pityrosporum were observed in 76.7% of the patients and 91.5% of the normal subjects. The incidence of Pityrosporum was lower particularly in t,he patients with inflammatory seborrheic dermatitis t,han in other pa~tients groups. Conclusion : According to the results of the study, it, is difficult to conclude that Pityrosporum is a main causative ager t of seborrheic dermatitis. In addition, it is thought t.hat further studies of the role of Pityrosporum in seborrheic dermatitis are needed. (Kor J Dermatol 1997;35(1): 22-32)

WiFi 기반 IoT 기기에 대한 실시간 공격 차단 시스템

윤필도(Pil-Do Yoon),정현주(Hyeon-Joo Jeong),김정윤(Jung-Yoon Kim),황경호(Gyung-Ho Hwang) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.11

무선 공유기를 통해 와이파이 통신을 사용 중인 IoT 기기들에 외부로부터의 공격 시도가 있는지를 머신러닝 모델을 통해 확인하여 사용자의 인가 없이 IoT 기기에 대한 공격을 감행하는 것을 감지한다. 사용자는 이와 같은 정보를 반응형 웹을 통해 실시간으로 모니터링할 수 있으며, 직관적인 UI를 통해 공격에 대한 구체적인 정보를 확인할 수 있다. 시스템을 구성하기 위해 무선공유기 오픈 소스를 활용하여 와이파이 통신 환경을 구축하고, IoT 기기의 송수신 패킷을 캡처한다. 패킷 캡처 파일은 학습된 머신러닝 모델을 사용하여 공격 여부를 판단한다. 판단된 공격 여부와 상응하는 패킷의 정보를 데이터베이스에 저장하여 이를 웹에서 확인할 수 있는 시스템을 구현하였다.

소아 $Henoch-Sch\"{o}nlein$ 자반병 신염의 임상양상 및 병리소견과 임상경과

허윤정,신재일,박지민,정현주,이재승,Huh Yun-Jung,Shin Jae-Il,Park Jee-Min,Jeong Hyeon-Joo,Lee Jae-Seung 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.1

목적 : $Henoch-Sch\"{o}nlein$ 자반병은 자연 관해 질환으로 예후는 대체로 양호하나, 신장침범 유무가 장기적 예후의 중요한 인자로 알려져 있다. 이에 저자들은 $Henoch-Sch\"{o}nlein$ 자반병 신염을 진단받은 환아를 대상으로 임상양상 및 병리학적 소견과 그에 따른 임상결과를 알아보고자 본 연구를 시행하였다. 방법 : 1990년부터 2002년까지 연세대학교병원 소아과에서 $Henoch-Sch\"{o}nlein$ 자반병으로 진단받은 260명 중 $Henoch-Sch\"{o}nlein$ 자반병 신염이 100명이었으며 그 중 신장 조직검사를 한 60명을 대상으로 임상양상 및 병리학적 소견과 임상결과와의 관련성을 후향적으로 조사하였다. 결과 : 1) 남녀 비는 1.2 : 1이었다. 2) $Henoch-Sch\"{o}nlein$ 자반병 신염 환아 60명 중 81%에서 질병발병 후 3개월 이내 신장을 침범한 것으로 나타났다. 3) 현미경적 혈뇨를 동반한 경우는 100%, 단독 혈뇨 15%, 신염 증후군 7%, 신증후군을 동반한 경우는 22%였으며 임상양상과 임상결과 간에 관련성이 있었다. 4) 혈청 IgA의 증가는 60%에서 보였으며 임상결과와 관련성이 없었다. 5) 임상양상은 병리학적 소견과 연관성이 없었다. 6) 신조직 병리소견의 ISKDC의 분류에 따른 빈도는 G I 5.0%, G II 30.0%, G III 58.3%, G IV 5.0%, G V는 1.7%로 G II와 G III가 가장 많았다. 7) G I, G II는 비교적 양성 경과를 보였고, G IV는 임상결과 B를 G V는 임상결과 D를 보여 병리학적 소견은 임상결과와 관련성이 있었다. 결론 : $Henoch-Sch\"{o}nlein$ 자반병 신염에서, 신장 침범의 임상양상은 임상결과와 관련성이 있었고 병리학적 소견도 임상결과와 관련성이 있었다. 조직학적 변화가 심할수록 예후가 불량한 것으로 나왔으며 향후 병리학적 소견에 따른 치료에 대한 적극적인 연구 및 추적관찰이 필요하다고 사료된다. Purpose : $Henoch-Sch\"{o}nlein$ purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven $Henoch-Sch\"{o}nlein$ purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings. Methods : The clinical features, initial laboratory and pathologic findings, and clinical out-come were evaluated in 60 children with biopsy-proven $Henoch-Sch\"{o}nlein$ purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002. Results : The ratio of male to female patients was 1.2:1. The interval between the onset of $Henoch-Sch\"{o}nlein$ purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome In 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome. Conclusion : Renal manifestation and pathologic findings correlated with the clinical out-come. It is necessary to evaluate the correlation between pathologic findings and treatment.

이종 간장 및 신장을 통한 자연항체 흡수후 이종이식 신장에서의 초급성 거부반응 변화에 관한 연구

오창권(Chang Kwon Oh),정현주(Hyeon Joo Jeong),김주형(Joo Hyung Kim),왕희정(Hee Jung Wang),김명욱(Myung Wook Kim) 대한외과학회 1999 Annals of Surgical Treatment and Research(ASRT) Vol.56 No.1

종격동에 발생한 악성 섬유성 조직구종

오제덕 ( Jea Duk Oh ),김형중 ( Hyung Jung Kim ),안철민 ( Chul Min Ahn ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ),정현주 ( Hyeon Joo Jeong ),이광길 ( Kwang Kyl Lee ),이두연 ( Doo Yun Lee ) 대한결핵 및 호흡기학회 1989 Tuberculosis and Respiratory Diseases Vol.36 No.4

Thin Glomerular Basement Membrane Disease를 동반한 베게너육아종증

황학진 ( Hak Jin Hwang ),손주익 ( Ju Ik Son ),인병현 ( Byeong Hyun In ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ),정현주 ( Hyeon Joo Jung ),송정식 ( Jung Sik Song ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3

Wegener`s granulomatosis is a necrotizing, granulomatous vasculitis that involves multiple organs including the upper and lower respiratory tract and the kidney. The kidney initially exhibits focal necrotizing glomerulonephritis, which progresses to crescentic glomerulonephritis in Wegener`s granulomatosis. We experienced a case of Wegener`s granulmatosis which was associated with a thin glomerular basement membrane disease. The patient suffered from nasal stuffiness, recurrent serous otitis media, and tinnitus. Despite antibiotic therapy and ventral tube insertion, symptoms did not improve and hearing difficulty was aggravated. Ulcerative, necrotizing granulomatous inflammations with multinucleated giant cells were seen on nasal biopsy. She had recurrent microscopic hematuria and the renal biopsy findings by light and immunofluorescent microscopy did not reveal any abnormalities but diffuse thinning of the glomerular basement membrane (226nm) was observed by electronmicroscopy. With the above clinical findings and biopsy results, we diagnosed Wegener`s granulmatosis with thin glomerular basement membrane disease. Thin glomerular basement membrane disease, also called benign recurrent hematuria, is characterized by diffuse thinning of the glomerular basement membrane and hematuria. Weekly low-dose methotrexate together with prednisone was used as treatment regimen because nonglomerular microscopic hematuria may be the first sign of cyclophosphamide-induced renal toxicity. With the above combination therapy, she felt well-being sense and her hearing difficulty was also much improved. She has been treated as an outpatient with glucocorticoid.

신조직 검사로 입증된 루푸스 신염에 대한 치료 효과 및 예후 인자에 대한 후향적 연구

이찬희 ( Chan Hee Lee ),서창희 ( Chang Hee Suh ),이충원 ( Choong Won Lee ),이원기 ( Won Ki Lee ),이지수 ( Ji Soo Lee ),박용범 ( Yong Beom Park ),송정식 ( Jung Sik Song ),송창호 ( Chang Ho Song ),정현주 ( Hyeon Joo Jeong ),최규헌 ( 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.1

Objectives: To evaluate the clinicopathologic character, therapeutic outcome, and prognostic factor of biopsy-proven lupus nephritis. Methods: Biopsy proven lupus nephritis patients who were admitted at Yonsei Medical Center from January 1986 to June 1997 were included in this study. We retrospectively reviewed the medical records. Patients were treated with steroid regimen with or without cyclophosphamide. According to the therapeutic response, patients were divided into two groups: therapeutic response group and therapeutic nonresponse group. Results: The results are as follows; 1. Among 68 biopsy-proven lupus nephritis cases, 54 patients who were treated at least 6 months were included in this study. 2. The mean follow up duration was 51 months. Mean serum creatinine was 1.4mg/dl, 24-hour proteinuria was 4,868mg, and anti-DNA antibody was positive in 76% at the time of renal biopsy. 3. Diffuse proliferative nephritis was the most common pathologic findings(32 cases, 59%). Activity index was highest in diffuse proliferative nephritis. 4. Overall 5-year renal survival rate was 25% and there was no difference between steroid single therapy and cyclophosphamide combination therapy. In diffuse proliferative nephritis, 5-year renal survival rate was 18% and there was no difference according to treatment. 5. Factor affecting therapeutic response was pathologic classification; diffuse proliferative nephritis was associated with poor therapeutic response(p=0.032). 6. Six patients(11%) progressed to end stage renal disease. 7. Major complications with treatment were infections including herpes zoster. Conclusion: In our series of lupus nephritis, diffuse proliferative nephritis was poor prognostic factor.