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정진환,이상칠,김동우,박대송,이슬기,박철휘,염학렬,김현민,송민석,Jung, Jin-Hwan,Lee, Sang-Chil,Kim, Dong-Woo,Park, Dae-Song,Lee, Seul-Ki,Park, Chul-Hui,Yeom, Hak-Ryul,Kim, Hyeon-Min,Song, Min-Seok 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.1
Carcinoma ex pleomorphic adenoma is transformed at the incidence of 1-20% in pleomorphic adenoma and frequently recurred. It accounts for 10% of all malignant salivary tumors and its average age of occurrence is 60s. It will present in a large, long-standing pleomorphic adenoma or in one that was previously treated but has recurred. According to cell composition in malignant cell carcinoma, and clear cell adenocarcinoma. Most (75%) occur in parotid gland, while about 20% occur in the minor gland of the oral mucosa. The metastasis rate to regional lymph node is about 25%, and to distant organs about 33% and the 5-year survival rates are 40%. Though the treatment of the carcinoma ex pleomorphic adenoma is not established, it is treated ideally with and extensive resection, neck dissection, postoperative radiotherapy, and chemotherapy. When occurred in parotid gland, facial paralysis is reported. With a review of literatures, we report a case of carcinoma ex pleomorphic adenoma which operated with total parotidectomy and supraomohyoid neck dissection.
위장관 ; 대장 톱니샘종에서 p53, Bcl-2, Ki-67 단백의 면역조직화학 발현
정진환 ( Jin Hwan Jung ),권헌주 ( Heon Ju Kwon ),김태정 ( Tae Jung Kim ),조형준 ( Hyung Jun Cho ),김혜강 ( Hye Kang Kim ),정대영 ( Dae Young Cheung ),김진일 ( Jin Il Kim ),김재광 ( Jae Kwang Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.6
목적: 대장의 톱니샘종은 증식폴립과 샘종폴립의 특성을 동시에 가지는 샘종으로 기존의 샘종암종연쇄경로와는 다른 톱니 모양경로를 통해 암으로 진행한다. 전통 톱니샘종은 대롱샘종이나 증식폴립과 비교하여 어떤 분자유전학적인 특징이 있는지 알아보고자 하였다. 대상 및 방법: 2007년 1월부터 2012년 12월까지 가톨릭대학교 여의도성모병원에서 폴립절제술로 절제된 전통 톱니샘종, 증식폴립, 대롱샘종 각각 20예를 대상으로 나이, 성별, 위치, 크기 및 p53, Bcl-2, Ki-67단백의 면역조직화학적 발현을 비교하였다. 결과: 전통 톱니샘종과 증식폴립의 비교에서 p53, Bcl-2의 발현에 있어서 차이가 없었고, Ki-67의 발현은 전통 톱니샘종에서 더 높았다. 전통 톱니샘종과 대롱샘종의 비교에서는 p53과 Ki-67의 발현에는 유의한 차이가 없었고, Bcl-2의 발현은 대롱샘종에서 더 높았다. 전통 톱니샘종에서 p53, Bcl-2, Ki-67 발현은 나이, 성별, 위치 및 크기에 있어서 통계적으로 의미있는 차이가 없었다. 결론: p53의 발현은 세 군 간에 통계적으로 유의한 차이가 없어서, 전통 톱니샘종과 대롱샘종의 구분에 유용하지 않을 수도 있음을 시사했다. Ki-67의 발현은 전통 톱니샘종에서 증식폴립보다 높아서, Ki-67단백이 전통 톱니샘종과 증식폴립의 감별에 도움이 될 수도 있음을 보여주었다. 전통 톱니샘종은 대롱샘종보다 Bcl-2 발현이 낮아서 전통 톱니샘종의 종양 형성이 대롱샘종보다 낮을 것으로 나타났다. Background/Aims: Serrated adenomas of the colon show mixed characteristics of both hyperplastic and adenomatous polyps. Serrated adenomas are known to progress via the serrated pathway than the adenoma-carcinoma pathway. The aim of this study was to evaluate the characteristics of traditional serrated adenomas compared to hyperplastic polyps and tubular adenomas by using immunohistochemical staining for p53, Bcl-2, and Ki-67. Methods: Age, sex, location, size and the immunoexpression of p53, Bcl-2, and Ki-67 were retrospectively analyzed in 20 traditional serrated adenomas, 20 hyperplastic polyps, and 20 tubular adenomas from January 2007 to December 2012 at The Catholic University of Korea, Yeouido St. Mary`s Hospital. Results: There was no difference in Bcl-2 and p53 expression between traditional serrated adenomas and hyperplastic polyps. Ki-67 Expression of traditional serrated adenomas was higher than that of hyperplastic polyps (p=0.001). Ki-67 and p53 expression was similar between traditional serrated and tubular adenomas. Bcl-2 expression of traditional serrated adenomas was lower than that of tubular adenomas (p=0.001). Regarding the expression of p53, Bcl-2, and Ki-67 in traditional serrated adenomas, there were no statistical differences among age, sex, location, and size. Conclusions: Our study suggested that Ki-67 may be helpful in distinguishing traditional serrated adenomas from hyperplastic polyps, and p53 expression may be ineffective in distinguishing between traditional serrated and tubular adenomas. From Bcl-2 expression, it is suggested that the tumorigenesis of traditional serrated adenomas is lower than that of tubular adenomas. (Korean J Gastroenterol 2013;62:336-343)
정진환(Jin Hwan Cheung),허정옥(Jung Ok Hur) 한국강구조학회 1995 韓國鋼構造學會誌 Vol.7 No.2
There are several kind of stiffeners in the steel box-girder bridges. It is somewhat difficult to model the steel box-girder bridges, exactly although it is relatively easy to the past to use the high speed computer and their programs. In this study, several approximate methods of modelling the box girders are tested and their results are compared. A general purpose structural analysis program which is based on the finite element method is used to analysis the box girders. The authors try to suggested an approximate method which can give reasonable results in to analysis of steel box girder bridges.