유기성폐기물의 바이오에너지화 현황과 전망

정진영,Jung, Jin-Young 대한환경공학회 2008 대한환경공학회지 Vol.30 No.9

식도 평활근종증이 동반된 Alport 증후군 1례

정진영,김철민,임연정,김자형,유종우,최보화,홍수종,박영서,Jung, Jin Young,Kim, Cheol-Min,Lim, Yean Jung,Kim, Ja Hyung,You, Chong Woo,Choi, Bo-Hwa,Hong, Soo-Joung,Park, Young Seo 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.9

저자들은 반복적인 천명과 폐렴을 주소로 내원한 환아에서 식도 평활근종이 동반된 Alport 증후군 1례를 경험하였기에 보고하는 바이다. We report a case of Alport syndrome associated with esophageal leiomyomatosis, presenting as recurrent pneumonia. A 5-year old girl who had a history of cataract visited the out patient clinic with a complaint of recurrent wheezing and respiratory difficulty which had started five months previously. Chest magnetic resonance image(MRI) and esophagography, checked on the suspicion of achalasia, revealed esophageal leiomyomatosis and renal biopsy revealed Alport syndrome. In the pediatric population, this tumor is a rare cause of dysphagia and is often misdiagnosed as an esophageal motility disorder. Although a number of Alport syndrome associated with leiomyomatosis were reported in the literature, this is a second case report presented with recurrent pneumonia in Korea.

The Vasodilating Mechanism of Atrial Natriuretic Peptide in 2-kidney 1 Clip Renovascular Hypertensive Rats

정진영,안영철,김헌식,고규영,안희열,김명석,Jung, Jin-Young,Ahn, Young-Chul,Kim, Hun-Sik,Koh, Gou-Young,Ahn, Hee-Yul,Kim, Myung-Suk The Korean Society of Pharmacology 1996 대한약리학잡지 Vol.32 No.1

본 연구의 목적은 2-kidney 1 clip (2K-1C) 신혈관성 고혈압흰쥐에서 심방이뇨펩이드의 혈관 이완작용의 기전을 규명하고 정상혈압흰쥐에서의 혈관이완작용과 비교하는 것이다. 2K-1C 신혈관성 고혈압흰쥐는 정상혈압흰쥐에 비하여 평균동맥압의 유의한 상승과 혈장레닌활성의 증가가 관찰되었다. 2K-1C 신혈관성 고혈압흰쥐의 대동맥에서 norepinephrine (NE)의 수축력의 감수성 및 최대 수축력이 정상혈압흰쥐의 대동맥보다 증가하였다. 심방이뇨펩타이드는 NE에 의한 수축을 농도-의존적으로 각각의 혈압군에서 억제하였다. 그러나, 2K-1C 신혈관성 고혈압흰쥐에서 심방이뇨펩타이드의 NE 억제 작용은 전체적으로 정상혈압흰쥐에서 보다 감소되었다. 그러나 최대 용량의 심방이뇨펩타이드의 NE 이완작용은 양 고혈압군에서 차이가 없었다. 2K-1C 신혈관성 고혈압흰쥐에서 NE에 의하여 $Ca^{2+}$의 유입이 유의하게 증가하였고, 심방이뇨펩타이드는 이 증가를 억제하였다. 정상혈압흰쥐에서도 심방이뇨펩타이드는 NE에 의하여 유의하게 증가된 $Ca^{2+}$의 유입을 억제하였다. 이상과 같은 결과로 볼 때 정상혈압흰쥐와 2K-1C 신혈관성 고혈압흰쥐의 심방이뇨펩타이드의 이완작용의 기전에는 $Ca^{2+}$의 유입 차단이 관여할 것으로 추측되며, 이때 심방이뇨펩타이드의 NE 수축억제에 대한 potency는 2K-1C 신혈관성 고혈압 흰쥐에서 감소하였으나 efficacy는 정상혈압흰쥐와 비교하여 변함이 없음이 관찰되었다. The objectives of this study is to find out mechanism of vasodilating effects of ANP in 2K-1C renovascular hypertensive rat aorta and to compare with those of normotensive rat aorta. In 2K-1C renovascular hypertensive rat, average arterial blood pressure and plasma renin activity were higher than in normotensive rat. In 2K-1C renovascular hypertensive rat aorta, NE sensitivity was more increased and maximal contraction of aorta by NE was higher than those of normotensive rat aorta. ANP inhibited NE-induced contraction in both 2K-1C renovascular hypertensive and normotensive rat aorta, concentration-dependently. However, ANP was less effective for relaxing NE-induced contraction in 2K-1C renovascular hypertensive rat aorta than in normotensive rat aorta. ANP inhibited $^{45}Ca^{2+}$ uptake induced by NE in both 2K-1C renovascular hypertensive and normotensive rat aorta. From these results. inhibition of $Ca^{2+}$ influx may be one of the vasodilating mechanism of ANP in 2K-1C renovascular hypertensive rat aorta. Although the potency of ANP in relaxing NE-induced contractions was attenuated, the efficacy of ANP was not changed in 2K-1C renovascular hypertensive rat aorta compared with that of ANP in normotensive rat aorta. Abbreviations: ANP, Atrial natriuretic peptide; 2K-1C, 2-kidney 1 clip; NE, norepinephrine; SHR, Spontaneously hypertensive rat; DOC, Deoxycorticosterone; EDTA, Ethylenediaminetetra-acetic acid; PSS, Physiological salt solution; TRIS, tris(hydroxymethyl) aminomethane

柱枝加黃기湯으로 치료한 소아 아토피 피부염의 한방치험 3례-삼출을 주증상으로 하는 환자를 대상으로

정진영,김윤범,Jung Jin-yiung,Kim Yoon-bum 大韓外官科學會 2004 大韓外官科學會誌 Vol. No.

Background: Infantile atopic dermatitis involves the face, with erythematous weepy patches. This weeping eczema has severe itching and causes eczema secondarily. Also it has a profound effect on the quality of life. Many infantile AD patient and parent suffer troubles because of weeping eczema. Objective: The purpose of this study was to evaluate the efficacy of Gyejigahwanggitang(桂枝加黃?湯) in infantile AD patient with weeping eczema. Method: I treated them with Gyejigahwanggitang(桂枝加黃?湯) for balancing YoungWi(調和榮衛). I also used acupuncture therapy.

Fluorescent fullerene nanoparticle-based lateral flow immunochromatographic assay for rapid quantitative detection of C-reactive protein

정진영,강태준,Mijin Choi,Da Jung Chung,Kyung Mi Park 나노기술연구협의회 2019 Nano Convergence Vol.6 No.35

A fluorescent fullerene nanoparticle (NP)-based lateral flow immunochromatographic assay (LFIA) was developed for the rapid and quantitative detection of C-reactive protein (CRP) in serum. The polyclonal CRP-antibody-conjugated fullerene NPs were simply prepared by 1-ethyl-3-(3-dimethyllaminopropyl)-carbodiimide hydrochloride coupling after carboxylation of fluorescent fullerene NPs. By applying the CRP-antibody-conjugated fullerene NPs to a lateral flow test strip, quantitative analysis of CRP in serum was possible at a concentration range of 0.1–10 ng/ml within 15 min. We anticipate that this novel fluorescent fullerene NP-based LFIA can be useful for the rapid and accurate sensing of biological and chemical species, contributing to the disease diagnosis and prognosis, environmental monitoring, and food safety.

난치성 암성 통증 제어를 위한 뇌정위적 대상회 절개술

정진영,장종희,장진우,박용구,정상섭,Jung, Jin Young,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.4

Objective : Although cingulotomy has been applied to patients with affective disorders more frequently, there are numerous reports of its use for the control of severe pain. The goal of this study was to investigate the role of stereotactic bilateral anterior cingulotomy for intractable cancer pain. Method : Between January and June, 2000, we underwent stereotactic bilateral anterior cingulotomy in 6 patients for intractable cancer pain with poor response to opioids. The patients were suffering from widespread musculoskeletal or visceral pain. We made four lesions along the two tracks on either side of the cingulate cortex. Result : In all patients, pain reliefs after cingulotomy were dramatic and immediate. Five out of six patients did not require any opioids and one patient could reduce dose of opioids. There were no deaths or serious complications related to the procedure. Conclusion : These results suggested that a bilateral anterior cingulotomy might be useful method to control intractable cancer pain associated with the widespread metastatic disease. To provide rationale of bilateral anterior cingulotomy in intractable cancer pain, the theoretical mechanisms and role of bilateral anterior cingulotomy are discussed, along with our surgical techniques and the course of our patients.

소아 중환자실에 입원한 혈액-종양 환아에서 발생한 폐 합병증의 원인과 예후에 대한 분석

정진영,홍수종,안영준,김자형,서종진,문형남,김태형,Jung, Jin Young,Hong, Soo-Jong,An, Young Jun,Kim, Ja Hyung,Seo, Jong Jin,Moon, Hyung Nam,Ghim, Thad 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.8

Purpose : In the course of treatment, patients with hematological or oncological disorders often develop pulmonary complication. The patients who develop a severe pulmonary complication have a poor outlook. The causes of pulmonary complication are either infectious or non-infectious in origin. We have analyzed the etiology and outcome of these patients admitted to the pediatric intensive care unit of Asan Medical Center. Methods : Medical records of 95 patients on Pediatric oncology service who were admitted to pediatric intensive care unit(PICU) of Asan Medical Center from Jan 1997 to May 2000 were retrospectively reviewed. Results : The mean age of the patients was 8.5 years(2 months-18 years). The underlying malignancies of these 95 patients were as following; acute lymphoblastic leukemia(31 cases), lymphoma (11 cases), acute myeloid leukemia(nine cases), brain tumor(eight cases) and other solid tumors(25 cases). Pulmonary complications included pneumonia, acute respiratory failure, pneumothorax and pleural effusion. The most common cause of pulmonary complication was infection(88%) in etiology. The overall mortality rate was 56.8%. Pulmonary complications in these patients carried high rates of mortality regardless of whether they were immune compromised(76%) or not(69%). Even without pulmonary complications, the hematological or oncological patients admitted to PICU had high mortality rates of 43%. Conclusion : Pulmonary complications are frequent finding in the hematological or oncological patients admitted to Intensive Care Unit. The main etiology of these pulmonary complications was infection, which carried a high mortality rate regardless of their immune status at the time when they were admitted to PICU. 목 적 : 혈액-종양 환자에서 항암화학요법으로 치료하는 과정 중에서 중증 폐 질환 합병증이 발생할 수 있다. 그 원인으로는 감염성 또는 비 감염성의 원인들이 있고 특히 이들 환자에서 폐 질환 합병증 또는 호흡부전으로 인한 인공환기 치료시에는 예후가 나쁘다고 알려져 있다. 저자들은 본원 소아 중환자실에 입원한 혈액-종양 환아에서 면역 저하상태(절대 호중구수 < $1,000/mm^3$)의 지표의 하나인 호중구 감소증과 폐합병증의 유무에 따른 원인과 예후를 분석하였다. 방 법: 1997년 1월부터 2001년 5월까지 서울중앙병원 소아 중환자실에 입원한 혈액-종양 환아 95명의 의무기록을 후향적으로 분석하여 폐 합병증의 원인과 진단 방법, 호중구 감소상태와 폐 합병증의 유무에 따른 사망률을 분석하였다. 결 과 : 연령 분포는 생후 2개월에서 18세까지 평균 8.5세였고, 원인 혈액-종양 질환으로는 급성 림프성 백혈병 31명, 급성 골수성 백혈병 9명, 림프선 종양 11명, 뇌종양 8명, 고형종양 25명, 그 외 혈액질환이 11명이었다. 95명의 환아 중 중환자실 입원당시의 원인으로는 패혈증 23명(24%), 패혈증을 동반한 폐렴 22명(23%), 급성 호흡부전 12명(12.5%), 의식소실 16명(17%), 급성 신부전, 심부전의 기타 질환이 15명(16%)이었다. 이들 중에서 폐 합병증을 동반한 환아는 42명(44%), 동반하지 않은 환아는 53명(56%)이었다. 폐 합병증으로는 폐렴, 늑막삼출, 급성호흡부전, 기흉이 있었다. 폐 합병증이 있는 환아 중 호중구 감소상태의 환아는 29명(69%), 호중구 감소상태가 아닌 환아는 13명(31%)이었다. 원인으로는 감염성인 경우가 37명(88%), 비 감염성인 경우가 2명(5%)이었고, 구분이 어려운 경우가 3명(7%)이었다. 시행된 각각의 검체에서 균이 검출된 빈도를 비교하면 혈액배양검사는 42명중 15명(36%), 객담검사는 42명 중 7명(16%), 소변 배양검사는 42명 중 3명(7%), 인공환기요법 중인 환아에서 시행한 기도내 분비물 배양검사는 28명 중 5명(18%)이었다. 주요 원인균으로는 Candida species 12명(33%), MRSA 6명(17%), Pseudomonas aeruginosa 4명(11%), Klebsiella pneumoniae 4명(11%)이었다. 골수이식술을 받은 환자는 모두 10명으로 이중 7명에서 폐 합병증이 있었고, 원인균이 동정된 경우는 모두 3명으로 각각 S.maltophilia, K.pneumoniae, Parainfluenza virus이었다. 10명의 환아 중 8명이 사망하였고 사망 원인으로는 폐혈증이 5명, 급성호흡부전 증후군이 2명, 뇌출혈이 1명이었다. 전체 사망률은 56.8%였고, 사망률을 보면 이중 폐 합병증이 있고 호중구 감소상태의 환아는 76%(22명), 폐 합병증이 있으나 호중구 감소상태가 아닌 환아는 69% (9명), 폐 합병증이 없으나 호중구 감소상태의 환아는 46%(7명), 폐 합병증이 없으며 호중구 감소상태가 아닌 환아는 43%(16명)이었다. 결 론 : 중환자실에 입원한 혈액-종양 환아에서 폐 합병증의 원인으로 감염성인 경우가 많았다. 사망률은 폐 합병증이 있는 경우가 없는 경우에 비해 높았으며, 특히 폐 합병증이 있는 환아 중 호중구 감소상태의 환아에서 사망률이 높았다. 이 결과로 미루어 폐 합병증이 있는 혈액-종양 환자에서 더 적극적인 원인 규명과 치료를 시도해야 할 것으로 생각된다.

18세기 영남 노론의 존재형태

정진영(Jung, Jin-Young) 한국사연구회 2015 한국사연구 Vol.- No.171

This research reviewed the specific form of the Noron Party, which was significantly revealing its existence in Yeongnam province after the 18th century, focusing on the leading powers of the establishment of Kim Sang-heon Lecture Hall in Andong in the 14th year of King Yeongjo’s reign(1728). It was the Noron Party who led the establishment of Kim Sang-heon Lecture Hall. They can be called ‘Neo-Noron (新老)’ as they newly emerged in Yeongnam Province, which was dominated by Namin. The Neo-Noron Party promoted to establish the lecture hall to foster the Noron forces under the active support and cooperation of governors, local government officials and the ruling Noron party. Then, the existing ruling powers of Hyangchon strongly opposed to the action. Therefore, intensive conflicts and confrontations arose between Namin and Noron in each area in Yeongnam. The establishment and destruction of Kim Sang-heon Lecture Hall in Andong was part of the conflicts. The most existence forms of the Noron Party who led the establishment of Kim Sang-heon Lecture Hall were based on the similar social and economic foundation of the Namin Party except that they claimed to politically support the Noron Party. Therefore, many of the Noron Party were participating in the Hyangrok (recording the local elites) work. In addition, the substance of the existence of those who are so-called ‘son of a person in charge of the military service (軍保之子)’ was unclear. Most of them were from respectful classical scholar families, and the existence of middle class (Jung-in) and people out of wedlock (Seo-earl) were ambiguous. Therefore, the so-called ‘new powers’ who have new social and economic footings in the establishment of the lecture hall just refer to those who are in different interests. The Noron Party was developed in the late 18<SUP>th</SUP> century in Andong, which was set up as a hometown of Namin. Therefore, Hanggyo became the base of the Noron Party. This means that Andong, which was believed to strongly support the position of Namin until the end of the Joseon Dynasty, also collapsed by the attack of the Noron Party. This was because of the existing classical scholar families and the conversion of the neglected families by them rather than the growth or expansion of new powers. Although some Seo-earls turned into Noron, there were still limitations. The situation in Yeongnam may not be that much different from this.

통규탕(通竅湯)이 알레르기 비염 모델 횐 쥐에 미치는 영향

정진영,김윤범,Jung, Jin-Young,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.2

Background and Objectives: Allergic rhinitis is an allergic reaction characterized by sneezingm itchy nose, mouth and throat, congestion and/or nasal discharge. The offending allergenes are usually pollens, molds, dust mites and animal allergen. Recently, the incidence of infectious nasal diseases tend to decrease. However, allergic rhinitis has increased and treatment in most cases has only deat with the symptom. Tongkyu-tang was composed of sixteen crude drugs. The Oriental Medical References mention therapeutic effects of Tongkyu-tang on nasal obstruction, watery nasal discharg. And Tongkyu-tang has clinically been used for the treatment of common cold, headache, sternutation, rhinitis etc. Speacially Tongkyu-tang is one of the most frequently used medical treatment for the allergic rhinitis. Experimental studies were conducted to investigate for the effect of Tongkyu-tang on the changes of neutrophil segment, lymphocyte, total IgE and nassal tissue in allergic rhinitis of ovalbumin-inhalation rat. Meterial and Methods: Fifteen Sprague-Dawley rats were divided into three group: normal group, control group, experimental group. To induce the allergic rhinitis in control group and experimental group, rats were sentitized intraperitoneally with 0.1 % ovalbumin solution 3 times at intervals of I week. Then intranasal sensitization was performed by diffusing 0.1 % ovalbumin solution 3 times at intervals of 2 days. After that time, rat in the experimental group were oral administration treated by Tongkyu-tang for 28 days. We observed changes in nasal tissue; changes in the number of white blood cell, red blood cell and total Ig E; also changes in the segment of neutrophil and lymphocyte in blood. And we observed the changes of AST, ALT of three group. We used anova test statistically. Result: The number of leucocyte remained unchanged between three group. The number of erythrocyte was increased in experimental group and control group when compared with the normal group. The segment of neutrophil, in blood was decreased in experimental group when compared with the control group but, that was not significant statistically(p<0.05). The promotion of lymphocyte in blood was significantly decreased in experimental group when compared with the Control group(p<0.05). Total IgE was decreased in experimental group when compared with the control group but, that was not significant statistically(p<0.05). The cilium be well preserved in experimental group: the nasal tissue in experimental group was similar to in the normal group. Congestion and expantion of grandular cell in nasal submucosa, hypertropy of epithelium in nasal mucosa, acid mucus in epithelium and neutral mucus in subepithelium were decreased in experimental group when compared with the control group. Effect of Tongkyu-tang on the liver function were also studies in rats. Treatment of Tongkyu-lang did not affected on AST and ALT. Conclusion: Considering the above experimental results, it is suggested that oral administration treatment using Tongkyu-lang, without worry about liver function injury, decreased response on an Animal model with Allergic Rhinitis.

파프리카즙을 첨가한 증편의 품질 특성

정진영(Jin Young Jung),최민희(Min Hee Choi),황정현(Jung Hyun Hwang),정해정(Hai-Jung Chung) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.5

본 연구에서는 전통 쌀 가공 식품인 증편의 색을 다양화하고 파프리카의 이용을 증대시키기 위한 방안으로 증편에 파프리카즙을 첨가하여 제조하고 그 품질 특성을 살펴보았다. 주황색 파프리카즙을 물 첨가량의 0%, 10%, 25%, 50%로 대체하여 증편을 제조한 후 일반 성분을 분석한 결과 파프리카즙 첨가량이 증가할수록 수분함량은 감소하였고 지질과 회분 함량은 증가하여 50% 첨가구에서 가장 높았으며 단백질 함량에는 큰 차이가 없었다. 증편 반죽의 pH는 발효가 진행되면서 계속 저하하여 발효 4시간 후에는 pH 4.27~4.38을 나타내었다. 증편 반죽의 부피는 대조구와 모든 실험구에서 발효가 진행됨에 따라 증가하기 시작하였고 그 중 대조구는 발효 3.5시간 후 최대 부피에 도달하여 처음 부피의 2.7배로 증가하였고 10% 첨가구는 2.2배를 나타낸 반면, 25%와 50% 첨가구는 각각 1.7배와 1.4배의 부피 증가를 나타내었다. 색도 측정 결과 lightness는 대조구에서 가장 높은 값을 나타내었고 파프리카즙 첨가량의 증가에 따라 감소하였으나 유의적인 차이는 없었다. Redness는 50% 첨가구에서 유의적으로 높게 나타났으며 yellowness는 파프리카 첨가량이 증가할수록 증가하였다. Texture 특성을 측정한 결과 hardness와 cohesiveness는 시료간에 유의적인 차이가 없었으며 springiness는 대조구보다 파프리카 첨가구에서 높았고 gumminess는 50% 첨가구에서 유의적으로 높게 나타났다. 관능 검사 결과 파프리카즙을 첨가하지 않은 대조구의 특성이 전반적으로 높게 나타났으나 기포의 균일한 정도, 맛, 촉촉한 정도 및 전체적인 바람직성 등은 10% 첨가구와 차이가 없었다. 위의 결과를 종합하여 보면 10% 파프리카즙 첨가 증편이 이화학적 특성 및 관능적 특성에서 대조구와 비교하여 큰 차이가 없는 것으로 나타났다. 따라서 앞으로 다른 한과 및 병과류의 제조에 파프리카즙을 적정량 첨가한다면 색, 맛, 향을 다양화할 수 있으리라 기대된다. This study was conducted to investigate the effects of paprika juice on the quality characteristics of Jeung-Pyun (fermented and steamed rice cake). Jeung-Pyun was prepared with four different levels of orange paprika juice (0%, 10%, 25% and 50% replacement of water). The proximate composition analysis showed that moisture contents of Jeung-Pyun were 48.72~49.36%, and crude protein, lipid and ash contents were 2.94~3.13%, 0.46~0.63% and 0.60~0.65%, respectively. The pH of Jeung-Pyun batters was decreased from 4.74~4.83 to 4.27~4.38 during 4 hours of fermentation at 35℃. The maximum expanded volume was observed in control group, followed by 10% group, 25% group and 50% group and the volume expansion was decreased with the increased amount of paprika juice. The “L” value (lightness) was the highest in control group and decreased with paprika juice addition, while the “b” value (yellowness) was increased as the amount of paprika juice was increased. Rheology test showed that there were no significant differences in hardness and cohesiveness among four groups. Springiness and gumminess were the lowest in control group and increased with the increased amount of paprika juice. Results of sensory evaluation showed that there were no significant differences in scores of cell uniformity, sweetness, moistness and overall desirability between control and 10% group. Therefore, Jeung-Pyun prepared with 10% paprika juice was evaluated as the most acceptable one among test groups when compared to control.