http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
대장선종 발생과 연관된 대사증후군의 위험 표지자로서의 혈청요산: 검진 대장내시경을 받은 한국인을 대상으로 한 연구
김효진 ( Hyo Jin Kim ),김지은 ( Jee Eun Kim ),정지혜 ( Ji Hye Jung ),김은란 ( Eun Ran Kim ),홍성노 ( Sung Noh Hong ),장동경 ( Dong Kyung Chang ),손희정 ( Hee Jung Son ),이풍렬 ( Poong Lyul Rhee ),김재준 ( Jae J Kim ),김영호 ( Youn 대한소화기학회 2015 대한소화기학회지 Vol.66 No.4
Background/Aims: An association between serum uric acid and cancer risk has been noted over the past few decades. There is ongoing debate about whether hyperuricemia represents an independent risk factor for colorectal neoplasm. We investigated the association between serum uric acid and prevalence of colorectal adenoma considering numerous confounding factors. Methods: A cross-sectional study was performed with individuals who underwent a routine health check-up examination, including a screening colonoscopy and blood chemistry. The association between serum uric acid and prevalence of colorectal adenoma was estimated from the results of a logistic regression analysis. Results: Of the 1,066 participants, 402 had colorectal adenoma (37.7%). In univariate models, the prevalence of colorectal adenoma was higher in participants in the fourth quartile uric acid level, compared to those in the first quartile uric acid level (OR, 1.67, 95% CI, 1.17-2.42, p=0.004). However, no significant association was detected between serum uric acid and prevalence of colorectal adenoma in multiple logistic regression analysis. A number of metabolic syndrome components exhibited a strong association with the prevalence of colorectal adenoma in the multivariate model (OR, 3.46 for highest vs. lowest, 95% CI, 1.30-9.20, p=0.021). Moreover, serum uric acid was strongly associated with metabolic syndrome-associated variables, including waist circumference, fasting blood glucose, systolic blood pressure, diastolic blood pressure, triglyceride, and high-density lipoprotein. Conclusions: Uric acid is not an independent risk factor for colorectal adenoma but is a risk indicator for metabolic syndrome-related colorectal adenoma. (Korean J Gastroenterol 2015,66:202-208)