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- 저자 : 정지행(Jee-haeng Jeong) (검색결과 4 건)
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이태후,문정배,정지행,임강현,김희택,Lee, Tae-Hoo,Moon, Jung-Bae,Jeong, Jee- Haeng,Leem, Kang-Hyun,Kim, Hee-Taek 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3
Objectives : This study was planed to evaluate clinical status of the alopecia patients who had visited Korean medicine clinic. And the result from this study would provide a standard in Korean medical diagnostic and classification method of alopecia. Methods : Clinical records of 183 patients with alopecia seen from January 2004 to April 2005 at Korean medical clinic was examined. They were classified into 4 different types according to chief complains besides alopecia by 2 Korean medical doctors. Results and conclusions : We made clinical analysis of patients of alopecia from January 2004 to April 2005. Among the alopecia patients who visit Korean medical clinic, people age between 20 and 30 had high ratio. The duration from the recognition of initial hair loss to the time of the first visit to the Korean medical clinic was less than 12 months in 20.8%(38/138), and less than 60 months in 72.2% (132/183). The condition of alopecia was more worse than other alopecia patients who visit the west medical clinic. Also the ratio with increased temperature of face or scalp is chief complaint except alopecia in alopecia patients was high in men and the ratio with dysfunction of digestive system or chronic weakness was high in women. Among the incidence of alopecia, the androgenic alopecia was most in number; 43.7%(80/183) and the sex distribution showed 83 men and 100 women.
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小柴胡湯이 肥滿誘導白鼠의 肝 및 副睾丸脂肪組織과 血淸脂質의 變化에 미치는 影響
申鉉大,金性洙,鄭智行 慶熙大學校韓醫科大學韓醫學硏究所 1997 慶熙韓醫大論文集 Vol.20 No.2
This experimental study was designed to investigate the effects of Soshihotang on the weight and lipid metabolism in obese rats induced by high fat diet. Total population of sixty male rats(Sprague-Dawley) were utilized for this investigation. All rats selected for this study were six weeks old with weight of 190±5g. The first group of twenty rats(Normal) were fed with normal diet(Samyang Co. Korea), second group of twenty rats(Control) were fed with high fat diet(Harlan. TD94095, USA), and the remaining twenty rats(Sample) fed with high fat diet and the Soshihotang. The measurement has been performed on (1) the weight of epididymal fat pad with electric weight gauge(Librorel-1200H, Shimadzu, Japan) (2) the average size and the number of epididymal fat cells with light microscope(Olympus, Japan) and personal computer(Image Analysis System. LECO 2001, Canada) (3) the area % of fat drops in hepatic lobule with Light microscope and Computer image analysis system (4) the quantity of total cholesterol in serum on enzyme method COD-POD system (5) the quantity of triglyceride in serum on enzyme method LPL-GK-GPO system (6) the quantity of free fatty acid in serum on enzyme method ACS-ACO system (7) the quantity of total lipid in serum on Sulfo-phosphovanillin method (8) the quantity or insulin in serum on Radioimmunoassay method. The results are as follows : 1. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the weight of rats compare to control group. 2. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the epididymal fat pad weight, the average size of epididymal fat cells and the number of epididymal fat cells compare to control group. 3. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the area % of rat drops in hepatic lobule compare to control group. 4. It showed significant evidence that high fat diet conjunction with Soshihotang decreased total cholesterol, triglyceride, free fatty acid and total lipid in serum compare to control group. 5. It showed significant evidence that high fat diet conjunction with Soshihotang decreased insulin level in serum to control group. Based on these results, it is proved that Soshihotang decreased the weight of fat, the size of fat cells and the number of fat cells. So it is concluded that the clinical application of Soshihotang can help the treatment of obesity.
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대식세포에서 산화질소 생성에 대한 當歸 에탄올 추출물의 억제효과
정미영,박히준,정지행,김진용,강전모,이나경,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Objective : The Angelica gigas Nakai ethanol extract (AGE) was investigated to compare nitric oxide (NO) production and NF-kB activity from RAW 264.7 cells, since NO and nuclear factor-kB(NF-kB) have been shown to be factors implicated In inflammatory disease. Method : AGE was prepared by extracting medicinal herb with 70% (v/v) ethanol solution. We investigated production nitric oxide (NO) and inducible nitric oxide synthase (iNOS) gene expression by ARE in LPS-stimulated RAW 264.7 macrophage cells. We also investigated inhibition of LPS-induced activation of NF-kB on western blot. Result : LPS-induced RAW 264.7 cells increascd NO production and ,iNOS expression. Upon treatment with AGE, nitrite production was significantly inhibited in a concentration-dependent manner compared to the untreated control. AGE inhibited this LPS-induced ,iNOS mRNA and protein in a dose-dependent manner. AGE markedly inhibited the expression of iNOS mRNA and protein at a concentration of 100 μg/ml. LPS-induced RAW 264.7 cells with AGE blocked inhibitory factor-kBα degradation. Conclusion : This study shows that AGE seems to attenuate inflammation through inhibition of NO production and iNOS expression by blockade of NF-kB activation in LPS-stimulated RAW 264.7 cells.
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