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서민준(Minjun Seo),박진한(Jinhan Park),이제현(Jehyun Lee),정지욱(Jiwook Jung) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.1
Objective : In the present study, we assessed the enhancing effect of the fermented Angelicae Gigantis Radix on memory and cognitive function in scopolamine induced amnesia mice. Method : The memory and cognitive enhancing effect of the fermented Angelicae Gigantis Radix was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine. Result : The fermented Angelicae Gigantis Radix significantily reversed the scopolamine-induced cognitive impairments in the passive avoidance test. Moreover, the fermented Angelicae Gigantis Radix also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze. On the Y-maze test, fermented Angelicae Gigantis Radix also significantily reversed the scopolamine-induced cognitive impairments in mice. Conclusion : The fermented Angelicae Gigantis Radix possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.