개심술 전후의 Alpha 1-Proteinase Inhibitor 의 추이

정종화,김송명,Jeong, Jong-Hwa,Kim, Song-Myeong 대한흉부심장혈관외과학회 1989 Journal of Chest Surgery (J Chest Surg) Vol.22 No.3

Extracorporeal circulation leads to functional disorder and structural damage of organs, especially hematologic and pulmonary system, mainly by sequestration of neutrophils and deposition of macrophages at lung. Then, proteases are secreted, which insult vascular basement membrane of pulmonary capillary and alveolar septa of the lung. Among these, the most important protease at lung is elastase, because major component of lung is elastin. For prevention of lung injury, inactivators or antidotes to elastase should be necessary and Alpha 1-Proteinase Inhibitor is the elastase inactivator. Clinical experimental study was carried out to investigate the immediate postoperative change of serum Alpha 1-PI level following cardiopulmonary bypass for 20 heart cases [congenital 16 cases, acquired 4 cases] and 10 control [subtotal gastrectomy] cases. Also preliminary study was performed for 31 cases of open heart patients. The results were as follows: l. Immediate postoperative serum levels of Alpha 1-PI was significantly decreased at open heart surgery group [P< 0.005], but not decreased at control group. 2. There were no significant difference in change of serum Alpha 1-PI level between and membrane and bubble oxygenator group.Z 3. There were no significant difference in changes of serum Alpha 1-PI level between CHD and AHD. Alpha 1-PI is consumed at lung during cardiopulmonary bypass and increase after operation compensatedly and protect multiple organic damage especially lung. Therefore, Alpha 1-PI can be indicator for evaluation of prevention and treatment of pump-lung syndrome.

(1) 간질, (2) 발광 험방

정종화,Jeong, Jong-Hwa 대한한약협회 1998 大韓漢藥 Vol.2 No.-

Nitric oxide, Isosorbide dinitrate 및 Sodium nitroprusside가 쥐의 허혈성 심근에 미치는 영향

정종화,김수현,김송명,Jeong, Jong-Hwa,Kim, Su-Hyeon,Kim, Song-Myeong 대한흉부심장혈관외과학회 1996 Journal of Chest Surgery (J Chest Surg) Vol.29 No.10

혈관확장의 기전으로 혈류를 증가시킨다고 보고된 nitric oxide(이하 NO), Isosorbide dinitrate(이하 ISDW), 그리고 sodium nitroprusside(이하 SWP)에 대해 어떤 물질이 허혈성 심근에서 더 효과적인지를 알아보기 위해 이 실험을 시행하였다. 그리고 실험군은 정상대조군(1군), WO군(2군), ISDW군(3군), SWP군(4군)으로 나누었다. 실험 대상은 쥐의 심근을 채택하였으며, 실험 모델은 isolated constant pressure Langendorfr system을 채택하였다. 그리고 효과를 비교하기 위해서 냉동 심근과 관혈류내의 lactate와 CK-MB수치, 관혈류량, LVDP, dp/dt등을 측정하였다. 결과는 12군과 4군에서 허혈전 상태에서의 lactate치가 낮았다(p<0.0025). 2. 반면에 관혈류량은 2군과 4군에서 높았다. 3. 허혈전과 허 혈후에 생산된 lactate수치의 비는 2군과 4군에서 낮았다(p< 0.005). 4.관혈류내의 CK-MB치는 2군과 3군에서 낮았으며,냉동 심장내의 CK-MB치는 2군과4군에서 낮았 다. 5. 관혈류량은 전 실험 과정 에서 2군과 4군에서 높았다(p<0.005) 6. 허혈전 상태 에서의 LWP는 2군에서 가장 높았다. 7. +maximal dp/dt는 2군에서 가장 높았다. 8. 허혈전과 재\ulcorner류후의 회복률은 1군이 가장 높았다. 9. (-dp/dt)1(+dp/dt)의 비는 각군에서 각각 116%, 100%, 100%, 55%였다. 0. total dp/dt의 회복률은 각각 34%, 67%, 51%, 76%였다 결론적으로 nitric oxide는 관상혈관의 확장에 상당한 효과가 있는것으로 생각되며, lactate와 CK-MB 의 생산은 NO 군과 ISDW군에서 효과적으로 낮았다. This experiment was undertaken to assess the effect of nitric oxide, isosorbide dinitrate, and sodium nitroprusside, which are known to increase coronary flow by vasodilation and to improve the cardiac function of an ischemic heart The experiment was carried out to investigate the effect of nitric oxide on the coronary artery of an ischemic rat myocardium using isolated constant pressure Langendorfr system. The experimental parameters were lactate and CK-MB for the frozen myocardium and coronary flow. the quantity of coyonary flow, left ventricular developed pressure (LVDP), and dp/dt. The experimental groups were decided as control group (Group I), nitric oxide group (Group II), Iso orbide dinitrate group (Group III) and sodium nitroprusside group (Group IV). Statistical analysis was performed using repeated measured analysis of variance and 2tudent t-test The results were as follows: 1 . The lactic acid contents of group II and IV were less than other groups for the frozen myocardium at preischemic state (p< 0.0025), whereas the determined coronary flows were higher. 2. In the ratio of produced lactic acid between the preischemia and reperfusion for the coronary flow, group II and IV exhibitrod less value than others (p< 0.005). 3. Group II and III were less than others in the coronary flow for the quantity of CK-MB, but or the frozen myocardium, group II and IV were less. 4. Group II and IV showed higher coronary flow compared to others throughout entire experimental period (p< 0.005). 5. Group II was highest at the preischemic state for the left ventricular developed pressure. 6. The +maximal dp/dt of group II was highest compared to others. 7. Group I exhibi ed the highest recovery rate of coronary flow between prelschemla and reperfusion. 8. The(-dp/dt)1(+dp/dt) ratio was 116%, 100%, 100%, and 55% for the 4 groups, respectively And the recovery rate of total dp/dt was 34%, 67%, 51%, and 76% for the four groups, respectively.

고리 및 비고리 폴리에테르와 알킬암모늄 이온과의 호스트-게스트 상호작용

정종화,김대연,이심성,Jeong, Jong Hwa,Kim, Dae Yeon,Lee, Sim Seong 대한화학회 1994 대한화학회지 Vol.38 No.7

고리(12C4, 15C5, 18C6, DT18C6, DA18C6) 및 비고리$(Q_2O_5)$ 폴리에테르와 11가지의 1차 및 2차 알킬암모늄 이온과의 상호작용을 NMR 적정과 전기전도도법으로 조사하였다. 모든 알킬암모늄 이온은 크라운 에테르 및 비고리 폴리에테르와 수소결합에 의해 비교적 안정한 1:1 착물을 형성하였다. 알킬암모늄 이온과 동공의 크기가 다른 동일계열 호스트와의 상호작용의 세기는 18C6 > 15C5 > 12C4 순이었으며, 알킬암모늄 이온에 대한 호스트 주개원자의 세기는 N > O > S 순이었다. 18C6는 2차 알킬암모늄 이온에 비해 1차 알킬 암모늄 이온과 더 강한 상호작용을 하는 반면, DA18C6는 2차 알킬암모늄 이온과 더 강한 상호작용을 하였다. 또한 25$^{\circ}C$ 메탄올에서 18C6와 알킬암모늄 이온과의 착물형성에 대한 안정도 상수를 전기전도도법에 의해 구하였다. 착물의 안정도는 주로 알킬암모늄의 차수(또는 수소결합 수), 알킬기의 길이, 알킬기의 구조에 의한 입체장애 등에 의해 크게 영향을 받았다. The interactions of 11 kinds of primary and secondary alkylammonium ions with cyclic (12C4, 15C5, 18C6, DT18C6 and DA18C6) and acyclic$(Q_2O_5)$ polyethers were investigated by NMR titration and conductometry. All of the alkylammonium ions under investigation form the relatively stable 1 : 1 complexes with crown ethers and acyclic polyether by H-bond. The interactions of alkylammonium ions with analogeous hosts having different size were in the order of 18C6 > 15C5 > 12C4, and the strengthes of donor atoms toward the alkylammonium ions were in the order of N > O > S. 18C6 forms more favorable interactions with primary alkylammonium ions than secondary alkylammonium ions, otherwise DA18C6 shows the opposite behaviors. The stability constants for complexations of 18C6 with the alkylammonium ions were determined conductometrically in methanol at 25$^{\circ}C$. The major factors affecting the stability of complexes were the type of alkylammonium ions, the length of alkyl-chain and the steric hindrance due to the structure of alkyl groups on complexation.

SEM 측정법에 의한 정밀절삭 가공면의 평가

정종화(Jong Hwa Jeong),이갑조(kab jo Lee),김종관(Jong kwan Kim) 한국기계가공학회 2003 한국기계가공학회 춘추계학술대회 논문집 Vol.2003 No.-

보호자에 대한 폐재활 교육프로그램이 폐암 환자의 폐절제술 후 폐기능과 호흡근 근력, 호흡곤란, 통증에 미치는 효과

정종화(Jong-Hwa Jeong),윤정호(Jung-Ho Youn),김호봉(Ho-Bong Kim) 대한심장호흡물리치료학회 2014 대한심장호흡물리치료학회지 Vol.2 No.1

Purpose : The purpose of this study was to evaluate effects of Pulmonary Rehabilitation Education Program for caregivers of patients undergoing lung resection surgery. Methods:Subjects with lung resection using Visual Assisted Thoracotomy(VATs) were consist of control group 19 and experimental group 22. The subjects averaged 60.22±10.89 years in age, 163.01±8.77 cm in height, 61.39±11.35 kg in weight and 23.01±3.34 in BMI. Experimental group received pulmonary rehabilitation education program for caregivers during the control group received usual care for 4 weeks. We assessed subjects at 2 weeks after surgery(baseline) and 6 weeks after surgery(4 weeks). We measured Forced vital capacity (FVC) and Foced expiratory volume in 1 second(FEV1) for the evaluation of pulmonary function, Maximal inspiratory pressure(MIP) and Maximal expiratory pressure(MEP) for the evaluation of respiratory muscular strength, Modified Dyspnea Borg Scale for evaluation of dyspnea, Visual Analogue Scale for evaluation of pain. Results:The pulmonary function(FVC, FEV1) of Experimental group were statistically significantly increased as compared to control group( p <.01). the pulmonary muscular strength(MIP and MEP) of experimental group were shown statistically significantly increased as compared to control group, But not shown statistically significant differences according in relation to the flow of time and group. Both VAS and Modified Borg Scale were shown significant differences at 4 weeks, as compared to baseline, but not shown statistically significant differences according in relation to the flow of time and group. Conclusion:Pulmonary Rehabilitation Education Program for caregiver has positive effects on improving pulmonary function with lung cancer patients after lung resection.

장애인 의료재활시설 운영 실태분석 : 서울시를 중심으로

정종화(JEONG, Jong-Hwa),이완희(LEE, Wan-Hee),오홍진(OH, Hong-Jin) 한국복지경영학회 2020 복지경영학연구 Vol.9 No.-

장애인 의료재활시설은 장애인을 입원 또는 통원하게 하여 상담, 진단판정, 치료 등의 의료서비스를 제공함으로써 손상된 신체적, 정신적 재활을 지원하는 병원이나 의원을 지칭하는 것으로 본 연구의 목적은 우리나라에서 의료기관이 가장 많은 서울시를 중심으로 장애인 의료재활시설의 실태를 파악하고 이를 토대로 정책 제언을 하고자 한다. 조사대상은 서울시 소재 6개의 장애인 의료재활 시설(병원급 3개소, 의원급 3개소)을 대상으로 조사가 이루어졌으며, 서울시가 보조금을 지원하는 병원과 의원을 대상으로 연구가 수행되었다. 연구결과는 첫째, 3개의 재활병원과 3개의 재활의원의 보조금 집행기준은 달라야 한다는 것이다. 병원의 경우, 인건비가 차지하는 비중이 60% 정도의 수준이나 재활의원의 경우 인건비차지 비율이 80%를 넘고 있고 종합재활치료를 추구하는 재활병원과 재활의원의 보조금 지급방식은 다르게 설정되어야 할 필요가 있기 때문이다. 둘째, 서울시가 보조금 지급기준으로 적용하고 있는 기준은 재활병원 인증기준을 참고하여 보완되어야 할 필요가 있다. 셋째, 재활 병·의원의 경우 일반병원과는 달리 소아재활의 빈도(1-19세 연령대)가 높은데 재활 수가가 낮은 관계로 소아재활의 외래진료는 재활병원·의원 모두에게 보조금 지원 필요성을 높여 지원 규모를 확대하여야 한다. 넷째, 장애인 의료재활 시설 보조금 지원을 위한 기준이 마련되어야 한다. 특히, 민간병원에서 시행하기에 부담이 따르는 희귀난치성 질환자에 대한 재활 치료를 위해서도 공공의료 서비스 수준에서 재활 의료서비스의 질적 향상과 공공지원의 확대가 절실히 필요한 상황으로 판단된다. 마지막으로 보조금 지원기준으로 병원의 경우 병상 및 낯 병동의 평균 운영병상수를 기준으로 보조금 집행기준을 정해야 하며, 유효가동률이 적용되어야 한다. 또한, 의원의 경우는 적정진료와 재활 치료의 기준을 제시하고 실태조사에서 나타난 3대 장애(지체, 뇌병변, 발달장애)로 특화된 재활 의료서비스를 제언하였다. The medical rehabilitation institutions for disabled people refer to hospitals or clinics supporting disabled people s physical and mental rehabilitation through offering counseling, diagnosis judgment, and treatment by letting them hospitalized or receive outpatient treatment. The purpose of this research is to identify the situation of the medical rehabilitation institutions for disabled people, focusing on Seoul City where the most medical institutions are located in Korea. Based on the result, this research aims to present policy suggestions. The subjects of investigation were six medical rehabilitation institutions for disabled people in Seoul (three hospitals and three clinics). The research was carried out targeting the hospitals and clinics to which Seoul City offers subsidies. The results of this research are as follows: First, the subsidy execution standards of the three rehabilitation hospitals and three rehabilitation clinics should be different. Although the ratio of labor cost was 60% in the hospitals, the ratio exceeded 80% in the clinics. Therefore there is a need for a subsidy payment method for the rehabilitation hospitals and clinics to be separately set Second, the standards applied by Seoul City for subsidy payment need to be complemented by referring to the rehabilitation hospital certification standards. Third, child rehabilitation frequency (aged 1- 19 years) is high in rehabilitation hospitals and clinics, compared to general hospitals and clinics. However outpatient treatment of child rehabilitation increases the need for subsidy support for both rehabilitation hospitals and clinics and the support size should be expanded due to low medical fees. Fourth, standards of subsidy support for medical r ehabilitation institutions for disabled people need to be devised. For rehabilitation treatment for patients with rare and incurable diseases, the quality improvement of rehabilitation medical service and public support expansion at public medial service level are urgently required. Lastly, subsidy execution standards should be set, based on the number of sickbeds and the average number of operated sickbeds during the daytime in hospitals, and effective operation rate needs to be applied. For clinics, proper medical treatment and rehabilitation treatment standards need to be presented. This research suggested the rehabilitation medical service specialized to three major disabilities (physical, brain, and developmental disabilities) found in the fact-finding survey.

장애인⋅노인을 위한 지역밀착형긴급지원패트롤 시범사업의 효과성과 향후 추진과제

정종화(Jeong Jong Hwa),최원희(Choi Won Hi),박선아(Park Sun A),이경준(Lee Kyong Jun),허수경(Heo Soo Kyung) 한국장애인재활협회 2015 재활복지 Vol.19 No.4

본 연구는 장애인⋅노인 등 사회취약계층을 위한 사회적보호의 강화를 통하여 복지사각지대 해소를 위한 긴급지원방안을 제시하고자 하는 것이다. 이 목적을 달성하기 위하여 현재 우리나라에서 처음으로 우체국 공익재단지원 사업으로 수행 된 “지역밀착형 장애인⋅노인을 위한 긴급지원 패트롤(Patrol)시범사업”의 서비스 대상자에게 설 문조사 및 집중인터뷰 FGI)를 실시하여, 시범사업의 효과성을 제시하고자 하였다. 연구결과, 서비스만족도 평가결과 15문항 75점 만점에 63.11점의 만족스러운 결과를 보였으며, 서비스 제공전담인력(간병인⋅사회복지사)을 대상으로 실시한 초점집단인터뷰(FGI)에서는 서비 스제공시간 및 서비스 제공기간 조정의 필요성이 제기되었으며, 이용자 특성에 따른 개별적 서비 스사정 결과의 반영, 24시간 연계지원시스템, 의료인력 배치를 통한 보건복지의료의 포괄적 케어 시스템의 필요성을 제시하였다.향후 추진과제로써 서비스 지역을 확대하고 긴급지원 콜 센터를 통합적으로 운영하고 응급의료및 재난, 긴급생활안전과의 연계망을 구축하여, 포괄적 국민생활안전시스템 모델(안)을 제시하였다. The purpose of this study is to suggest emergency assistance methods to eliminate welfare blind spot by fortifying social protection for social vulnerable groups like disabled and elderly. For this study, 203 people with disabilities and elderly population were asked to complete the surveys of service satisfaction about ommunity-based Emergency Assistance patrol Care Services. Service providers(personal assistant and social workers)were also asked questionaries through focused group interviews(FGI) that were executed to subjects of community-based emergency assistance patrol pilot project for disabled and elderly which was performed as first project of post office public foundation support in South Korea and intended to prove effectiveness of the project. This research study showed that people with disabilities and elderly people reported a high service satisfaction and rated an average score of 63.11(rated from 15 to 75). In focus group interviews(FGI), personal assistant and social workers suggested necessity of adjusting service provision period, and this service should be reflected an individual characteristics(people withdisabilities and elderly people). They also insisted the Korean government should be made the 24 hour linked support systems and comprehensive heal h and welfare service systems for people with disabilities and elderly people. Comprehensive national life safety system(draft) was suggested as the future initiative by means of expanding service area, operating integrated emergency assistance call center, and establishing linked networks of emergency medical treatment, disaster, and emergency life safety. The implications for social work practices and policies will be discussed.

바닥재의 차이가 신체자세동요에 미치는 영향

정종화(Jeong Jong-Hwa),허진강(Hur Jin-Gang),이주상(Lee Ju-Sang) 대한치료과학회 2010 대한치료과학회지 Vol.2 No.1

Objective: The aim of this research is to determine the influence of the difference of platforms on postural stability during standing for an adult target. Method: This research was conducted on 30 adult students from H University in Gangwon Province from April 2010 to July 2010. 3 different platforms were tested. Measurement tools used were the Tetrax Interactive Balance System to determine static balance, 7-item BBS-3P and the Functional Reach Test to determine dynamic balance. To determine the change in balance according to platform, ANOVA was used. Scheffe was used to determine the similarities in the 3 platforms. Results: The softer the platform, the smaller the static balance and dynamic balance (p<.05>). Blocking of vision also showed a decrease in static balance (p<.05>). The firm platform showed a larger decrease in dynamic balance compared to static balance, whereas soft platform showed a larger decrease in static balance over dynamic balance. Conclusion: This study reveals that high hardness is favorable to achieve safety. In the case that static balance is important, a soft platform should be selected. In the case that dynamic balance is important, a firm platform should be selected.

자폐성장애인의 지역사회 케어서비스 연구

정종화(Jeong, Jong Hwa),김용성(Kim, Yong Sung) 한국장애인재활협회 2014 재활복지 Vol.18 No.1

본 연구는 자폐성장애인 자녀의 양육과정 속에서 어머니가 경험한 지역사회 케어서비스의 필요성을 제시하는 현상학적 연구이다. 지역사회에서 양육과정의 어려움을 생애주기별로 신체, 심리, 교육, 관계, 경제, 사회제도 등으로 나누어 고찰하였으며, 연구의 대상은 자폐성장애자녀의 양육경험이 있는 5명의 어머니를 선택하였다. 연구결과는 첫째, 자폐성장애인 어머니의 경험을 중심으로 볼 때, 장애자녀의 출산과 조기개입을 통한 의료적 진단 및 판정, 전문상담 및 치료가 가능한 케어시스템이 필요하다는 것이다. 둘째, 자폐성장애인에게 있어서 케어서비스는 생애 전 과정에 걸쳐 제공되어야 하고, 그 케어서비스는 제도화된 서비스는 물론, 심리적, 대인적인 관계의 케어를 포함하여, 자폐성장애 부모가 자녀를 위하여 수행하는 모든 과정 속에 동반되는 케어를 의미한다. 따라서 자폐성장애인의 케어서비스는 생애주기별 돌봄 차원에서 보편적으로 제공되어야 하며, 장애발견의 조기개입 시스템구축, 학령기의 공교육서비스의 충실, 성인기의 자립생활과 취업지원이 케어서비스로서 구축되어야 한다. This is a phenomenological study which suggests the necessity of care service for autistic disabilities in a local community focused on mothers'experience of fostering autistic children. Considering each and different period of lifetime and the areas of physicality, psychology, education, relation, finance and social system, the in-depth interviews of five mothers of autistic children were done. In conclusion, first, the early care service system which enables the early intervention not only of medical diagnosis and evaluation but of counselling and treatment right after childbirth is needed. Second, for autistic disabilities, care service must be given in their lifetime. It does not simply mean personal assistance or personal aid. It is closely related with each and every activities of mothers for their children with autistic disabilities. Therefore, the future care service for autistic disabilities must be provided in their lifetime. In particular, the important thing in the stage of school age is that public education have to be given to all, and the care service for self-sufficient life of independent living and employment is needed to be systematically organized in the stage of adulthood.